The Open Ophthalmology Journal最新文献

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Teaching Ophthalmology for Machines. 机器眼科学教学。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-06-29 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010127
Thiago Gonçalves Dos Santos Martins, Maria Carolina Francisco Kuba, Thomaz Gonçalves Dos Santos Martins
{"title":"Teaching Ophthalmology for Machines.","authors":"Thiago Gonçalves Dos Santos Martins, Maria Carolina Francisco Kuba, Thomaz Gonçalves Dos Santos Martins","doi":"10.2174/1874364101812010127","DOIUrl":"https://doi.org/10.2174/1874364101812010127","url":null,"abstract":"In 1996, a survey conducted in Canada found that more than half of the curricula of medical schools in that country did not have a mandatory internship in ophthalmology [2]. In the United Kingdom, the average duration of medical curriculum of ophthalmology is 7.6 days, with 21% of medical schools not having compulsory education in ophthalmology [3]. The same could be true for nursing curriculum. Therefore, the resolution of all ophthalmological problems is concentrated in about 2% of trained physicians. In some countries, there is an aggravating factor including the unequal distribution of the medical doctors within the territory [4].","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"127-129"},"PeriodicalIF":0.3,"publicationDate":"2018-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36365034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Comparison of Dynamic Contour Tonometry and Non-contact Tonometry in Older Patients Presenting with Headache or Vision Loss. 动态等高线眼压测量与非接触式眼压测量在老年头痛或视力丧失患者中的比较。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-06-22 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010104
Edsel Ing, Angela Zhang, Evan Michaelov, Wendy Wang
{"title":"Comparison of Dynamic Contour Tonometry and Non-contact Tonometry in Older Patients Presenting with Headache or Vision Loss.","authors":"Edsel Ing,&nbsp;Angela Zhang,&nbsp;Evan Michaelov,&nbsp;Wendy Wang","doi":"10.2174/1874364101812010104","DOIUrl":"https://doi.org/10.2174/1874364101812010104","url":null,"abstract":"<p><strong>Background: </strong>Dynamic Contour Tonometry (DCT) is touted to be the most accurate tonometer for Intraocular Pressure (IOP) measurement. Non-Contact \"air puff\" Tonometry (NCT) may be the most commonly used tonometer for screening of IOP. Elevated IOP is important to exclude in patients presenting with headache or vision loss.</p><p><strong>Objective: </strong>To determine the agreement between DCT and NCT.</p><p><strong>Methods: </strong>The IOP of adult patients 50 years of age or older presenting with headache or vision loss for possible temporal artery biopsy were prospectively recorded. NCT and DCT measurements were obtained within thirty minutes. The right eye IOP measurements were compared with paired t-test, and Bland- Altman plot analysis. The left eye IOP measurements were subsequently analyzed for confirmation of results.</p><p><strong>Results: </strong>There were 106 subjects with complete right eye data, and 104 subjects with complete left eye data. The average age was 72 years, and 70% were female. The NCT IOP was on average 3.9 mm Hg lower in the right eye, and 3.5 mm Hg lower in the left eye compared with DCT. (p<.001) In the right eye the Bland-Altman analysis showed the 95% agreement interval between the two tonometers was -2.5 to 10.4 mmHg and in the left eye -3.0 to 9.9 mmHg.</p><p><strong>Conclusion: </strong>The IOP from NCT and DCT should not be used interchangeably because their level of disagreement includes clinically important discrepancies of up to 10 mm Hg.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"104-109"},"PeriodicalIF":0.3,"publicationDate":"2018-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36313768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Evaluation of Preloaded IOL Delivery System and Hydrophobic Acrylic Intraocular Lens in Cataract Surgery. 预载人工晶状体和疏水丙烯酸人工晶状体在白内障手术中的应用评价。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-06-14 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010094
Banu Acar, Isil M Torun, Suphi Acar
{"title":"Evaluation of Preloaded IOL Delivery System and Hydrophobic Acrylic Intraocular Lens in Cataract Surgery.","authors":"Banu Acar,&nbsp;Isil M Torun,&nbsp;Suphi Acar","doi":"10.2174/1874364101812010094","DOIUrl":"https://doi.org/10.2174/1874364101812010094","url":null,"abstract":"<p><strong>Background: </strong>Advancements in cataract surgery have necessitated the availability of intraocular lens preloaded delivery systems that can safely, effectively and predictably deliver IOLs in the eye. Preloaded delivery systems simplify and reduce procedural variability during surgery preparation.</p><p><strong>Objective: </strong>The objective of this study was to evaluate clinical acceptability, delivery characteristics and clinical outcomes in patients implanted with new generation hydrophobic acrylic Intraocular Lens with Preloaded delivery system.</p><p><strong>Methods: </strong>This was a single centre retrospective study. Total 41 patients were enrolled in the study to get at least 38 patients for evaluation. All patients were assessed on day1 and 1, 3 and 6 months after surgery.</p><p><strong>Results: </strong>EYECRYL-SERT showed 'excellent' ease of insertion and handling in all 41(100%) patients. Corrected Distance Visual Acuity (CDVA) improved from 0.74±0.58 logMAR during screening to 0.03±0.04 logMAR 6 months after surgery. The Corrected Intermediate Visual Acuity (CIVA) and Corrected Near Visual Acuity (CNVA) were 0.10±0.04 and 0.01±0.02 logMAR post 6 months surgery, respectively. The refractive spherical equivalence was -1.94±2.51 D during screening, which improved significantly (p=0.0018) to -0.21±0.47 D post 6 months surgery. The low and high contrast sensitivity was 0.06±0.06 and -0.05±0.06 logMAR after 6 months surgery, respectively. The endothelial cell loss was 5.67%, 7.22% and 9.75% at 1, 3, and 6 months after surgery, respectively, as compared to screening. None of the subjects reported any adverse event during the study period.</p><p><strong>Conclusion: </strong>The IOL delivery system (EYECRYL_SERT) provided desired delivery characteristics during cataract surgery and was effective in improving clinical outcomes in cataract patients.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"94-103"},"PeriodicalIF":0.3,"publicationDate":"2018-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6008983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36313767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Visual Outcomes and Higher Order Aberrations Following LASIK on Eyes with Low Myopia and Astigmatism. 低近视眼和散光LASIK术后的视力结果和高阶像差。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-05-31 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010084
Smita Agarwal, Erin Thornell, Chris Hodge, Gerard Sutton, Paul Hughes
{"title":"Visual Outcomes and Higher Order Aberrations Following LASIK on Eyes with Low Myopia and Astigmatism.","authors":"Smita Agarwal,&nbsp;Erin Thornell,&nbsp;Chris Hodge,&nbsp;Gerard Sutton,&nbsp;Paul Hughes","doi":"10.2174/1874364101812010084","DOIUrl":"https://doi.org/10.2174/1874364101812010084","url":null,"abstract":"<p><strong>Background: </strong>Laser-Assisted <i>in situ</i> Keratomileusis (LASIK) can induce corneal aberrations that can impact vision and patient satisfaction. Recent developments in laser technologies have helped minimise these aberrations.</p><p><strong>Objective: </strong>To assess the quality of vision and change in Higher-Order Aberrations (HOAs) following wavefront-optimized LASIK in low-myopic astigmatic patients.</p><p><strong>Methods: </strong>LASIK was performed on a total of 76 eyes in patients with myopia <4.0 D and cylinder <2.0 D using the WaveLight® EX500 excimer and FS200 femtosecond laser platform. Visual acuity, contrast sensitivity and HOAs were measured at 1 and 3 months postoperatively and compared to preoperative values. Subjective quality of vision was assessed pre- and postoperatively using a VF14 questionnaire.</p><p><strong>Results: </strong>Mean postoperative Spherical Equivalent (SE) was -0.09 ± 0.26 µm with 95% of patients within ± 0.5 D of attempted SE. Postoperative uncorrected distance visual acuity was 20/20 or better for 96% of patients. Contrast sensitivity increased against horizontal and vertical gratings at all spatial frequencies except for vertical gratings at 18 cycles/degree. Spherical aberration and total HOA increased by 0.085 µm and 0.13 µm respectively. The mean VF14 score increased from 89.2 ± 16.7% to 99 ± 1.4% postoperatively.</p><p><strong>Conclusion: </strong>LASIK performed using the WaveLight® EX500 excimer and WaveLight® FS200 laser platform provided improved contrast sensitivity and visual acuity with minimal introduction of HOAs, making it a suitable platform for low myopic astigmatic patients.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"84-93"},"PeriodicalIF":0.3,"publicationDate":"2018-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36305322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Reproducibility of Central Corneal Thickness Measurements in Normal Eyes Using the Zeiss Cirrus 5000 HD-OCT and Pentacam HR. 使用蔡司Cirrus 5000 HD-OCT和Pentacam HR测量正常眼睛中央角膜厚度的可重复性。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-05-18 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010072
Elmira Baghdasaryan, Xiwen Huang, Kenneth M Marion, Tudor C Tepelus, Homayoun Bagherinia, SriniVas R Sadda, Hugo Y Hsu
{"title":"Reproducibility of Central Corneal Thickness Measurements in Normal Eyes Using the Zeiss Cirrus 5000 HD-OCT and Pentacam HR.","authors":"Elmira Baghdasaryan,&nbsp;Xiwen Huang,&nbsp;Kenneth M Marion,&nbsp;Tudor C Tepelus,&nbsp;Homayoun Bagherinia,&nbsp;SriniVas R Sadda,&nbsp;Hugo Y Hsu","doi":"10.2174/1874364101812010072","DOIUrl":"https://doi.org/10.2174/1874364101812010072","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the repeatability and reproducibility of Central Corneal Thickness (CCT) measurements using two different anterior segment imaging modalities, including those obtained with the new anterior segment lens attachments for the Cirrus 5000 HD-OCT.</p><p><strong>Methods: </strong>A total of 32 eyes from 16 normal volunteers (8 male, 8 female) were enrolled in this prospective study. CCT was measured by the same examiner using the Cirrus 5000 HD-OCT and Pentacam HR. The results of CCT obtained by each method were averaged and compared using t-test analysis. The agreement between the measurement methods was evaluated. Coefficient of Repeatability (CoR) and Intra-Class Correlation Coefficient (ICC) were computed.</p><p><strong>Results: </strong>The mean measurements taken with the Cirrus OCT anterior chamber lens (CCT<sub>AC</sub>), HD cornea lens (CCT<sub>HDC</sub>) and pachymetry scans (CCT<sub>Pach</sub>) were 545.35 ± 31.02, 537.87 ± 26.82, and 532.04 ± 29.82 µm, respectively. The mean CCT obtained with the Pentacam (CCT<sub>Pent</sub>) was 545.51 ± 30.71 µm. CCT<sub>Pent</sub> were significantly higher than CCT<sub>HDC</sub> and CCT<sub>Pach</sub> (<i>p</i>< 0.0001). In contrast, the CCT<sub>Pent</sub> and CCT<sub>AC</sub> were similar (<i>p</i>=0.87). CCT, as evaluated by the two different instruments, showed excellent correlation (<i>r</i> > 0.98, <i>p</i>< 0.0001) with an ICC > 0.99 (95% CI, 0.97 - 0.99). CoR was the highest for CCT<sub>Pach</sub> (3.7 ± 1.4, 95% CI (3.0- 4.6)).</p><p><strong>Conclusion: </strong>CCT measurements from the Cirrus OCT using the new anterior segment lens attachments and the Pentacam HR are highly correlated. This should allow the use of a standardized correction factor if necessary to inter-relate the measurements between the two devices.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"72-83"},"PeriodicalIF":0.3,"publicationDate":"2018-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874364101812010072","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36196696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Outcomes of LASIK for Myopia or Myopic Astigmatism Correction with the FS200 Femtosecond Laser and EX500 Excimer Laser Platform. FS200飞秒激光和EX500准分子激光平台矫正近视或近视散光的LASIK疗效。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-05-18 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010063
Muanploy Niparugs, Napaporn Tananuvat, Winai Chaidaroon, Chulaluck Tangmonkongvoragul, Somsanguan Ausayakhun
{"title":"Outcomes of LASIK for Myopia or Myopic Astigmatism Correction with the FS200 Femtosecond Laser and EX500 Excimer Laser Platform.","authors":"Muanploy Niparugs,&nbsp;Napaporn Tananuvat,&nbsp;Winai Chaidaroon,&nbsp;Chulaluck Tangmonkongvoragul,&nbsp;Somsanguan Ausayakhun","doi":"10.2174/1874364101812010063","DOIUrl":"https://doi.org/10.2174/1874364101812010063","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy, predictability, stability and safety of laser in situ keratomileusis (LASIK) using the FS200 femtosecond laser and EX500 excimer laser platform.</p><p><strong>Methods: </strong>The outcomes of 254 eyes of 129 consecutive patients with myopia or myopic astigmatism who underwent full correction femtosecond laser-assisted LASIK at CMU LASIK Center were assessed. Pre-operative and post-operative parameters including manifest refraction, Uncorrected Distance Visual Acuity (UDVA), Best Corrected Distance Visual Acuity (BDVA), corneal topography and tomography were analyzed. The results between low to moderate myopia and high myopia were compared up to 12 months.</p><p><strong>Results: </strong>Mean pre-operative Spherical Equivalent (SE) was -5.15±2.41 Diopters (D) (range -0.50 to -11.50 D) and -0.13±0.28 D, -0.13±0.27 D, -0.13±0.28 D and -0.14±0.30 D at 1, 3, 6, and 12 months, post-operatively. At 12 months, the propor¬tion of eyes achieving UDVA ≥ 20/20 was 90.0% and ≥20/40 was 98.8%. The proportion of eyes achieving post-operative mean SE ±0.5 D, and ±1 D was 91.3%, and 98.5%. No eyes lost more than two lines of BDVA. The low to moderate myopic group had a statistically significant better UDVA at one (<i>p</i>=0.017) and three months (<i>p</i>=0.014) but no difference at six (<i>p</i>=0.061) and 12 months (<i>p</i>=0.091). The mean post-operative SE was better in low to moderate myopic group at every follow-up visit (<i>p</i>=0.001, 0.007, <0.001 and <0.001).</p><p><strong>Conclusion: </strong>One-year clinical results of LASIK with the FS200 femtosecond laser and EX500 excimer laser showed high efficacy, predictability, stability and safety.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"63-71"},"PeriodicalIF":0.3,"publicationDate":"2018-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36196695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Relative Proportion Of Different Types Of Refractive Errors In Subjects Seeking Laser Vision Correction. 寻求激光视力矫正的受试者中不同类型屈光不正的相对比例。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-04-30 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010053
Talal A Althomali
{"title":"Relative Proportion Of Different Types Of Refractive Errors In Subjects Seeking Laser Vision Correction.","authors":"Talal A Althomali","doi":"10.2174/1874364101812010053","DOIUrl":"https://doi.org/10.2174/1874364101812010053","url":null,"abstract":"<p><strong>Background: </strong>Refractive errors are a form of optical defect affecting more than 2.3 billion people worldwide. As refractive errors are a major contributor of mild to moderate vision impairment, assessment of their relative proportion would be helpful in the strategic planning of health programs.</p><p><strong>Purpose: </strong>To determine the pattern of the relative proportion of types of refractive errors among the adult candidates seeking laser assisted refractive correction in a private clinic setting in Saudi Arabia.</p><p><strong>Methods: </strong>The clinical charts of 687 patients (1374 eyes) with mean age 27.6 ± 7.5 years who desired laser vision correction and underwent a pre-LASIK work-up were reviewed retrospectively. Refractive errors were classified as myopia, hyperopia and astigmatism. Manifest refraction spherical equivalent (MRSE) was applied to define refractive errors.</p><p><strong>Outcome measures: </strong>Distribution percentage of different types of refractive errors; myopia, hyperopia and astigmatism.</p><p><strong>Results: </strong>The mean spherical equivalent for 1374 eyes was -3.11 ± 2.88 D. Of the total 1374 eyes, 91.8% (n = 1262) eyes had myopia, 4.7% (n = 65) eyes had hyperopia and 3.4% (n = 47) had emmetropia with astigmatism. Distribution percentage of astigmatism (cylinder error of ≥ 0.50 D) was 78.5% (1078/1374 eyes); of which % 69.1% (994/1374) had low to moderate astigmatism and 9.4% (129/1374) had high astigmatism.</p><p><strong>Conclusion and relevance: </strong>Of the adult candidates seeking laser refractive correction in a private setting in Saudi Arabia, myopia represented greatest burden with more than 90% myopic eyes, compared to hyperopia in nearly 5% eyes. Astigmatism was present in more than 78% eyes.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"53-62"},"PeriodicalIF":0.3,"publicationDate":"2018-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36196694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Transcriptome Analysis of Orbital Adipose Tissue in Active Thyroid Eye Disease Using Next Generation RNA Sequencing Technology. 利用新一代RNA测序技术对活动性甲状腺眼病眼眶脂肪组织进行转录组分析。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-04-16 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010041
Bradford W Lee, Virender B Kumar, Pooja Biswas, Audrey C Ko, Ramzi M Alameddine, David B Granet, Radha Ayyagari, Don O Kikkawa, Bobby S Korn
{"title":"Transcriptome Analysis of Orbital Adipose Tissue in Active Thyroid Eye Disease Using Next Generation RNA Sequencing Technology.","authors":"Bradford W Lee,&nbsp;Virender B Kumar,&nbsp;Pooja Biswas,&nbsp;Audrey C Ko,&nbsp;Ramzi M Alameddine,&nbsp;David B Granet,&nbsp;Radha Ayyagari,&nbsp;Don O Kikkawa,&nbsp;Bobby S Korn","doi":"10.2174/1874364101812010041","DOIUrl":"https://doi.org/10.2174/1874364101812010041","url":null,"abstract":"<p><strong>Objective: </strong>This study utilized Next Generation Sequencing (NGS) to identify differentially expressed transcripts in orbital adipose tissue from patients with active Thyroid Eye Disease (TED) <i>versus</i> healthy controls.</p><p><strong>Method: </strong>This prospective, case-control study enrolled three patients with severe, active thyroid eye disease undergoing orbital decompression, and three healthy controls undergoing routine eyelid surgery with removal of orbital fat. RNA Sequencing (RNA-Seq) was performed on freshly obtained orbital adipose tissue from study patients to analyze the transcriptome. Bioinformatics analysis was performed to determine pathways and processes enriched for the differential expression profile. Quantitative Reverse Transcriptase-Polymerase Chain Reaction (qRT-PCR) was performed to validate the differential expression of selected genes identified by RNA-Seq.</p><p><strong>Results: </strong>RNA-Seq identified 328 differentially expressed genes associated with active thyroid eye disease, many of which were responsible for mediating inflammation, cytokine signaling, adipogenesis, IGF-1 signaling, and glycosaminoglycan binding. The IL-5 and chemokine signaling pathways were highly enriched, and very-low-density-lipoprotein receptor activity and statin medications were implicated as having a potential role in TED.</p><p><strong>Conclusion: </strong>This study is the first to use RNA-Seq technology to elucidate differential gene expression associated with active, severe TED. This study suggests a transcriptional basis for the role of statins in modulating differentially expressed genes that mediate the pathogenesis of thyroid eye disease. Furthermore, the identification of genes with altered levels of expression in active, severe TED may inform the molecular pathways central to this clinical phenotype and guide the development of novel therapeutic agents.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"41-52"},"PeriodicalIF":0.3,"publicationDate":"2018-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36099245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Best Prophylactic Strategy in Groups at Risk of Intraoperative Floppy Iris Syndrome Development: Comparison Between Atropine Instillation and Adrenaline Intracameral Injection. 术中虹膜松弛综合征高危人群的最佳预防策略:阿托品滴注与肾上腺素眶内注射的比较。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-03-30 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010034
Raffaele Nuzzi, Paolo Arnoffi, Federico Tridico
{"title":"Best Prophylactic Strategy in Groups at Risk of Intraoperative Floppy Iris Syndrome Development: Comparison Between Atropine Instillation and Adrenaline Intracameral Injection.","authors":"Raffaele Nuzzi,&nbsp;Paolo Arnoffi,&nbsp;Federico Tridico","doi":"10.2174/1874364101812010034","DOIUrl":"https://doi.org/10.2174/1874364101812010034","url":null,"abstract":"<p><strong>Background: </strong>Intraoperative Floppy Iris Syndrome (IFIS) is an important cause of surgical complications and iris defects in patients undergoing phacoemulsification that were treated with selective subtype α1A receptor antagonists for a long period of time. To date, no definitive preventive strategy has emerged, yet. The need of prophylaxis is dictated by the high prevalence of males affected by benign prostatic hyperplasia undergoing cataract surgery.</p><p><strong>Objective: </strong>To identify the best prophylactic strategy in groups at risk of IFIS development by comparing two mydriatic treatments in course of phacoemulsification surgery.</p><p><strong>Methods: </strong>81 eyes of 81 patients in treatment with Tamsulosin were enrolled in the study. 43 eyes were treated with atropine sulfate 1% while 38 eyes received an injection of mydriatic solution containing epinephrine in the anterior chamber. All phacoemulsifications were videotaped in order to assess the occurrence of IFIS and the severity of the syndrome.</p><p><strong>Results: </strong>The treatment group showed a statistically significant reduction (p = 0.0115) of floppy iris syndrome incidence, from 86.05% (37/43) of the atropine group to 60.53% (23/38). The analysis showed a reduction of IFIS mild form only, whereas the incidence of severe forms remained unchanged.</p><p><strong>Conclusions: </strong>We believe that IFIS may arise through two different mechanisms: pharmacological antagonism and anatomical modifications. Patients suffering from mild forms of the disease showed a statistically significant reduction of IFIS incidence after intraoperative prophylaxis due to epinephrine's ability to displace Tamsulosin, resulting in the increase of iris tone when the disease is caused mainly by receptorial antagonism. On the contrary, prophylaxis does not deliver any valuable result in case of severe forms where the anatomical variations play a major role.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"34-40"},"PeriodicalIF":0.3,"publicationDate":"2018-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36099244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Higher Intraocular Pressure Levels Associated With Lower Hysteresis In Type 2 Diabetes. 高眼压水平与2型糖尿病低迟滞相关。
IF 0.3
The Open Ophthalmology Journal Pub Date : 2018-03-28 eCollection Date: 2018-01-01 DOI: 10.2174/1874364101812010029
Sinan Bekmez, Tolga Kocaturk
{"title":"Higher Intraocular Pressure Levels Associated With Lower Hysteresis In Type 2 Diabetes.","authors":"Sinan Bekmez,&nbsp;Tolga Kocaturk","doi":"10.2174/1874364101812010029","DOIUrl":"https://doi.org/10.2174/1874364101812010029","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the differences of corneal biomechanic characteristics using Ocular Response Analyzer (ORA, Reichert; USA) on type 2 diabetics and healthy subjects.</p><p><strong>Methods: </strong>One hundred eyes of 100 subjects (between the ages of 17-91) who applied to Adnan Menderes University's Ophthalmology Clinic between January-March 2015 were included in this study, 50 diabetics (Group 1) and 50 healthy controls (Group 2). The eyes included in the study were randomly chosen. Corneal Hysteresis (CH), Corneal Resistance Factor (CRF), Goldmann correlated Intraocular Pressure (IOPg) and corneal compensated Intraocular Pressure (IOPcc) of patients were measured by ORA. Detailed ophthalmological examinations were done for every subject. Kolmogorov-Smirnov test was used to analyze the distribution of quantitative variables and t test was used for the data that were normally distributed. Any p value <0.05 was considered as statistically significant.</p><p><strong>Results: </strong>The mean ages were 63.3±9.0 and 61.7±11.6 in Group 1 and 2, respectively (p=0.459). 25 (50.0%) were female, 25 (50.0%) were male in Group 1 and 26 (52.0%) were female, 24 (48.0%) were male in Group 2 (p=1.000). Mean IOPcc values were 17.8±3.6 (12.1-29.0) and 16.0±3.1 (10.9-23.8) mmHg (p=0.006); mean IOPg values were 16.9±3.5 (10.9-25.9) and 15.4±2.9 (9.0-24.7) mmHg (p=0.032); mean CH values were 9.9±1.5 (6.1-13.3) and 10.5±1.7 (6.5-15.7) (p=0.080) and mean CRF values were 10.4±1.6 (7.5-14.0) and 10.5±1.7 (6.6-15.4) (p=0.730) in Groups 1 and 2, respectively.</p><p><strong>Conclusions: </strong>There was no any statistical difference between the groups in terms of CH and CRF. However, mean CH and CRF values were found less in diabetic group. Corneal biomechanical differences seen in diabetic patients may be associated with a statistically significantly higher IOP measurements.</p>","PeriodicalId":512318,"journal":{"name":"The Open Ophthalmology Journal","volume":"12 ","pages":"29-33"},"PeriodicalIF":0.3,"publicationDate":"2018-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35999534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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