Journal of Steroid Biochemistry and Molecular Biology最新文献_第8页

GPER expression prevents estrogen-induced urinary retention in obese mice GPER 的表达可防止肥胖小鼠因雌激素引起的尿潴留。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-08-27 DOI: 10.1016/j.jsbmb.2024.106607

Donna F. Kusewitt , Geetanjali Sharma , Christine D. Woods , Emmanuel Rosas , Helen J. Hathaway , Eric R. Prossnitz

{"title":"GPER expression prevents estrogen-induced urinary retention in obese mice","authors":"Donna F. Kusewitt , Geetanjali Sharma , Christine D. Woods , Emmanuel Rosas , Helen J. Hathaway , Eric R. Prossnitz","doi":"10.1016/j.jsbmb.2024.106607","DOIUrl":"10.1016/j.jsbmb.2024.106607","url":null,"abstract":"<div><p>Long-term administration of exogenous estrogen is known to cause urinary retention and marked, often fatal, bladder distention in both male and female mice. Estrogen-treated mice have increased bladder pressure and decreased urine flow, suggesting that urinary retention in estrogen-treated mice is due to infravesicular obstruction to urine outflow. Thus, the condition is commonly referred to as bladder outlet obstruction (BOO). Obesity can also lead to urinary retention. As the effects of estrogen are mediated by multiple receptors, including estrogen receptors ERα and ERβ and the G protein-coupled estrogen receptor (GPER), we sought to determine whether GPER plays a role in estrogen-induced BOO, particularly in the context of obesity. Wild type and GPER knockout (KO) mice fed a high-fat diet were ovariectomized or left ovary-intact (sham surgery) and supplemented with slow-release estrogen or vehicle-only pellets. Supplementing both GPER KO and wild type obese mice with estrogen for 8 weeks resulted in weight loss, splenic enlargement, and thymic atrophy, as expected. However, estrogen-treated obese GPER KO mice developed abdominal distension, debilitation, and ulceration of the skin surrounding the urogenital opening. At necropsy, these mice had prominently distended bladders and hydronephrosis. In contrast, estrogen-treated obese wild type mice only rarely displayed these signs. Our results suggest that, under conditions of obesity, estrogen induces BOO as a result of ERα-driven pathways and that GPER expression is protective against BOO.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106607"},"PeriodicalIF":2.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex hormone-binding globulin and its critical role in prostate cancer: A comprehensive review 性激素结合球蛋白及其在前列腺癌中的关键作用：全面回顾。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-08-23 DOI: 10.1016/j.jsbmb.2024.106606

Anirban Goutam Mukherjee, Abilash V G

{"title":"Sex hormone-binding globulin and its critical role in prostate cancer: A comprehensive review","authors":"Anirban Goutam Mukherjee, Abilash V G","doi":"10.1016/j.jsbmb.2024.106606","DOIUrl":"10.1016/j.jsbmb.2024.106606","url":null,"abstract":"<div><p>Prostate cancer (PC) is a common and widespread cancer that affects men globally. A complicated interaction of hormonal variables influences its development. Sex hormone-binding globulin (SHBG) is a crucial element in controlling the availability of sex hormones, especially androgens, which have a notable impact on the development and progression of PC. SHBG controls the levels of free, active androgens in the body, which helps regulate androgen-dependent processes associated with PC. The equilibrium between SHBG and androgens plays a critical role in maintaining the stability of the prostate. When this balance is disrupted, it is associated with the development and advancement of PC. The processes responsible for SHBG's role in PC are complex and have multiple aspects. SHBG primarily binds to androgens, preventing them from interacting with androgen receptors (ARs) in prostate cells. It reduces the activation of androgen signaling pathways essential for tumor development and survival. In addition, SHBG can directly affect prostate cells by interacting with specific receptors on the cell surface. This review thoroughly examines the role of SHBG in PC, including its physiological activities, methods of action, and clinical consequences.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"245 ","pages":"Article 106606"},"PeriodicalIF":2.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer OBHSA是一种新型选择性雌激素受体降解剂，可通过细胞周期停滞和未折叠蛋白反应介导的细胞凋亡克服乳腺癌对他莫昔芬的耐药性。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-08-13 DOI: 10.1016/j.jsbmb.2024.106599

Rong Shen , Jiawei Zhou , Lilan Xin , Hai-Bing Zhou , Jian Huang

{"title":"OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer","authors":"Rong Shen , Jiawei Zhou , Lilan Xin , Hai-Bing Zhou , Jian Huang","doi":"10.1016/j.jsbmb.2024.106599","DOIUrl":"10.1016/j.jsbmb.2024.106599","url":null,"abstract":"<div><p>Breast cancer (BC) is a highly heterogeneous tumor that has surpassed lung cancer as the most frequently diagnosed cancer in women. In clinical practice,the primary approach for treating estrogen receptor alpha (ERα)-positive BC is through endocrine therapy, which involves targeting the ERα using medications like tamoxifen and fulvestrant. However, the problem of de novo or acquired resistance poses a significant clinical challenge, emphasizing the critical need for the development of novel therapeutic strategies. In this regard, we have successfully designed and developed a novel selective estrogen receptor degrader (SERD) called OBHSA, which specifically targets and degrades ERα, demonstrating remarkable efficacy. Our findings revealed the effectiveness of OBHSA in inhibiting the proliferation of various BC cells, including both tamoxifen-sensitive and tamoxifen-resistant BC cells, indicating its great potential to overcome endocrine resistance. In terms of mechanism, we discovered that OBHSA overcame tamoxifen resistance through two distinct pathways. Firstly, OBHSA degraded cyclin D1 in an ERα-dependent manner, thereby blocking the cell cycle. Secondly, OBHSA induced an elevation in intracellular reactive oxygen species, triggering an excessive activation of the unfolded protein response (UPR) and ultimately leading to apoptotic cell death. In summary, our finding demonstrated that OBHSA exerts anti-tumor effects by inducing cell cycle arrest and UPR-mediated apoptosis. These findings hold promise for the development of novel therapeutic drugs targeting endocrine-resistant BC.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106599"},"PeriodicalIF":2.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In memory of V. Craig Jordan (1947–2024): “Father of tamoxifen” and discoverer of SERMs 纪念 V. Craig Jordan（1947-2024 年）："他莫昔芬之父 "和 SERMs 的发现者。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-08-10 DOI: 10.1016/j.jsbmb.2024.106598

Philipp Y. Maximov

引用次数: 0

Secosteroid diacylhydrazines as novel effective agents against hormone-dependent breast cancer cells 仲烷基二酰肼作为新型有效药物，可对抗激素依赖性乳腺癌细胞。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-08-08 DOI: 10.1016/j.jsbmb.2024.106597

Alexey I. Ilovaisky , Alexander M. Scherbakov , Elena I. Chernoburova , Marina A. Shchetinina , Valentina M. Merkulova , Fedor B. Bogdanov , Danila V. Sorokin , Diana I. Salnikova , Eugene I. Bozhenko , Igor V. Zavarzin , Alexander O. Terent’ev

{"title":"Secosteroid diacylhydrazines as novel effective agents against hormone-dependent breast cancer cells","authors":"Alexey I. Ilovaisky , Alexander M. Scherbakov , Elena I. Chernoburova , Marina A. Shchetinina , Valentina M. Merkulova , Fedor B. Bogdanov , Danila V. Sorokin , Diana I. Salnikova , Eugene I. Bozhenko , Igor V. Zavarzin , Alexander O. Terent’ev","doi":"10.1016/j.jsbmb.2024.106597","DOIUrl":"10.1016/j.jsbmb.2024.106597","url":null,"abstract":"<div><p>This research aimed to develop novel selective secosteroids that are highly active against hormone-dependent breast cancer. A simple and convenient approach to N′-acylated 13,17-secoestra-1,3,5(10)-trien-17-oic acid hydrazides was disclosed and these novel types of secosteroids were screened for cytotoxicity against the hormone-dependent human breast cancer cell line MCF7. Most secosteroid N′-benzoyl hydrazides have demonstrated high cytotoxicity against MCF7 cells with IC<sub>50</sub> values below 5 μM, which are superior to that of the reference drug cisplatin. Hit compounds <strong>2c</strong>, <strong>2e</strong> and <strong>2i</strong> were characterized by high cytotoxicity (IC<sub>50</sub> = 1.6–1.9 μM) and very good selectivity towards MCF7 breast cancer cells. The lead secosteroids <strong>2c</strong>, <strong>2e</strong> and <strong>2i</strong> also exhibit antiestrogenic effects and alter the expression of cell cycle regulating proteins. The effect of selected compounds on PARP (poly(ADP-ribose) polymerase) and Bcl-2 (B-cell CLL/lymphoma 2) indicates their proapoptotic potential. The synthesized secosteroids may be considered as new promising anti-breast cancer agents targeting ERα and apoptosis pathways.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106597"},"PeriodicalIF":2.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sex hormonal replacement: Some effects over mitochondria 跨性别激素替代：对线粒体的一些影响。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-08-05 DOI: 10.1016/j.jsbmb.2024.106595

Montserrat Cardenas , Fabián Alvarez , Alfredo Cabrera-Orefice , Cristina Paredes-Carbajal , Alejandro Silva-Palacios , Salvador Uribe-Carvajal , José J. García – Trejo , Natalia Pavón

{"title":"Cross-sex hormonal replacement: Some effects over mitochondria","authors":"Montserrat Cardenas , Fabián Alvarez , Alfredo Cabrera-Orefice , Cristina Paredes-Carbajal , Alejandro Silva-Palacios , Salvador Uribe-Carvajal , José J. García – Trejo , Natalia Pavón","doi":"10.1016/j.jsbmb.2024.106595","DOIUrl":"10.1016/j.jsbmb.2024.106595","url":null,"abstract":"<div><p>Transgender is a term for people whose gender identity or expression differs from their natal sex. These individuals often seek cross-hormonal therapy to simulate the individual´s desired gender. However, the use of estrogens and testosterone has side effects such as a higher propensity to cancer, weight changes and cardiovascular diseases. Testosterone has also been linked with hypertension. Still, little is known about the outcomes and prevalence of metabolic perturbations in the trans community. Here we aim to analyze if cross-administering sexual hormones affects heart mitochondrial function. Mitochondria produces the ATP needed for heart function. In fact, different studies show that mitochondrial dysfunction precedes cardiac damage. In this work we used either female rats castrated and injected with testosterone or male rats castrated and injected with estrogens for 4 months. We performed an electrocardiogram, and then we isolated heart mitochondria to measure the rate of oxygen consumption, calcium fluxes, membrane potential, superoxide dismutase activity, lipoperoxidation and cytokines. We detected wide modifications in all parameters associated to cross-hormonal administration.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106595"},"PeriodicalIF":2.7,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-analytical stability and physiological fluctuations affect plasma steroid hormone outcomes: A real-world study 分析前稳定性和生理波动对血浆类固醇激素结果的影响：一项真实世界研究。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-07-31 DOI: 10.1016/j.jsbmb.2024.106596

Jian Zhong , Danchen Wang , Shaowei Xie , Ming Li , Yicong Yin , Jialei Yu , Chaochao Ma , SongLin Yu , Ling Qiu

{"title":"Pre-analytical stability and physiological fluctuations affect plasma steroid hormone outcomes: A real-world study","authors":"Jian Zhong , Danchen Wang , Shaowei Xie , Ming Li , Yicong Yin , Jialei Yu , Chaochao Ma , SongLin Yu , Ling Qiu","doi":"10.1016/j.jsbmb.2024.106596","DOIUrl":"10.1016/j.jsbmb.2024.106596","url":null,"abstract":"<div><p>Since steroids are crucial for diagnosing endocrine disorders, the lack of research on factors that affect hormone levels makes interpreting the results difficult. Our study aims to assess the stability of the pre-analytical procedure and the impact of hormonal physiological fluctuations using real-world data. The datasets were created using 12,418 records from individuals whose steroid hormone measurements were taken in our laboratory between September 2019 and March 2024. 22 steroid hormones in plasma by a well-validated liquid chromatography tandem mass spectrometry method were measured. After normalization transformation, outlier removal, and z-score normalization, generalized additive models were constructed to evaluate preanalytic stability and age, sex, and sample time-dependent hormonal fluctuations. Most hormones exhibit significant variability with age, particularly steroid hormone precursors, sex hormones, and certain corticosteroids such as aldosterone. 18-hydroxycortisol, 18-oxocortisol. Sex hormones varied between males and females. Levels of certain hormones, including cortisol, cortisone, 11-deoxycortisol, 18-hydroxycortisol, 18-oxocortisol, corticosterone, aldosterone, estrone, testosterone, dihydrotestosterone, dehydroepiandrosterone sulfate, 11-ketotestosterone, and 11-hydroxytestosterone, fluctuated with sampling time. Moreover, levels of pregnenolone and progesterone decreased within 1 hour of sampling, with pregnenolone becoming unstable with storage time at 4 degrees after centrifugation, while other hormone levels remained relatively stable for a short period of time without or after centrifugation of the sample. This is the first instance real-world data has been used to assess the pre-analytic stability of plasma hormones and to evaluate the impact of physiological factors on steroid hormones.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106596"},"PeriodicalIF":2.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of aldosterone biosynthesis during fetal and pediatric periods; Histological analysis of CYP11B2-positive cell distribution in the zona glomerulosa of human adrenal 胎儿期和儿童期醛固酮生物合成的发展；人体肾上腺肾小球透明带 CYP11B2 阳性细胞分布的组织学分析。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-07-31 DOI: 10.1016/j.jsbmb.2024.106593

Tsubasa Shironomae , Yuto Yamazaki , Junji Takeyama , Kiyohide Sakai , Hironobu Sasano , Takashi Suzuki

{"title":"Development of aldosterone biosynthesis during fetal and pediatric periods; Histological analysis of CYP11B2-positive cell distribution in the zona glomerulosa of human adrenal","authors":"Tsubasa Shironomae , Yuto Yamazaki , Junji Takeyama , Kiyohide Sakai , Hironobu Sasano , Takashi Suzuki","doi":"10.1016/j.jsbmb.2024.106593","DOIUrl":"10.1016/j.jsbmb.2024.106593","url":null,"abstract":"<div><p>The distribution of CYP11B2-positive or aldosterone producing adrenocortical cells in human fetuses and children and their age-dependent changes has not been studied. We aimed to explore the changes of aldosterone biosynthesis and age-related histological alterations of the zona glomerulosa in human adrenal gland during fetal and pediatric periods. We first reviewed 125 fetal and pediatric autopsy cases and retrieved 78 adrenals from 70 cases. CYP11B2 immunohistochemistry and quantitative image analysis of its results were performed in all adrenal glands. The ratio of the definitive zone (DZ) or zona glomerulosa (ZG) / the whole adrenocortical areas started to increase in the 2nd trimester, subsequently decreased in the 3rd, increased after birth, peaked in infancy, and then gradually decreased. The ratio of CYP11B2-positive / whole adrenocortical areas remained low during the fetal period but increased after birth, peaked at infancy, and then decreased. The ratio of CYP11B2-positive / DZ or ZG areas and CYP11B2-positive areas / depth of DZ or ZG demonstrated a distinctive bimodal pattern, with one peak in the fetal period and another in the neonatal period to infancy. This is the first study to perform quantitative analysis of the distribution of CYP11B2-positive cells, the histological DZ or ZG, and the development of aldosterone biosynthesis in human adrenal glands during fetal and pediatric periods.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106593"},"PeriodicalIF":2.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0960076024001419/pdfft?md5=899c91d409197a539bb97cef85722e12&pid=1-s2.0-S0960076024001419-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen receptor knockdown suggests its role in gonadal development regulation in Manila clam Ruditapes philippinarum 雌激素受体敲除表明其在马尼拉蛤蜊 Ruditapes philippinarum 的性腺发育调节中发挥作用

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-07-29 DOI: 10.1016/j.jsbmb.2024.106594

Min Ding , Lianxue Han , Jingjing Miao , Xuening Wang , Lu Wang , Luqing Pan

{"title":"Estrogen receptor knockdown suggests its role in gonadal development regulation in Manila clam Ruditapes philippinarum","authors":"Min Ding , Lianxue Han , Jingjing Miao , Xuening Wang , Lu Wang , Luqing Pan","doi":"10.1016/j.jsbmb.2024.106594","DOIUrl":"10.1016/j.jsbmb.2024.106594","url":null,"abstract":"<div><p>The estrogen receptor (ER), a ligand-dependent transcription factor, is critical for vertebrate reproduction. However, its role in bivalves is not well understood, with ongoing debates regarding its function in regulating reproduction similarly to vertebrates. To investigate ER's function, we conducted a 21-day RNA interference experiment focusing on its role in gonadal development in bivalves. Histological analyses revealed that ER inhibition significantly suppressed ovarian development in females and, conversely, promoted gonadal development in males. Additionally, levels of 17β-estrogen (E2) were markedly reduced in the gonads of both sexes following ER suppression. Transcriptomic analysis from RNA-seq of testes and ovaries after ER interference showed changes in the expression of key genes such as Vtg, CYP17, 3β-HSD, and 17β-HSD. These genes are involved in the estrogen signaling pathway and steroid hormone biosynthesis. Furthermore, ER suppression significantly affected the expression of genes linked to gametogenesis and the reproductive cycle. Our findings highlight ER's crucial, yet complex and sex-specific roles in gonadal development in bivalves, emphasizing the need for further detailed studies.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"243 ","pages":"Article 106594"},"PeriodicalIF":2.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The mediating role of steroid hormones in the relationship between bisphenol A and its alternatives bisphenol S and F exposure and preeclampsia 类固醇激素在双酚 A 及其替代品双酚 S 和 F 暴露与先兆子痫之间的关系中的中介作用。

IF 2.7 2区生物学

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2024-07-24 DOI: 10.1016/j.jsbmb.2024.106591

Yudong Pu , Yue Du , Jie He , Shuzhen He , Ya Chen , Aitong Cao , Yuhui Dang

{"title":"The mediating role of steroid hormones in the relationship between bisphenol A and its alternatives bisphenol S and F exposure and preeclampsia","authors":"Yudong Pu , Yue Du , Jie He , Shuzhen He , Ya Chen , Aitong Cao , Yuhui Dang","doi":"10.1016/j.jsbmb.2024.106591","DOIUrl":"10.1016/j.jsbmb.2024.106591","url":null,"abstract":"<div><p>Steroid hormone imbalance is believed to increase the odds of developing PE. Bisphenol A (BPA) and its substitutes (e.g., bisphenol S (BPS) and bisphenol F (BPF)) have estrogen-like effects, and its exposure may be related to the development of preeclampsia (PE). To explore the effects of bisphenol exposure on maternal serum steroid hormones and the potential mediating role of steroid hormones in the association between bisphenol exposure and developing PE, concentrations of bisphenols and steroid hormones in serum samples of 383 pregnant women were examined before delivery (including 160 PE cases and 223 control cases). Multivariable logistic and linear models were used to explore the associations of maternal serum bisphenols concentrations with both maternal steroid hormones and PE risk. Mediation modeling was employed to evaluate the mediating role of steroid hormones in the association between bisphenols and PE. Results showed that maternal serum BPS concentrations were positively associated with testosterone (T) concentrations. The mediation analyses suggested that approximately 10.17 % of the associations between BPS concentrations and the development of PE might be mediated by maternal T. In conclusion<strong>,</strong> maternal exposure to BPS during pregnancy is linked to higher maternal T concentrations, which might increase the odds of developing PE. T might mediate the association between BPS exposure and the development of PE.</p></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"244 ","pages":"Article 106591"},"PeriodicalIF":2.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0