Journal of Pain最新文献

{"title":"Contemporary media campaigns for musculoskeletal pain: A systematic review and meta-analysis with social marketing benchmarking.","authors":"Felicity A Braithwaite, Sameer Deshpande, Rachelle Buchbinder, Liz Dennett, Craig St Jean, Brandon Krebs, Douglas P Gross","doi":"10.1016/j.jpain.2024.104739","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104739","url":null,"abstract":"<p><p>Musculoskeletal pain is a global public health problem. Social marketing aims to increase adoption of desired behaviours in target audiences and may uncover new strategies to improve uptake of helpful pain-related behaviours at the population-level. We systematically evaluated effects of contemporary mass media campaigns targeting musculoskeletal pain and used social marketing benchmarking to explore strategies associated with campaign success. Published evaluations of campaigns involving an online/digital component and a comparator/control condition were eligible. The primary outcome was population beliefs; secondary outcomes were healthcare provider beliefs, behavioural (e.g., healthcare-related, work-related), clinical (e.g., pain), and economic outcomes. Decision-rules and meta-analyses (random-effects models) were used to synthesise findings. Eight databases and grey literature were searched from inception to May-2024. Thirteen eligible publications evaluated eight campaigns (N=5 back pain, N=2 rheumatic pain; N=1 work-related pain) from eight Western/high-income countries. All evaluations reported historical control data (interrupted time-series/before-and-after designs); three also compared selected outcomes to an unexposed geographical region (quasi-experimental designs). Risk of bias was weak-moderate for all evaluations. Population beliefs improved from baseline vs. final follow-up (1.5-10yrs) for items related to 'staying active' [RR=1.38 (95%CI: 1.14-1.67), N=4 campaigns, n=12,568 participants] and 'rest' [RR=1.35 (95%CI: 1.14-1.60), N=5 campaigns, n=14,571 participants] for pain management, however, certainty of evidence was very low. Other outcomes were not pooled due to heterogeneity, and evidence was mixed. Greater numbers of social marketing benchmarks were associated with successful campaign outcomes. Future campaigns should implement social marketing strategies beyond education alone, including behaviour change support, to facilitate adoption of desired pain-related behaviours. REGISTRATION: PROSPERO registration number: CRD42023400456; Open Science Framework (detailed Social Marketing Benchmarking analysis plan): https://osf.io/npyck/ PERSPECTIVE: We systematically evaluated contemporary mass media campaigns targeting musculoskeletal pain. Promising improvements in population beliefs about pain supports continued investment into campaigns. Our review provides critical new information including social marketing strategies to ensure future campaign efforts shift population-level pain-related behaviours, towards reducing the societal burden of pain.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104739"},"PeriodicalIF":4.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain-induced functional and structural alterations in the brain: a multi-modal meta-analysis.","authors":"Xinglin Zeng, Yinghao Sun, Zhao Zhiying, Lin Hua, Zhen Yuan","doi":"10.1016/j.jpain.2024.104740","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104740","url":null,"abstract":"<p><p>Chronic pain is a debilitating condition associated with brain alterations. However, the variability in neuroimaging results across modalities necessitates a comprehensive multi-modal meta-analysis for a cohesive understanding. This study aims to elucidate brain alterations in chronic pain patients using a multi-modal meta-analysis approach encompassing structural, resting-state functional connectivity, and pain processing paradigms in functional magnetic resonance imaging. A systematic literature search was conducted across PubMed, OVID Embase, OVID Medline, and Web of Science, encompassing studies published up to May 30^th, 2022, to identify relevant research articles on chronic pain and MRI techniques in three modalities. Inclusion criteria encompassed experiments reporting three modality brain alterations in chronic pain patients, with sufficient statistical thresholds and enough sample size. We conducted voxel-wise meta-analyses using seed-based d mapping to identify significant alterations in each modality. Additionally, conjunction analyses were executed to identify common alterations across these modalities. Ultimately, 47 structure studies, 37 resting state functional connectivity studies, and 41 pain-processing studies were selected for formal analysis. Chronic pain patients displayed notable structural and functional alterations in the insular cortex, characterized by reduced gray matter, disruptions in functional connectivity with the frontoparietal network, and enhanced activation during painful stimuli processing. Distinct activation patterns were observed in the left and right insular cortex for pain stimulus processing versus anticipation. Furthermore, the superior temporal gyrus and superior frontal gyrus exhibited joint alterations across modalities. This multi-modal meta-analysis reveals consistent brain alterations in chronic pain patients, shedding light on the complex interplay between structural and functional changes. PERSPECTIVE: This multi-modal meta-analysis integrates findings from structural, resting-state functional connectivity, and pain processing paradigms in fMRI, revealing consistent brain alterations in chronic pain patients. Notable brain changes highlight the intricate interplay between structural and functional brain changes, advancing our understanding of chronic pain's neural underpinnings.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104740"},"PeriodicalIF":4.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language Errors in Pain Medicine: An Umbrella Review.","authors":"Bastien Léo Béraud, André Meichtry, Kay-Uwe Hanusch, Roger Hilfiker","doi":"10.1016/j.jpain.2024.104738","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104738","url":null,"abstract":"<p><p>Errors in language are common in pain medicine, but the extent of such errors has not been systematically measured. This pre-registered umbrella review explored Embase, PubMed, Medline and CINAHL and seeks to quantify the prevalence of errors in language in review articles since the last IASP definition revision. To be eligible, studies must have met the following criteria: 1) Primary aim was stated as to provide neurophysiological explanations of nociception and/or pain in humans in context of a pathology/condition; 2) Any type of review article; 3) Written in English; 4) Published in a peer-reviewed journal. Studies were excluded if they met any of the following criteria: 5) Published prior to the last revision of the IASP definition; 6) Published after May 2023; 7) Published in a predatory journal. Out of 5,470 articles screened, 48 review articles met the inclusion criteria. All articles contained at least one error in language, there were no differences in the proportions of errors in language in review articles between years of publication, and various predictors were mostly not associated with a higher or lower number of errors in language counts in articles. Our findings reveal the need for heightened awareness among researchers, clinicians, journals and editorial boards regarding the prevalence and impact of these errors. Given our findings and their limitations, further research should focus on examining the contextual influence of misnomer usage and replication of these results. PERSPECTIVE: This umbrella review explored the main biomedical databases to see how many review articles contained language errors. Our findings underscore the imperative for prompt action in regulating pain medicine terminology. PRE-REGISTRATION: This umbrella review was pre-registered on OSF registries (https://doi.org/10.17605/osf.io/kau8m). ONLINE MATERIAL: https://osf.io/kdweg/.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104738"},"PeriodicalIF":4.0,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Within-Person Relationships between Catastrophizing and Pain Intensity During a Mind-Body Intervention to Prevent Persistent Pain and Disability after Acute Traumatic Orthopedic Injury.","authors":"Madelyn Frumkin, Julie R Brewer, Julia E Hooker, Kate N Jochimsen, Ana-Maria Vranceanu","doi":"10.1016/j.jpain.2024.104737","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104737","url":null,"abstract":"<p><p>Interventions aimed at preventing chronic pain after acute traumatic injury have significant potential to reduce healthcare expenditures and improve quality of life for millions of individuals. Given recent development of such interventions, limited research has examined mechanisms of change using repeated measures (e.g., session-by-session assessments). This study examines within-person relationships between pain catastrophizing and intensity during and after a four-session mind-body intervention for individuals with acute traumatic orthopedic injury (N = 76, T = 445). Random intercept cross-lagged panel models were used to examine within-person autoregressive, contemporaneous, and cross-lagged effects between pain catastrophizing and pain intensity, after accounting for stable between-person differences. Our primary hypothesis that improvements in catastrophizing would be associated with subsequent reductions in pain intensity was partially supported by a significant within-person cross-lagged effect between catastrophizing at post-test and pain with activity reported at three-month follow-up (β = 0.421, SE = 0.099, p <.001). Improvement in catastrophizing was also associated with same-session improvement in pain intensity midway through the intervention. Importantly, bidirectional within-person analyses allowed us to rule out the possibility that improvements in pain were responsible for subsequent improvements in catastrophizing, but not vice versa. Together, these findings suggest improvements in catastrophizing during psychosocial intervention may prevent transition from acute to chronic pain after injury. Future research with larger between-person sample sizes, more frequent within-person assessment, and comparable control group data is necessary to facilitate greater understanding of psychosocial mechanisms for preventing chronic pain after injury. PERSPECTIVE: This study examines within-person relationships between pain catastrophizing and intensity during and after a four-session mind-body intervention to prevent persistent pain after acute traumatic orthopedic injury. Improved catastrophizing at post-test was associated with reduced pain with activity at three-month follow-up. Within-person analyses enhance understanding of psychosocial mechanisms for preventing chronic pain after injury.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104737"},"PeriodicalIF":4.0,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the trustworthiness of pain research: A call to action.","authors":"Neil E O'Connell, Joletta Belton, Geert Crombez, Christopher Eccleston, Emma Fisher, Michael C Ferraro, Anna Hood, Francis Keefe, Roger Knaggs, Emma Norris, Tonya M Palermo, Gisèle Pickering, Esther Pogatzki-Zahn, Andrew Sc Rice, Georgia Richards, Daniel Segelcke, Keith M Smart, Nadia Soliman, Gavin Stewart, Thomas Tölle, Dennis Turk, Jan Vollert, Elaine Wainwright, Jack Wilkinson, Amanda C de C Williams","doi":"10.1016/j.jpain.2024.104736","DOIUrl":"10.1016/j.jpain.2024.104736","url":null,"abstract":"<p><p>The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing, and managing chronic pain. Yet patients with chronic pain, clinicians and the public are sometimes poorly served by an evidence architecture that contains multiple structural weaknesses. These include incomplete research governance, a lack of diversity and inclusivity, inadequate stakeholder engagement, poor methodological rigour and incomplete reporting, a lack of data accessibility and transparency, and a failure to communicate findings with appropriate balance. These issues span pre-clinical research, clinical trials and systematic reviews and impact the development of clinical guidance and practice. Research misconduct and inauthentic data present a further critical risk. Combined, they increase uncertainty in this highly challenging area of study and practice, drive the provision of low value care, increase costs and impede the discovery of more effective solutions. In this focus article, we explore how we can increase trust in pain science, by examining critical challenges using contemporary examples, and describe a novel integrated conceptual framework for enhancing the trustworthiness of pain science. We end with a call for collective action to address this critical issue. PERSPECTIVE: Multiple challenges can adversely impact the trustworthiness of pain research and health research more broadly. We present ENTRUST-PE, a novel, integrated framework for more trustworthy pain research with recommendations for all stakeholders in the research ecosystem, and make a call to action to the pain research community.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104736"},"PeriodicalIF":4.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The association between smoking, chronic pain, and prescription opioid use: 2013-2021” [J Pain 26 (2025) 104707]","authors":"William Encinosa PhD ,&nbsp;Didem Bernard PhD ,&nbsp;R. Burciaga Valdez PhD, MHSA","doi":"10.1016/j.jpain.2024.104734","DOIUrl":"10.1016/j.jpain.2024.104734","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104734"},"PeriodicalIF":4.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Pelvic floor and diaphragm.","authors":"Bruno Bordoni","doi":"10.1016/j.jpain.2024.104731","DOIUrl":"10.1016/j.jpain.2024.104731","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104731"},"PeriodicalIF":4.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Individual Sensitivity to the Thermal Grill Illusion: A Two-Dimensional Adaptive Psychophysical Approach.","authors":"Camila Sardeto Deolindo, Jesper Fischer Ehmsen, Arthur S Courtin, Alexandra G Mitchell, Camilla E Kraenge, Niia Nikolova, Micah G Allen, Francesca Fardo","doi":"10.1016/j.jpain.2024.104732","DOIUrl":"10.1016/j.jpain.2024.104732","url":null,"abstract":"<p><p>In the thermal grill illusion (TGI), the spatial alternation of non-noxious warm and cool temperatures elicits burning sensations that resemble the presence of noxious stimuli. Previous research has largely relied on the use of specific temperature values (i.e., 20°C and 40°C) to study this phenomenon in both healthy individuals and patient populations. However, this methodology fails to account for inter-individual differences in thermal sensitivity, limiting the precision with which TGI responses can be evaluated across diverse populations. To address this gap, we created a Two-Dimensional Thermal Grill Calibration (2D-TGC) protocol, enabling an efficient and precise estimation of the combinations of warm and cool temperatures needed to elicit burning sensations tailored to each individual. By applying the 2D-TGC protocol in 43 healthy participants, we demonstrated key findings: (1) The TGI can be thresholded using an adaptive psychophysical method. (2) Multiple combinations of warm and cool temperatures can elicit this phenomenon. (3) The protocol facilitated the identification of temperature combinations that elicit TGI with varying levels of probability, intensity, and perceived quality ranging from freezing cold to burning hot. (4) TGI responsivity can be quantified as a continuous variable, moving beyond the conventional classification of individuals as responders vs. non-responders based on arbitrary temperature values in the innocuous temperature range. The 2D-TGC offers a comprehensive approach to investigate the TGI across populations with altered thermal sensitivity, and can be integrated with other methods (e.g., neuroimaging) to elucidate the mechanisms responsible for perceptual illusions in the thermo-nociceptive system. PERSPECTIVE: This study reveals that the Thermal Grill Illusion can be accurately measured using psychophysical methods. The innovative Two-Dimensional Thermal Grill Calibration protocol allows for personalized temperature assessments, enhancing our understanding of thermal sensitivity variations and perceptual illusions in the thermo-nociceptive system across different populations.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104732"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaphorical markers of pain catastrophizing, depression, anxiety, and pain interference in people with chronic pain","authors":"Jasmine Heath Hearn Dr ,&nbsp;Imogene Munday Dr ,&nbsp;Stella Bullo Dr ,&nbsp;Kris Rogers Dr ,&nbsp;Toby Newton-John Dr ,&nbsp;Ian Kneebone Dr","doi":"10.1016/j.jpain.2024.104733","DOIUrl":"10.1016/j.jpain.2024.104733","url":null,"abstract":"<div><div>Metaphor to communicate chronic pain can reflect psychological appraisals of pain, and its impact, and may be beneficial in enhancing understanding of pain, its aetiology, and facilitating communication and shared decision-making. This cross-sectional study examined metaphor use and relationships with pain intensity, pain interference, mood, and pain catastrophizing. Seventy participants with chronic pain completed measures of depression, anxiety and stress, the Brief Pain Inventory, and the Pain Catastrophizing Scale. They provided descriptions of their pain through metaphor and a primary condition related to their pain. Pain catastrophizing significantly predicted frequency of metaphor use (<em>R</em>² =.07, <em>F</em>(1, 62)= 4.55, <em>p</em> = .041). More frequent use of metaphor was correlated with pain catastrophizing (<em>r =</em> .29, <em>p =</em> .03), rumination (<em>r =</em> .26, <em>p =</em> .05), magnification (<em>r =</em> .28, <em>p =</em> .03), helplessness (<em>r =</em> .28, <em>p =</em> .04), depression (<em>r =</em> .30, <em>p =</em> .02), and pain interference (<em>r =</em> .30, <em>p =</em> .02). Metaphors relating pain to physical damage were significantly associated with anxiety (OR 1.17, 95% CI 1.03–1.35, <em>p =</em> .02) and magnification (OR 1.27, 95% CI 1.05–1.57, <em>p</em> = .02). Metaphors referring to pain as caused by an external agent were significantly associated with depression (OR 1.11, 95% CI 1.01–1.23, <em>p =</em> .04) and pain duration (OR 1.05, 95% CI 1.00–1.11, <em>p</em> = .04). The findings indicate that there may be specific metaphorical markers of psychological and pain-related outcomes in the language used by people with chronic pain. Appreciation of metaphor may facilitate enhanced patient-provider communication and support for people with chronic pain.</div></div><div><h3>Perspective</h3><div>People with chronic pain can use metaphorical expressions to communicate their experiences. This study found that pain interference, depression, anxiety, and pain catastrophizing are reflected in metaphor use by people with chronic pain. In particular, pain catastrophizing was significantly predictive of more frequent metaphor use, demonstrating the reflection of pain catastrophizing in language.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104733"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripherally mediated opioid combination therapy in mouse and pig.","authors":"C D Peterson, C M Larson, D J Bruce, B M Clements, K R Pflepsen, E Akgün, K F Kitto, M M Lunzer, C A Fairbanks, P S Portoghese, G L Wilcox","doi":"10.1016/j.jpain.2024.104735","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104735","url":null,"abstract":"<p><p>The concomitant epidemics of chronic pain and opioid misuse in the United States have led to a call for novel analgesics with limited abuse potential. Previously, we have shown that co-delivery of a novel combination targeting both μ- and δ-opioid receptors in the peripheral and central nervous systems can produce synergistic analgesia. Loperamide, a peripherally restricted μ-opioid agonist, and oxymorphindole, a δ-opioid receptor partial agonist, synergize in multiple mouse models of hyperalgesia. We predicted this effect would generalize across species and therefore assessed this combination for analgesic synergy in a mouse model of post-incisional hypersensitivity. In mice, oxymorphindole and loperamide displayed significant analgesic synergy. Similar synergy was observed with N-benzyl-oxymorphindole and loperamide. In cross-bred pigs, we compared the analgesic effects of either morphine alone or the combinations of oxymorphindole and loperamide or the combination of N-benzyl-oxymorphindole and loperamide. Both combinations showed increased potency as compared to morphine sulfate and effectively reduced hypersensitivity following injury without side effects. From these data we conclude that the combination of oxymorphindole and loperamide or the combination of N-benzyl-oxymorphindole reverse incisional hyperalgesia, likely by acting in the periphery, in a large animal model without adverse effects on respiration or heart rate. PERSPECTIVE: This article presents novel opioid combinations, the μ-opioid agonist loperamide with a δ-opioid agonist, either oxymorphindole (OMI) or N-benzyl-oxymorphindole (BOMI), that relieve pain in mice and pigs without adverse side effects. These therapies could help clinicians manage pain in patients while reducing overall opioid burden and limiting side effects.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104735"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}