Journal of Pain最新文献

{"title":"Letter: Further nuanced data on the role of P2RX7 SNPs in chronic pain states","authors":"Samiha Shaikh, Michael Nahorski, Yunisa Pamela, Nicholas Shenker, Clare Bryant, Christopher Geoffrey Woods","doi":"10.1016/j.jpain.2024.104635","DOIUrl":"10.1016/j.jpain.2024.104635","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 10","pages":"Article 104635"},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model","authors":"Heather N. Allen ,&nbsp;Sara Hestehave ,&nbsp;Paz Duran ,&nbsp;Tyler S. Nelson ,&nbsp;Rajesh Khanna","doi":"10.1016/j.jpain.2024.104664","DOIUrl":"10.1016/j.jpain.2024.104664","url":null,"abstract":"<div><div>Osteoarthritis (OA) represents a significant pain challenge globally, as current treatments are limited and come with substantial and adverse side effects. Voltage-gated calcium channels have proved to be pharmacologically effective targets, with multiple Food and Drug Administration-approved Ca_V2.2 modulators available for the treatment of pain. Although effective, drugs targeting Ca_V2.2 are complicated by the same obstacles facing other pain therapeutics—invasive routes of administration, narrow therapeutic windows, side effects, and addiction potential. We have identified a key regulator of Ca_V2.2 channels, collapsin response mediator protein 2, that allows us to indirectly regulate Ca_V2.2 expression and function. We previously developed a peptidomimetic modulator of collapsin response mediator protein 2, CBD3063, that effectively reverses neuropathic and inflammatory pain without negative side effects by reducing membrane expression of Ca_V2.2. The potent analgesic properties of CBD3063, combined with the lack of negative side effects, prompted us to assess the efficacy of CBD3063 in a rodent model of OA pain. Here, we demonstrate the intraperitoneal administration of CBD3063 alleviates both evoked and nonevoked behavioral hallmarks of OA pain. Further, we reveal that CBD3063 reduces OA-induced increased neural activity in the parabrachial nucleus, a key supraspinal site modulating the pain experience. Together, these studies suggest that CBD3063 is an effective analgesic for OA pain.</div></div><div><h3>Perspective</h3><div>Despite the high prevalence of OA pain worldwide, current treatment options remain limited. We demonstrate that CBD3063-mediated disruption of the Ca_V2.2-collapsin response mediator protein 2 interaction alleviates pain in a preclinical joint pain model, providing a promising basis for the development of new OA pain treatments.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 12","pages":"Article 104664"},"PeriodicalIF":4.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Relationship Between Pain and Mental Health Conditions Among Children and Young People—A Population-Based Register Study in Sweden","authors":"Elisabeth Bondesson ,&nbsp;Beata Borgström Bolmsjö ,&nbsp;Fabian Larrosa Pardo ,&nbsp;Anna Saxne Jöud","doi":"10.1016/j.jpain.2024.104662","DOIUrl":"10.1016/j.jpain.2024.104662","url":null,"abstract":"<div><div>Both pain and mental health conditions are common among young people. They often co-occur, but we wanted to investigate further whether it is pain (abdominal pain, headache, musculoskeletal pain, menstrual pain) that precedes mental health conditions (depression, anxiety, stress, phobia) or whether it is the other way around, mental health conditions that precede pain. Using electronic health records—the Skåne Healthcare Register—we identified and followed young people aged 7 to 18 over a 13-year period and tracked all their registered diagnoses. Using Poisson regression, we analyzed the incidence rate ratio (IRR) of being diagnosed with mental health conditions after an initial diagnosis of pain and vice versa the IRR of being diagnosed with pain after an initial diagnosis of a mental health condition. Among individuals with pain, 12,054 (23%) later received a diagnosis of a mental health condition. The IRR for a mental health condition after pain was 2.86 (95% (confidence interval) CI = 2.78–2.94) compared to not having pain, adjusted for age, sex, and prior health care consultations. Among individuals with mental health conditions, 3,688 (17%) later received a diagnosis of pain. The adjusted IRR was 1.57 (95% CI = 1.52–1.63). Compared to boys, girls had consistently higher estimates, and the same was found for the younger individuals compared to the older ones. Individuals with pain have a 3-fold increased risk of developing mental health conditions, while the risk of developing pain after mental health conditions was lower although still elevated compared to young people seeking care regardless of cause.</div></div><div><h3>Perspective</h3><div>Young people with pain have a 3-fold increased risk of developing mental health conditions, while the reverse risk is lower but still elevated compared to young people without these conditions. Health care professionals must recognize the interplay between pain and mental health in young patients when diagnosing and planning treatment.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 12","pages":"Article 104662"},"PeriodicalIF":4.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Care Discrimination Affects Patient Activation, Communication Self-Efficacy, and Pain for Black Americans","authors":"Veronica Derricks ,&nbsp;Adam T. Hirsh ,&nbsp;Anthony J. Perkins ,&nbsp;Joanne K. Daggy ,&nbsp;Marianne S. Matthias","doi":"10.1016/j.jpain.2024.104663","DOIUrl":"10.1016/j.jpain.2024.104663","url":null,"abstract":"<div><div>This study examines whether a key psychosocial factor—perceiving racial discrimination in health care—is associated with worse patient activation, communication self-efficacy, and physical health outcomes for Black veterans with chronic pain. Moreover, we explore the role of physician-patient working alliance as a moderator that may alleviate the potential consequences of perceiving racial discrimination. This work is a secondary analysis of baseline data from a clinical trial with 250 U.S. Black veterans with chronic musculoskeletal pain. Participants were recruited from primary care clinics at a Midwestern VA hospital between 2018 and 2021. Perceiving racial discrimination in health care was associated with lower patient activation, lower self-efficacy in communicating with one’s physician, higher pain intensity, and lower pain management self-efficacy (<em>p</em>s &lt; .049) but was unrelated to reports of pain interference or use of pain coping strategies (<em>p</em>s &gt; .157). Although the relationship between perceived discrimination and patient activation was moderated by working alliance (<em>P</em> = .014), having a stronger working alliance improved patient activation to varying degrees across levels of perceived discrimination (rather than buffering against negative outcomes when perceiving higher levels of discrimination). Moderation was not significant on any other measures. This study deepens our understanding of the broad range of health outcomes that are (not) associated with perceiving racial discrimination in health care. Contrary to prior theorizing, this work also indicates that having a strong working alliance does not attenuate the consequences of perceiving discrimination among Black individuals living with pain. These results highlight the need for system-level interventions to address perceptions of racial mistreatment in health care.</div></div><div><h3>Perspective</h3><div>This work has important public health implications by identifying the broad range of outcomes associated with perceived discrimination in health care among Black Americans. Importantly, a strong physician-patient relationship did not buffer Black individuals from the consequences of perceiving discrimination. These findings inform intervention targets to mitigate racial health disparities.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 12","pages":"Article 104663"},"PeriodicalIF":4.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142114474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Letter to Pamela E Macintyre’s Letter to the Editor","authors":"Shania Liu,&nbsp;Asad E. Patanwala,&nbsp;Justine M. Naylor,&nbsp;Jennifer A. Stevens,&nbsp;Bernadette Bugeja,&nbsp;David Begley,&nbsp;Kok E. Khor,&nbsp;Eric Lau,&nbsp;Sam Adie,&nbsp;Jonathan Penm","doi":"10.1016/j.jpain.2024.104558","DOIUrl":"10.1016/j.jpain.2024.104558","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 9","pages":"Article 104558"},"PeriodicalIF":4.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor re Tapentadol Versus Oxycodone for Opioid-related Adverse Drug Events and Clinical Outcomes After Inpatient Surgery","authors":"Pamela E. Macintyre","doi":"10.1016/j.jpain.2024.104524","DOIUrl":"10.1016/j.jpain.2024.104524","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 9","pages":"Article 104524"},"PeriodicalIF":4.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142040936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Measures of Pain Intensity During Sickle Cell Disease Vaso-Occlusive Episodes","authors":"Mitchell R. Knisely ,&nbsp;Huiman X. Barnhart ,&nbsp;Stephanie O. Ibemere ,&nbsp;Patricia Kavanagh ,&nbsp;Judith A. Paice ,&nbsp;John J. Strouse ,&nbsp;Paula J. Tanabe","doi":"10.1016/j.jpain.2024.104658","DOIUrl":"10.1016/j.jpain.2024.104658","url":null,"abstract":"<div><div>We aimed to determine the minimal clinically important difference (MCID) in pain severity and agreement between the visual analog scale (VAS) and the verbal numeric rating scale (NRS) in people with sickle cell disease (SCD) experiencing an acute vaso-occlusive episode in the emergency department. In the COMPARE-VOE trial (NCT03933397), participants were administered the VAS (0–100), NRS (0–100), and descriptor scale (<em>a lot better</em>, <em>a little better</em>, <em>same</em>, <em>a little worse</em>, <em>much worse</em>) every 30 minutes while in the emergency department. We analyzed data from 100 participants (mean age 30.2 years; 61% female). We calculated the mean differences and 95% confidence intervals (CIs) between current and preceding scores when the participant reported <em>a little worse</em> or <em>a little better</em> pain for each scale (255 VAS and 150 NRS observations) to assess the MCID for the VAS and NRS. Pearson correlation and the Bland-Altman method were used to assess the agreement among 411 paired VAS and NRS observations. Our results indicated that the MCID for the VAS was 8.77 mm (95% CI: 7.43 mm, 10.83 mm) and the NRS was 8.29 (95% CI: 6.47, 11.60). The VAS and NRS scales had a correlation of .88 (<em>P</em> &lt; .001). The Bland-Altman method indicated a mean difference of −4.6 ± 1.96 and the 95% limits of agreement ranged from 20 to −29. Despite high correlation, there was considerable variability of agreement between the VAS and NRS scales, indicating that these scales are not interchangeable to assess pain during a vaso-occlusive event.</div></div><div><h3>Perspective</h3><div>The MCID in pain severity for individuals with a SCD vaso-occlusive episode using the VAS (8.77 mm) is lower than previously reported, and the MCID for NRS was 8.29. The agreement between the VAS and NRS was determined and the scales cannot be used interchangeably to measure SCD pain intensity.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 12","pages":"Article 104658"},"PeriodicalIF":4.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based EEG Neurofeedback for the Treatment of Chronic Pain: A Randomized Controlled Clinical Trial","authors":"David A. Rice ,&nbsp;Christine Ozolins ,&nbsp;Riya Biswas ,&nbsp;Faisal Almesfer ,&nbsp;Irene Zeng ,&nbsp;Ankit Parikh ,&nbsp;Willis Glen Vile ,&nbsp;Usman Rashid ,&nbsp;Jon Graham ,&nbsp;Michal T. Kluger","doi":"10.1016/j.jpain.2024.104651","DOIUrl":"10.1016/j.jpain.2024.104651","url":null,"abstract":"<div><div>This parallel, 2-arm, blinded, randomized controlled superiority trial examined whether, when added to usual care, active-electroencephalography neurofeedback (EEG NFB) was safe and more effective than sham control-EEG NFB for chronic pain. In total, 116 participants with chronic pain were randomly assigned (1:1) to usual care plus ≥32 sessions of active-EEG NFB upregulating relative alpha power over C4 or usual care plus ≥32 sessions of sham control-EEG NFB. Per-protocol analyses revealed no significant between-group differences in the primary outcome, Brief Pain Inventory average pain (mean difference [95% confidence interval]: −.04 [−.39 to .31], <em>P</em> = .90), or any secondary outcomes. However, 44% of participants in the active-EEG NFB group and 45% in the control-EEG NFB group reported at least a moderate (≥30%), clinically important improvement in Brief Pain Inventory average pain. The number of treatment-emergent adverse events were similar in both groups (<em>P</em> = .83), and none were serious. Post hoc analyses revealed similar upregulated relative alpha power in both groups during training, with concordant positive rewards delivered to the active-EEG group 100% of the time and the control-EEG group ∼25% of the time, suggesting a partially active sham intervention. When added to usual care, the active-EEG NFB intervention used in this study was not superior to the sham control-EEG NFB intervention. However, a large proportion of participants in both groups reported a clinically important reduction in pain intensity. A partially active sham intervention may have obscured between-group differences. The intervention was free of important side effects, with no safety concerns identified.</div></div><div><h3>Perspective</h3><div>This study is the first attempt at an appropriately blinded, randomized, sham-controlled trial of alpha EEG NFB for the treatment of chronic pain. The findings may interest people living with chronic pain, clinicians involved in chronic pain management, and may inform the design of future EEG NFB trials.</div></div><div><h3>Trial Registration</h3><div>Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12621000667819.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 11","pages":"Article 104651"},"PeriodicalIF":4.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THC Vapor Inhalation Attenuates Hyperalgesia in Rats Using a Chronic Inflammatory Pain Model","authors":"Leslie K. Kelley ,&nbsp;Savannah H.M. Lightfoot ,&nbsp;Matthew N. Hill ,&nbsp;Jason W. Middleton ,&nbsp;Nicholas W. Gilpin","doi":"10.1016/j.jpain.2024.104649","DOIUrl":"10.1016/j.jpain.2024.104649","url":null,"abstract":"<div><div>Humans use cannabinoid drugs to alleviate pain. As cannabis and cannabinoids are legalized in the United States for medicinal and recreational use, it has become critical to determine the potential utilities and harms of cannabinoid drugs in individuals living with chronic pain. Here, we tested the effects of repeated ∆⁹-tetrahydrocannabinol ^(THC) vapor inhalation on thermal nociception and mechanical sensitivity, in adult male and female Wistar rats using a chronic inflammatory pain model (ie, treated with complete Freund’s adjuvant [CFA]). We report that repeated THC vapor inhalation rescues thermal hyperalgesia in males and females treated with CFA and also reduces mechanical hypersensitivity in CFA males but not females. Many of the antihyperalgesic effects of chronic THC vapor were still observable 24 hours after cessation of the last THC exposure. We also report plasma levels of THC and its major metabolites, some of which are cannabinoid type-1 receptor agonists, after the first and tenth days of THC vapor inhalation. Finally, we report that systemic administration of the cannabinoid type-1 receptor inverse agonist AM251 (1 mg/kg, I.P.) blocks the antihyperalgesic effects of THC vapor in males and females. These data provide a foundation for future work that will explore the cells and circuits underlying the antihyperalgesic effects of THC vapor inhalation in individuals with chronic inflammatory pain.</div></div><div><h3>Perspective</h3><div>Cannabinoids are thought to have potential utility in the treatment of chronic pain, but few animal studies have tested the effects of chronic THC or cannabis in animal models of chronic pain. We tested the effects of repeated THC vapor inhalation on chronic pain-related outcomes in male and female animals.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 11","pages":"Article 104649"},"PeriodicalIF":4.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141914506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Applied Mindfulness Practice, Chronic Pain, and Pain-Related Functioning in Veterans","authors":"Collin M. Calvert ,&nbsp;Alex Haley ,&nbsp;Emily M. Hagel Campbell ,&nbsp;Ann Bangerter ,&nbsp;Brent C. Taylor ,&nbsp;Mariah Branson ,&nbsp;Lee J.S. Cross ,&nbsp;Kelli D. Allen ,&nbsp;John E. Ferguson ,&nbsp;Jessica Friedman ,&nbsp;Laura A. Meis ,&nbsp;Diana J. Burgess","doi":"10.1016/j.jpain.2024.104648","DOIUrl":"10.1016/j.jpain.2024.104648","url":null,"abstract":"<div><div>Mindfulness-based interventions (MBIs) have been shown to improve chronic pain and associated conditions like depression, anxiety, and sleep disorders. However, there is limited research on how veterans with chronic pain apply mindfulness skills to manage pain in daily life. This cross-sectional study examined the association between applied mindfulness practice, pain, and several pain-related conditions among 1,737 veterans with chronic pain prior to enrollment in a trial of 2 MBIs. Applied mindfulness practice was assessed using the Applied Mindfulness Process Scale (AMPS). The outcomes included pain interference, pain intensity, pain catastrophizing, fatigue, sleep disturbance, anxiety, depression, post-traumatic stress disorder, physical function, and social participation. Higher overall AMPS scores, as well as the positive and negative emotional regulation subscales of the AMPS, were associated with less pain interference and catastrophizing, as well as better outcomes for all pain-related conditions. The positive emotional regulation subscale had the strongest associations with outcomes. There was no significant association between the AMPS and pain intensity. The results suggest applied mindfulness practice, especially positive emotional regulation, may improve pain and functioning. In addition, the AMPS shows promise as a process measure of mindfulness skills applied in daily life. Additional research is needed to examine different aspects of mindfulness in the context of MBIs.</div></div><div><h3>Perspective</h3><div>This article describes the relationship between applied mindfulness practice and pain-related outcomes, prior to a MBI, using a novel measure of mindfulness practice. These findings underscore the importance of measuring applied mindfulness practice prior to and during clinical interventions to treat chronic pain.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"25 11","pages":"Article 104648"},"PeriodicalIF":4.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}