Medicinski Glasnik最新文献_第9页

Tibiotalocalcaneal arthrodesis in a rare case of tuberculosis of the talus. 一例罕见的距骨结核病人的胫骨-踝关节置换术。

Medicinski Glasnik Pub Date : 2024-02-01 DOI: 10.17392/1699-23

Chiara Comisi, Tommaso Greco, Michele Inverso, Antonio Mascio, Chiara Polichetti, Marco Barbaliscia, Vincenzo La Vergata, Massimiliano Mosca, Silvio Caravelli, Nicola Mondanelli, Elisa Troiano, Giulio Maccauro, Carlo Perisano

引用次数: 0

Correlation of localization and size of the parathyroid glands by ultrasound and intraoperative findings in hyperparathyroidism. 甲状旁腺功能亢进症患者甲状旁腺超声定位和大小与术中发现的相关性

Medicinski Glasnik Pub Date : 2024-02-01 DOI: 10.17392/1639-23

Almedina Ramaš, Sabrina Uščuplić, Šekib Umihanić, Hasan Altumbabić, Almir Salkić, Merima Kasumović

{"title":"Correlation of localization and size of the parathyroid glands by ultrasound and intraoperative findings in hyperparathyroidism.","authors":"Almedina Ramaš, Sabrina Uščuplić, Šekib Umihanić, Hasan Altumbabić, Almir Salkić, Merima Kasumović","doi":"10.17392/1639-23","DOIUrl":"https://doi.org/10.17392/1639-23","url":null,"abstract":"Aim To determine a correlation between the localization of the parathyroid gland (PTG), based on ultrasound (US) examination and the operative findings, as well as the correlation between the size of the parathyroid glands measured by ultrasonography (USG) with pathological findings+, and prevalence of enlarged parathyroid glands in various forms of hyperparathyroidism. Methods A total of 83 patients with hyperparathyroidism who had undergone parathyroidectomy over a period of seven years were included in the study. US examinations of the neck and scintigraphy were performed before surgery in 83 and 42 patients, respectively. In the pathohistological analysis, in addition to diagnosis, the size and weight of the parathyroid gland were measured. Results US examination revealed 125 enlarged parathyroid glands and two normal-sized glands. Scintigraphy revealed 52 enlarged and three normal-sized parathyroid glands. Enlarged parathyroid glands were more frequently found in the projection of the lower pole thyroid glands. A significantly higher number of enlarged upper parathyroid glands were found by the operative findings than by US. There was no statistically significant difference in the diagnosis of enlarged parathyroid glands in all three forms of hyperparathyroidism. There was a positive correlation between the size of the parathyroid glands obtained by US and the size of the operative finding (κ=0.51; p=0.00 and p<0.0005, respectively). The relationship between parathyroid gland size measured by ultrasound and pathological analysis showed a positive correlation. Conclusion Ultrasound was useful in evaluating enlarged parathyroid glands, especially in combination with scintigraphy.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"45-51"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphometric analysis of clinically significant parameters of the main trunk of the left coronary artery. 左冠状动脉主干临床重要参数的形态学分析。

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1566-23

Almira Lujinović, Lejla Dervišević, Zurifa Ajanović, Dina Kapić, Azra Metović, Esad Ćosović, Maida Šahinović, Jasmin Mušanović, Jelena Kovačević-Prstojević, Esad Pepić

{"title":"Morphometric analysis of clinically significant parameters of the main trunk of the left coronary artery.","authors":"Almira Lujinović, Lejla Dervišević, Zurifa Ajanović, Dina Kapić, Azra Metović, Esad Ćosović, Maida Šahinović, Jasmin Mušanović, Jelena Kovačević-Prstojević, Esad Pepić","doi":"10.17392/1566-23","DOIUrl":"https://doi.org/10.17392/1566-23","url":null,"abstract":"Aim To determine the value of angles between the left coronary artery main trunk (LMT) and its branches, the anterior interventricular branch (LAD) and the circumflex branch (CX), and their possible relationship with the LMT length. Methods A total of 29 cadaveric hearts were used. The left coronary artery and its branches were dissected. The hearts were then classified according to the number of branches. The LMT length was measured with a digital gauge, and the LAD-CX angle, LMTLAD angle and LMT-CX angle with a manual goniometer. Results The average value of the LMT length was 9.0 mm (6.0-13.5). In 20 (68.97%) samples, the LMT was divided into two terminal branches. There was no statistically significant difference (p=0.321) in LMT length between the hearts with a bifurcation and without it. The average value of the LAD-CX angle was 89.0⁰ (74.5-93.0), with a statistically significant difference (p=0.020) comparing to hearts with trifurcation. The mean value of the LMT-LAD angle was 30.83±9.23⁰ and it was significantly lower (p=0.006) in the group of hearts with bifurcation compared to the group with trifurcation of the main trunk. Conclusion The LMT length shows great variability and is not related to the LAD-CX, LMT-LAD or the LMT-CX angle. Knowledge of the left coronary variation is essential in order to avoid misinterpretation of arteriogram.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9509331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone healing during electrostimulation. 在电刺激过程中骨愈合。

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1602-23

Yurii Bezsmertnyi, Viktor Shevchuk, Yankai Jiang, Olena Shevchuk

{"title":"Bone healing during electrostimulation.","authors":"Yurii Bezsmertnyi, Viktor Shevchuk, Yankai Jiang, Olena Shevchuk","doi":"10.17392/1602-23","DOIUrl":"https://doi.org/10.17392/1602-23","url":null,"abstract":"Aim To investigate the effect of direct epineural electrical stimulation of the nerve on the nature of reparative processes in the bone stump. Methods Three series of experiments were carried out with amputation of the thigh in the middle third and muscle plasty. In the 1st and 2nd experimental series a perineural catheter was brought to the stump of the sciatic nerve, through which mechanical irritation of the nerve was performed for 20 days daily for 20 minutes. In the 2nd series, an electrode was added to the nerve and epineural electrical stimulation was performed daily for 20 days. Animals of the 3rd series served as control. The observation periods were 1, 3, 6 months. Histological research method with filling vessels with ink-gelatin mixture was applied. Results In the 1st series, there was a sharp distortion of the reparative process, which consisted of a violation of microcirculation, changes in shape, resorption of the cortical diaphyseal plate, fractures, deformations. In most experiments of the 2nd series, organotypic stumps were formed with normalization of microcirculation. In the 3rd series, results of the formation of the stump were better than in the 1st, but worse than in the 2nd series. Conclusions Painful nerve irritation after amputation leads to a significant disturbance of microcirculation and reparative regeneration at the end of the bone stump with the development of pathological restructuring of bone tissue. Electrostimulation of the nerve improves microcirculation and reparative regeneration of the bone tissue.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secretome of hypoxia-preconditioned mesenchymal stem cells enhance the expression of HIF-1a and bFGF in a rotator cuff tear model. 在肩袖撕裂模型中，缺氧预处理间充质干细胞分泌组增强HIF-1a和bFGF的表达。

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1605-23

Meiky Fredianto, Herry Herman, Yoyos Dias Ismiarto, Agung Putra, Iffan Alif, Nur Dina Amalina, Muhammad Ariq Nazar

{"title":"Secretome of hypoxia-preconditioned mesenchymal stem cells enhance the expression of HIF-1a and bFGF in a rotator cuff tear model.","authors":"Meiky Fredianto, Herry Herman, Yoyos Dias Ismiarto, Agung Putra, Iffan Alif, Nur Dina Amalina, Muhammad Ariq Nazar","doi":"10.17392/1605-23","DOIUrl":"https://doi.org/10.17392/1605-23","url":null,"abstract":"Aim To determine the effect of secretome hypoxia mesenchymal stem cells (SH-MSCs) on the relative gene expression of hypoxia inducible factor-1a (HIF-1a) and basic fibroblast growth factor (bFGF) in accelerating histomorphometric repair of tendon to bone interface healing in rats acute rotator cuff tear (RCT) model. Methods This is experimental research with posttest control group design. Thirty-male Wistar rats were divided into five treatment groups: healthy group and rotator cuff reconstruction group included four groups: SH-MSCs W2 (the treatment group was given a SH-MSCs 0.5 mL and terminated at weeks 2), NaCl W2 (the control vehicle group was given NaCl 0.5 mL and terminated at weeks 2), SH-MSCs W8 (the treatment group was given a SH-MSCs 0.5 mL and terminated at weeks 8), and NaCl W8 (the control vehicle group was given NaCl 0.5 mL and terminated at weeks 8). On the termination day, all the rats were terminated and HIF-1a and bFGF gene expression were analysed using qRT-PCR. Results SH-MSCs significantly increased the HIF-1a and bFGF gene expression than NaCl group even in week 2 and week 8. The highest increased gene expression of HIF-1a and bFGF was on week 8. Conclusion SH-MSCs are important in the healing repair process of tendon-to-bone interface in acute RCT model rats through increasing gene expression of HIF-1α and bFGF.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10138294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between brain-derived neurotrophic factor serum levels with the severity of melasma. 血清脑源性神经营养因子水平与黄褐斑严重程度的关系。

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1581-23

Putri Astrid Novianti Nazli, Ariyati Yosi, Khairina Nasution

{"title":"Relationship between brain-derived neurotrophic factor serum levels with the severity of melasma.","authors":"Putri Astrid Novianti Nazli, Ariyati Yosi, Khairina Nasution","doi":"10.17392/1581-23","DOIUrl":"https://doi.org/10.17392/1581-23","url":null,"abstract":"Aim To determine the relationship between brain-derived neurotrophic factor (BDNF) levels and the severity of melasma. Methods This cross-sectional analytic study included consecutive patients from the Dermatology and Venereology Polyclinic at Prof. dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara (Prof. dr. CPL USU) Hospital Medan from May to December 2022. Serum BDNF levels and the severity of melasma were analysed using the Kruskal-Wallis test. Results Of the total of 30 patients enrolled in the study, the majority were in the age group of 36-45 (average of 44) years and work as housewives. The highest risk factor was sun exposure. The melasma pattern was dominated by centrofacial patterns, majority of melasma types were epidermal, and the most severe degree was moderate. A moderate negative correlation between BDNF levels and the duration of melasma was found (p=0.007; r= -0.485). There was no significant relationship between BDNF levels and the severity of melasma (p=0.387). Conclusion No significant relationship between BDNF levels and the severity of melasma indicates that the causes of melasma are multifactorial, such as sun exposure, genetic, hormonal, and other factors (drugs, neural and psychological, and lipid metabolism).","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":"202-206"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10004507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of mesenchymal stem cells in allergic rhinitis and its relationship with IL-10, plasma cells and regulatory T cells. 间充质干细胞在变应性鼻炎中的作用及其与IL-10、浆细胞和调节性T细胞的关系

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1541-23

Delfitri Munir, Iqbal Pahlevi Nasution, Lia Restimulia, Agung Putra, Nur Dina Amalina

{"title":"The role of mesenchymal stem cells in allergic rhinitis and its relationship with IL-10, plasma cells and regulatory T cells.","authors":"Delfitri Munir, Iqbal Pahlevi Nasution, Lia Restimulia, Agung Putra, Nur Dina Amalina","doi":"10.17392/1541-23","DOIUrl":"https://doi.org/10.17392/1541-23","url":null,"abstract":"Aim Allergic rhinitis (AR) is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs), plasma cells and inflammatory cytokines have shown to play a critical role in allergic airway inflammation. The aim of the study was to investigate the role of mesenchymal stem cells (MSCs) in generating Treg cells and plasma cells associated with regulating interlukin-10 (IL-10) in AR model. Methods Fifteen male Wistar rats (6 to 8 weeks old) were randomly divided into three groups (control group, sham group, and MSCs treatment group). Ovalbumin (OVA) nasal challenge was conducted daily from day 15 to 21, and MSCs (1x106) were administrated intraperitoneally to OVA-sensitized rats on day 21. Sneezing was observed from day 24 to 27. The rats were sacrificed on day 24 and day 27. The expression of Treg and plasma cells was analysed by flow cytometry assay. The level of IL-10 was analysed under ELISA assay. Results This study showed that the percentage of sneezing and rubbing times significantly decreased in MSCs treatment associated with the regulation of IL-10 level and plasma cell. This finding was aligned with the significant increase of Treg level. Conclusion MSCs administration regulates IL-10 and plasma cell-mediated immune and inflammatory responses while increasing Treg cell production. MSCs may be a promising therapeutic target for treating Treg-mediated allergic diseases.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":"175-180"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10016136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung cancer screening in the healthcare system of Bosnia and Herzegovina. 波斯尼亚和黑塞哥维那医疗保健系统的肺癌筛查。

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1583-23

Larisa Gavran, Gina Fatahi, Maja Račić

引用次数: 0

Correlation between signal transducer and activator of transcription 1 (STAT 1), vascular endothelial growth factor (VEGF), and signal to noise ratio (SNR) value in otoacoustic emission (OAE) examination on organ of Corti cochlea due to cisplatin. 顺铂所致耳蜗耳声发射(OAE)检测信号换能器和转录激活因子1 (STAT 1)、血管内皮生长因子(VEGF)与信噪比(SNR)值的相关性

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1554-23

Nelfi Disya Amalia Lubis, Tengku Siti Hajar Haryuna, Khalisanni Khalid, Rahadian Zainul

{"title":"Correlation between signal transducer and activator of transcription 1 (STAT 1), vascular endothelial growth factor (VEGF), and signal to noise ratio (SNR) value in otoacoustic emission (OAE) examination on organ of Corti cochlea due to cisplatin.","authors":"Nelfi Disya Amalia Lubis, Tengku Siti Hajar Haryuna, Khalisanni Khalid, Rahadian Zainul","doi":"10.17392/1554-23","DOIUrl":"https://doi.org/10.17392/1554-23","url":null,"abstract":"Aim To assess the cochlear damage caused by cisplatin in the rat cochlea based on decreased signal to noise ratio (SNR) values on otoacoustic emission (OAE) examination and increased expression of signal transducer and activator of transcription 1 (STAT 1) and vascular endothelial growth factor (VEGF) on immunohistochemical examination. Methods Twenty-four Rattus norvegicus were divided into 4 groups and injected with 8 mg/kgBW of cisplatin intraperitoneally except for control group. The SNR on OAE examination were checked before the treatment and on day 3, 4, and 7 after the treatment. The cochleas were stained immunohistochemically, followed by assessment of the cochlear organ of Corti damage based on STAT 1 and VEGF expression. Results A decrease in the mean of SNR value was found in accordance with the length of cisplatin exposure. The STAT 1 and VEGF expression increased with duration of cisplatin exposure. A correlation was found between SNR values, STAT 1, and also VEGF expression (p<0.05). Conclusion An increase of STAT 1 and VEGF expression influences cochlear damage due to cisplatin administration. There was a correlation between STAT 1 and VEGF expression with SNR values in the cochlear organ of Corti of Rattus norvegicus exposed to cisplatin.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9241763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of two fixation methods on blood loss in patients with trochanteric fracture: dynamic hip screw vs. proximal femoral nail anti-rotation. 两种固定方法对转子骨折患者失血量的影响:动力髋螺钉与股骨近端防旋钉。

Medicinski Glasnik Pub Date : 2023-08-01 DOI: 10.17392/1616-23

Mirza Sivro, Faruk Lazović, Ðemil Omerović, Adnan Papović

{"title":"The effects of two fixation methods on blood loss in patients with trochanteric fracture: dynamic hip screw vs. proximal femoral nail anti-rotation.","authors":"Mirza Sivro, Faruk Lazović, Ðemil Omerović, Adnan Papović","doi":"10.17392/1616-23","DOIUrl":"https://doi.org/10.17392/1616-23","url":null,"abstract":"Aim The two most commonly used implants for treatment of trochanteric fractures are the dynamic hip screw (DHS) and proximal femoral nail antirotation (PFNA). The aim of this study was to evaluate blood loss in patients with trochanteric fracture treated with DHS or PFNA. Methods This retrospective comparative study included 61 patients with trochanteric fracture, who were divided according to a surgical method into DHS and PFNA groups. In the PFNA group, a short third generation gamma-nail was used for osteosynthesis (Supernail GT, Lima Corporate, Italy), and in the DHS group a dynamic hip screw was used (Synthes, Oberdorf, Switzerland). Complete blood count with haemoglobin and haematocrit values was taken preoperatively and on the first day postoperatively and a number of red blood cell transfusions (RBC) were evaluated. Electronic medical records from 2022 were used to collect patient data. Results There were no significant differences in terms of gender and age between the groups (p=0.510 and p=0.087, respectively), as well as in the fracture type distribution (p=0.886). The duration of postoperative hospitalisation was similar between the groups (p=0.643). There was no statistically significant association between the number of RBC transfusions and fixation method (p=0.091), as well as in postoperative haemoglobin and haematocrit levels between the groups (p=0.180 and p=0.225, respectively). Conclusion Both DHS and PFNA implants are safe surgical techniques for the treatment of trochanteric fractures, with similar blood loss, number of blood transfusions and hospital stay.","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"20 2","pages":"249-254"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10016134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0