Journal of Pain最新文献

{"title":"Community leaders' perceptions of pain and research engagement: Implications for participant diversity and inclusion in pain clinical trials.","authors":"Shannon K Jajko, Elise V Hoffman, Kushang V Patel, Allison M Cole, Linda K Ko","doi":"10.1016/j.jpain.2025.105389","DOIUrl":"10.1016/j.jpain.2025.105389","url":null,"abstract":"<p><p>Clinical trials lack diversity and representation of minoritized groups, reducing generalizability and potentially the effectiveness of interventions across these populations. The purpose of this study was to identify how community perceptions of pain and pain research shape participation in pain-related clinical trials among underrepresented groups from the perspective of community organization leaders. We conducted a qualitative study with in-depth, semi-structured interviews with representatives from community-based organizations (N=20). Interviews represented experiences of leaders serving minoritized populations, including Black/African American, Hispanic/Latino, and Asian communities in the Greater Seattle Area. Data were analyzed in Dedoose using thematic analysis. We identified five main themes: (1) Community perceptions of and communication around pain, (2) Pain research is an extension of Western medicine, (3) Community leaders' experiences with researchers, (4) Returning the results to the community increases research meaning, (5) Understand the community experience with social determinants of health. Participants believed that their communities were largely uninterested in pain clinical trials because they perceived a misalignment between trial treatment options and their communities' preferences and needs. Future research investigating integrative approaches to pain care, engaging the community in research design, and considering ways to address social determinants of health may help overcome this misalignment and improve the relevance of pain research to diverse communities. PERSPECTIVE: This article presents perspectives on pain and participation in pain research among community organization leaders serving minoritized communities in the Greater Seattle Area. The expertise of community organization leaders may inform efforts to design pain research that best engages minoritized and underrepresented groups to improve equitable pain medicine and research.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105389"},"PeriodicalIF":4.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods to discriminate between nociceptive, neuropathic and nociplastic in children & adolescents: A systematic review of psychometric properties and feasibility","authors":"Aayushi Khillan ,&nbsp;Liam Carter ,&nbsp;David J. Amor ,&nbsp;Carolyn Berryman ,&nbsp;Adrienne Harvey","doi":"10.1016/j.jpain.2025.105388","DOIUrl":"10.1016/j.jpain.2025.105388","url":null,"abstract":"<div><div>The aim of this systematic review was to identify and critically analyse the tools available for categorising pain as nociceptive, neuropathic and nociplastic pain in children and adolescents. Studies were included if they (i) included children and adolescents with a mean age of 0–24 years old, (ii) examined assessment tools that categorise pain as nociceptive, neuropathic or nociplastic, and (iii) examined the psychometric properties of the tools. Sensitive searches were conducted in five online databases in March 2024. Eligible studies were assessed for risk of bias and quality by two authors using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) criteria. The search yielded 26 studies for 11 tools. No assessment tool had evidence for all nine recommended psychometric properties. Quantitative Sensory Testing, a tool used to identify signs and symptoms of nociplastic and neuropathic pain, was the most studied tool and had moderate evidence for construct validity, criterion validity and reliability. Three self-reported questionnaires, the Self-reported Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS), Central Sensitisation Inventory (CSI) and PainDETECT, had moderate evidence for construct validity and show promise as preliminary tools to identify possible neuropathic or nociplastic pain. However, they had low specificity when used in isolation. All assessment methods would benefit from further psychometric evaluation and validation in children and adolescents.</div></div><div><h3>Perspective</h3><div>This systematic review highlights the limited validation of pain assessment tools for children and adolescents. While Quantitative Sensory Testing and self-reported questionnaires show promise in identifying pain mechanisms, their applicability remains uncertain. Further psychometric validation is crucial to improve pain assessment and guide personalized treatment in young populations.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"31 ","pages":"Article 105388"},"PeriodicalIF":4.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational and leisure-time physical activity and prospective musculoskeletal pain-relief prescribed medication among blue-collar workers: 24-h device-measured physical activity and Danish registers","authors":"Stavros Kyriakidis ,&nbsp;Søren Mose ,&nbsp;Karen Søgaard ,&nbsp;Andreas Holtermann ,&nbsp;Charlotte Diana Nørregaard Rasmussen ,&nbsp;Nidhi Gupta","doi":"10.1016/j.jpain.2025.105387","DOIUrl":"10.1016/j.jpain.2025.105387","url":null,"abstract":"<div><div>Musculoskeletal pain is the biggest contributor to burden of disease, causing excessive use of pain-relief medication. Non-pharmaceutical measures are called on for handling this burden. Guidelines recommend physical activity as an effective non-pharmaceutical measure. However, it is unknown if occupational physical activity has the same preventive effects on redeeming pain-relief medication as when performed during leisure-time (“The Physical Activity Paradox”). We aimed to investigate if the paradox contributes to the redemption of prescribed pain relief-medication. 24-h device-measured physical activity data [sitting, standing, light physical activity, moderate-to-vigorous physical activity (MVPA) and time in bed)] were collected from 824 workers using a thigh-worn accelerometer during work and leisure-time. Redeemed pain-relief prescribed medication was retrieved from the Danish National Prescription Registry during a 4-year follow-up. The prospective association between occupational and leisure-time physical activity and number of redeemed pain-relief prescribed medication was analyzed using a generalized linear model, adjusted for potential confounders. During follow-up, 53% of the workers redeemed a pain-relief medication. In leisure-time, 30 min more of MVPA per day were associated with 23% lower risk (RR = 0.77; 95% CI 0.64 - 0.94) of redeeming pain-relief medication. In contrast, occupational physical activity was not associated with the risk of redeeming pain-relief medication [RR = 1.04 (95% CI 0.89 - 1.20)]. Leisure-time MVPA was associated with lower risk of redeeming pain-relief medication, while no beneficial association was found for occupational MVPA. These findings support the paradox that the domain of physical activity is important for redeeming pain-relief medication.</div></div><div><h3>Perspective</h3><div>Leisure-time MVPA differs from occupational MVPA in its association with redeeming pain-relief medication. Increasing leisure-time MVPA may serve as an effective non-pharmacological strategy to reduce pain-relief medication redemption. These findings could potentially inform guidelines for managing musculoskeletal pain, highlighting the need to differentiate between occupational and leisure-time physical activity.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"31 ","pages":"Article 105387"},"PeriodicalIF":4.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to \"Effects of Acceptance and Commitment Therapy plus Exercise for Older Adults with Chronic Low Back Pain: A Preliminary Cluster Randomized Controlled Trial with Qualitative Interviews\".","authors":"Hong Sun, Feng Sui, Binbin Wang, Zhifeng Liang","doi":"10.1016/j.jpain.2025.105386","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105386","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105386"},"PeriodicalIF":4.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing The Inflammatory and Behavioral Consequences of Peripheral Nerve Injury","authors":"Corinne M. Augusto,&nbsp;Nikhil K. Acharya,&nbsp;Andras Hajnal,&nbsp;Nelli Horvath,&nbsp;Cole Moran-Bariso,&nbsp;Jennifer E. Nyland","doi":"10.1016/j.jpain.2025.104867","DOIUrl":"10.1016/j.jpain.2025.104867","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104867"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Tomivosertib (MNK1/2 Inhibitor) In Mitigating Pain in a RDEB Mouse Model","authors":"Grace Lank,&nbsp;Rishi Shah,&nbsp;Lynna Yang,&nbsp;Zhengyi Lin,&nbsp;Emmy Lev,&nbsp;Jordan Raizer,&nbsp;Jacqueline Wang,&nbsp;Dareen Elgindi,&nbsp;Iyanna Clay,&nbsp;Luke Yin,&nbsp;Brenda Abreu Molnar,&nbsp;Bryan Enriquez,&nbsp;Ziyou Ren,&nbsp;Nihal Kaplan,&nbsp;Amy Paller","doi":"10.1016/j.jpain.2025.104838","DOIUrl":"10.1016/j.jpain.2025.104838","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104838"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Chronic Bodily Pain Across Multisystemic Illnesses: A Comparative Analysis Using Exploratory Factor Analysis And Invariance Testing","authors":"Suvetha Ravichandran,&nbsp;Leonard Jason","doi":"10.1016/j.jpain.2025.104841","DOIUrl":"10.1016/j.jpain.2025.104841","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104841"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdermal Optogenetic Technique Reduces Nociceptive Behaviors in an Acute Cystitis Mouse Model","authors":"Gabriella Robilotto,&nbsp;Rebecca Bornstein,&nbsp;Daniel Zelmanoff,&nbsp;Nia Dufeal,&nbsp;Ofer Yizhar,&nbsp;Aaron Mickle","doi":"10.1016/j.jpain.2025.104873","DOIUrl":"10.1016/j.jpain.2025.104873","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104873"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human iPSC-Derived Sensory Neurons Reveal Pain Mechanisms in Fibrodysplasia Ossificans Progressiva","authors":"Hajira Elahi,&nbsp;Theodore Price,&nbsp;Patrick Dougherty","doi":"10.1016/j.jpain.2025.104843","DOIUrl":"10.1016/j.jpain.2025.104843","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104843"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Driven Predictive Modeling for Opioid Use Disorder in Chronic Pain Patients on Long-Term Opioid Use","authors":"Yoonjae Lee,&nbsp;Christal N. Davis,&nbsp;Peggy A. Compton,&nbsp;Rosemary C. Polomano,&nbsp;Martin D. Cheatle","doi":"10.1016/j.jpain.2025.104833","DOIUrl":"10.1016/j.jpain.2025.104833","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 104833"},"PeriodicalIF":4.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}