Journal of Pain最新文献

{"title":"Vestibulodynia Presentation is Differentiated by the Presence of Additional Chronic Primary Pain Conditions.","authors":"Chloe Shudt, Shad Smith, Andrey Bortsov, Kayla Parr, Sheila Gaynor, Gary Slade, Denniz Zolnoun, Andrea Nackley","doi":"10.1016/j.jpain.2025.105450","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105450","url":null,"abstract":"<p><p>Vestibulodynia (VBD) is a common chronic primary pain condition (CPPC) defined by the presence of recurrent vulvovaginal pain with no obvious root cause. As many as 3 in 4 women with VBD may have co-occurring CPPCs, such as episodic migraine, fibromyalgia, irritable bowel syndrome, and temporomandibular disorder. The purpose of the present study was to compare pain and pain-related factors in women with VBD alone and those with VBD and co-occurring CPPCs (VBD+). We enrolled 45 women with VBD, 106 with VBD+, and 198 pain-free controls, who underwent a highly specific gynecological examination, quantitative sensory testing at remote body sites, and completed an extensive array of questionnaires assessing various physical and psychological experiences. Blood samples were also collected for genome-wide association study (GWAS). Results demonstrated that women with VBD+ had distinct patterns of heightened local vulvovaginal pain intensity and increased pain sensitivity at remote body site compared to those with VBD. Further women with VBD+ reported taking more medications indicated for pain and greater adverse mood states, somatic and psychological symptoms, and pain catastrophizing. Finally, case-control GWAS analysis identified distinct genetic variants associated with VBD and VBD+ subtypes. Variants associated with VBD were located in genes that regulate reproductive and nervous system development, while those associated with VBD+ were located in genes implicated in synaptic transmission and related CPPC pathophysiology. Together, these findings emphasize the critical need for accounting for CPPC status in VBD diagnostic, mechanistic, and therapeutic methodologies. Perspective This study identifies co-occurring chronic primary pain conditions as a differentiating factor in vestibulodynia presentation, highlighting the need for precise diagnostic criteria and personalized treatment approaches to address heightened symptom burden and complexity.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105450"},"PeriodicalIF":4.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter to the Editor concerning \"Effects of Acceptance and Commitment Therapy plus Exercise for Older Adults with Chronic Low Back Pain: A Preliminary Cluster Randomized Controlled Trial with Qualitative Interviews\" by Liu et al. (J PAIN [2025]: doi.org/10.1016/j.jpain.2025.105350).","authors":"Jae Qj Liu, Yim Wah Mak, Aled Ly Tang, Crystal Y Kwan, Fadi Al Zoubi, Timmy Kt Wong, Gordon Sh Tsang, Heidi Cw Kwong, Sabrina Wt Lai, Sam Ps Sze, Kelvin Tk Hui, Chelsia Kc Cheung, Dino Samartzis, Karen Ks Chow, Arnold Yl Wong","doi":"10.1016/j.jpain.2025.105437","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105437","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105437"},"PeriodicalIF":4.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the differences in resting state functional magnetic resonance imaging brain activity in patients with chronic low back pain based on ALE meta-analysis","authors":"Huibiao Li ,&nbsp;Xiaonan Zhan ,&nbsp;Xin Zhao ,&nbsp;Jianhao Zhou ,&nbsp;Ke Chen ,&nbsp;Youmei Chen ,&nbsp;Hong Liu ,&nbsp;Zheng Jiang","doi":"10.1016/j.jpain.2025.105442","DOIUrl":"10.1016/j.jpain.2025.105442","url":null,"abstract":"<div><div>Chronic low back pain (cLBP) is a prevalent condition, yet neuroimaging findings across studies remain inconsistent. This inconsistency may stem from overreliance on a priori regions of interest (ROI) hypotheses in prior studies, which neglected the spatial distribution of true functional abnormalities in cLBP. To address methodological heterogeneity, this study conducted an activation likelihood estimation (ALE) meta-analysis, guided by high-quality neuroimaging meta-analysis guidelines, to identify reliable neural features across 17 eligible cLBP studies, providing more robust conclusions than individual neuroimaging studies. Significantly, the cLBP group exhibited enhanced activity in the bilateral medial frontal gyrus (MFG), right precentral gyrus, and right cingulate gyrus. Based on the data-driven and objective ROI, we further analyzed the functional interactions or connectivity between brain regions by including a cohort of 30 patients with chronic non-specific low back pain (CNLBP) and 30 age- and sex-matched healthy controls. The results revealed decrease functional connectivity in the cortico-limbic circuit in the CNLBP group, particularly between the left MFG and the right hippocampus. Furthermore, effective connectivity from the right to left MFG was significantly reduced in the CNLBP group. Multivariate regression analysis established significant associations between cortico-limbic circuit connectivity alterations and pain catastrophizing. These findings highlight the cortico-limbic circuit as a key biomarker for cLBP, suggesting its targeted modulation could inform novel therapeutic strategies. This study provides novel neurobiological insights into cLBP pathophysiology, while underscoring the necessity for replication in larger cohorts to validate clinically valuable.</div></div><div><h3>Perspective</h3><div>This study utilized ALE meta-analysis to investigate abnormal activation regions in cLBP patients, and further analysis revealed functional interactions or connectivity between brain regions. The results highlighted the cortico-limbic circuit as a key biomarker of cLBP, suggesting that modulating this circuit may provide insights into potential therapeutic strategies.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105442"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersection of alcohol use, pain symptoms, and negative affect in total knee arthroplasty patients and people with HIV","authors":"Taylor Fitzpatrick-Schmidt ,&nbsp;Vinod Dasa ,&nbsp;Claudia Leonardi ,&nbsp;Tekeda F. Ferguson ,&nbsp;David A. Welsh ,&nbsp;Patricia E. Molina ,&nbsp;Martin J.J. Ronis ,&nbsp;Scott Edwards","doi":"10.1016/j.jpain.2025.105446","DOIUrl":"10.1016/j.jpain.2025.105446","url":null,"abstract":"<div><div>Alcohol is a well-known analgesic, although excessive alcohol use can lead to hyperalgesia and heightened negative affect. This cross-sectional study examined associations between alcohol use, self-reported pain, and negative affective symptoms in two distinct cohorts of patients vulnerable to chronic pain: individuals undergoing total knee arthroplasty (TKA) surgery and a cohort of people with HIV (PWH). Participants were enrolled in two clinical studies: a retrospective study of patients undergoing TKA and a longitudinal study of PWH, the New Orleans Alcohol Use in HIV (NOAH) cohort. Based on the Alcohol Use Disorders Identification Test – Consumption (AUDIT-C) score, participants in both cohorts were stratified as alcohol drinkers (AUDIT-C ≥ 1) or non-drinkers (AUDIT-C &lt; 1). In the NOAH cohort, pain intensity and interference were assessed using the 36-Item Short Form Survey (SF-36). In the TKA cohort, self-reported pain was quantified using the Pain Intensity and Pain Interference items from the Patient-Reported Outcomes Measurement Information System® (PROMIS-29) and the Knee Osteoarthritis and Outcomes Score (KOOS) Pain scores. Alcohol drinkers reported fewer pain symptoms compared to non-drinkers across both cohorts, and females with HIV reported more pain compared to males with HIV. Furthermore, pain symptoms were associated with increased anxiety and depression symptoms in both cohorts, and in PWH these associations appeared stronger in drinkers compared to non-drinkers. These findings suggest that although alcohol may offer some analgesic benefits, patients should be cautioned about its use for self-medication, as it may increase risk for pain-related negative affective comorbidities.</div></div><div><h3>Perspective</h3><div>Alcohol can both relieve and exacerbate pain. The current study discovered that ongoing alcohol use was associated with fewer self-reported pain symptoms but appeared to increase associations between pain and negative affective symptoms in two vulnerable cohorts. Findings support cautioning patients against the recurring use of alcohol for pain management.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105446"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scale Development of the Osteoarthritis Conceptualisation Questionnaire: Phase 2 Construct Validity.","authors":"Brian W Pulling, Felicity Braithwaite, Adela-Maria Isvoranu, David S Butler, Anna R Vogelzang, G Lorimer Moseley, Mark J Catley, Tasha R Stanton","doi":"10.1016/j.jpain.2025.105435","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105435","url":null,"abstract":"<p><p>An individual's knowledge, beliefs and/or expectations about their osteoarthritis can influence their engagement with physical activity and their treatment decisions surrounding recommended non-surgical management. Yet there is no widely accepted questionnaire to assess complex mental frameworks surrounding osteoarthritis. Therefore, this study aimed to develop an Osteoarthritis Conceptualisation Questionnaire (OACQ) to assess an individual's conceptual framework for osteoarthritis via psychometric evaluation of an established item-bank. The Osteoarthritis Conceptualisation Questionnaire item-bank, co-developed with pain experts and people with lived experience of knee pain, was administered online to people with painful knee osteoarthritis. Psychometric evaluation was undertaken using factor and exploratory graph analyses to create a data-driven model of the Osteoarthritis Conceptualisation Questionnaire which was then compared with the existing theoretical model (construct validity). Four hundred and fifty-four participants completed the survey (n=336 female; 64.52 ±9.21 years). Psychometric evaluation resulted in the Osteoarthritis Conceptualisation Questionnaire, consisting of 36 items across four domains: 'Expectations'; 'Context'; 'Physiology'; and 'Conceptual Change'. Data-driven models aligned with theoretical models, providing preliminary evidence of construct validity. The resultant Osteoarthritis Conceptualisation Questionnaire could be used to assess osteoarthritis conceptualisations in people with painful knee osteoarthritis. Further research to evaluate scale and item functioning and test-retest reliability is warranted. PERSPECTIVE: Classical and innovative psychometric methods were utilised to develop a novel assessment of conceptualisations of osteoarthritis. The combined use of these methods provided a rigorous evaluation of construct validity. The OACQ may be useful for evaluating the effectiveness of pain science education interventions.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105435"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A group-based, online-delivered pain management programme (iSelf-help) is not inferior to a group-based, in-person programme in reducing pain-related disability for people with persistent pain: A non-inferiority randomised, two-arm, parallel, open-label trial","authors":"Leigh Hale ,&nbsp;Meredith Perry ,&nbsp;Andrew R. Gray ,&nbsp;William Leung ,&nbsp;Sarah G. Dean ,&nbsp;Dagmar Hempel ,&nbsp;Cheryl Davies ,&nbsp;Antony Dowell ,&nbsp;Rebecca Grainger ,&nbsp;Tristram Ingham ,&nbsp;Bernadette Jones ,&nbsp;Barbara Saipe ,&nbsp;Suranga Dassanayake ,&nbsp;Hemakumar Devan","doi":"10.1016/j.jpain.2025.105447","DOIUrl":"10.1016/j.jpain.2025.105447","url":null,"abstract":"<div><div>A group-based, online-delivered version (iSelf-help) of an existing group-based in-person pain management programme was developed. Development included Māori (New Zealand’s Indigenous population) cultural considerations of content. This study determined whether offering iSelf-help was non-inferior to the in-person pain management programme in reducing pain-related disability at six months. The study used a non-inferiority randomised, two-arm, parallel, open-label trial with blinding of assessors, including health economic and process evaluations. Participants were adults (age≥18 years) with persistent non-cancer pain referred to a hospital-based regional pain service who were deemed eligible for a pain management programme. iSelf-help groups participated in two 60-minute video-conferencing sessions (first, peer support facilitated; second, clinician facilitated) weekly for 12 weeks with access to resources via smartphone app and website. In-person groups received 12-week in-person pain management programme. The primary outcome was the Modified Roland Morris Disability Questionnaire. Secondary outcomes included anxiety, depression, stress, pain severity and interference, health related quality of life, self-efficacy, acceptance, and satisfaction. Recruited were 113 participants (56 iSelf-help, 57 in-person), mean(SD) age 38.2(13.7) years, 75% female, 16% Māori. Using modified intention-to-treat analysis on the primary outcome at six months (n=73), iSelf-help was non-inferior to in-person pain management programme with a point estimate (95% one-sided CI) of −0.4 (∞, 1.5). It was also non-inferior for secondary outcomes of anxiety, depression, stress, activity interference, health related quality of life, and self-efficacy. iSelf-help was cheaper, had similar overall satisfaction, but higher accessibility, scores. iSelf-help showed non-inferior clinical outcomes for improving pain-related disability in people with persistent non-cancer pain.</div></div><div><h3>Perspective</h3><div>This article evaluates a novel online-delivered pain management programme (iSelf-help) co-created with people with persistent pain, with committed and ongoing collaboration with Māori whānau (Indigenous population of New Zealand). iSelf-help may improve access to the regional pain service used in this study for more people living with persistent pain.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105447"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient partnership is essential to the advancement of pain research.","authors":"Kathryn A Birnie, Alexandra Neville","doi":"10.1016/j.jpain.2025.105438","DOIUrl":"10.1016/j.jpain.2025.105438","url":null,"abstract":"<p><p>Patient partnership is becoming a cornerstone of pain research advancement. It is a key strategy in promoting inclusive research practices and is now a requirement of many funding bodies. The involvement of people with lived experience as partners in research not only enhances research quality, relevance, and impact, but also embodies the principles of health equity and social justice. Indeed, patient partnership is fundamentally about the democratization of science. Historically, patient involvement and advocacy have been key drivers of change in health research, including in the field of pain. This commentary highlights key areas where patient partners are actively shaping the pain research ecosystem and the leading practices being implemented to guide the pain research community. As patient partnership rapidly evolves both within pain research and beyond, it is imperative to stay aware of and educate ourselves on advancements occurring in the broader patient partnership sphere. The integration of patient partnership in research calls for reflexivity, cultural responsiveness, and trauma-informed approaches to ensure diverse experiences are included and respected. Ultimately, patient partnership has the potential to advance pain research, leading to better understanding, prevention, and management of pain across diverse populations and improved health outcomes. PERSPECTIVE: Concerted efforts are needed to expand patient partnership in pain research. In addition to enhancing research quality and impact, patient partnership is also fundamentally about the democratization of science, health equity, and an act of social justice that is essential to the advancement of pain research, practice, and policy.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105438"},"PeriodicalIF":4.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future research directions on neuroplasticity in manual therapy and exercise for chronic neck pain.","authors":"Jinghua Hou, Jiawei Du","doi":"10.1016/j.jpain.2025.105443","DOIUrl":"10.1016/j.jpain.2025.105443","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105443"},"PeriodicalIF":4.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Future research directions on neuroplasticity in manual therapy and exercise for chronic neck pain.","authors":"Rungtawan Chaikla, Munlika Sremakaew, Suwit Saekho, Suchart Kothan, Sureeporn Uthaikhup","doi":"10.1016/j.jpain.2025.105444","DOIUrl":"10.1016/j.jpain.2025.105444","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105444"},"PeriodicalIF":4.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Uterine Artery Embolization Therapy on ReHo Values in Brain Regions Related to Pain Perception and Emotion Regulation in Adenomyosis Patients Accompanied by Dysmenorrhea.","authors":"Yanying Chen, Rujin Li, Wenjiang Wei, Kelei Hua, Zhihua Zhou, Bin Xia, Zichao Chen, Man Liang, Jiejing Li, Yunfan Wu","doi":"10.1016/j.jpain.2025.105445","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105445","url":null,"abstract":"<p><p>This study investigates changes in regional homogeneity (ReHo) of the brain in patients with adenomyosis accompanied by dysmenorrhea (AMD) before and after uterine artery embolization (UAE) surgery. ReHo is a resting-state functional magnetic resonance imaging (fMRI)-based analysis for assessing the temporal synchronization of local neuronal activity in the brain. This study involved 32 patients with AMD who underwent UAE surgery. Resting-state functional magnetic resonance imaging (fMRI) scans were performed before and after the procedure. A paired t-test analyzed ReHo images to identify significant changes across various brain regions. Each participant underwent relevant laboratory tests and was evaluated using pain and emotional scales. Correlation analyses were subsequently conducted to examine relationships between these clinical features and pre-treatment ReHo values in the identified brain regions. This study found that compared with pre-treatment, ReHo values decreased in the left hippocampus, left caudate nucleus, and left putamen, while increasing in the right paracentral lobule and right cuneus. Particularly, pre-treatment ReHo values in the left hippocampus were positively correlated with scores on the Visual Analog Scale (VAS), Hamilton Anxiety Rating Scale (HAMA), and Hamilton Depression Rating Scale (HAMD), suggesting that the left hippocampus plays an important role in the processing of pain and adverse emotions in AMD. These findings provide evidence for reversible central plasticity following pain relief in AMD, offering new insights into the neurobiological mechanisms of AMD, and may assist in developing more effective treatment strategies. PERSPECTIVE: This study identified significant changes in ReHo in several brain regions of AMD patients before and after treatment with UAE, especially the hippocampus was associated with preoperative pain level and related emotions, demonstrating that reversible central plasticity can occur after dysmenorrhea relief, which may help clinicians to formulate therapeutic strategies.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105445"},"PeriodicalIF":4.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}