Journal of Pain最新文献

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Exposure to perinatal trauma modifies nociception and gene expression in the prefrontal cortex and hypothalamus of adolescent rats 暴露于围产期创伤改变青春期大鼠前额叶皮层和下丘脑的伤害感受和基因表达。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-12-25 DOI: 10.1016/j.jpain.2024.104762
Marissa Sgro , Zoe Kodila , Sabrina Salberg , Crystal N. Li , Madeleine J. Smith , James Freeman , Elaina Vlassopoulos , Sydney Harris , Sandy R. Shultz , Glenn R. Yamakawa , Melanie Noel , Richelle Mychasiuk
{"title":"Exposure to perinatal trauma modifies nociception and gene expression in the prefrontal cortex and hypothalamus of adolescent rats","authors":"Marissa Sgro ,&nbsp;Zoe Kodila ,&nbsp;Sabrina Salberg ,&nbsp;Crystal N. Li ,&nbsp;Madeleine J. Smith ,&nbsp;James Freeman ,&nbsp;Elaina Vlassopoulos ,&nbsp;Sydney Harris ,&nbsp;Sandy R. Shultz ,&nbsp;Glenn R. Yamakawa ,&nbsp;Melanie Noel ,&nbsp;Richelle Mychasiuk","doi":"10.1016/j.jpain.2024.104762","DOIUrl":"10.1016/j.jpain.2024.104762","url":null,"abstract":"<div><div>The perinatal period encompasses a critical window for neurodevelopment that renders the brain highly responsive to experience. Trauma, such as intimate partner violence (IPV) and early life stress/neglect, during this period negatively affects physical and mental health outcomes, including increasing ones risk for chronic pain. Although epigenetic programming likely contributes, the mechanisms that drive the relationship between perinatal trauma and adverse health outcomes, are not fully understood. Therefore, we explored the relationship between perinatal trauma (<em>in utero</em> exposure to IPV and/or early life neglect) and socio-emotional functioning, nociceptive sensitivity, and transcriptomic changes within the prefrontal cortex (PFC) and hypothalamus in dams and their adolescent offspring. Rat dams were randomly assigned to an IPV (i.e., combined mild traumatic brain injury and strangulation) or sham procedure during pregnancy. Following birth, offspring were subsequently assigned the early life neglect or control paradigm. In adolescence, offspring received a plantar incision or sham injury. Perinatal trauma altered nociception and emotional functioning in a sex-dependent manner when combined with the surgical procedure. We identified transcriptomic changes related to DNA transcription and expression within the PFC and hypothalamus of the dams. Examination of the offspring transcriptome highlighted impairment in immune regulation, dysfunction in stress-reactivity, as well as microglia activation. We also identified altered expression of genes associated with chronic pain. This demonstrates that perinatal trauma modifies offspring behaviour, including nociceptive sensitivity. We provide insight into the mechanisms that contribute to the chronification of pain, thereby informing future research targeted at the generation of prevention and therapeutic strategies.</div></div><div><h3>Perspective</h3><div>Perinatal trauma impaired cognitive, socio-emotional, and pain processing in offspring, while also inducing changes in gene expression, in both mothers and offspring. The findings highlight possible mechanisms responsible for intergenerational transmission of risk for chronic pain and provide targets for therapeutics which could potentially reverse perinatal-trauma induced epigenetic change.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104762"},"PeriodicalIF":4.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodology for determining minimally clinically important differences in acute pain intensity with the double stopwatch technique. 利用双秒表技术确定急性疼痛强度最小临床意义差异的方法。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-12-15 DOI: 10.1016/j.jpain.2024.104759
Christopher J Miller, John T Farrar
{"title":"Methodology for determining minimally clinically important differences in acute pain intensity with the double stopwatch technique.","authors":"Christopher J Miller, John T Farrar","doi":"10.1016/j.jpain.2024.104759","DOIUrl":"10.1016/j.jpain.2024.104759","url":null,"abstract":"<p><p>Minimum clinically important differences (MCIDs) in acute pain intensity have not been well established. Conventional approaches for estimating MCIDs require an independent reference scale, with a threshold that must be presumed to accurately classify meaningful change in pain for all study participants, to serve as an anchor. The double stopwatch technique is the gold standard for measuring the time to meaningful relief, where participants actively press the second stopwatch when they experience pain relief that is meaningful to them. This technique eliminates the problem of misclassification with arbitrary anchors at a single time point, but the censored nature of the data is not amenable for determining MCIDs using standard methods. We propose a stopwatch-based MCID methodology that employs the double stopwatch technique to identify individualized thresholds for meaningful change in pain. This approach enables direct classification of changes in pain for each participant based on whether they perceived the change as meaningful and whether it exceeded the study cut-off being tested. Pain values of participants who do not achieve meaningful relief are incorporated into the analysis to address censoring and avoid bias. The performance (e.g., sensitivity, specificity) of different thresholds to serve as an MCID can be estimated using standard approaches with variance estimates derived by cluster bootstrapping. The advantages of the stopwatch-based MCID methodology are illustrated relative to a conventional approach using data from a randomized trial in third molar extraction. PERSPECTIVE: This article describes a methodology for determining MCIDs using the double stopwatch technique, the gold standard for assessing meaningful changes in acute pain. This methodology can be used to establish MCIDs in different acute pain settings, providing a useful basis to evaluate the meaningfulness of clinical trial results.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104759"},"PeriodicalIF":4.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of pain on gait in older people: A systematic review and meta-analysis 疼痛对老年人步态的影响:系统回顾和荟萃分析。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-12-12 DOI: 10.1016/j.jpain.2024.104758
Mahsa Seydi , Kim Delbaere , Dae Uk Han , Lloyd Chan , Meghan Ambrens , Kimberley S. van Schooten
{"title":"The effect of pain on gait in older people: A systematic review and meta-analysis","authors":"Mahsa Seydi ,&nbsp;Kim Delbaere ,&nbsp;Dae Uk Han ,&nbsp;Lloyd Chan ,&nbsp;Meghan Ambrens ,&nbsp;Kimberley S. van Schooten","doi":"10.1016/j.jpain.2024.104758","DOIUrl":"10.1016/j.jpain.2024.104758","url":null,"abstract":"<div><div>Multi-site pain is common in people aged 60 years and over and is associated with a high risk of falls. To prevent and treat pain-related disabilities, it is crucial to identify the mechanisms underlying these associations. There is some evidence that pain leads to changes in walking, such as slower gait speed and shorter walking distance, which impair mobility and may increase the risk of falls. This review evaluated evidence on the relationship between pain and gait characteristics in older people. A comprehensive search on PubMed and Embase included observational studies and clinical trials assessing objective measures of walking, such as gait speed, cadence, stride length, and double-limb support time, in older people with and without pain. Of the 1218 studies screened, thirteen met the inclusion criteria from the primary search. An additional study was identified through the secondary search, resulting in fourteen studies included in this systematic review and meta-analysis. None of these studies investigated the relationship between fear of pain and gait characteristics in older people. Results showed that older people with pain had slower gait speed than those without pain, with a small effect size (Hedge’s <em>g</em> = −0.30, 95% CI = −0.41 to −0.19, p &lt; 0.0001). There were no statistically significant differences in cadence, stride length, and double-limb support time. These findings suggest that pain impacts walking speed in older people, highlighting the importance of addressing this association to manage mobility deficits and fall risk.</div></div><div><h3>Perspective</h3><div>This systematic review and meta-analysis show that pain is associated with reduced gait speed in older people. Recognising and addressing the impact of pain on walking may be important for preventing mobility-related disorders and falls in this population.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104758"},"PeriodicalIF":4.0,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reassurance use and reassurance-related outcomes for low back pain in primary care: A scoping review 初级保健中腰痛的安慰使用和与安慰相关的结果:范围综述。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-12-04 DOI: 10.1016/j.jpain.2024.104753
Annie Young MRes , Simon D. French PhD , Adrian C. Traeger PhD , Mark Hancock PhD , Ben Darlow PhD , Leticia Corrêa PhD , Hazel J. Jenkins PhD
{"title":"Reassurance use and reassurance-related outcomes for low back pain in primary care: A scoping review","authors":"Annie Young MRes ,&nbsp;Simon D. French PhD ,&nbsp;Adrian C. Traeger PhD ,&nbsp;Mark Hancock PhD ,&nbsp;Ben Darlow PhD ,&nbsp;Leticia Corrêa PhD ,&nbsp;Hazel J. Jenkins PhD","doi":"10.1016/j.jpain.2024.104753","DOIUrl":"10.1016/j.jpain.2024.104753","url":null,"abstract":"<div><div>We used a scoping review design to map the available evidence describing the use of reassurance in clinical practice, interventions to increase the delivery of reassurance, and reassurance-related outcome measures. We searched CINAHL, MEDLINE, EMBASE and Cochrane Central from inception to October 2024. Publications were included if they described the use of reassurance or reassurance-related outcome measures in patients with non-specific low back pain (LBP) presenting to primary care. We did not exclude publications on the basis of study design. Data were extracted and charted in accordance with study aims. We included 88 publications describing 66 primary studies. Twenty-one papers described how clinicians used reassurance in primary care, including: information provided (n=16), frequency of use (n=6), challenges providing reassurance (n=7), and importance of individualising reassurance (n=11). Reassurance interventions were investigated in 46 trials. Reassurance interventions were delivered verbally by clinicians to individuals (n=29) or groups (n=14), or via educational materials (n=18). Only one trial measured how reassured the patient felt after the intervention using a single-item non-validated question. Thirty-six trials used indirect measurements of reassurance success, including reductions in: fear-avoidance (n=23), worry (n=8), anxiety (n=8), pain catastrophising (n=10), and further healthcare utilisation (n=12). Relatively few papers have described how clinicians use reassurance in primary care. Reassurance interventions were investigated in 46 trials; however, reassurance was rarely the primary component of the intervention and was often delivered as part of an education intervention. There are no validated measures to directly assess how reassured a patient feels after an intervention.</div></div><div><h3>Perspective</h3><div>This review maps the available evidence describing how patient reassurance is used and assessed in the management of low back pain. There is limited assessment of the effectiveness of reassurance interventions. Reassurance is rarely the primary component of interventions and there are no validated measures to directly assess patient reassurance.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104753"},"PeriodicalIF":4.0,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice 脊髓垂体腺苷酸环化酶激活多肽和PAC1受体信号系统参与奥沙利铂诱导小鼠急性冷性异位性痛
IF 4 2区 医学
Journal of Pain Pub Date : 2024-11-28 DOI: 10.1016/j.jpain.2024.104751
Ichiro Takasaki Ph.D. , Ryota Nagashima , Takahiro Ueda , Yuya Ashihara , Tomoya Nakamachi , Takuya Okada , Naoki Toyooka , Atsuro Miyata , Takashi Kurihara
{"title":"Spinal pituitary adenylate cyclase-activating polypeptide and PAC1 receptor signaling system is involved in the oxaliplatin-induced acute cold allodynia in mice","authors":"Ichiro Takasaki Ph.D. ,&nbsp;Ryota Nagashima ,&nbsp;Takahiro Ueda ,&nbsp;Yuya Ashihara ,&nbsp;Tomoya Nakamachi ,&nbsp;Takuya Okada ,&nbsp;Naoki Toyooka ,&nbsp;Atsuro Miyata ,&nbsp;Takashi Kurihara","doi":"10.1016/j.jpain.2024.104751","DOIUrl":"10.1016/j.jpain.2024.104751","url":null,"abstract":"<div><div>Chemotherapy-induced peripheral neuropathy (CIPN) is a type of peripheral neuropathy that develops in patients treated with certain anticancer drugs. Oxaliplatin (OXA) causes CIPN in approximately 80–90 % of patients; thus, it is necessary to elucidate its underlying mechanism and develop effective treatments and prevention methods. The purpose of this study was to determine whether the pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1 receptor system in the spinal dorsal horn is involved in OXA-induced acute cold allodynia and examine the effect of a PAC1 receptor antagonist. Administration of OXA induced acute cold allodynia in wild-type mice, but not in PACAP-/- mice. In the dorsal root ganglia, OXA upregulated PACAP expression, particularly in small-sized neurons. OXA-induced cold allodynia was ameliorated by intrathecal (i.t.) injection of PACAP6–38 (peptide antagonist for PACAP receptor) and PA-8 (small-molecule antagonist specific for PAC1 receptor). I.t. PACAP, but not vasoactive intestinal polypeptide, resulted in cold allodynia, which was blocked by PA-8. OXA induced the activation of spinal astrocytes in a PAC1 receptor-dependent manner. The results suggest that spinal PACAP/PAC1 receptor systems are involved in OXA-induced acute cold allodynia through astrocyte activation. Furthermore, we demonstrated that the systemic administration of PA-8 resulted in therapeutic and preventative effects on OXA-induced acute cold allodynia. Because PA-8 did not affect the anticancer effects of OXA, we propose PAC1 receptor inhibition as a new strategy for the treatment and prevention of CIPN.</div></div><div><h3>Perspective</h3><div>Cold allodynia is a hallmark of OXA-induced peripheral neuropathy. This study demonstrated the involvement of spinal PACAP/PAC1 receptors in OXA-induced acute cold allodynia. We propose PAC1 receptor inhibition as a new strategy for the treatment and prevention of OXA-induced acute cold allodynia.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"27 ","pages":"Article 104751"},"PeriodicalIF":4.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychometric properties of performance based tests in patients with Fibromyalgia: A systematic review 纤维肌痛患者基于性能测试的心理测量特性:系统回顾。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-11-28 DOI: 10.1016/j.jpain.2024.104749
José Luis Socorro-Cumplido , Joaquim Chaler , Miriam Almirall , Judith Sánchez-Raya , Mireia Cano , Blanca Roman-Viñas
{"title":"Psychometric properties of performance based tests in patients with Fibromyalgia: A systematic review","authors":"José Luis Socorro-Cumplido ,&nbsp;Joaquim Chaler ,&nbsp;Miriam Almirall ,&nbsp;Judith Sánchez-Raya ,&nbsp;Mireia Cano ,&nbsp;Blanca Roman-Viñas","doi":"10.1016/j.jpain.2024.104749","DOIUrl":"10.1016/j.jpain.2024.104749","url":null,"abstract":"<div><div>Fibromyalgia (FM) impacts patients’ health status, functioning and quality of life. Accurate diagnosis and effective treatment planning require reliable, valid and responsive measures of these domains. This study aimed to assess the psychometric properties of performance based tests (PBTs) in FM and to quantify the availability of reliable, valid and responsive PBTs linked to key International Classification of Functioning, Disability and Health (ICF) categories related to functional impact. A systematic review was conducted following the PRISMA checklist, and four databases (PubMed, EMBASE, Cochrane Library and Web of Science) were searched. Eligible studies contained information on population, intervention (assessment), and outcomes (PBTs and their psychometric properties). The risk of bias and the methodological quality were assessed according to the COSMIN criteria. Twenty-two studies evaluating twenty-six PBTs were included. PBTs were linked to five ICF categories: exercise tolerance, muscle power and muscle endurance and changing basic body position and walking. The psychometric properties assessed were reliability, validity and responsiveness. The 6 min walking test was the most often assessed PBT with moderate quality of evidence for reliability, and very good methodological quality for validity. Overall, the methodological quality for reliability was rated as doubtful with very low to moderate evidence, for validity we found very good methodological quality with low to high evidence. No studies investigated criterion validity, and construct validity and responsiveness were seldom determined. Clinicians assessing FM patients should carefully select PBTs. Future research on PBTs psychometrics in FM should follow COSMIN recommendations, ensuring control of symptom variability.</div></div><div><h3>Perspective</h3><div>This review confirms that the current understanding of the psychometric properties of PBTs for FM patients is limited, hindered by heterogeneous tests and insufficient evidence, complicating outcome comparisons across studies. This gap underscores the need for future research to enhance methodological quality and address missing ICF categories related to FM.</div></div><div><h3>Registered protocol at Prospero</h3><div>Registration number: CRD42022380709</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104749"},"PeriodicalIF":4.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are some people more susceptible to placebos? A systematic review and meta-analysis of inter-individual variability in musculoskeletal pain 是不是有些人更容易受到安慰剂的影响?肌肉骨骼疼痛个体差异的系统回顾和荟萃分析。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-11-28 DOI: 10.1016/j.jpain.2024.104745
Tobias Saueressig PT, Dipl.-Vw , Patrick J. Owen PhD (A/Prof.) , Hugo Pedder PhD (Dr) , Svenja Kaczorowski PT, MSc , Clint T. Miller PhD (Dr) , Lars Donath PhD (Prof.) , Daniel L. Belavý PhD (Prof.)
{"title":"Are some people more susceptible to placebos? A systematic review and meta-analysis of inter-individual variability in musculoskeletal pain","authors":"Tobias Saueressig PT, Dipl.-Vw ,&nbsp;Patrick J. Owen PhD (A/Prof.) ,&nbsp;Hugo Pedder PhD (Dr) ,&nbsp;Svenja Kaczorowski PT, MSc ,&nbsp;Clint T. Miller PhD (Dr) ,&nbsp;Lars Donath PhD (Prof.) ,&nbsp;Daniel L. Belavý PhD (Prof.)","doi":"10.1016/j.jpain.2024.104745","DOIUrl":"10.1016/j.jpain.2024.104745","url":null,"abstract":"<div><div>Existing data suggest placebo responses to treatments are small, but some people may be more likely to respond. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) on interindividual variability in response to placebo interventions MEDLINE, EMBASE, CINAHL, Web of Science Core Collection, CENTRAL, and SPORTDiscus were searched from inception to September 2023. Trial registry searches, citation tracking, and searches for prior systematic reviews were completed. The PEDro scale assessed study quality. Random effects robust variance estimation estimated the log variability ratio (VR), identifying subgroups with varying responses. Twenty-six studies were included, comprising various musculoskeletal pain conditions. Analysis of pain intensity (VR: 1.06, 95%-confidence interval (CI):[0.97; 1.16], 95%-prediction interval (PI):[0.75; 1.51], p = 0.17, k = 26 studies, N = 52 outcomes, GRADE: low), physical function (VR: 1.14, 95%-CI:[0.97; 1.34], 95%-PI:[0.62; 2.11], p = 0.11, k = 19, N = 40, GRADE: low), and health-related quality of life (VR: 1.14, 95%-CI:[0.91; 1.41], 95%-PI:[0.72; 1.80], p = 0.19, k = 7, N = 13, GRADE: low) outcomes revealed minimal, non-statistically significant variability in placebo response compared to control. However, wide prediction intervals suggest uncertainty regarding individual response patterns. There are likely no distinct subgroups of people who are more likely to respond to placebo interventions in musculoskeletal pain; although the available data limits the certainty of this assessment. Future work should consider individual participant data meta-analyses to better elucidate potential responder subgroups and optimize treatment strategies for musculoskeletal pain.</div></div><div><h3>Perspective</h3><div>This study systematically reviewed and analyzed RCTs to assess interindividual variability in placebo responses for musculoskeletal pain. Findings suggest minimal variability in placebo response, with no distinct subgroups more likely to respond. Wide prediction intervals indicate uncertainty, highlighting the need for future individual participant data meta-analyses to better elucidate potential responder subgroups.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104745"},"PeriodicalIF":4.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142755776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture in postoperative recovery: Exploring individual differences, long-term effects, and synergistic approaches 针刺在术后恢复中的作用:探讨个体差异、长期效果和协同方法
IF 4 2区 医学
Journal of Pain Pub Date : 2024-11-27 DOI: 10.1016/j.jpain.2024.104742
Ningyuan Lai
{"title":"Acupuncture in postoperative recovery: Exploring individual differences, long-term effects, and synergistic approaches","authors":"Ningyuan Lai","doi":"10.1016/j.jpain.2024.104742","DOIUrl":"10.1016/j.jpain.2024.104742","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"27 ","pages":"Article 104742"},"PeriodicalIF":4.0,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neighborhood disadvantage and pain-related experiences in a pain psychology clinic: The mediating roles of pain catastrophizing and pain-related fear 疼痛心理诊所中的邻里劣势与疼痛相关体验:疼痛灾难化和与疼痛相关的恐惧的中介作用》(The Mediating Roles of Pain Catastrophizing and Pain-Related Fear.
IF 4 2区 医学
Journal of Pain Pub Date : 2024-11-23 DOI: 10.1016/j.jpain.2024.104744
Fenan S. Rassu Ph.D. , Kavya Bhattiprolu , Claudia M. Campbell , Stephen T. Wegener , Rachel V. Aaron
{"title":"Neighborhood disadvantage and pain-related experiences in a pain psychology clinic: The mediating roles of pain catastrophizing and pain-related fear","authors":"Fenan S. Rassu Ph.D. ,&nbsp;Kavya Bhattiprolu ,&nbsp;Claudia M. Campbell ,&nbsp;Stephen T. Wegener ,&nbsp;Rachel V. Aaron","doi":"10.1016/j.jpain.2024.104744","DOIUrl":"10.1016/j.jpain.2024.104744","url":null,"abstract":"<div><div>This study investigated the relationship between neighborhood disadvantage, measured by the Area Deprivation Index (ADI), and pain-related variables in a pain psychology clinic. We also examined the sequential mediating roles of pain catastrophizing and pain-related fear on these relationships. Participants (N = 509) completed questionnaires assessing usual pain intensity, fatigue, emotional distress, and interference with daily activities. The mean ADI score was 32.57 (SD = 22.65), with scores ranging from 1 to 100. Linear regression analysis, adjusting for age and gender, revealed that higher ADI (i.e., less advantage) was significantly associated with higher scores on pain-related variables (pain intensity: B = 0.026, p &lt; .001; fatigue: B = 0.018, p &lt; .001; emotional distress: B = 0.020, p &lt; .001; interference with daily activities: B = 0.014, p = .006). Sequential mediation analysis revealed pain catastrophizing and pain-related fear mediated these relationships, with significant indirect effects for fatigue (B = 0.001, 95% CI [0.000, 0.002]) and interference with daily activities (B = 0.001, 95% CI [0.001, 0.003]) — but not pain intensity or emotional distress. Pain catastrophizing alone mediated neighborhood disadvantage-pain relationship for all variables. The results suggest that neighborhood disadvantage is associated with higher scores on pain-related experiences and that consistent with the fear avoidance model, pain catastrophizing and pain-related fear may play a role in these relationships for fatigue and interference with daily activities. These findings underscore that neighborhood disadvantage is associated with worse pain-related experiences and highlight the importance of considering neighborhood factors in chronic pain management.</div></div><div><h3>Perspective</h3><div>This study identifies potential pathways linking neighborhood disadvantage to chronic pain variables, highlighting the roles of pain catastrophizing and pain-related fear. The findings underscore the need for a holistic approach to pain management that recognizes both individual cognitive-emotional factors and the broader social context in which pain occurs.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"27 ","pages":"Article 104744"},"PeriodicalIF":4.0,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical phenotype and management of sound-induced pain: Insights from adults with pain hyperacusis 声源性疼痛的临床表型和管理:从患有痛性听力障碍的成年人身上获得的启示。
IF 4 2区 医学
Journal of Pain Pub Date : 2024-11-23 DOI: 10.1016/j.jpain.2024.104741
Kelly N. Jahn , Sean Takamoto Kashiwagura , Muhammad Saad Yousuf
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