Maternal and Child Nutrition最新文献

{"title":"Nutrition and Nurture in Infancy and Childhood: Bio-Cultural Perspectives","authors":"","doi":"10.1111/mcn.70095","DOIUrl":"10.1111/mcn.70095","url":null,"abstract":"","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":"21 S2","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Folate Concentration Corresponding to the Red Blood Cell Folate Threshold for Increased Risk of Neural Tube Defects Among Ethiopian Women of Reproductive Age.","authors":"Biniyam Tesfaye, Meseret Woldeyohannes, Masresha Tessema, Charles Dale Arnold, Christine M McDonald, Kenneth H Brown","doi":"10.1111/mcn.70121","DOIUrl":"https://doi.org/10.1111/mcn.70121","url":null,"abstract":"<p><p>Neural tube defects (NTDs) are severe birth defects linked to insufficient maternal folate status during early pregnancy. Red blood cell (RBC) folate concentration is the recommended biomarker for predicting NTD risk, with a threshold of 748 nmol/L using the US Centers for Disease Control and Prevention (CDC) microbiological assay. However, in large surveys, serum folate concentration is often measured instead of RBC folate. This study aimed to (1) identify the serum folate concentration that corresponds to the RBC folate threshold for NTD risk using data from Ethiopian women of reproductive age (WRA); (2) evaluate the performance of the serum threshold for population-level NTD risk assessment; and (3) compare the serum folate cutoff determined with the Ethiopian data versus the cutoff derived from a Southern Indian population. Biomarker data from 1570 Ethiopian nonpregnant, non-lactating WRA who participated in the 2015 Ethiopian National Micronutrient Survey were analyzed. Serum and RBC folate concentrations were measured using the CDC microbiological assay. Serum folate cutoffs were identified using unadjusted and adjusted regression models and receiver operating characteristics (ROC) analysis. Adjusted models included the following covariates: age, body mass index (BMI), serum vitamin B₁₂ concentration, presence of inflammation, region, and site of residence. Three serum folate cutoffs were identified: 15.3 nmol/L (unadjusted model), 15.2 nmol/L (adjusted model), and 17.9 nmol/L (ROC analysis). Regression-based cutoffs balanced sensitivity (~76%) and specificity (~62%), while the ROC-derived cutoff improved sensitivity (~83%) but reduced specificity (~50%). Ethiopian cutoffs showed fair discriminatory performance (~AUC:0.7) while the Indian cutoff (~AUC:0.6) showed poorer performance. Because of suboptimal NTD risk prediction using serum folate, future surveys should use RBC folate when possible. In situations where it is not possible to measure RBC folate, population-specific serum folate cutoffs should be determined.</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70121"},"PeriodicalIF":2.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Dietary Inflammatory Index and Biomarkers of Inflammation at Birth.","authors":"Courtney Dow, Rosalie Delvert, Blandine de Lauzon-Guillain, Judith van der Waerden, Laetitia Davidovic, Olfa Khalfallah, Susana Barbosa, Marie-Aline Charles, Cédric Galera, Barbara Heude","doi":"10.1111/mcn.70108","DOIUrl":"https://doi.org/10.1111/mcn.70108","url":null,"abstract":"<p><p>We evaluated the association between the inflammatory potential of the maternal diet during pregnancy and levels of inflammatory biomarkers measured in cord blood and maternal serum at birth. Dietary inflammatory potential was calculated using the energy-adjusted dietary inflammatory index (E-DII) in the French EDEN and ELFE birth cohorts. Biomarkers of inflammation (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor α [TNF-α]) were measured from cord blood (EDEN [n = 758]; ELFE [n = 899]) and maternal serum (in ELFE only; [n = 911]) collected at birth. Additionally, leptin was also measured from cord blood in EDEN (n = 1202) and C-reactive protein was measured from cord blood in ELFE (n = 895). Linear regression models, adjusted for confounders, were used to investigate the association between tertiles of the E-DII score and each log-transformed biomarker. There were no significant associations between the E-DII score and maternal or cord blood biomarkers in either cohort. The energy-adjusted dietary inflammatory index score during pregnancy was not associated with concentrations of inflammatory biomarkers in either maternal serum or cord blood at birth.</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70108"},"PeriodicalIF":2.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ABA-Feed Infant Feeding Training for Peer Supporters and Coordinators: Development and Mixed-Methods Evaluation.","authors":"Joanne Clarke, Gill Thomson, Nicola Crossland, Stephan Dombrowski, Pat Hoddinott, Jenny Ingram, Debbie Johnson, Christine MacArthur, Jennifer McKell, Ngawai Moss, Julia Sanders, Nicola Savory, Beck Taylor, Kate Jolly","doi":"10.1111/mcn.70115","DOIUrl":"https://doi.org/10.1111/mcn.70115","url":null,"abstract":"<p><p>The assets-based feeding help before and after birth (ABA-feed) intervention aims to improve breastfeeding rates by offering proactive peer support to first-time mothers, regardless of feeding intention. Based on behaviour change theory and an assets-based approach, the intervention involved training existing peer supporters to become infant feeding helpers (IFHs). A train-the-trainer model was used, with coordinators delivering four 2-h training sessions to IFHs. Training covered a study overview, IFH role, role-play scenarios and signposting to local assets. Due to COVID-19, training was delivered online. Post-training questionnaires were completed by 22/30 (73.3%) coordinators and 119/193 (61.7%) IFHs, and qualitative interviews were conducted with 24 coordinators and 72 IFHs. Researchers observed training at five sites, assessing fidelity, engagement and delivery quality. Questionnaire data were analysed descriptively, and qualitative data were analysed using framework analysis. Findings indicated that coordinators valued the train-the-trainer model, particularly information on formula feeding and antenatal discussions. IFHs found training engaging and felt prepared, though some were apprehensive about formula feeding support. While online training was convenient, challenges included monitoring discussions and role-play in breakout rooms. Most participants favoured a hybrid approach, with in-person sessions for interactive activities. Observations showed high training fidelity, participant engagement and confidence in delivering intervention components. The ABA-feed training was acceptable to coordinators and IFHs and was delivered with fidelity. Future training should adopt a hybrid approach, incorporating diverse resources and prioritising in-person interactive components such as role-play. Trial Registration: ISRCTN17395671.</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70115"},"PeriodicalIF":2.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Informal Human Milk Sharing Practices: A Cross-Sectional Survey of Donors and Recipients in Ireland.","authors":"Niamh Vickers, Anne Matthews, Gillian Paul","doi":"10.1111/mcn.70113","DOIUrl":"https://doi.org/10.1111/mcn.70113","url":null,"abstract":"<p><p>The provision of human milk is a global public health priority underpinned by its extensive benefits to infant and maternal health, and significant positive impacts within economic, societal, and environmental spheres. Informal human milk sharing (IHMS) is a contemporary and increasingly prevalent phenomenon which involves the exchange of human milk outside formal structures such as milk banks. This study aimed to investigate the characteristics, motivations, practices and experiences of donors and recipients who engage in IHMS in Ireland. A national cross-sectional survey included a validated questionnaire and was administered online in Ireland following ethical approval. The study is reported according to STROBE guidelines. Recipients reported significantly higher rates of cesarean sections, birth complications, and traumatic births compared to donors, with postpartum anxiety prevalent in both donors and recipients (51.4%). Recipients primarily sought donor milk due to perceived lactation insufficiency, concerns regarding commercial milk formula, infant related factors and belief in human milk benefits. Donors were motivated by altruism and the desire not to waste their expressed milk. Most donors (84.5%) considered formal milk bank donations but were inhibited by practical barriers, favoring informal sharing via online platforms and direct exchanges. There was minimal discussions with healthcare professionals about IHMS. The increasing significance of IHMS in Ireland is driven by diverse maternal and infant needs, and online communities. Future research should investigate safety outcomes and long-term impacts of IHMS, the lived experiences of donors and recipients, as well as the examination of strategies to enhance engagement with formal milk banks.</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70113"},"PeriodicalIF":2.6,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breastfeeding and Water Security","authors":"Rafael Pérez-Escamilla,&nbsp;Victoria Hall Moran","doi":"10.1111/mcn.70114","DOIUrl":"10.1111/mcn.70114","url":null,"abstract":"&lt;p&gt;Water security has been defined by the United Nations as “&lt;i&gt;The capacity of a population to safeguard sustainable access to adequate quantities of acceptable quality water for sustaining livelihoods, human well-being, and socioeconomic development, for ensuring protection against water-borne pollution and water-related disasters, and for preserving ecosystems in a climate of peace and political stability”&lt;/i&gt; (United Nations &lt;span&gt;2013&lt;/span&gt;). As such, water security is crucial for human and planetary health and the development of nations. As addressed at the 2025 World Water Week held in Stockholm August 24-28, climate change has become a formidable challenge for water security globally. In this editorial we make the case that investing in breastfeeding protection, promotion and support should be a key component of national and global strategies to address water insecurity.&lt;/p&gt;&lt;p&gt;Global recommendations call for infants to be exclusively breastfed for 6 months, making breastmilk is the only source of water for infants of this age. As over 85% of breastmilk is water, babies can indeed meet their water needs through breastfeeding (Martin et al. &lt;span&gt;2016&lt;/span&gt;). Once complementary foods are introduced at around 6 months infants are recommended to continue to breastfeed for at least their first 2 years of life, hence breast milk can also be an important source of water security for infants and toddlers beyond the first 6 months of life.&lt;/p&gt;&lt;p&gt;It is estimated that 2,562.5 billion liters of water are used every year in the production and use of commercial milk formula (CMF) by infants under 6 months (Smith et al. &lt;span&gt;2024&lt;/span&gt;). Therefore, investing in breastfeeding protection, promotion and support can reduce substantially the use of water across the globe. Climate change mitigation requires bringing down the levels of greenhouse gases (GHG) which mainly come from industrial activity. The CMF industry generates between 5.9 and 7.5 billion kg CO2 eq. every year because of environmental degradation and fossil fuel use related to dairy farming, milk processing, and CMF production, transportation, storage and preparation. Exclusive breastfeeding, in contrast, produces a far lower carbon footprint compared to feeding with CMF (Andresen et al. &lt;span&gt;2022&lt;/span&gt;; Karlsson et al. &lt;span&gt;2019&lt;/span&gt;). The massive impact of the CMF industry on climate change and water use is evident at the country level. Using India as an example, CMF consumption among infants under 6 months utilizes 250.6 billion liters of water and GHG emissions range from 579 to 737 million kg CO2 eq. annually, despite the country's high breastfeeding prevalence among infants under 6 months (Smith et al. &lt;span&gt;2024&lt;/span&gt;). For this reason, it has been recommended for breastfeeding to be included in climate change mitigation agreements and investments within countries and across the globe (Smith et al. &lt;span&gt;2024&lt;/span&gt;) (Figure 1).&lt;/p&gt;&lt;p&gt;Moreover, climate change is driving an inc","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":"21 4","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/mcn.70114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview: Existing Context and the Need to Generate Evidence of the Impact of Large-Scale Food Fortification on the Prevalence of Anemia","authors":"Manpreet Chadha,&nbsp;Daniel Lopez de Romana,&nbsp;Helena Pachón,&nbsp;Mandana Arabi","doi":"10.1111/mcn.70093","DOIUrl":"10.1111/mcn.70093","url":null,"abstract":"&lt;p&gt;Anemia remains a significant global public health challenge, particularly affecting women and children. According to the World Health Organization (WHO), in 2019, 30% of women aged 15–49 years, and 40% of children under the age of 5 were anemic (WHO &lt;span&gt;2024&lt;/span&gt;). Anemia is associated with adverse maternal and child outcomes, linked to inadequate cognitive and motor development in children, as well as reduced work capacity in adults, thereby impacting a nation's economic progress (WHO &lt;span&gt;2024&lt;/span&gt;).&lt;/p&gt;&lt;p&gt;The World Health Organization endorsed global anemia targets for 2025: to reduce anemia prevalence among women by 50% (WHO &lt;span&gt;2014&lt;/span&gt;). To reach these targets, multiple interventions with evidence of impact must be scaled up and delivered to the populations at large and to specific target population groups.&lt;/p&gt;&lt;p&gt;The etiology of anemia is complex and is known to be multifactorial. Some of these causes are related to nutrient deficiencies while others are non-nutritional in nature (WHO &lt;span&gt;n.d&lt;/span&gt;.). It was previously believed that approximately 50% of all anemias were attributed to iron deficiency, however, it is now known that the contribution of iron deficiency to anemia will significantly vary across contexts (Petry et al. &lt;span&gt;2016&lt;/span&gt;; Chaparro and Suchdev &lt;span&gt;2019&lt;/span&gt;). Factors driving the context-specific contribution of iron deficiency to anemia include inadequate dietary iron intake, blood loss from parasitic infections, hemorrhage associated with childbirth or menstrual loss, impaired iron absorption, low iron stores at birth, and interactions between iron and other nutrients (WHO &lt;span&gt;2023a&lt;/span&gt;). Besides iron, deficiency in one or more of the micronutrients involved in hemoglobin synthesis or maintenance, including folate, vitamins A, B6 and B12, and riboflavin, could lead to nutritional anemia (Chaparro and Suchdev &lt;span&gt;2019&lt;/span&gt;).&lt;/p&gt;&lt;p&gt;Food fortification is the addition of vitamins and minerals to foods while they are being processed (WHO, &amp; Food and Agriculture Organization of the United Nations &lt;span&gt;2006&lt;/span&gt;). It can effectively deliver multiple nutrients to populations that consume processed foods such as milk, oil, rice, and wheat flour. Fortification reduces nutrient deficiencies and can reduce the prevalence of anemia due to nutrient deficiencies (Keats et al. &lt;span&gt;2019&lt;/span&gt;). In May 2023, the 76th World Health Assembly adopted the resolution on accelerating efforts to prevent micronutrient deficiencies through food fortification, which urges the Member States to establish and scale up food fortification initiatives (WHO &lt;span&gt;2023b&lt;/span&gt;).&lt;/p&gt;&lt;p&gt;This technical supplement aims to shed light on the critical issue of anemia and its potential reduction through large-scale food fortification (LSFF) programs. We explore the impact of LSFF as a strategy to combat anemia by increasing the intake of key nutrients essential for hemoglobin synthesis. Along with mandating a well-desig","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":"22 1","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/mcn.70093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Coverage of Essential Interventions Across the Health System Continuum of Care for Improving Child Nutrition in Ethiopia.","authors":"Alemnesh Petros, Meron Girma, Tsedey Moges, Alemayehu Hussen, Tadesse Kebebe, Meseret Woldeyohannes, Teshome Asefa, Daniel Abera, Yirgalem Tadesse, Getachew Tollera, Mesay Hailu, Arnaud Laillou, Stanley Chitekwe, Kaleab Baye, Ramadhani Noor, Masresha Tessema","doi":"10.1111/mcn.70107","DOIUrl":"https://doi.org/10.1111/mcn.70107","url":null,"abstract":"<p><p>This study aimed to assess the coverage of essential nutrition interventions delivered through the health system and explored the relationship between co-coverage and child- and maternal-level factors, household-level factors, and access to healthcare facilities. We used data from the Ethiopia Food and Nutrition Strategy Baseline Survey, a population-based cross-sectional study conducted between July 2021 and October 2022. The survey was conducted in 10 regions and 2 city administrations of Ethiopia. A total of 7931 women of reproductive age (15-49 years) and children aged 0-59 months (mother-child pairs) were included. We assessed coverage for 16 essential nutrition and health interventions. Our findings show that the coverage of essential nutrition interventions is suboptimal. Notably, interventions delivered during pregnancy and in early infancy had the highest coverage compared to those provided in late childhood. We identified missed opportunities to deliver of nutrition interventions in the corresponding health platforms. Despite 41% of women reporting having four or more antenatal care visits during their last pregnancy, only 17% took 90 or more iron/folic acid tablets. We also found pro-rich and pro-urban inequalities in access for almost all interventions. Among children eligible to receive all 16 interventions (12-59 months), 8% had zero exposure to interventions. Child age, household wealth, maternal education, place of residence, and walking time to the nearest health facility were significantly associated with co-coverage. The observed low coverage, coupled with existing inequities and identified opportunity gaps in intervention delivery, emphasizes the need to better leverage the health system to reduce undernutrition.</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70107"},"PeriodicalIF":2.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Haemoglobin Concentrations From Venous and From Finger-Pricked Capillary Blood in a Region With a High Prevalence of Anaemia in Ethiopia.","authors":"Desalegn Kuche, Masresha Tessema, Kaleab Baye, Zeweter Abebe, Ramadhani Noor, Teshome Assefa, Alemayehu Hussen, Meseret Woldeyohannes, Stanley Chitekwe, Barbara J Stoecker","doi":"10.1111/mcn.70109","DOIUrl":"https://doi.org/10.1111/mcn.70109","url":null,"abstract":"<p><p>This cross-sectional study was conducted in the Somali Regional State in Ethiopia. The purpose of the study was to compare haemoglobin (Hb) concentrations from venous and finger-pricked capillary blood using the HemoCue 301 as well as estimating anaemia prevalence. Participants were non-pregnant women of reproductive age (WRA), 18-49 years old (n = 884). Blood was collected by trained laboratory technologists using standard protocols. Venous blood was transferred from the EDTA-coated vacutainer to a HemoCue microcuvette. An automatic safety lancet was used to obtain capillary blood, and a microcuvette was filled with the third drop. Both venous and capillary blood were analysed immediately in the field using the same HemoCue analyser. The mean (±SD) Hb concentration was 11.6 ± 2.2 g/dL for venous blood and 11.4 ± 2.3 g/dL for capillary blood. The mean Hb difference was 0.2 ± 0.8 g/dL (p < 0.0001). After adjustment for altitude, anaemia prevalence was estimated. Both blood collection methods confirmed anaemia prevalence as a severe public health problem; the prevalence was 66.6% from venous and 70.7% from capillary blood. Using venous Hb as the standard, the sensitivity of capillary Hb was 94.9%, and its specificity was 77.5% in identifying anaemia. The differences in anaemia estimates using venous and capillary blood have the potential to impact both public health strategies and programme evaluations.</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70109"},"PeriodicalIF":2.6,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saccharomyces cerevisiae Yeast-Based Supplement and Breast Milk Supply: A Randomised Placebo-Controlled Trial.","authors":"Lili Jia, Louise Brough, Janet L Weber","doi":"10.1111/mcn.70112","DOIUrl":"https://doi.org/10.1111/mcn.70112","url":null,"abstract":"<p><p>Saccharomyces cerevisiae yeast-based supplements (SCYS) are frequently used as galactagogues with limited evidence of their efficacy. This study investigates the effect of SCYS on human milk oligosaccharide (HMO) concentration and indicators of milk supply. Sixty-eight breastfeeding women with a healthy singleton infant aged 1-7 months were randomly assigned to consume a SCYS product (5 g/day) or placebo for 4 weeks. The primary outcome was the change in the total HMO concentration. The secondary outcomes included participants' perceptions of milk supply, intervention effectiveness, postnatal distress, infant feeding patterns, infant anthropometry, and adverse effects. Intention-to-treat analysis was performed. Multivariable linear regression analysis showed no significant effect of SCYS on individual or total HMO concentrations. However, 65% of women in the SCYS group, compared to 35% in the placebo group, perceived an increase in milk production (p < 0.05). No significant differences were found for other secondary outcomes. However, mothers in the SCYS group had a small but significant improvement in perception of their milk quantity and quality (p < 0.05). SCYS use was also associated with significantly lower formula use at 6 months postpartum (4% vs. 27%, p < 0.05). While SCYS does not impact HMO concentration, it may improve women's perceptions of milk supply. A larger randomised controlled trial is needed to assess its potential effects on actual milk production and composition and address issues of perceived insufficient milk. Trial Registration: This trial was registered at the Australian New Zealand Clinical Trials Registry (trial registration number: ACTRN12619000704190).</p>","PeriodicalId":51112,"journal":{"name":"Maternal and Child Nutrition","volume":" ","pages":"e70112"},"PeriodicalIF":2.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145034570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}