{"title":"Prediction of pulmonary embolism and its complication in diabetes mellitus type 2: a 5-year retrospective study.","authors":"Jasmina Bošnjić","doi":"10.17392/1673-23","DOIUrl":"https://doi.org/10.17392/1673-23","url":null,"abstract":"<p><p>Aim To investigate the association between type 2 diabetes mellitus (T2DM) and pulmonary embolism, as well as to determine the prognostic value of troponin, D-dimer, prothrombotic, and proinflammatory markers in patients with T2DM. Methods The retrospective cohort study included 305 patients with pulmonary embolism, divided into two groups: the first group with type 2 diabetes mellitus (n=165) and the control group without type 2 diabetes mellitus (n=140). Data were collected from May 2018 to May 2023. In all patients the following parameters were analysed: anthropometric parameters, laboratory parameters (troponin, D-dimer, CRP, fibrinogen, uric acid, glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides), arterial blood pressure, antiphospholipid antibodies, HOMA-IR index, CT angiography of the pulmonary artery, rate of adverse clinical events in pulmonary embolism (need for inotropic catecholamine support, fibrinolysis, cardiopulmonary resuscitation) and the rate of intrahospital mortality from pulmonary embolism. Results Patients with T2DM had elevated troponin, D-dimer, CRP, uric acid, fibrinogen, HOMA-IR and more severe clinical complications with higher mortality rates within 10 days of hospital admission. Significant predictors of PE in T2DM patients were found. Patients with pulmonary embolism in T2DM had a 4.38 times higher chance of death compared to patients with pulmonary embolism without T2DM. Conclusions Troponin, D-dimer, prothrombotic, and proinflammatory markers have good prognostic value for short-term outcomes in PE among patients with T2DM.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"36-44"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The assessment of Spondyloarthritis International Society Health Index (ASAS HI) in patients with spondyloarthritis - a single centre experience.","authors":"Maida Skokić, Almira Ćosićkić, Adin Alić","doi":"10.17392/1676-23","DOIUrl":"https://doi.org/10.17392/1676-23","url":null,"abstract":"<p><p>Aim The Assessment of Spondyloarthritis International Society Health Index (ASAS HI) Croatian version was used to assess health and functioning of patients with spondyloarthritis (SpA) covering aspects of physical, emotional and social functioning. Methods A cross sectional study was conducted at the Clinic for Internal Diseases Tuzla from January to June 2021. Inclusion criteria: fulfilled the ASAS diagnostic criteria for SpA. Exclusion criteria: failure to fulfil the diagnostic criteria, acute infection, the use of antibiotics in the past month, malignancy, associated disorders, psychiatric disorders, pregnancy, patient's refusal to take part in the study. The Disease Activity Score with C reactive protein values (ASDAS-CRP) was assessed. Results Eighty three patients (43 male and 40 female) fulfilled the study criteria with median age of 54 years. The median value of ASDAS-CRP was 2.15, since ASAS HI had the median of 8 (interquartile range; IQR: 2-13) points. Patients with inactivity and with low disease activity had the ASAS HI median of 2 (IQR: 0-6) and 5 (IQR: 1-9) points, respectively. Significantly higher values of ASAS HI were found in patients with moderate and high disease activity, males (13.5 and 16) and females (13 and 14), respectively. The correlation between ASDAS-CRP and ASAS HI, (r=0.62; p<0.0009) was positive, statistically significant. However, the significant correlation between disease duration and ASAS HI values was not found (r=0.11; p=0.28). Conclusion The ASAS HI, Croatian version, is valid and reliable disease specific questionnaire for the assessment of health status in patients with SpA in the Bosnian speaking area.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"118-125"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deflazacort and Nevridol 800 to prevent acute carpal tunnel syndrome in adult distal radius fractures.","authors":"Luigi Meccariello","doi":"10.17392/1679-23","DOIUrl":"https://doi.org/10.17392/1679-23","url":null,"abstract":"<p><p>Aim Acute carpal tunnel syndrome (ACTS) is a well-recognized and common condition following a distal radius fracture. The aim of this study was to test deflazacort associated with Nevridol®800 or deflazacort alone in order to prevent moderate or severe ACTS after the distal radius fracture in adults. Methods Sixty-four patients suffering from extraarticular wrist fractures were divided into three groups. The first group (n=26) was treated by plaster cast. The second group (n=20) was treated by cast and deflazacort (heterocyclic glucocorticoids prodrug belonging to the class of oxazoline steroids) 30 mg/day for 15 days. The third group (n=18) was treated by cast and deflazacort 30 mg/ day for 15 days + Nevridol (food supplements) 800 mg a day for 40 days. The criteria to evaluate the patients were: the complication of ACTS, the duration of symptoms, the functional results were evaluated according to The Disabilities of the Arm, Shoulder and Hand (DASH) life correlated with wrist function by the Short Form 12 Health Survey (SF-12), and positive Tinel and Phalen test. The correlation between ACTS signs and volar tilt in the latero-lateral at X-rays in the three studied groups was assessed. The endpoints were set on 7 days, 15 days, 1 months, 2 months and 3 months after a trauma. Results In the first group, 12 of 26 (46.15%) and the second group 7 of 20 (35%) patients suffered from ACTS, while in the third group only two of 18 (11%) patients (p=0.033). After 3 months of treatment, the third group had better results in DASH (p=0.034), SF-12 (p=0.044), Tinel (0.045) and Phalen (0.048) tests. Conclusion Deflazacort associated with Nevridol 800 may reduce the prevalence of postoperative median nerve dysfunction.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"229-235"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vascularization of a bone stump.","authors":"Viktor Shevchuk, Yurii Bezsmertnyi, Yankai Jiang, Olexander Branitsky, Halyna Bezsmertna, Dmytro Bondarenko","doi":"10.17392/1677-23","DOIUrl":"https://doi.org/10.17392/1677-23","url":null,"abstract":"<p><p>Aim To study the character of blood circulation in the bone stump at tight and loose closure of the medullary cavity. Methods Two series of experiments on 39 rabbits with mid-third femoral amputation and muscular plasty were carried out. In the 1st (experimental) series, the bone scapula was closed by thin cortical autograft taken from the epimetaphyseal area, and then the muscles were sutured, and in the 2nd - the scapula was closed by myoplasty only. Follow-up periods: 1st series - 7, 14, 21 days and 1, 3, 6 months, 2nd series - 1, 3, 6 months. Histological methods with infusion of vessels with ink-gelatin mixture and morphometry was used. Results In the 1st series there was a rapid restoration of the disturbed macro- and microcirculation due to the reserve sources of blood circulation and the development of extravascular ways of microcirculation. In the 2nd series, blood circulation recovery was significantly slower and occurred mainly due to the development of extravascular microcirculatory pathways. Conclusion The study established undeniable usefulness of tight closure of the bone marrow cavity during amputation.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"214-221"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A systematic evaluation of big data-driven colorectal cancer studies.","authors":"Eslam Bani Mohammad, Muayyad Ahmad","doi":"10.17392/1684-23","DOIUrl":"https://doi.org/10.17392/1684-23","url":null,"abstract":"<p><p>Aim To assess machine-learning models, their methodological quality, compare their performance, and highlight their limitations. Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were applied. Electronic databases Science Direct, MEDLINE through (PubMed, Google Scholar), EBSCO, ERIC, and CINAHL were searched for the period of January 2016 to September 2023. Using a pre-designed data extraction sheet, the review data were extracted. Big data, risk assessment, colorectal cancer, and artificial intelligence were the main terms. Results Fifteen studies were included. A total of 3,057,329 colorectal cancer (CRC) health records, including those of adult patients older than 18, were used to generate the results. The curve's area under the curve ranged from 0.704 to 0.976. Logistic regression, random forests, and colon flag were often employed techniques. Overall, these trials provide a considerable and accurate CRC risk prediction. Conclusion An up-to-date summary of recent research on the use of big data in CRC prediction was given. Future research can be facilitated by the review's identification of gaps in the literature. Missing data, a lack of external validation, and the diversity of machine learning algorithms are the current obstacles. Despite having a sound mathematical definition, area under the curve application depends on the modelling context.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"63-77"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele Coviello, Antonella Abate, Giovanni Vicenti, Francesco Ippolito, Vittorio Nappi, Andrea Michele Abbaticchio, Elio Caiaffa, Giulia Colasuonno, Vincenzo Caiaffa, Giuseppe Solarino
{"title":"Comparison of cutout risk factors between single- and doublescrew proximal nails in intertrochanteric femur fractures - a multicentric study.","authors":"Michele Coviello, Antonella Abate, Giovanni Vicenti, Francesco Ippolito, Vittorio Nappi, Andrea Michele Abbaticchio, Elio Caiaffa, Giulia Colasuonno, Vincenzo Caiaffa, Giuseppe Solarino","doi":"10.17392/1683-23","DOIUrl":"https://doi.org/10.17392/1683-23","url":null,"abstract":"<p><p>Aim Significant risk factors for femoral nail cutout are well-documented, primarily in the context of single-screw proximal nails. However, it remains uncertain whether those same risk factors are applicable when considering different implant devices. The aim of this retrospective cohort study was to compare cutout risk factors between single- versus double-screw proximal femoral nails. Methods Patients over the age of 75 with intertrochanteric femur fractures (AO Classification 31-A1 or 31-A2) were included in the multicentre study. A study group was treated with a double-screw nail, while a control group received single-screw device. Demographic data, surgical time (min), fracture pattern, distal locking, reduction quality, comorbidities, tip-apex distance (TAD) and 12-month functional scores was collected. Results Two hundred patients were enrolled, 100 for each group. Nine patients experienced a cutout complication, five in the study and four in the control group. The main differences were in distal locking configurations (p<0.05) and in TAD values (p<0.05). The TAD value was higher in the study than in the control group (30.40±0.89 versus 26.79±1.79). No differences at 12-month follow up were reported according to functional scores. Conclusion This study provides insights into the choice of nail systems for intertrochanteric femur fractures, highlighting the importance of distal locking configurations and TAD values. The double screw nail exhibits quite a tolerance by having a higher average TAD value. These findings may guide clinical decisionmaking in the treatment of this challenging fracture type.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"208-213"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Histopathological spectrum of lumbar disc changes in obesity: analysis of intervertebral discs in lumbar hernia patients in Zenica-Doboj Canton, Bosnia and Herzegovina.","authors":"Fatima Juković-Bihorac, Hakija Bečulić, Emir Begagić, Ragib Pugonja, Jovana Radovanović, Amina Džidić-Krivić, Binasa Bašić, Andrej Popov, Haso Sefo, Ermina Iljazović","doi":"10.17392/1698-23","DOIUrl":"https://doi.org/10.17392/1698-23","url":null,"abstract":"<p><p>Aim To investigate the correlation of body mass index (BMI) with severity of intervertebral disc degeneration. Methods The study enrolled patients who had undergone surgical intervention for a herniated disc at the Department of Neurosurgery of the Cantonal Hospital Zenica. Patients underwent thorough preoperative evaluation, including medical history, neurological and physical assessments, and radiological analysis. The surgical intervention consisted of a posterior lumbar discectomy, and the excised disc material was preserved and subjected to histopathological analysis based on Histopathologic Degeneration Score (HDS). Patients were divided in two groups according to Body Mass Index (BMI): study group with BMI≥25 and control group with BMI<25. Results Among 69 patients with herniated IVD, 26 (37.7%) were with BMI≥25 (study group), and 43 (62.3%) were with BMI<25 (controls). The study group displayed substantial increase in height, 1.80±0.06 m compared to controls, 1.74±0.06 m (p=0.001). Weight and BMI were significantly higher in the study group of patients (weight: 91.60±10.22 vs. 67.37±9.20 kg, BMI: 28±2 vs. 22±2; p<0.001). Differences were confirmed in HDS values in the study group comparing to the control group (p<0.001). The study group exhibited significant differences in chondrocyte proliferation, tears and clefts, granular changes, and mucous degeneration (p<0.05), and positive correlations were found between BMI and these alterations found in the herniated discs (p<0.05). Therefore, HDS showed positive correlations with BMI (R=0.599; p<0.001) and weight (R=0.696; p<0.001). Conclusion The study's findings confirmed that BMI has a significant impact on intervertebral disc degeneration, emphasizing the importance of weight management in preventing disc degeneration.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"140-146"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Morphometric and Ki-67 proliferative index-related characteristics of meningiomas and their correlation with demographic, clinical, histopathological, and postoperative features.","authors":"Ragib Pugonja, Hakija Bečulić, Emir Begagić, Rasim Skomorac, Edin Selimović, Mirza Moranjkić","doi":"10.17392/1650-23","DOIUrl":"https://doi.org/10.17392/1650-23","url":null,"abstract":"<p><p>Aim To investigate the correlations between tumour characteristics, symptoms, intraoperative findings, and outcomes in patient with meningioma. Methods A retrospective study was conducted on 86 surgically treated patients at Department of Neurosurgery of Cantonal Hospital Zenica from 2010 to 2020. Patients with intracranial meningiomas underwent neurological evaluation and MRI scans to analyse tumour characteristics, including volume (TV), peritumoral brain oedema (PTBE) and oedema index (EI). Surgical treatment was performed, followed by postoperative MRI and outcome assessment. Intraoperatively, the tumour's relationship with cortex, pial membrane, skull bones, and sinuses was evaluated, and the extent of tumour resection was graded. Meningioma samples underwent histopathological analysis to assess the grade and regularity of borders, and Ki-67 labelling index was determined using immunohistochemistry. Results Significant correlations were found between PTBE and Ki67 expression (p<0.001), PTBE and vomiting/nausea (p=0.002), cognitive impairment (p=0.047), venous compression (p=0.001), cortical, pial and dural invasion (p<0.05), and the postoperative presence of oedema (p=0.002). Venous compression, cortical, pial, dural and bone invasion positively correlated with Ki-67 expression (p<0.001). Grade and tumour border positively correlated with Ki-67 expression (p<0.001). Oedema persistence postoperatively showed a positive correlation with Ki-67 expression (p<0.001). Conclusion The study revealed significant correlations between Ki-67 expression and PTBE, with notable associations with clinical symptoms, tumour characteristics, and postoperative oedema presence.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"132-139"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The level of occlusion of small saphenous vein after endovenous laser ablation.","authors":"Anel Okić, Hasib Mujić, Amel Hadžimehmedagić, Nermina Babić, Alma Krvavac Hafizović, Azra Kajmaković Kožo","doi":"10.17392/1672-23","DOIUrl":"https://doi.org/10.17392/1672-23","url":null,"abstract":"<p><p>Aim To determine the success of endovenous laser ablation (EVLA) treatment and long-term occlusion of small saphenous vein (SSV), as well as factors and conditions that influence the effectiveness of EVLA treatment. Methods A total of 250 patients treated with EVLA method over a period of seven years were followed one year after treatment. The main factors monitored and recorded during EVLA treatment were laser power (W), amount of delivered energy (J), duration of treatment (sec), veins length (cm), diameter (mm) and reflux (sec). Results Within the first six months, the recanalization or insufficiently occluded SSV was noticed in ten, and after one year in one patient. The overall assessment of occlusion and satisfactory findings after one year of SSV was 95.6%. Conclusion It is important to choose adequate power and the amount of delivered energy. The physician's assessment and selection of an adequate patient greatly improves the outcome of the treatment. It is important to treat larger branches and double SSV between two fascias. Successful and effective EVLA treatment greatly reduces the possibility of recanalization of the treated vein.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"147-153"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139717990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Availability and quality of primary health care in the compulsory health insurance system in Kazakhstan.","authors":"Makhabbat Shurenova, Kuralbay Kurakbayev, Tleukhan Abildaev, Aigul Tazhiyeva","doi":"10.17392/1675-23","DOIUrl":"https://doi.org/10.17392/1675-23","url":null,"abstract":"<p><p>Aim To evaluate patient satisfaction with primary healthcare services and determine effectiveness indicators within Kazakhstan's compulsory health insurance system. Methods An analytical observational study with cross-examination was conducted in Kazakhstan's primary healthcare (PHC) organizations. Patient satisfaction was assessed through a 35-item closed-question questionnaire. An analysis of stimulating component result indicators for per capital standard financing in PHC organizations based on their achieved outcomes was performed. Results Among surveyed patients, 54.0% (1.80±1.108) expressed complete satisfaction with medical care, while 59.4% (1.82±1.269) perceived laboratory tests as readily accessible. Notably, males exhibited higher satisfaction levels with medical care and the availability of laboratory tests compared to females. The city polyclinics № 3 and № 14 in Almaty, Kazakhstan, achieved significant performance indicators, resulting in a 1.1-fold increase in the incentive component of per capital funding. Conclusion Within the framework of compulsory health insurance, primary healthcare organizations in Kazakhstan offer affordable and effective medical care, as attested by surveyed patients and the final result indicators of the polyclinics.</p>","PeriodicalId":51129,"journal":{"name":"Medicinski Glasnik","volume":"21 1","pages":"159-165"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139718039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}