Journal of Pain最新文献

{"title":"Pain Sensitivity Questionnaire in Endometriosis.","authors":"Avonae J Gentles, Sarah Wong, Natasha L Orr, Heather Noga, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Caroline Lee, John Kramer, Paul J Yong","doi":"10.1016/j.jpain.2025.105357","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105357","url":null,"abstract":"<p><p>There is increasing recognition that nociplastic pain and central sensitization may play a role in endometriosis-associated pain. The Pain Sensitivity Questionnaire Minor (PSQ-M) evaluates subjective widespread pain sensitivity, and is linked to pain outcomes in chronic pain populations. However, evidence connecting the PSQ-M to central sensitization in endometriosis is limited. Using the Central Sensitization Inventory (CSI) as a comparison, this study compared the PSQ-M as a clinical proxy for central sensitization in endometriosis individuals. Data collected from 983 endometriosis participants (mean age of 34 years), between January 2020 and December 2022, were analyzed from a prospective registry. A significant but weak positive correlation was observed between PSQ-M and CSI scores (r=0.099, p<0.05). A significant but weak correlation was found between the number of central sensitivity syndromes and pelvic pain-related comorbidities with the PSQ-M (r=0.093, p<0.05), compared to a stronger correlation with the CSI (r=0.687, p<0.05). PSQ-M scores were not significantly associated with baseline (r=0.013, p=0.68) or post-operative (r=-0.046, p=0.57) quality-of-life. There was no change in the PSQ-M and a small change in CSI after endometriosis surgery, suggesting that surgical treatment of endometriosis does not directly address central sensitization. In conclusion, the PSQ-M may not be the optimal clinical proxy for central sensitization in endometriosis. PERSPECTIVE: This study evaluates the Pain Sensitivity Questionnaire - Minor (PSQ-M) as a proxy for central sensitization in endometriosis. The PSQ-M showed weak correlations with central sensitivity syndromes and pain scores and was not associated with post-surgical quality-of-life, suggesting it may not be the optimal tool for assessing central sensitization in endometriosis.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105357"},"PeriodicalIF":4.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary media campaigns for musculoskeletal pain: A systematic review and meta-analysis with social marketing benchmarking","authors":"Felicity A. Braithwaite Dr ,&nbsp;Sameer Deshpande ,&nbsp;Rachelle Buchbinder ,&nbsp;Liz Dennett ,&nbsp;Craig Richard St. Jean ,&nbsp;Brandon Krebs ,&nbsp;Douglas P. Gross","doi":"10.1016/j.jpain.2024.104739","DOIUrl":"10.1016/j.jpain.2024.104739","url":null,"abstract":"<div><div>Musculoskeletal pain is a global public health problem. Social marketing aims to increase adoption of desired behaviours in target audiences and may uncover new strategies to improve uptake of helpful pain-related behaviours at the population-level. We systematically evaluated effects of contemporary mass media campaigns targeting musculoskeletal pain and used social marketing benchmarking to explore strategies associated with campaign success. Published evaluations of campaigns involving an online/digital component and a comparator/control condition were eligible. The primary outcome was population beliefs; secondary outcomes were healthcare provider beliefs, behavioural (e.g., healthcare-related, work-related), clinical (e.g., pain), and economic outcomes. Decision-rules and meta-analyses (random-effects models) were used to synthesise findings. Eight databases and grey literature were searched from inception to May 2024. Thirteen eligible publications evaluated eight campaigns (N = 5 back pain, N = 2 rheumatic pain; N = 1 work-related pain) from eight Western/high-income countries. All evaluations reported historical control data (interrupted time-series/before-and-after designs); three also compared selected outcomes to an unexposed geographical region (quasi-experimental designs). Risk of bias was weak-moderate for all evaluations. Population beliefs improved from baseline vs. final follow-up (1.5–10yrs) for items related to ‘staying active’ [RR = 1.38 (95%CI: 1.14–1.67), N = 4 campaigns, n = 12,568 participants] and ‘rest’ [RR = 1.35 (95%CI: 1.14–1.60), N = 5 campaigns, n = 14,571 participants] for pain management, however, certainty of evidence was very low. Other outcomes were not pooled due to heterogeneity, and evidence was mixed. Greater numbers of social marketing benchmarks were associated with successful campaign outcomes. Future campaigns should implement social marketing strategies beyond education alone, including behaviour change support, to facilitate adoption of desired pain-related behaviours.</div></div><div><h3>Registration</h3><div>PROSPERO registration number: CRD42023400456; Open Science Framework (detailed Social Marketing Benchmarking analysis plan): https://osf.io/npyck/.</div></div><div><h3>Perspective</h3><div>We systematically evaluated contemporary mass media campaigns targeting musculoskeletal pain. Promising improvements in population beliefs about pain supports continued investment into campaigns. Our review provides critical new information including social marketing strategies to ensure future campaign efforts shift population-level pain-related behaviours, towards reducing the societal burden of pain.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104739"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the trustworthiness of pain research: A call to action.","authors":"The ENTRUST-PE Network,&nbsp;Neil E. O’Connell ,&nbsp;Joletta Belton ,&nbsp;Geert Crombez ,&nbsp;Christopher Eccleston ,&nbsp;Emma Fisher ,&nbsp;Michael C. Ferraro ,&nbsp;Anna Hood ,&nbsp;Francis Keefe ,&nbsp;Roger Knaggs ,&nbsp;Emma Norris ,&nbsp;Tonya M. Palermo ,&nbsp;Gisèle Pickering ,&nbsp;Esther Pogatzki-Zahn ,&nbsp;Andrew SC Rice ,&nbsp;Georgia Richards ,&nbsp;Daniel Segelcke ,&nbsp;Keith M. Smart ,&nbsp;Nadia Soliman ,&nbsp;Gavin Stewart ,&nbsp;Amanda C.de C. Williams","doi":"10.1016/j.jpain.2024.104736","DOIUrl":"10.1016/j.jpain.2024.104736","url":null,"abstract":"<div><div>The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing, and managing chronic pain. Yet patients with chronic pain, clinicians and the public are sometimes poorly served by an evidence architecture that contains multiple structural weaknesses. These include incomplete research governance, a lack of diversity and inclusivity, inadequate stakeholder engagement, poor methodological rigour and incomplete reporting, a lack of data accessibility and transparency, and a failure to communicate findings with appropriate balance. These issues span pre-clinical research, clinical trials and systematic reviews and impact the development of clinical guidance and practice. Research misconduct and inauthentic data present a further critical risk. Combined, they increase uncertainty in this highly challenging area of study and practice, drive the provision of low value care, increase costs and impede the discovery of more effective solutions.</div><div>In this focus article, we explore how we can increase trust in pain science, by examining critical challenges using contemporary examples, and describe a novel integrated conceptual framework for enhancing the trustworthiness of pain science. We end with a call for collective action to address this critical issue.</div></div><div><h3>Perspective</h3><div>Multiple challenges can adversely impact the trustworthiness of pain research and health research more broadly. We present ENTRUST-PE, a novel, integrated framework for more trustworthy pain research with recommendations for all stakeholders in the research ecosystem, and make a call to action to the pain research community.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104736"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative sensory testing and exercise-induced hypoalgesia protocols in low back pain: A scoping review","authors":"Lee-Ran Goodman MSc,&nbsp;Ronessa Dass MSc,&nbsp;Eden Daniel MSc,&nbsp;Shirin Modarresi PT, PhD,&nbsp;Lisa Carlesso PT, PhD,&nbsp;Ada Tang PT, PhD,&nbsp;Luciana Macedo PT, PhD","doi":"10.1016/j.jpain.2024.104725","DOIUrl":"10.1016/j.jpain.2024.104725","url":null,"abstract":"<div><div>A significant driver of pain in individuals with low back pain (LBP) is alterations to endogenous pain modulation (EPM). EPM can be measured using quantitative sensory testing (QST), however; there are inconsistencies in the way QST has been implemented across the low back pain literature. The objective of this scoping review was to summarize protocols used to assess EPM using QST (pain pressure threshold (PPT), temporal summation (TS), conditioned pain modulation (CPM)) or exercise-induced hypoalgesia (EIH) in LBP. Databases Medline, Embase, CINAHL and AMED were searched on June 15, 2023, for articles that used QST or EIH protocols in LBP populations. Data was extracted on participants, study design, setting and details on QST and EIH protocols. Of the 221 studies included in the review, 196 used PPT, 62 used TS and 60 used CPM; only 5 studies investigated EIH. For all QST, there was high variability in the type of equipment, timing, trials, and testing location with many studies not reporting this information. There were 4 testing modalities used for TS, and 7 different test stimuli, and 3 different conditioning stimuli used across the studies for CPM. For CPM and EIH, PPT was the most common testing modality. There were 4 types of exercises used across the 5 EIH studies. This scoping review provides a summary of QST and EIH protocols in LBP that may be used as a guide for assessment in future studies. These results demonstrate a need for the development of standardized protocols and reporting guidelines.</div></div><div><h3>Perspective</h3><div>This article presents a summary of measures used to assess EPM in LBP. The results show the wide variability of protocols used in the literature. Future research should focus on creating standardized protocols, reporting guidelines and providing more guidance for researchers in selecting appropriate tests for their research questions.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104725"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread and Prolonged Pain May Reduce Brain Clearance Capacity Only via Sleep Impairment: Evidence from Participants with Knee Pain.","authors":"Pedro A Valdes-Hernandez, Soamy Montesino-Goicolea, Chavier Laffitte Nodarse, Alisa J Johnson, Roger B Fillingim, Yenisel Cruz-Almeida","doi":"10.1016/j.jpain.2025.105356","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105356","url":null,"abstract":"<p><p>The brain is key in the pain-sleep relationship, and sleep is needed for glymphatic clearance. However, no studies have examined how pain relates to the glymphatic system (GS). Characterizing the GS alongside sleep quality in well-characterized pain samples is essential for advancing this understanding. Non-invasive MRI techniques, such as Diffusion Tensor Imaging-Analysis aLong the Perivascular Space (DTI-ALPS), are particularly valuable as they are approved for humans. Although the relationship between the DTI-ALPS index and the GS is primarily deductive, the index may be a proxy for waste clearance capacity in deep white matter. Its sensitivity to interstitial space changes-known to be modulated by norepinephrine-offers a unique opportunity to investigate how sleep impairment and chronic pain regulation affect specific components of brain waste clearance. We thus fitted two longitudinal models linking pain, sleep quality and the DTI-ALPS index. We hypothesized that variations in pain characteristics would predict DTI-ALPS index changes, either directly or mediated by sleep quality changes. Alternatively, we hypothesized that variations in sleep quality would predict changes in pain characteristics via DTI-ALPS index modifications. Knee pain participants (n=87) completed an MRI and self-reported measures of pain and sleep impairment at baseline and two years later. We only found evidence supporting that more widespread and longer pain at baseline significantly influenced decreases in the DTI-ALPS index in the left hemisphere through increased sleep impairment two years later (p=0.039, corrected). Perspective: Findings highlight the need for research on the relationship between pain and sleep quality and its implications for brain health.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105356"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain-induced functional and structural alterations in the brain: A multi-modal meta-analysis","authors":"Xinglin Zeng PhD ,&nbsp;Yinghao Sun BSc ,&nbsp;Zhao Zhiying PhD ,&nbsp;Lin Hua PhD ,&nbsp;Zhen Yuan PhD","doi":"10.1016/j.jpain.2024.104740","DOIUrl":"10.1016/j.jpain.2024.104740","url":null,"abstract":"<div><div>Chronic pain is a debilitating condition associated with brain alterations. However, the variability in neuroimaging results across modalities necessitates a comprehensive multi-modal meta-analysis for a cohesive understanding. This study aims to elucidate brain alterations in chronic pain patients using a multi-modal meta-analysis approach encompassing structural, resting-state functional connectivity, and pain processing paradigms in functional magnetic resonance imaging. A systematic literature search was conducted across PubMed, OVID Embase, OVID Medline, and Web of Science, encompassing studies published up to May 2022, to identify relevant research articles on chronic pain and MRI techniques in three modalities. Inclusion criteria encompassed experiments reporting three modality brain alterations in chronic pain patients, with sufficient statistical thresholds and enough sample size. We conducted voxel-wise meta-analyses using seed-based d mapping to identify significant alterations in each modality. Additionally, conjunction analyses were executed to identify common alterations across these modalities. Ultimately, 47 structure studies, 37 resting state functional connectivity studies, and 41 pain-processing studies were selected for formal analysis. Chronic pain patients displayed notable structural and functional alterations in the insular cortex, characterized by reduced gray matter, disruptions in functional connectivity with the frontoparietal network, and enhanced activation during painful stimuli processing. Distinct activation patterns were observed in the left and right insular cortex for pain stimulus processing versus anticipation. Furthermore, the superior temporal gyrus and superior frontal gyrus exhibited joint alterations across modalities. This multi-modal meta-analysis reveals consistent brain alterations in chronic pain patients, shedding light on the complex interplay between structural and functional changes.</div></div><div><h3>Perspective</h3><div>This multi-modal meta-analysis integrates findings from structural, resting-state functional connectivity, and pain processing paradigms in fMRI, revealing consistent brain alterations in chronic pain patients. Notable brain changes highlight the intricate interplay between structural and functional brain changes, advancing our understanding of chronic pain’s neural underpinnings.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104740"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language errors in pain medicine: An umbrella review","authors":"Bastien Léo Béraud ,&nbsp;André Meichtry ,&nbsp;Kay-Uwe Hanusch ,&nbsp;Roger Hilfiker","doi":"10.1016/j.jpain.2024.104738","DOIUrl":"10.1016/j.jpain.2024.104738","url":null,"abstract":"<div><div>Errors in language are common in pain medicine, but the extent of such errors has not been systematically measured. This pre-registered umbrella review explored Embase, PubMed, Medline and CINAHL and seeks to quantify the prevalence of errors in language in review articles since the last IASP definition revision. To be eligible, studies must have met the following criteria: 1) Primary aim was stated as to provide neurophysiological explanations of nociception and/or pain in humans in context of a pathology/condition; 2) Any type of review article; 3) Written in English; 4) Published in a peer-reviewed journal. Studies were excluded if they met any of the following criteria: 5) Published prior to the last revision of the IASP definition; 6) Published after May 2023; 7) Published in a predatory journal. Out of 5470 articles screened, 48 review articles met the inclusion criteria. All articles contained at least one error in language, there were no differences in the proportions of errors in language in review articles between years of publication, and various predictors were mostly not associated with a higher or lower number of errors in language counts in articles. Our findings reveal the need for heightened awareness among researchers, clinicians, journals and editorial boards regarding the prevalence and impact of these errors. Given our findings and their limitations, further research should focus on examining the contextual influence of misnomer usage and replication of these results.</div></div><div><h3>Perspective</h3><div>This umbrella review explored the main biomedical databases to see how many review articles contained language errors. Our findings underscore the imperative for prompt action in regulating pain medicine terminology.</div></div><div><h3>Pre-registration</h3><div>This umbrella review was pre-registered on OSF registries (https://doi.org/10.17605/osf.io/kau8m).</div></div><div><h3>Online material</h3><div><span><span>https://osf.io/kdweg</span><svg><path></path></svg></span>/</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104738"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to TRPA1 agonist-responsive afferents contribute to central sensitization by suppressing spinal GABAergic interneurons through somatostatin 2A receptors [J Pain 25 12 (2024) 104686]","authors":"Ramesh Pariyar,&nbsp;Jigong Wang,&nbsp;Regan Hammond,&nbsp;Ho Koo,&nbsp;Nicholas Dalley,&nbsp;Jun-Ho La","doi":"10.1016/j.jpain.2025.105355","DOIUrl":"10.1016/j.jpain.2025.105355","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 105355"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Acceptance and Commitment Therapy plus Exercise for Older Adults with Chronic Low Back Pain: A Preliminary Cluster Randomized Controlled Trial with Qualitative Interviews.","authors":"Jae Qj Liu, Wah Y Mak, Aled Ly Tang, Crystal Y Kwan, Fadi Al Zoubi, Timmy Kt Wong, Gordon Sh Tsang, Heidi Cw Kwong, Sabrina Wt Lai, Sam Ps Sze, Kelvin Tk Hui, Chelsia Kc Cheung, Dino Samartzis, Karen Ks Chow, Arnold Yl Wong","doi":"10.1016/j.jpain.2025.105350","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105350","url":null,"abstract":"<p><p>Chronic low back pain (CLBP) is increasingly prevalent in older adults and often leads to functional disability and depressive symptoms. This 2-arm, double-blinded, pilot cluster RCT, with semi-structured interviews, aimed to evaluate the acceptability, feasibility, and preliminary clinical efficacy of ACT plus exercise training (ACT+Ex) on improving pain-related outcomes, psychological outcomes, and physical fitness in older adults with CLBP at post-treatment and 6-month follow-up. Forty community-dwelling older adults (62-85 years) with CLBP, predominantly female, were randomized to ACT+Ex (n=20) or Education plus exercise program (Edu+Ex) (n=20) for 8 weekly group-based sessions, with assessments at baseline, post-treatment, and 6-month follow-up (primary endpoint). Self-reported outcomes included pain intensity, functional disability (Roland Morris Disability Questionnaires, RMDQ), health-related quality of life (EuroQol-5 Dimensions, EQ-5D-5L), psychological inflexibility (Acceptance and Action Questionnaire-Version 2, AAQ-II), and psychological well-being (Depression Anxiety Stress Scale). Physical fitness was assessed using the functional reach test (FRT), Timed Up and Go test (TUG), 6-minute walk test (6MWT), hand grip strength (HGS), and 30-second sit-to-stand (STS-30) test. This trial achieved high recruitment (23.5 participants per week) and completion rates (92.5%). Exploratory analyses revealed that ACT+Ex significantly improved pain intensity, disability, psychological inflexibility, HRQoL, and physical fitness at post-treatment and 6-month follow-up. Qualitative data identified 3 superordinate themes: previous healthcare experience affecting pain beliefs; acceptance strategies guiding behavioral changes; and facilitators and barriers to treatment compliance. These findings support the need for a definitive RCT and form a valuable basis for future exploration regarding the behavioral mechanisms of ACT in clinical applications. PERSPECTIVE: A multimodal therapy incorporating ACT and exercise promotes positive behavioral changes and its treatment effects are maintained at the 6-month follow-up especially for physical performance.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105350"},"PeriodicalIF":4.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying comorbid obstructive sleep apnea in chronic musculoskeletal pain: A systematic review.","authors":"Julya Perea, Julia Kortstee, Zosia Goossens, Nils Runge, Céline Labie, Jo Nijs, Liesbet De Baets","doi":"10.1016/j.jpain.2025.105351","DOIUrl":"10.1016/j.jpain.2025.105351","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is common in patients with chronic musculoskeletal pain (CMP). Understanding the characteristics of the CMP population with comorbid OSA is important for proper screening and management. This systematic review compiles evidence on methods used to identify OSA in patients with CMP and identifies the characteristic features of patients with CMP and comorbid OSA. A systematic search was conducted in Medline (PubMed), Embase and Web of Science. Broad search terms related to sleep apnea and CMP were used. Studies had to include individuals with CMP diagnosed with OSA or individuals with CMP in whom OSA symptoms were assessed as outcomes. The protocol was pre-registered on PROSPERO (CRD42024516140). The initial search identified 3832 records, and 30 studies (total n=7085 participants) were included. Laboratory sleep polysomnography was the most used objective assessment method, while the Berlin and STOP-BANG questionnaires were the most used self-report instruments. However, these questionnaires showed poor agreement with polysomnography. The results consistently showed that fatigue and pain distribution did not differ between CMP patients with and without OSA. Inconsistent results were found regarding higher age, higher body mass index, psychological factors, decreased sleep quality, increased sleepiness, and pain intensity as characteristic features of the CMP with OSA population compared to the CMP without OSA. No factors consistently characterized the CMP with OSA population. Further research is required to explore the factors that consistently characterize patients with CMP with comorbid OSA to improve the effectiveness of screening for OSA in daily practice. PERSPECTIVE: This work summarizes the tools used to assess obstructive sleep apnea in populations with chronic musculoskeletal pain and highlights the features of individuals with both conditions compared to those with only chronic musculoskeletal pain.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105351"},"PeriodicalIF":4.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}