Statistics and Its Interface最新文献

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Rank-R matrix autoregressive models for modeling spatio-temporal data 用于时空数据建模的 Rank-R 矩阵自回归模型
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2024-02-01 DOI: 10.4310/23-sii812
Nan-Jung Hsu, Hsin-Cheng Huang, Ruey S. Tsay, Tzu-Chieh Kao
{"title":"Rank-R matrix autoregressive models for modeling spatio-temporal data","authors":"Nan-Jung Hsu, Hsin-Cheng Huang, Ruey S. Tsay, Tzu-Chieh Kao","doi":"10.4310/23-sii812","DOIUrl":"https://doi.org/10.4310/23-sii812","url":null,"abstract":"We develop a matrix-variate autoregressive (MAR) model to analyze spatio-temporal data organized on a regular grid in space. The model is an extension of the bilinear MAR spatial model of Hsu, Huang and Tsay $href{ https://doi.org/10.1080/10618600.2021.1938587 }{[10]}$ by increasing its flexibility and applicability in empirical applications. Specifically, we propose to model each autoregressive (AR) coefficient matrix of the MAR model by $R$ bilinear terms, thereby establishing a rank‑R model. The extension can be interpreted as decomposing the AR dynamics of the data into $R$ bilinear MAR components. We further incorporate a banded neighborhood structure for AR coefficient matrices and utilize a flexible nonstationary low-rank covariance model for the spatial innovation process, leading to a parsimonious model without sacrificing its flexibility. We estimate all parameters of the model by the maximum likelihood method and develop a computationally efficient alternating direction method of multipliers algorithm, involving only closed-form expressions in all steps. Applications to a wind-speed dataset and an employment dataset, as well as two simulation experiments, demonstrate the effectiveness of the proposed method in estimation, model selection, and prediction.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139659193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latent class proportional hazards regression with heterogeneous survival data 潜在类别比例风险回归与异质生存数据
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii785
Teng Fei, John J. Hanfelt, Limin Peng
{"title":"Latent class proportional hazards regression with heterogeneous survival data","authors":"Teng Fei, John J. Hanfelt, Limin Peng","doi":"10.4310/23-sii785","DOIUrl":"https://doi.org/10.4310/23-sii785","url":null,"abstract":"Heterogeneous survival data are commonly present in chronic disease studies. Delineating meaningful disease subtypes directly linked to a survival outcome can generate useful scientific implications. In this work, we develop a latent class proportional hazards (PH) regression framework to address such an interest. We propose mixture proportional hazards modeling, which flexibly accommodates class-specific covariate effects while allowing for the baseline hazard function to vary across latent classes. Adapting the strategy of nonparametric maximum likelihood estimation, we derive an Expectation-Maximization (E‑M) algorithm to estimate the proposed model. We establish the theoretical properties of the resulting estimators. Extensive simulation studies are conducted, demonstrating satisfactory finite-sample performance of the proposed method as well as the predictive benefit from accounting for the heterogeneity across latent classes. We further illustrate the practical utility of the proposed method through an application to a mild cognitive impairment (MCI) cohort in the Uniform Data Set.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frequentist Bayesian compound inference 频率贝叶斯复合推理
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii797
Jinfeng Xu, Ao Yuan
{"title":"Frequentist Bayesian compound inference","authors":"Jinfeng Xu, Ao Yuan","doi":"10.4310/23-sii797","DOIUrl":"https://doi.org/10.4310/23-sii797","url":null,"abstract":"In practice often either the Bayesian or frequentist method is used, although there are some combined uses of the two methods, a formal unified methodology of the two hasn’t been seen. Here we first give a brief review of the two methods and some combination of the two, then propose a procedure using both the frequentist likelihood and the Bayesian posterior loss in parameter estimation and hypothesis testing, as an attempt to unify the two methods. Basic properties of the proposed method are studied, and simulation studies are carried out to evaluate the performance of the method.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guiding light: An essay for Professor Lincheng Zhao on the occasion of his 80th birthday 指路明灯:赵林成教授八十大寿随笔
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/22-sii772
Zhidong Bai
{"title":"Guiding light: An essay for Professor Lincheng Zhao on the occasion of his 80th birthday","authors":"Zhidong Bai","doi":"10.4310/22-sii772","DOIUrl":"https://doi.org/10.4310/22-sii772","url":null,"abstract":"Lincheng Zhao was admitted to the Department of Applied Mathematics of the University of Science and Technology of China (USTC) in 1960, three years before me, and then took a year off due to illness and transferred to the entering class of 1961. We were both not good at socializing, so although we had been classmates for three years, we didn’t know each other. In 1978, when we were both admitted to the Department of Mathematics for graduate studies, we got to know each other. Since then, we have known each other, made friends, and helped each other in all aspects of research and life, and we have become good mentors and friends with each other. On the occasion of Professor Zhao’s 80th birthday, I would like to recall a little of the past events of our acquaintance and friendship to express my gratitude to Academic Elder Brother Zhao.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copy number variation detection based on constraint least squares 基于约束最小二乘的拷贝数变异检测
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii814
Xiaopu Wang, Xueqin Wang, Aijun Zhang, Canhong Wen
{"title":"Copy number variation detection based on constraint least squares","authors":"Xiaopu Wang, Xueqin Wang, Aijun Zhang, Canhong Wen","doi":"10.4310/23-sii814","DOIUrl":"https://doi.org/10.4310/23-sii814","url":null,"abstract":"Copy number variations (CNVs) are a form of structural variation of a DNA sequence, including amplification and deletion of a particular DNA segment on chromosomes. Due to the huge amount of data in every DNA sequence, there is a great need for a computationally fast algorithm that accurately identifies CNVs. In this paper, we formulate the detection of CNVs as a constraint least squares problem and show that circular binary segmentation is a greedy approach to solving this problem. To solve this problem with high accuracy and efficiency, we first derived a necessary optimality condition for its solution based on the alternating minimization technique and then developed a computationally efficient algorithm named AMIAS. The performance of our method was tested on both simulated data and two realworld applications using genomic data from diagnosed primal glioblastoma and the HapMap project. Our proposed method has competitive performance in identifying CNVs with high-throughput genotypic data.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of nonparametric regression methods for longitudinal data 纵向数据的非参数回归方法综述
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii801
Changxin Yang, Zhongyi Zhu
{"title":"A review of nonparametric regression methods for longitudinal data","authors":"Changxin Yang, Zhongyi Zhu","doi":"10.4310/23-sii801","DOIUrl":"https://doi.org/10.4310/23-sii801","url":null,"abstract":"Longitudinal data, which involve measuring a group of subjects repeatedly over time, frequently arise in many clinical and biomedical applications. To identify the complex patterns of change in the outcome and their association with covariates over time, a sufficiently flexible model is always required. Nonparametric regression, known for being data-adaptive and less restrictive than parametric approaches, becomes a promising tool for handling longitudinal data. This paper reviews various nonparametric regression methods for longitudinal data, including specific traditional nonparametric methods for the univariate case and several representative methods for the multivariate case, among which tree-based techniques are dominant. We summarize their motivations and provide a brief practical performance comparison of these methods in simulations, as well as discuss potential future research directions.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138542339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Aligning sample size calculations with estimands in clinical trials with time-to-event outcomes 将样本量计算与临床试验的估计与事件发生时间结果相一致
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii804
Yixin Fang, Man Jin, Chengqing Wu
{"title":"Aligning sample size calculations with estimands in clinical trials with time-to-event outcomes","authors":"Yixin Fang, Man Jin, Chengqing Wu","doi":"10.4310/23-sii804","DOIUrl":"https://doi.org/10.4310/23-sii804","url":null,"abstract":"The ICH E9(R1) guidance recommended a framework to align planning, design, conduct, analysis, and interpretation of any clincial trial with its objective and estimand. How to handle intercurrent events (ICEs) is one of the five attributes of an estimand and sample size calculation is a key step in the trial planning and design. Therefore, sample size calculation should be aligned with the estimand and, in particular, with how the ICEs are handled. ICH E9(R1) summarized five strategies for handling ICEs, and five approaches have been proposed in the literature for sample size calculation when planning trials with quantitative and binary outcomes. In this paper, we discuss how to apply the five strategies to deal with ICEs in clinical trials with time-to-event outcomes and propose five approaches for sample size calculation that are aligned with the five strategies, respectively.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nonparametric concurrent regression model with multivariate functional inputs 具有多元函数输入的非参数并发回归模型
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii782
Yutong Zhai, Zhanfeng Wang, Yuedong Wang
{"title":"A nonparametric concurrent regression model with multivariate functional inputs","authors":"Yutong Zhai, Zhanfeng Wang, Yuedong Wang","doi":"10.4310/23-sii782","DOIUrl":"https://doi.org/10.4310/23-sii782","url":null,"abstract":"Regression models with functional responses and covariates have attracted extensive research. Nevertheless, there is no existing method for the situation where the functional covariates are bivariate functions with one of the variables in common with the response function. In this article, we propose a nonparametric function-on-function regression method. We construct model spaces using a Gaussian kernel function and smoothing spline ANOVA decomposition. We estimate the nonparametric function using penalized likelihood and study properties of the Gaussian kernel function and the convergence rate of the proposed estimation method. We evaluate the proposed methods using simulations and illustrate them using two real data examples.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Robust and powerful gene-environment interaction tests using rare genetic variants in case-control studies 在病例对照研究中使用罕见的遗传变异进行稳健和强大的基因环境相互作用测试
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii800
Yanan Zhao, Hong Zhang
{"title":"Robust and powerful gene-environment interaction tests using rare genetic variants in case-control studies","authors":"Yanan Zhao, Hong Zhang","doi":"10.4310/23-sii800","DOIUrl":"https://doi.org/10.4310/23-sii800","url":null,"abstract":"Many association analysis methods have been developed to detect disease related rare genetic variants or gene-environment interactions. Most of them are based on prospectively likelihood, so they are robust but might not be powerful enough. On the other hand, retrospective likelihood based methods assuming gene-environment independence can effectively improve the association test power, but they suffer from type‑I error rate inflation if the independence assumption is violated. The aim of this paper is to develop novel test methods to balance power and robustness by appropriately weighting the above retrospective likelihood based tests and the existing prospective likelihood based tests. The desired finite sample performances of the proposed methods are demonstrated through simulation studies and the application to a real dataset.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymptotic properties of relative error estimation for accelerated failure time model with divergent number of parameters 参数数分散的加速失效时间模型相对误差估计的渐近性质
IF 0.8 4区 数学
Statistics and Its Interface Pub Date : 2023-11-27 DOI: 10.4310/23-sii816
Fei Ye, Hongyi Zhou, Ying Yang
{"title":"Asymptotic properties of relative error estimation for accelerated failure time model with divergent number of parameters","authors":"Fei Ye, Hongyi Zhou, Ying Yang","doi":"10.4310/23-sii816","DOIUrl":"https://doi.org/10.4310/23-sii816","url":null,"abstract":"The paper considers the problem of parameter estimation in the accelerated failure time model with divergent number of parameters under fixed design. We propose an estimator based on the general relative error criterion. We show that the proposed estimator is consistent and asymptotically normal under mild regular conditions. We also propose a variable selection procedure and show its oracle property as well as the consistency of model selection. Numerical studies have been conducted to compare the performance of different general relative error based estimators.","PeriodicalId":51230,"journal":{"name":"Statistics and Its Interface","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138525573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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