Journal of Pain最新文献

{"title":"Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light","authors":"Matthew R. Sapio ,&nbsp;Diana M. King ,&nbsp;Dragan Maric ,&nbsp;Samay R. Shah ,&nbsp;Thomas L. Talbot ,&nbsp;Allison P. Manalo ,&nbsp;Pranavi Nara ,&nbsp;Wenting Ma ,&nbsp;Andre Ghetti ,&nbsp;Christopher E. Ramsden ,&nbsp;Michael J. Iadarola ,&nbsp;Andrew J Mannes","doi":"10.1016/j.jpain.2025.105359","DOIUrl":"10.1016/j.jpain.2025.105359","url":null,"abstract":"<div><div>Background autofluorescence is enhanced in human tissue relative to small animals and presents a barrier to fully realizing the potential of novel multiplex methods in human studies. In particular, lipofuscin (LF) is an interfering pigment in multiplex fluorescence assays. Lipofuscin (LF) is a highly cross-linked aggregate of oxidized lipids, proteins, sugars, and metal ions that accumulates in lysosomes with age, and is strongly fluorescent across wavelengths that interfere with signals from common fluorophores. This is particularly apparent in dorsal root ganglion (DRG), where the LF deposits occupy up to 80% of the visible neuronal cytoplasm, affecting ∼45% of neurons in a typical section. This report describes a straightforward, scalable, pre-staining, white-light photobleaching method that near-totally reduces LF autofluorescence, and improves signal detection across the color spectrum without negatively impacting the multiplex fluorescence detection assay. It is effective for peripheral and central nervous system structures as well as pathological tissue such as Alzheimer’s disease brain, which contains high levels of autofluorescent interference. This demonstrates the broad applicability to improving signal detection in human disease states to enable translational investigations in humans. This low-cost procedure can be rapidly implemented into existing research programs to increase the accessibility of high-plex fluorescent microscopy methodologies to enable direct-in-human research.</div></div><div><h3>Perspective</h3><div>White light photobleaching of lipofuscin before multiplex fluorescent in situ hybridization allows for rapid, near-total quenching of autofluorescence in healthy and diseased human nervous system tissue. Given the importance of direct-in-human investigations for validating translational studies and ensuring medical relevance, this simple yet powerful advance enables future anatomical investigations.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"30 ","pages":"Article 105359"},"PeriodicalIF":4.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes toward patient engagement in clinical pain research: Insights from individuals with chronic pain in the United States.","authors":"Katherine J Holzer, Haley E Bernstein, Christin Veasley, Simon Haroutounian, Dagmar Amtmann, Aderonke Bamgbose Pederson, Bryce B Reeve, Dennis C Turk, Robert H Dworkin, Dale J Langford","doi":"10.1016/j.jpain.2025.105358","DOIUrl":"10.1016/j.jpain.2025.105358","url":null,"abstract":"<p><p>The value of engaging people with lived experience into chronic pain research is becoming increasingly recognized, yet the perspectives of individuals with chronic pain who have not previously participated in research are underexplored. This study aims to fill this gap by assessing the attitudes, preferences, and barriers related to patient engagement among adults living with chronic pain in the United States (US). An online survey was developed in collaboration with an advisory board and community engagement studio and distributed through Qualtrics panels from December 2023-January 2024. Quotas for age, gender, and race were employed to reach a representative sample for each of these variables based on the 2020 US census.^1,2 Of the 505 participants, 267 reported chronic low back pain (53%) and 144 had headaches or migraines (22%). A majority (65%-79%) were familiar with medical research, and 64% (n = 327) expressed interest in engaging as patient partners. Key facilitators for engagement included the desire to help others and learn about their condition, while compensation was also an important motivator. Barriers were time constraints, lack of payment, and worry about privacy. Younger participants (Chi-square p = 0.04) and those with higher education (Chi-square p = 0.01) were more likely to express interest in research partnerships. Strategies to enhance patient engagement should focus on reducing barriers and providing clear, meaningful opportunities for engagement, potentially increasing both recruitment and retention in chronic pain research. Future research should explore these dynamics further and consider international perspectives to develop comprehensive patient engagement strategies. PERSPECTIVE: This study surveys over 500 individuals with chronic pain to understand their attitudes towards engagement in clinical pain research. It identifies key facilitators and barriers, such as time constraints and low compensation, and aims to refine strategies to enhance patient partner engagement and representation in clinical pain research.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105358"},"PeriodicalIF":4.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Sensitivity Questionnaire in Endometriosis.","authors":"Avonae J Gentles, Sarah Wong, Natasha L Orr, Heather Noga, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Caroline Lee, John Kramer, Paul J Yong","doi":"10.1016/j.jpain.2025.105357","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105357","url":null,"abstract":"<p><p>There is increasing recognition that nociplastic pain and central sensitization may play a role in endometriosis-associated pain. The Pain Sensitivity Questionnaire Minor (PSQ-M) evaluates subjective widespread pain sensitivity, and is linked to pain outcomes in chronic pain populations. However, evidence connecting the PSQ-M to central sensitization in endometriosis is limited. Using the Central Sensitization Inventory (CSI) as a comparison, this study compared the PSQ-M as a clinical proxy for central sensitization in endometriosis individuals. Data collected from 983 endometriosis participants (mean age of 34 years), between January 2020 and December 2022, were analyzed from a prospective registry. A significant but weak positive correlation was observed between PSQ-M and CSI scores (r=0.099, p<0.05). A significant but weak correlation was found between the number of central sensitivity syndromes and pelvic pain-related comorbidities with the PSQ-M (r=0.093, p<0.05), compared to a stronger correlation with the CSI (r=0.687, p<0.05). PSQ-M scores were not significantly associated with baseline (r=0.013, p=0.68) or post-operative (r=-0.046, p=0.57) quality-of-life. There was no change in the PSQ-M and a small change in CSI after endometriosis surgery, suggesting that surgical treatment of endometriosis does not directly address central sensitization. In conclusion, the PSQ-M may not be the optimal clinical proxy for central sensitization in endometriosis. PERSPECTIVE: This study evaluates the Pain Sensitivity Questionnaire - Minor (PSQ-M) as a proxy for central sensitization in endometriosis. The PSQ-M showed weak correlations with central sensitivity syndromes and pain scores and was not associated with post-surgical quality-of-life, suggesting it may not be the optimal tool for assessing central sensitization in endometriosis.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105357"},"PeriodicalIF":4.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary media campaigns for musculoskeletal pain: A systematic review and meta-analysis with social marketing benchmarking","authors":"Felicity A. Braithwaite Dr ,&nbsp;Sameer Deshpande ,&nbsp;Rachelle Buchbinder ,&nbsp;Liz Dennett ,&nbsp;Craig Richard St. Jean ,&nbsp;Brandon Krebs ,&nbsp;Douglas P. Gross","doi":"10.1016/j.jpain.2024.104739","DOIUrl":"10.1016/j.jpain.2024.104739","url":null,"abstract":"<div><div>Musculoskeletal pain is a global public health problem. Social marketing aims to increase adoption of desired behaviours in target audiences and may uncover new strategies to improve uptake of helpful pain-related behaviours at the population-level. We systematically evaluated effects of contemporary mass media campaigns targeting musculoskeletal pain and used social marketing benchmarking to explore strategies associated with campaign success. Published evaluations of campaigns involving an online/digital component and a comparator/control condition were eligible. The primary outcome was population beliefs; secondary outcomes were healthcare provider beliefs, behavioural (e.g., healthcare-related, work-related), clinical (e.g., pain), and economic outcomes. Decision-rules and meta-analyses (random-effects models) were used to synthesise findings. Eight databases and grey literature were searched from inception to May 2024. Thirteen eligible publications evaluated eight campaigns (N = 5 back pain, N = 2 rheumatic pain; N = 1 work-related pain) from eight Western/high-income countries. All evaluations reported historical control data (interrupted time-series/before-and-after designs); three also compared selected outcomes to an unexposed geographical region (quasi-experimental designs). Risk of bias was weak-moderate for all evaluations. Population beliefs improved from baseline vs. final follow-up (1.5–10yrs) for items related to ‘staying active’ [RR = 1.38 (95%CI: 1.14–1.67), N = 4 campaigns, n = 12,568 participants] and ‘rest’ [RR = 1.35 (95%CI: 1.14–1.60), N = 5 campaigns, n = 14,571 participants] for pain management, however, certainty of evidence was very low. Other outcomes were not pooled due to heterogeneity, and evidence was mixed. Greater numbers of social marketing benchmarks were associated with successful campaign outcomes. Future campaigns should implement social marketing strategies beyond education alone, including behaviour change support, to facilitate adoption of desired pain-related behaviours.</div></div><div><h3>Registration</h3><div>PROSPERO registration number: CRD42023400456; Open Science Framework (detailed Social Marketing Benchmarking analysis plan): https://osf.io/npyck/.</div></div><div><h3>Perspective</h3><div>We systematically evaluated contemporary mass media campaigns targeting musculoskeletal pain. Promising improvements in population beliefs about pain supports continued investment into campaigns. Our review provides critical new information including social marketing strategies to ensure future campaign efforts shift population-level pain-related behaviours, towards reducing the societal burden of pain.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104739"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the trustworthiness of pain research: A call to action.","authors":"The ENTRUST-PE Network,&nbsp;Neil E. O’Connell ,&nbsp;Joletta Belton ,&nbsp;Geert Crombez ,&nbsp;Christopher Eccleston ,&nbsp;Emma Fisher ,&nbsp;Michael C. Ferraro ,&nbsp;Anna Hood ,&nbsp;Francis Keefe ,&nbsp;Roger Knaggs ,&nbsp;Emma Norris ,&nbsp;Tonya M. Palermo ,&nbsp;Gisèle Pickering ,&nbsp;Esther Pogatzki-Zahn ,&nbsp;Andrew SC Rice ,&nbsp;Georgia Richards ,&nbsp;Daniel Segelcke ,&nbsp;Keith M. Smart ,&nbsp;Nadia Soliman ,&nbsp;Gavin Stewart ,&nbsp;Amanda C.de C. Williams","doi":"10.1016/j.jpain.2024.104736","DOIUrl":"10.1016/j.jpain.2024.104736","url":null,"abstract":"<div><div>The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing, and managing chronic pain. Yet patients with chronic pain, clinicians and the public are sometimes poorly served by an evidence architecture that contains multiple structural weaknesses. These include incomplete research governance, a lack of diversity and inclusivity, inadequate stakeholder engagement, poor methodological rigour and incomplete reporting, a lack of data accessibility and transparency, and a failure to communicate findings with appropriate balance. These issues span pre-clinical research, clinical trials and systematic reviews and impact the development of clinical guidance and practice. Research misconduct and inauthentic data present a further critical risk. Combined, they increase uncertainty in this highly challenging area of study and practice, drive the provision of low value care, increase costs and impede the discovery of more effective solutions.</div><div>In this focus article, we explore how we can increase trust in pain science, by examining critical challenges using contemporary examples, and describe a novel integrated conceptual framework for enhancing the trustworthiness of pain science. We end with a call for collective action to address this critical issue.</div></div><div><h3>Perspective</h3><div>Multiple challenges can adversely impact the trustworthiness of pain research and health research more broadly. We present ENTRUST-PE, a novel, integrated framework for more trustworthy pain research with recommendations for all stakeholders in the research ecosystem, and make a call to action to the pain research community.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104736"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative sensory testing and exercise-induced hypoalgesia protocols in low back pain: A scoping review","authors":"Lee-Ran Goodman MSc,&nbsp;Ronessa Dass MSc,&nbsp;Eden Daniel MSc,&nbsp;Shirin Modarresi PT, PhD,&nbsp;Lisa Carlesso PT, PhD,&nbsp;Ada Tang PT, PhD,&nbsp;Luciana Macedo PT, PhD","doi":"10.1016/j.jpain.2024.104725","DOIUrl":"10.1016/j.jpain.2024.104725","url":null,"abstract":"<div><div>A significant driver of pain in individuals with low back pain (LBP) is alterations to endogenous pain modulation (EPM). EPM can be measured using quantitative sensory testing (QST), however; there are inconsistencies in the way QST has been implemented across the low back pain literature. The objective of this scoping review was to summarize protocols used to assess EPM using QST (pain pressure threshold (PPT), temporal summation (TS), conditioned pain modulation (CPM)) or exercise-induced hypoalgesia (EIH) in LBP. Databases Medline, Embase, CINAHL and AMED were searched on June 15, 2023, for articles that used QST or EIH protocols in LBP populations. Data was extracted on participants, study design, setting and details on QST and EIH protocols. Of the 221 studies included in the review, 196 used PPT, 62 used TS and 60 used CPM; only 5 studies investigated EIH. For all QST, there was high variability in the type of equipment, timing, trials, and testing location with many studies not reporting this information. There were 4 testing modalities used for TS, and 7 different test stimuli, and 3 different conditioning stimuli used across the studies for CPM. For CPM and EIH, PPT was the most common testing modality. There were 4 types of exercises used across the 5 EIH studies. This scoping review provides a summary of QST and EIH protocols in LBP that may be used as a guide for assessment in future studies. These results demonstrate a need for the development of standardized protocols and reporting guidelines.</div></div><div><h3>Perspective</h3><div>This article presents a summary of measures used to assess EPM in LBP. The results show the wide variability of protocols used in the literature. Future research should focus on creating standardized protocols, reporting guidelines and providing more guidance for researchers in selecting appropriate tests for their research questions.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104725"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain-induced functional and structural alterations in the brain: A multi-modal meta-analysis","authors":"Xinglin Zeng PhD ,&nbsp;Yinghao Sun BSc ,&nbsp;Zhao Zhiying PhD ,&nbsp;Lin Hua PhD ,&nbsp;Zhen Yuan PhD","doi":"10.1016/j.jpain.2024.104740","DOIUrl":"10.1016/j.jpain.2024.104740","url":null,"abstract":"<div><div>Chronic pain is a debilitating condition associated with brain alterations. However, the variability in neuroimaging results across modalities necessitates a comprehensive multi-modal meta-analysis for a cohesive understanding. This study aims to elucidate brain alterations in chronic pain patients using a multi-modal meta-analysis approach encompassing structural, resting-state functional connectivity, and pain processing paradigms in functional magnetic resonance imaging. A systematic literature search was conducted across PubMed, OVID Embase, OVID Medline, and Web of Science, encompassing studies published up to May 2022, to identify relevant research articles on chronic pain and MRI techniques in three modalities. Inclusion criteria encompassed experiments reporting three modality brain alterations in chronic pain patients, with sufficient statistical thresholds and enough sample size. We conducted voxel-wise meta-analyses using seed-based d mapping to identify significant alterations in each modality. Additionally, conjunction analyses were executed to identify common alterations across these modalities. Ultimately, 47 structure studies, 37 resting state functional connectivity studies, and 41 pain-processing studies were selected for formal analysis. Chronic pain patients displayed notable structural and functional alterations in the insular cortex, characterized by reduced gray matter, disruptions in functional connectivity with the frontoparietal network, and enhanced activation during painful stimuli processing. Distinct activation patterns were observed in the left and right insular cortex for pain stimulus processing versus anticipation. Furthermore, the superior temporal gyrus and superior frontal gyrus exhibited joint alterations across modalities. This multi-modal meta-analysis reveals consistent brain alterations in chronic pain patients, shedding light on the complex interplay between structural and functional changes.</div></div><div><h3>Perspective</h3><div>This multi-modal meta-analysis integrates findings from structural, resting-state functional connectivity, and pain processing paradigms in fMRI, revealing consistent brain alterations in chronic pain patients. Notable brain changes highlight the intricate interplay between structural and functional brain changes, advancing our understanding of chronic pain’s neural underpinnings.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104740"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Widespread and prolonged pain may reduce brain clearance capacity only via sleep impairment: Evidence from participants with knee pain","authors":"Pedro A. Valdes-Hernandez ,&nbsp;Soamy Montesino-Goicolea ,&nbsp;Chavier Laffitte Nodarse ,&nbsp;Alisa J. Johnson ,&nbsp;Roger B. Fillingim ,&nbsp;Yenisel Cruz-Almeida","doi":"10.1016/j.jpain.2025.105356","DOIUrl":"10.1016/j.jpain.2025.105356","url":null,"abstract":"<div><div>The brain is key in the pain-sleep relationship, and sleep is needed for glymphatic clearance. However, no studies have examined how pain relates to the glymphatic system (GS). Characterizing the GS alongside sleep quality in well-characterized pain samples is essential for advancing this understanding. Non-invasive MRI techniques, such as Diffusion Tensor Imaging-Analysis aLong the Perivascular Space (DTI-ALPS), are particularly valuable as they are approved for humans. Although the relationship between the DTI-ALPS index and the GS is primarily deductive, the index may be a proxy for waste clearance capacity in deep white matter. Its sensitivity to interstitial space changes—known to be modulated by norepinephrine—offers a unique opportunity to investigate how sleep impairment and chronic pain regulation affect specific components of brain waste clearance. We thus fitted two longitudinal models linking pain, sleep quality and the DTI-ALPS index. We hypothesized that variations in pain characteristics would predict DTI-ALPS index changes, either directly or mediated by sleep quality changes. Alternatively, we hypothesized that variations in sleep quality would predict changes in pain characteristics via DTI-ALPS index modifications. Knee pain participants (n=87) completed an MRI and self-reported measures of pain and sleep impairment at baseline and two years later. We only found evidence supporting that more widespread and longer pain at baseline significantly influenced decreases in the DTI-ALPS index in the left hemisphere through increased sleep impairment two years later (p=0.039, corrected).</div></div><div><h3>Perspective</h3><div>Findings highlight the need for research on the relationship between pain and sleep quality and its implications for brain health.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"30 ","pages":"Article 105356"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language errors in pain medicine: An umbrella review","authors":"Bastien Léo Béraud ,&nbsp;André Meichtry ,&nbsp;Kay-Uwe Hanusch ,&nbsp;Roger Hilfiker","doi":"10.1016/j.jpain.2024.104738","DOIUrl":"10.1016/j.jpain.2024.104738","url":null,"abstract":"<div><div>Errors in language are common in pain medicine, but the extent of such errors has not been systematically measured. This pre-registered umbrella review explored Embase, PubMed, Medline and CINAHL and seeks to quantify the prevalence of errors in language in review articles since the last IASP definition revision. To be eligible, studies must have met the following criteria: 1) Primary aim was stated as to provide neurophysiological explanations of nociception and/or pain in humans in context of a pathology/condition; 2) Any type of review article; 3) Written in English; 4) Published in a peer-reviewed journal. Studies were excluded if they met any of the following criteria: 5) Published prior to the last revision of the IASP definition; 6) Published after May 2023; 7) Published in a predatory journal. Out of 5470 articles screened, 48 review articles met the inclusion criteria. All articles contained at least one error in language, there were no differences in the proportions of errors in language in review articles between years of publication, and various predictors were mostly not associated with a higher or lower number of errors in language counts in articles. Our findings reveal the need for heightened awareness among researchers, clinicians, journals and editorial boards regarding the prevalence and impact of these errors. Given our findings and their limitations, further research should focus on examining the contextual influence of misnomer usage and replication of these results.</div></div><div><h3>Perspective</h3><div>This umbrella review explored the main biomedical databases to see how many review articles contained language errors. Our findings underscore the imperative for prompt action in regulating pain medicine terminology.</div></div><div><h3>Pre-registration</h3><div>This umbrella review was pre-registered on OSF registries (https://doi.org/10.17605/osf.io/kau8m).</div></div><div><h3>Online material</h3><div><span><span>https://osf.io/kdweg</span><svg><path></path></svg></span>/</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"28 ","pages":"Article 104738"},"PeriodicalIF":4.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to TRPA1 agonist-responsive afferents contribute to central sensitization by suppressing spinal GABAergic interneurons through somatostatin 2A receptors [J Pain 25 12 (2024) 104686]","authors":"Ramesh Pariyar,&nbsp;Jigong Wang,&nbsp;Regan Hammond,&nbsp;Ho Koo,&nbsp;Nicholas Dalley,&nbsp;Jun-Ho La","doi":"10.1016/j.jpain.2025.105355","DOIUrl":"10.1016/j.jpain.2025.105355","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"29 ","pages":"Article 105355"},"PeriodicalIF":4.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}