Journal of Steroid Biochemistry and Molecular Biology最新文献

{"title":"High reliance on fortified foods when optimizing diets of adolescents in Sweden for adequate vitamin D intake and climate sustainability","authors":"André Hesselink ,&nbsp;Anna Winkvist ,&nbsp;Anna Karin Lindroos ,&nbsp;Patricia Eustachio Colombo ,&nbsp;Linnea Bärebring ,&nbsp;Elinor Hallström ,&nbsp;Hanna Augustin","doi":"10.1016/j.jsbmb.2025.106759","DOIUrl":"10.1016/j.jsbmb.2025.106759","url":null,"abstract":"<div><div>The global food system contributes roughly one-third of global greenhouse gas emissions (GHGEs) making shifts towards more sustainable food consumption an imperative. Such diets also need to factor in nutrient requirements and cultural acceptability. Our aim was to simulate dietary changes for adolescents in Sweden to achieve the recommended intake (RI) for vitamin D while factoring in additional nutrients, cultural acceptability and keeping the diet within planetary boundaries for climate change. A baseline diet was estimated from Sweden’s national dietary survey Riksmaten Adolescents 2016–17 (n = 3099, ages 11–18 years), which provided food intake via two 24-hour recalls. Intake data were linked to the Swedish Food Agency’s food composition database and GHGE estimates from the Research Institutes of Sweden’s (RISE) Food Climate Database. Linear programming was used to optimize the baseline diet to meet the RI for vitamin D (10 µg/day), reduce GHGEs to ≤ 1.7 kg CO₂-equivalents/person/day, and minimize dietary changes from baseline to factor in cultural acceptability. A second optimization included 25 additional nutrients requirements. Both optimized diets met their respective requirements reducing GHGEs by 54 % but relied heavily on milk and yoghurt (fortified by law), which provided &gt; 60 % of vitamin D intake. Both diets also required major shifts toward plant-based foods and the second optimization demanded a five-fold greater change in diet from baseline compared to first optimization. Results suggest that adolescents in Sweden can achieve RIs for vitamin D and other nutrients while greatly reducing diet-related GHGEs, though cultural acceptability may be a challenge.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"251 ","pages":"Article 106759"},"PeriodicalIF":2.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of A. paeoniifolius extracts on bone growth and osteoporosis via inhibiting RANKL-mediated pathway","authors":"Mrinal Sanaye ,&nbsp;Maria Alva ,&nbsp;Tejal Wani ,&nbsp;Arindam Banerjee ,&nbsp;Rajasekaran R","doi":"10.1016/j.jsbmb.2025.106746","DOIUrl":"10.1016/j.jsbmb.2025.106746","url":null,"abstract":"<div><div>Osteoporotic fractures are commonly observed in postmenopausal women. The major risk factor involved is estrogen deficiency. Phytoestrogens, structurally identical to 17-estradiol, have been shown to decrease bone turnover markers, increase bone mineral density, and provide protection against osteoporosis. The present study involves probing the molecular mechanism of <em>Amorphophallus paeoniifolius (</em>AP<em>)</em> rich in phytoestrogens viz kaempferol, rutin, quercetin, and gallic acid, as some therapeutic moieties in the treatment of osteoporosis. The study involves extraction of AP followed by MTT assay for cytotoxicity, and RT-PCR for evaluating the mRNA expression of <em>RANKL</em>, <em>ALP</em>, <em>IL-6</em>, Osteopontin (<em>OPN</em>), and Osteocalcin (<em>OCN</em> <!-->) and western blot analysis of <em>RANKL</em>, along with bone mineralization assay. In the MTT assay, AP extracts showed biocompatibility in both MG-63 and UMR-106, with downregulation of osteoclast differentiation factors <em>RANKL</em>, and <em>IL-6</em> and upregulation of osteoblastic markers <em>OPN</em>, <em>OCN</em> <!-->, and <em>ALP</em> through RT-PCR analysis at 50 μg/ml. In western Blot analysis, decreased protein expression of RANKL indicates reduced bone resorption. A significant increase in Alizarin red dye staining intensity during treatment confirms the progression of calcium deposition, thereby ensuring bone remineralization. The study reveals that AP, promotes osteoblast differentiation, bone re-mineralization, and re-calcification by the downregulation of the <em>RANKL</em>-mediated pathway, suggesting potential therapeutic efficacy for the treatment of post-menopausal osteoporosis.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"251 ","pages":"Article 106746"},"PeriodicalIF":2.7,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zingerone modulates the circulating steroids hormone levels and testicular steroidogenic markers expression in mice: An in vivo and in silico study","authors":"Miti Jerang ,&nbsp;Guruswami Gurusubramanian ,&nbsp;Ved Prakash Singh ,&nbsp;Vikas Kumar Roy","doi":"10.1016/j.jsbmb.2025.106748","DOIUrl":"10.1016/j.jsbmb.2025.106748","url":null,"abstract":"<div><div>Zingerone (4-(4-hydroxy-3-methoxyphenyl)-2-butanone) is a phytochemical with potent anti-inflammatory and antioxidant properties. It has been shown that zingerone protects testis under pathological conditions by its antioxidant and anti-inflammatory effects. However, there is no direct evidence that zingerone specifically affects the testicular steroidogenesis in normal conditions. Therefore, in this study, we have investigated the effects of zingerone on testicular steroidogenesis by using in vivo and silico approaches. The mice were divided into four groups: Control, 10, 25, and 50 mg/kg dosages of zingerone, which were administered orally for 35 days. It was observed that zingerone treatment modulates both circulating hormone levels and the expression of steroidogenic protein markers. Specifically, the higher doses of zingerone resulted in an increase in the circulating estrogen and androstenedione levels, while progesterone, testosterone, and follicle-stimulating hormone levels were reduced. Further, no significant change was observed in the circulating LH level. The higher doses of zingerone resulted in an increased expression and localisation of 3βHSD, CYP19A1, LHR and decreased expression and localisation of StAR, CYP11A1, and 17βHSD protein. Our silico studies showed that the steroidogenic proteins (CYP11A1, 3βHSD, 17βHSD) when double docked with zingerone alongside its native ligands (cholesterol, pregnenolone, androstenedione) showed an increase in the binding affinity. In contrast, StAR, CYP19A1 when double docked with zingerone and its native ligands exhibited a lesser binding affinity compared to when these proteins were single docked with their native ligand and zingerone. In conclusion, in vivo study showed zingerone stimulates androstenedione, estrogen secretion and up-regulates the expression of CYP19A1, LHR and 3βHSD proteins, whereas it down-regulates the expression of StAR, CYP11A1 and 17βHSD proteins and circulating testosterone, progesterone, follicle-stimulating hormone levels. Furthermore, in silico study has also shown the binding affinities of zingerone with the steroidogenic markers. Thus, zingerone has modulatory effects on testicular steroid biosynthesis in normal mice.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"251 ","pages":"Article 106748"},"PeriodicalIF":2.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143791891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Treatment response variations to a single large bolus of enteral cholecalciferol in vitamin D deficient critically ill children: Metabolomic insights for precision nutrition” [J. Steroid Biochem. Mol. Biol. 250 (2025) 106720]","authors":"Erick Helmeczi ,&nbsp;Haley Pandya ,&nbsp;Katie O’Hearn ,&nbsp;Dayre McNally ,&nbsp;Philip Britz-McKibbin","doi":"10.1016/j.jsbmb.2025.106741","DOIUrl":"10.1016/j.jsbmb.2025.106741","url":null,"abstract":"","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"250 ","pages":"Article 106741"},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Production of 11-ketotestosterone in childhood adrenal tumors with virilization or peripheral precocious puberty: Dominant expression of 11β-hydroxysteroid dehydrogenase type 2","authors":"Yasuko Fujisawa ,&nbsp;Shinichiro Sano ,&nbsp;Yuki Murai ,&nbsp;Kimiyoshi Sakaguchi ,&nbsp;Yohei Masunaga ,&nbsp;Kenichi Kinjo ,&nbsp;Wataru Tanikawa ,&nbsp;Maiko Ikeda ,&nbsp;Ibuki Oyama ,&nbsp;Tsutomu Ogata","doi":"10.1016/j.jsbmb.2025.106747","DOIUrl":"10.1016/j.jsbmb.2025.106747","url":null,"abstract":"<div><div>11-Oxygenated androgens are important components of the androgen pool in humans. Among them, 11-ketotestosterone (11-KT), a potent 11-oxygenated androgen primarily produced in peripheral tissues outside the adrenal glands, has garnered research interest for its crucial role in several diseases associated with androgen excess. This study aimed to investigate the biosynthesis of 11-oxygenated androgens, particularly 11-KT, in childhood adrenocortical tumors (ACTs) presenting with symptoms of androgen excess. This retrospective study included three patients, aged 6 months, 2 years, and 12 years, presenting with symptoms of androgen excess due to childhood ACTs. Multiple androgen metabolites were simultaneously measured using pre- or postoperative serum samples, tumors, and tumor-attached adrenal glands obtained from patients using liquid chromatography-tandem mass spectrometry. The expression of genes involved in androgen synthesis was analyzed using DNA microarray analysis. Serum androgen levels were elevated prior to tumor removal and decreased to within or near reference ranges after tumor removal. Notably, serum 11-KT levels were markedly elevated compared to reference ranges, similar to testosterone (T), and 11-KT was abundant within the tumor tissues. Unique gene expression patterns were observed across the three cases of childhood ACTs, including marked <em>HSD11B2</em>, attenuated <em>HSD11B</em>1, and elevated <em>HSD17B3</em> expression levels, which are involved in 11-KT biosynthesis. This study confirms the direct production of 11-KT in childhood ACTs; gene expression patterns observed in these cases favored 11-KT biosynthesis, providing insight into their potential role in androgen excess.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"251 ","pages":"Article 106747"},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secosteroid – 1,3,4-oxadiazole hybrids: Synthesis and evaluation of their activity against hormone-dependent breast cancer cells","authors":"Alexey I. Ilovaisky ,&nbsp;Alexander M. Scherbakov ,&nbsp;Dumitru Miciurov ,&nbsp;Elena I. Chernoburova ,&nbsp;Valentina M. Merkulova ,&nbsp;Fedor B. Bogdanov ,&nbsp;Diana I. Salnikova ,&nbsp;Danila V. Sorokin ,&nbsp;Mikhail A. Krasil’nikov ,&nbsp;Eugene I. Bozhenko ,&nbsp;Igor V. Zavarzin ,&nbsp;Alexander O. Terent’ev","doi":"10.1016/j.jsbmb.2025.106745","DOIUrl":"10.1016/j.jsbmb.2025.106745","url":null,"abstract":"<div><div>This study focused on the synthesis of secosteroids with good antiproliferative properties against hormone-dependent breast cancer. A straightforward and efficient method for synthesizing secosteroid – 1,3,4-oxadiazole hybrids was developed starting from 13α-hydroxy-3-methoxy-13,17-secoestra-1,3,5(10)-trien-17-oic acid hydrazide. The cyclization of hydrazide moiety with CS₂ into 1,3,4-oxadiazole-2(3<em>H</em>)-thione fragment followed by sulfur alkylation resulted in the formation of various secosteroid – 2-mercapto-1,3,4-oxadiazole hybrids. These novel compounds were evaluated for their antiproliferative activity against the hormone-dependent human breast cancer cell line MCF-7. Among the synthesized hybrids, compounds <strong>3i</strong>, <strong>3o</strong>, and <strong>3q</strong> displayed notable antiproliferative effects, with IC₅₀ values ranging from 6.5 to 8.9 µM, comparable to the reference drug cisplatin. Furthermore, compound <strong>3i</strong> showed minimal toxicity toward non-cancerous hFB-hTERT fibroblasts, indicating high selectivity. Compounds <strong>3o</strong> and <strong>3q</strong> exhibited antiestrogenic activity. Additionally, their effects on PARP and Bcl-2 suggest a pro-apoptotic mechanism of action. These findings highlight the potential of secosteroidal hybrids as promising candidates for the development of new anti-breast cancer agents targeting ERα and apoptosis pathways.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"251 ","pages":"Article 106745"},"PeriodicalIF":2.7,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143755636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From lipids to glucose: Investigating the role of dyslipidemia in the risk of insulin resistance","authors":"Mahtab Jahdkaran ,&nbsp;Mohammad Sistanizad","doi":"10.1016/j.jsbmb.2025.106744","DOIUrl":"10.1016/j.jsbmb.2025.106744","url":null,"abstract":"<div><div>Dyslipidemia is recognized as one of the most prevalent metabolic disorders and is frequently associated with other prevalent conditions, particularly diabetes mellitus. There appears to be a bidirectional connection between these two metabolic disorders. While considerable research has focused on how insulin resistance can lead to lipid abnormalities, the reverse relationship specifically, how dyslipidemia could assist in developing insulin resistance and diabetes mellitus has received relatively less attention. This review aims to comprehensively evaluate the mechanisms through which dyslipidemia can induce insulin resistance. Dyslipidemia is primarily classified into three main categories: hypercholesterolemia, hypertriglyceridemia, and low levels of HDL. These conditions may promote insulin resistance across multiple pathways, including the accumulation of lipid metabolites, dysfunction of pancreatic β-cells, increased reactive oxygen species, endoplasmic reticulum stress and inflammation, endothelial dysfunction, alterations in adiponectin levels, changes in bile acid composition and concentration, and dysbiosis of gut microbiota. However, further investigation is required to fully elucidate the cellular and molecular mechanisms underlying the relationship between lipid disorders and insulin resistance. Emphasizing such research could facilitate the development of therapeutic strategies targeting both conditions simultaneously.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"250 ","pages":"Article 106744"},"PeriodicalIF":2.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-dose vitamin D supplementation in pregnancy ameliorates obesity-induced increase in maternal IL-1β level without affecting obesity-induced increase in IL-6 and MCP","authors":"Helena H. Andersen ,&nbsp;Matilde K. Andersen ,&nbsp;Krista Agathe Bossow ,&nbsp;Anna Louise Vestergaard ,&nbsp;Pinar Bor ,&nbsp;Agnete Larsen","doi":"10.1016/j.jsbmb.2025.106742","DOIUrl":"10.1016/j.jsbmb.2025.106742","url":null,"abstract":"<div><h3>Background</h3><div>Maternal and placental inflammatory activity is carefully regulated during pregnancy and changes in inflammatory status are associated with pregnancy complications and health deficits in the offspring including adverse effects on neurodevelopment. Overweight/obesity is associated with chronic inflammation, thereby contributing to adverse effects. Disturbingly, overweight and obesity are highly prevalent among pregnant women worldwide. Vitamin D (vitD) possess immunomodulatory effects and is believed to support healthy pregnancy. Endocrinological societies recommend empiric vitD supplementation in pregnancy but there is no consensus on the minimal supplementation dose</div></div><div><h3>Methods</h3><div>An adjacent study to GRAVIT-D (no. NCT04291313, ClinicalTrial.gov), a double-blinded randomized trial investigating the clinical benefits of increasing vitD supplementation in pregnancy from 400IU to 3600IU/day from gestational week 11–16 onwards. In a subgroup, (n = 156), multiplex ELISA targeting third-semester serum levels of IL-1β, IL-6, IL-10, TNFα, MCP-1, and IL-17A was performed. Inflammation signals were correlated with the vitD dose given, subsequently analysing the effect of vitD in relation to the pre-pregnancy body mass index (BMI) within each treatment arm comparing the inflammatory response in WHO-defined BMI groups, &lt; 25, 25–30 and &gt; 30 kg/m².</div></div><div><h3>Main Results</h3><div>High pre-pregnancy BMI was associated with increased IL6 and MCP1 in both the 400IU and the 3600 IU exposed group. IL1β levels increased with BMI if using a 400IU/day supplement. High dose vitD supplementation ameliorated BMI effects on IL1β.</div></div><div><h3>Conclusion and Perspectives</h3><div>Increased vitD supplementation during pregnancy may ameliorate some overweight/obesity-induced inflammatory activity. Further studies are needed to determine the vitD need in pregnancies complicated by obesity and overweight.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"250 ","pages":"Article 106742"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytoestrogens as potential anti-osteoporosis nutraceuticals: Major sources and mechanism(s) of action","authors":"Mohammad Amir Khan ,&nbsp;Mohsin Ali Khan ,&nbsp;Sahabjada Siddiqui ,&nbsp;Aparna Misra ,&nbsp;Kusum Yadav ,&nbsp;Aditi Srivastava ,&nbsp;Anchal Trivedi ,&nbsp;Ishrat Husain ,&nbsp;Rumana Ahmad","doi":"10.1016/j.jsbmb.2025.106740","DOIUrl":"10.1016/j.jsbmb.2025.106740","url":null,"abstract":"<div><div>By 2050, the global aging population is predicted to reach 1.5 billion, highlighting the need to enhance the quality of life of the elderly population. Osteoporotic fractures are projected to affect one in three women and one in five men over age 50. Initial treatments for osteoporosis in postmenopausal women include antiresorptive agents such as bisphosphonates, strontium ranelate, estrogen replacement therapy (ERT) and selective estrogen receptor modulators (SERMs). However, these do not rebuild bone, limiting their effectiveness. Denosumab, an FDA-approved antiresorptive monoclonal antibody, also has drawbacks including high costs, biannual subcutaneous injections, slow healing, impaired bone growth and side effects like eczema, flatulence, cellulitis, osteonecrosis of the jaw (ONJ) and an increased risk of spinal fractures after discontinuation of treatment. Nutraceuticals, particularly phytoestrogens, are gaining attention for their health benefits and safety in osteoporosis prevention, management and treatment. Phytoestrogens are plant metabolites similar to mammalian estrogens and include isoflavones, coumestans, lignans, stilbenes, and flavonoids. They interact with estrogen receptor isoforms ERα and ERβ, acting as agonists or antagonists based on concentration and bioavailability. Their tissue-selective activities are particularly significant: anti-estrogenic effects in reproductive tissues may lower the risk of hormone-related cancers (such as ovarian, uterine, breast and prostate), while estrogenic effects on bone could contribute to the preservation of bone mineral density.Phytoestrogens are, thus, used in managing breast and prostate cancers, cardiovascular diseases, menopause and osteoporosis. The present review focuses on the botanical origin, classification, sources and mechanism(s) of action of major phytoestrogens, their potential in prevention and management of osteoporosis and the requirement for additional clinical trials to achieve more definitive outcomes in order to confirm their efficacy and dosage safety.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"251 ","pages":"Article 106740"},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive perspective on the role of vitamin D signaling in maintaining bone homeostasis: Lessons from animal models","authors":"Kayleigh Rillaerts,&nbsp;Lieve Verlinden,&nbsp;Stefanie Doms,&nbsp;Geert Carmeliet,&nbsp;Annemieke Verstuyf","doi":"10.1016/j.jsbmb.2025.106732","DOIUrl":"10.1016/j.jsbmb.2025.106732","url":null,"abstract":"<div><div>1,25(OH)₂D₃ is well known for its role in maintaining normal serum calcium levels. Through its receptor, 1,25(OH)₂D₃ enhances intestinal calcium absorption and renal calcium reabsorption, thereby ensuring serum calcium levels are within physiological range, which is in turn important for normal bone development and mineralization. The vitamin D receptor (VDR) achieves this via transcriptional induction of genes important in calcium transport. When intestinal and renal calcium (re)absorption is impaired, VDR-mediated signaling will stimulate bone resorption and inhibit mineralization in order to maintain normal serum calcium levels, as evidenced in mice with a systemic or intestine-specific deletion of the VDR. However, VDR signaling in bone is also reported to have anabolic effects. In this review we will discuss the effects of 1,25(OH)₂D₃-mediated VDR signaling on bone homeostasis and provide an overview of the <em>in vitro</em> experiments and various transgenic mice models that have been generated to unravel the role of VDR signaling in different bone cell types such as chondrocytes, (pre)osteoblasts, osteocytes, and (pre)osteoclasts.</div></div>","PeriodicalId":51106,"journal":{"name":"Journal of Steroid Biochemistry and Molecular Biology","volume":"250 ","pages":"Article 106732"},"PeriodicalIF":2.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}