{"title":"Reflexive standardization and the resolution of uncertainty in the genomics clinic.","authors":"Adam Hedgecoe, Kathleen Job, Angus Clarke","doi":"10.1177/03063127231154863","DOIUrl":"10.1177/03063127231154863","url":null,"abstract":"<p><p>In genomics, the clinical application of Next Generation Sequencing technologies (such as Whole Genome or Exome Sequencing) has attracted considerable attention from UK policymakers, interested in the benefits such technologies could bring the National Health Service. However, this boosterism plays little attention to the challenges raised by a kind of result known as a Variant of Uncertain Significance, or VUS, which require clinical geneticists and related colleagues to classify ambiguous genomic variants as 'benign' or 'pathogenic'. With a rigorous analysis based on data gathered at 290 clinical meetings over a two-year period, this paper presents the first ethnographic account of decision-making around NGS technology in a NHS clinical genomics service, broadening our understanding of the role formal criteria play in the classification of VUS. Drawing on Stefan Timmermans' concept of 'reflexive standardisation' to explore the way in which clinical genetics staff classify such variants this paper explores the application of a set of criteria drafted by the American College of Medical Genetics and Genomics, highlighting the flexible way in which various resources - variant databases, computer programmes, the research literature - are drawn on to reach a decision. A crucial insight is how professionals' perception of, and trust in, the clinical practice at other genomics centres in the NHS, shapes their own application of criteria and the classification of a VUS as either benign or pathogenic.</p>","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 3","pages":"358-378"},"PeriodicalIF":2.9,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7614615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9713232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole C Nelson, Stefan Timmermans, Andrew Warwick, Zdeněk Konopásek, Russell E Vance, Wen-Hua Kuo
{"title":"On first reading Bruno Latour.","authors":"Nicole C Nelson, Stefan Timmermans, Andrew Warwick, Zdeněk Konopásek, Russell E Vance, Wen-Hua Kuo","doi":"10.1177/03063127231158086","DOIUrl":"https://doi.org/10.1177/03063127231158086","url":null,"abstract":"","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"174-179"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9263116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jorge Castillo-Sepúlveda, Francisco Tirado, Ana Gálvez
{"title":"Biopolitics and speculative objects in Chilean health projects.","authors":"Jorge Castillo-Sepúlveda, Francisco Tirado, Ana Gálvez","doi":"10.1177/03063127221136804","DOIUrl":"https://doi.org/10.1177/03063127221136804","url":null,"abstract":"<p><p>'Biopolitics' is a much-used concept in recent academic literature. One of its main fields of application is in the analysis of public health projects. This article analyses the national Explicit Health Guarantees project in Chile from that perspective. However, we criticize the standard invocation of 'biopolitics' by observing that such public health projects require technoscientific operations that establish truths and regimes of obligation for the groups involved -understanding regime both as a set of imposed orders and a set of regulated processes. Specifically, the Explicit Health Guarantees project defines what we call 'speculative objects'. These have two characteristics: (a) They relate highly diverse entities into integrated wholes that are and involve objects of knowledge and uncertainty, and (b) this integration creates regimes of obligation considered as scientific truths on many different groups. We conclude by proposing new questions about the notion of biopolitics and its relationship with uncertainty and speculation.</p>","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"194-212"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"On body-environment continuities from a laboratory commensalism.","authors":"Morana Alač","doi":"10.1177/03063127221136556","DOIUrl":"https://doi.org/10.1177/03063127221136556","url":null,"abstract":"<p><p>The article attends to everyday practices in a laboratory of neural genetics that studies olfaction, with the fruit fly as its model organism. Practices in neural genetics exhibit one of the 'post' aspects in post-genomic science - a turn to the environment. To get at how laboratory members engage body-environment continuities, I pay attention to an occasion of designing experimental chambers for an optogenetics study. As practitioners deal with the body's continuities with the world by engaging the spatial character of olfaction, their accounts exhibit qualities of feelings of immediate experience, relatable to C.S. Peirce's phenomenological category of Firstness. While these traces of Firstness inevitably manifest themselves in mixtures with the other two of Peirce's categories - namely, Secondness and Thirdness - noticing them allows for an engagement of the environment that goes beyond action and meaning. I reflect on that environment by considering the involvement of scientists' bodies in life with flies, while not forgetting my inhabitation of the laboratory space. Rather than relying on a cross-mapping of attributes known from the human sphere (intentional states or features of the human body) while managing a measurable space observed from the outside, this is an environment lived from within and with others. I conclude the article by proposing its noticing as an orientation toward ecological preoccupations.</p>","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"242-270"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seven moments with Bruno Latour.","authors":"Noortje Marres","doi":"10.1177/03063127231159852","DOIUrl":"https://doi.org/10.1177/03063127231159852","url":null,"abstract":"","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"188-193"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/05/10.1177_03063127231159852.PMC10041569.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9632243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercises in irreduction: Some Latourian favourites.","authors":"Casper Bruun Jensen","doi":"10.1177/03063127231156649","DOIUrl":"https://doi.org/10.1177/03063127231156649","url":null,"abstract":"In the days after Bruno Latour passed away, many scholars celebrated his life by sharing lists of their favourite pieces of his. These primarily featured Latour’s newer works and well-known books, but almost none of the minor writings that first enamoured me with him some decades ago. In the spur of a moment, I shared a list on Twitter of my favourite lesser-known texts, which I expand on here. If a single word was to capture what I found so appealing about those older pieces, it would be irreduction: the insistence, as Latour wrote in the manifesto that back ended The Pasteurization of France, that ‘nothing is, by itself, either reducible or irreducible to anything else’ (Latour, 1988a, p. 158). So, without further ado, a few exercises in irreduction. ‘Unscrewing the Big Leviathan: How Actors Macro-Structure Society and How Sociologists Help Them to Do So’ made Thomas Hobbes’ political philosophy central to ANT. But the French electric car—a new and barely existing environmental technology in the 1970s—pushed Callon and Latour (1981) to redefine his Leviathan to make it possible to imagine a society without fixed scales. They called the essay a ‘teratology’; a term normally reserved for the medical study of abnormal bodily developments or monsters. Why did innovations in electric vehicles half a century ago require a teratology? Because Electricity of France, the state-owned utility company, had to imagine and shape heterogeneous relations for an entire world—including everything from technical models to new green subjects, changing economic systems to battery components—where the not-yet-existing electric vehicles would fit like hand in glove. Meanwhile, the carmaker Renault clearly understood that this brave new world would pose an existential threat to the already existing one, home to its gas-guzzling machines. Hence, it spared no effort to identify and undermine the weakest links in the world under construction.","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"183-187"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The sense of meaninglessness in bureaucratized science.","authors":"Mariusz Finkielsztein, Izabela Wagner","doi":"10.1177/03063127221117227","DOIUrl":"https://doi.org/10.1177/03063127221117227","url":null,"abstract":"<p><p>Looking at scientists (in the life sciences), we focus on the sense of meaninglessness associated with bureaucratization. We define the sense of meaninglessness as a perception of meaning deficit or meaning conflict in particular situations that can be associated with frustration, irritation, and/or boredom. We show that it can be caused by identity disturbance - particularly the incongruence between the ideal self as a researcher and the imposed self as a bureaucrat. We claim that the sense of meaninglessness is more likely to emerge in those activities that are further from an individual's core identity, and more identity work is needed to make them meaningful. We also claim that processes of rationalization imposed by external agendas, particularly transitions from substantive to formal rationality (predictability, control and calculability, efficiency) contribute to the proliferation of meaninglessness in academia. The sense of meaninglessness is, therefore, ignited by the external forces colonizing academic life and constitutes an instance of the 'irrationality of rationality'. It is an outcome or side effect of the collision between two incompatible logics of practice: bureaucratic and scientific. To show the incongruence of those competing logics, we analyze the data derived from a mixed-method study conducted between 2013 and 2014 among beneficiaries of an international research grant project. As a supplementary source of reference, we use our research on academic boredom and laboratory scientists' work and careers.</p>","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"271-286"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9315871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Actor Network Theory, Bruno Latour, and the CSI.","authors":"Madeleine Akrich","doi":"10.1177/03063127231158102","DOIUrl":"https://doi.org/10.1177/03063127231158102","url":null,"abstract":"When Nicole Nelson asked me to write a short piece on Latour and my work with him and Michel Callon articulating Actor Network Theory, I have to admit that I was a bit embarrassed, because this is not really how I remember my first years at the Centre de Sociologie de l’Innovation (CSI). When I arrived at the end of 1983, Bruno Latour had been there at Michel Callon’s invitation for a year, but they had begun their collaboration a few years earlier. They were attempting to evangelize the French social sciences to the emerging field of STS, chiefly by translating and publishing several collections of articles on the history and sociology of science and the history of technology from journals such as Social Studies of Science and Technology and Culture (Callon & Latour, 1982, 1985; Latour, 1985). Their proselytizing did not meet much success, but these collections became canonical for the young researchers transiting through CSI. They had also published their article on Leviathan, which proposed nothing less than to re-found sociology on a new basis (Callon & Latour, 1981). However, I did not feel—nor do I think others felt—that we were participating in the elaboration of a theory, at least not in the sense of a more or less closed set of hypotheses and concepts aimed at proposing an explanation of certain phenomena, let alone of the entire world. What we shared was rather something like a way of looking at and describing the world: a kind of a priori agnosticism as to the nature and intensity of the forces at work, and an equal attention to humans and non-humans (according to the established expressions of the time). Moreover, it did not arouse so much astonishment or discussion, in contrast to the outraged reactions of some outside researchers. The reason for this may be that, at the time, those who landed at the CSI came from a wide variety of backgrounds: engineering, history, business schools, development studies, urban planning; in","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"169-173"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9617363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The art of ignoring others' work among academics: A guessing game model of scholarly information search.","authors":"Mikhail Sokolov","doi":"10.1177/03063127221119808","DOIUrl":"https://doi.org/10.1177/03063127221119808","url":null,"abstract":"<p><p>Why do scholars pay attention to some works, but not others? This article explores a theoretical model in which scholars search the literature to make sure that their findings are new to their immediate audience. Within the present model, individuals easily disregard literatures of which their audiences are probably unaware. Institutionally organized audiences thus serve as enforcers of the information search. Their members may tacitly collaborate in maintaining unawareness of intellectual developments outside of their common attention space. This model allows us to explain phenomena on which earlier models fail - for example why academics sometimes ignore apparently relevant sources of information or how groups of scholars turn into bubbles, censoring information about findings made in the outside world.</p>","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"300-312"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9261502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Luck and the 'situations' of research.","authors":"Sarah R Davies, Bao-Chau Pham","doi":"10.1177/03063127221125438","DOIUrl":"https://doi.org/10.1177/03063127221125438","url":null,"abstract":"<p><p>This research note uses material from interviews with senior scholars in the natural sciences to highlight, and start to explore, the role and nature of 'luck' in scientific careers. By examining this in the context of STS work on the nature of contemporary academia, we argue for the importance of taking luck seriously as we interrogate life and work in research.</p>","PeriodicalId":51152,"journal":{"name":"Social Studies of Science","volume":"53 2","pages":"287-299"},"PeriodicalIF":3.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/05/10.1177_03063127221125438.PMC10041570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9262755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"社会学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}