Journal of Pain最新文献

{"title":"Metaphorical markers of pain catastrophizing, depression, anxiety, and pain interference in people with chronic pain","authors":"Jasmine Heath Hearn Dr ,&nbsp;Imogene Munday Dr ,&nbsp;Stella Bullo Dr ,&nbsp;Kris Rogers Dr ,&nbsp;Toby Newton-John Dr ,&nbsp;Ian Kneebone Dr","doi":"10.1016/j.jpain.2024.104733","DOIUrl":"10.1016/j.jpain.2024.104733","url":null,"abstract":"<div><div>Metaphor to communicate chronic pain can reflect psychological appraisals of pain, and its impact, and may be beneficial in enhancing understanding of pain, its aetiology, and facilitating communication and shared decision-making. This cross-sectional study examined metaphor use and relationships with pain intensity, pain interference, mood, and pain catastrophizing. Seventy participants with chronic pain completed measures of depression, anxiety and stress, the Brief Pain Inventory, and the Pain Catastrophizing Scale. They provided descriptions of their pain through metaphor and a primary condition related to their pain. Pain catastrophizing significantly predicted frequency of metaphor use (<em>R</em>² =.07, <em>F</em>(1, 62)= 4.55, <em>p</em> = .041). More frequent use of metaphor was correlated with pain catastrophizing (<em>r =</em> .29, <em>p =</em> .03), rumination (<em>r =</em> .26, <em>p =</em> .05), magnification (<em>r =</em> .28, <em>p =</em> .03), helplessness (<em>r =</em> .28, <em>p =</em> .04), depression (<em>r =</em> .30, <em>p =</em> .02), and pain interference (<em>r =</em> .30, <em>p =</em> .02). Metaphors relating pain to physical damage were significantly associated with anxiety (OR 1.17, 95% CI 1.03–1.35, <em>p =</em> .02) and magnification (OR 1.27, 95% CI 1.05–1.57, <em>p</em> = .02). Metaphors referring to pain as caused by an external agent were significantly associated with depression (OR 1.11, 95% CI 1.01–1.23, <em>p =</em> .04) and pain duration (OR 1.05, 95% CI 1.00–1.11, <em>p</em> = .04). The findings indicate that there may be specific metaphorical markers of psychological and pain-related outcomes in the language used by people with chronic pain. Appreciation of metaphor may facilitate enhanced patient-provider communication and support for people with chronic pain.</div></div><div><h3>Perspective</h3><div>People with chronic pain can use metaphorical expressions to communicate their experiences. This study found that pain interference, depression, anxiety, and pain catastrophizing are reflected in metaphor use by people with chronic pain. In particular, pain catastrophizing was significantly predictive of more frequent metaphor use, demonstrating the reflection of pain catastrophizing in language.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104733"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripherally mediated opioid combination therapy in mouse and pig.","authors":"C D Peterson, C M Larson, D J Bruce, B M Clements, K R Pflepsen, E Akgün, K F Kitto, M M Lunzer, C A Fairbanks, P S Portoghese, G L Wilcox","doi":"10.1016/j.jpain.2024.104735","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104735","url":null,"abstract":"<p><p>The concomitant epidemics of chronic pain and opioid misuse in the United States have led to a call for novel analgesics with limited abuse potential. Previously, we have shown that co-delivery of a novel combination targeting both μ- and δ-opioid receptors in the peripheral and central nervous systems can produce synergistic analgesia. Loperamide, a peripherally restricted μ-opioid agonist, and oxymorphindole, a δ-opioid receptor partial agonist, synergize in multiple mouse models of hyperalgesia. We predicted this effect would generalize across species and therefore assessed this combination for analgesic synergy in a mouse model of post-incisional hypersensitivity. In mice, oxymorphindole and loperamide displayed significant analgesic synergy. Similar synergy was observed with N-benzyl-oxymorphindole and loperamide. In cross-bred pigs, we compared the analgesic effects of either morphine alone or the combinations of oxymorphindole and loperamide or the combination of N-benzyl-oxymorphindole and loperamide. Both combinations showed increased potency as compared to morphine sulfate and effectively reduced hypersensitivity following injury without side effects. From these data we conclude that the combination of oxymorphindole and loperamide or the combination of N-benzyl-oxymorphindole reverse incisional hyperalgesia, likely by acting in the periphery, in a large animal model without adverse effects on respiration or heart rate. PERSPECTIVE: This article presents novel opioid combinations, the μ-opioid agonist loperamide with a δ-opioid agonist, either oxymorphindole (OMI) or N-benzyl-oxymorphindole (BOMI), that relieve pain in mice and pigs without adverse side effects. These therapies could help clinicians manage pain in patients while reducing overall opioid burden and limiting side effects.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104735"},"PeriodicalIF":4.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Sensory Testing and Exercise-Induced Hypoalgesia Protocols in Low Back Pain: A Scoping Review.","authors":"Lee-Ran Goodman, Ronessa Dass, Eden Daniel, P T Shirin Modarresi, P T Lisa Carlesso, P T Ada Tang, P T Luciana Macedo","doi":"10.1016/j.jpain.2024.104725","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104725","url":null,"abstract":"<p><p>A significant driver of pain in individuals with low back pain (LBP) is alterations to endogenous pain modulation (EPM). EPM can be measured using quantitative sensory testing (QST), however; there are inconsistencies in the way QST has been implemented across the low back pain literature. The objective of this scoping review was to summarize protocols used to assess EPM using QST (pain pressure threshold (PPT), temporal summation (TS), conditioned pain modulation (CPM)) or exercise-induced hypoalgesia (EIH) in LBP. Databases Medline, Embase, CINAHL and AMED were searched on June 15, 2023, for articles that used QST or EIH protocols in LBP populations. Data was extracted on participants, study design, setting and details on QST and EIH protocols. Of the 221 studies included in the review, 196 used PPT, 62 used TS and 60 used CPM; only 5 studies investigated EIH. For all QST, there was high variability in the type of equipment, timing, trials, and testing location with many studies not reporting this information. There were 4 testing modalities used for TS, and 7 different test stimuli, and 3 different conditioning stimuli used across the studies for CPM. For CPM and EIH, PPT was the most common testing modality. There were 4 types of exercises used across the 5 EIH studies. This scoping review provides a summary of QST and EIH protocols in LBP that may be used as a guide for assessment in future studies. These results demonstrate a need for the development of standardized protocols and reporting guidelines. PERSPECTIVE: This article presents a summary of measures used to assess EPM in LBP. The results show the wide variability of protocols used in the literature. Future research should focus on creating standardized protocols, reporting guidelines and providing more guidance for researchers in selecting appropriate tests for their research questions.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104725"},"PeriodicalIF":4.0,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the representativeness of a cohort study of low back pain: Using electronic health record data to make direct comparisons of study participants with non-participants from the study population","authors":"Pradeep Suri MD, MS ,&nbsp;Adrienne D. Tanus ,&nbsp;Ian Stanaway ,&nbsp;Hazel Scott ,&nbsp;Hannah F. Brubeck ,&nbsp;Bianca Irimia ,&nbsp;Clinton J. Daniels ,&nbsp;Mark P. Jensen ,&nbsp;Sean D. Rundell ,&nbsp;Andrew K. Timmons ,&nbsp;Daniel Morelli ,&nbsp;Patrick J. Heagerty","doi":"10.1016/j.jpain.2024.104730","DOIUrl":"10.1016/j.jpain.2024.104730","url":null,"abstract":"<div><div>Representativeness is an important component of generalizability. Few studies have rigorously examined the representativeness of randomized trials or observational studies of pain or musculoskeletal conditions with regards to a wide range of factors beyond age, sex, race, and ethnicity. We conducted the first study of a pain condition that uses individual-level data to directly compare the enrolled study sample to the population from which it was drawn. We used electronic health record data from the Veterans Affairs health system to compare participants in an observational study of low back pain (n = 417) with the study population of potentially eligible non-participants who were contacted about the study (n = 15,218). There were no statistically significant differences between participants and non-participants for most factors examined, and differences when present were of small or very small magnitude. Participants were more likely to be older (odds ratio [OR]=1.02 per each additional year of age [95 % CI 1.01–1.03], p &lt; 0.001), women (OR=1.59 [95 % CI 1.26–2.01], p &lt; 0.001), have had a prior diagnosis of lumbosacral radicular syndrome (OR=1.37 [95 % CI 1.08–1.74], p = 0.01), and report lower pain intensity (OR=0.96 per NRS point [95 % CI 0.93–1.00], p = 0.04). Current smokers (OR=0.54 [95 % CI 0.39–0.75], p &lt; 0.001) and people of Asian descent (OR=0.62 [95 % CI 0.39–0.98], p &lt; 0.001) were less likely to participate. This study illustrates an approach to directly compare research participants with non-participants from the study population. This approach can be considered as a standard method to examine the representativeness of study samples in pain research.</div></div><div><h3>Perspective</h3><div>This article illustrates how electronic health record data can be used to directly compare the representativeness of participants in a study of pain to the study population from which participants were selected. This approach should be considered as a standard method to examine the representativeness of study samples during reporting.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104730"},"PeriodicalIF":4.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female specific interactions of serotonin and testosterone in the rostral ventromedial medulla after activity-induced muscle pain","authors":"Ashley N. Plumb ,&nbsp;Joseph B. Lesnak ,&nbsp;Lynn Rasmussen ,&nbsp;Kathleen A. Sluka","doi":"10.1016/j.jpain.2024.104723","DOIUrl":"10.1016/j.jpain.2024.104723","url":null,"abstract":"<div><div>Classical preclinical studies show that serotonin (5-HT) injected into the rostral ventromedial medulla (RVM) produces analgesia that is blocked by 5-HT2 receptor antagonists. One key modulator of 5-HT activity is the serotonin transporter (SERT) which reduces serotonergic signaling through reuptake into the presynaptic terminal. In the activity-induced muscle pain model, females show widespread pain and increased SERT expression in the RVM whereas males show localized pain and no changes in SERT expression. Since prior studies show testosterone protects from the development of widespread pain, and females have widespread pain in the activity-induced pain model, we hypothesized that testosterone modulates serotonin signaling to enhance analgesia in female mice with widespread pain. We showed that testosterone reduced the enhanced SERT protein expression and increased 5-HT_2A receptor mRNA expression in the RVM normally observed in the activity-induced pain model in females, but not males. Inhibition of SERT in the RVM was analgesic in both female and male mice; this analgesia was blocked by co-administration of 5-HT_2A antagonist. Next, using <em>in situ</em> hybridization, we demonstrated co-expression of SERT, 5-HT_2A receptor, and androgen receptor mRNA in cells within the RVM in female mice. Lastly, activation of androgen receptors using dihydrotestosterone reduced hyperalgesia in female mice. These data therefore show for the first time expression of androgen receptors in the RVM in female mice, that activation of androgen receptors reduces nociceptive behaviors, and endogenous testosterone modulates SERT and 5-HT2 receptor expression. Thus, we show a sex-specific role for how testosterone modulates analgesia in mice.</div></div><div><h3>Perspective</h3><div>This article presents novel mechanisms testosterone’s protection against muscle pain in female mice showing modulation of the serotonin system in the rostral ventromedial medulla. Understanding the relationship between testosterone and serotonin could lead to better treatment of individuals with muscle pain.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104723"},"PeriodicalIF":4.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A database of naturalistic expressive faces for studying high arousal states","authors":"Christopher B. Buckland,&nbsp;Jessica Taubert","doi":"10.1016/j.jpain.2024.104728","DOIUrl":"10.1016/j.jpain.2024.104728","url":null,"abstract":"<div><div>Recent studies comparing behavior to different sets of facial stimuli have highlighted a need to employ more naturalistic, genuine facial expressions in cognitive research. To address this need, we identified and selected a large set of highly expressive face stimuli from the public domain, and used these stimuli to test whether participants can recognise when others are experiencing pain from their facial behaviour. After identifying 315 expressive faces to represent the kinds of facial behaviours often seen in three distinct contexts (i.e., injury-related, loss-related and victory-related), we ran six behavioural ratings tasks to characterise these faces along six dimensions; level of arousal, emotional valence, level of physical pain, attractiveness, familiarity, and perceived gender. The results indicate that injury-related expressions are recognised as lower in emotional valence than victory-related expressions, and higher in psychological arousal than both victory- and loss-related expressions. Overall, these findings suggest that the intense, energetic expressions of people in competitive situations are not rendered ambiguous to third parties by increased arousal. These results validate the use of naturalistic facial expressions in studies of non-verbal, injury-related behaviours and their recognition in forensic and clinical settings.</div></div><div><h3>Perspective</h3><div>Here we created and validated a large set of visual stimuli, which have been made available to the scientific community. Our results demonstrate that among high-arousal states, expressions related to feelings of intense pain and injury are visually distinct from expressions related to loss or triumph. Thus, the Wild Faces Database – High Arousal States (<strong>WFD-HAS</strong>) extension provides an important tool for understanding how we recognise injury-related facial expressions in the real world.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104728"},"PeriodicalIF":4.0,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial dimensions of pain disparities in youth diagnosed with unspecified abdominal pain in an emergency department.","authors":"Sarah R Martin, Theodore W Heyming, Michelle A Fortier, Zeev N Kain","doi":"10.1016/j.jpain.2024.104729","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104729","url":null,"abstract":"<p><p>Diagnosis ambiguity, paired with pain care inequities experienced by marginalized groups may increase risk for ongoing pain and impairment in children diagnosed with unspecified abdominal pain in the pediatric emergency department (PED). This cross-sectional study examined psychological, caregiver, cultural, and socio-ecological factors associated with pain-related impairment in an ethnically and socioeconomically diverse population diagnosed with unspecified abdominal pain in a PED. The sample included 111 children 8-17 years old (59.8 % female, 72.7 % Latinx) and their caregivers. Exclusion criteria included an Emergency Severity Index < 2, psychiatric complaint, or not fluent in English or Spanish. Children completed the PROMIS Pain Interference Scale and reported pain intensity, pain duration, and pain catastrophizing. Caregivers reported language preference, pain catastrophizing, trait anxiety, and child internalizing symptoms. Area Deprivation Index quantified socio-ecological deprivation according to 9-digit zip code. Multivariable logistic regression analyses identified independent associations with likelihood of reporting severe levels of pain-related impairment. Approximately 35.3 % of children reported severe levels of pain-related impairment. In logistic regression analysis, an increased likelihood of endorsing severe pain-related impairment was associated with pain for > 1 month (OR=9.19, p = .044), higher child pain catastrophizing (OR=1.23, p < .001), caregiver Spanish language (OR=11.11, p = .044), and clinically significant caregiver trait anxiety (OR=58.16, p = .004). Results highlight the incidence of severe pain-related impairment in children diagnosed with unspecified abdominal pain in a PED. Moreover, findings underscore the importance of screening pain-related impairment and caregiver anxiety, and addressing language barriers in this PED population. PERSPECTIVE: This paper highlights the incidence of severe pain-related impairment among pediatric patients diagnosed with unspecified abdominal pain in a pediatric emergency department (PED). Results could inform early assessment and targeted interventions in the PED to prevent outcome disparities.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104729"},"PeriodicalIF":4.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kratom (Mitragyna speciosa) use for self-management of pain: Insights from cross-sectional and ecological momentary assessment data","authors":"Chung Jung Mun Ph.D ,&nbsp;Leigh V. Panlilio Ph.D ,&nbsp;Kelly E. Dunn Ph.D ,&nbsp;Johannes Thrul Ph.D ,&nbsp;Christopher R. McCurdy Ph.D, FAAPS ,&nbsp;David H. Epstein Ph.D ,&nbsp;Kirsten E. Smith Ph.D","doi":"10.1016/j.jpain.2024.104726","DOIUrl":"10.1016/j.jpain.2024.104726","url":null,"abstract":"<div><div>Kratom (<em>Mitragyna speciosa</em>) is increasingly used in the US for self-management of pain, despite limited research on its efficacy and safety. To better understand how and why people use kratom for pain self-management, we analyzed baseline survey data (N = 395) and 15-day ecological momentary assessment (EMA) data (N = 357) from kratom consumers across the US. Although we recruited participants based on their kratom use, not on whether they used it for pain management, nearly half (49.1 %) met criteria for chronic pain, with many reporting substantial pain relief and high effectiveness of kratom in managing pain. A majority (69.2 %) reported difficulties in obtaining adequate pain treatment, and most indicated that these challenges impacted their decision to try kratom. Most participants did not report concerns about overuse or significant side effects. EMA data showed that, regardless of chronic-pain status, pain relief was the most frequently endorsed primary motivation for daily kratom use. There were no significant association between daily pain levels and kratom use frequency, and no difference in the daily kratom use between those with vs. without chronic pain. Recent kratom use was associated with lower current pain levels. Stronger subjective effects of kratom were associated with lower pain levels. This effect was significantly moderated by chronic-pain status: those with chronic pain showed a stronger link between subjective kratom effects and pain reduction. These findings underscore the urgent need for systematic, rigorous research on long-term implications, efficacy, and safety of kratom in pain management to guide informed clinical practices and regulatory policies.</div></div><div><h3>Perspective</h3><div>This study reveals that chronic pain is common among kratom consumers, who frequently use it for pain self-management and report significant relief, as shown by ecological momentary assessment. There is an urgent need for research into kratom's safety, efficacy, and mechanisms to guide clinical practice and inform policies.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"26 ","pages":"Article 104726"},"PeriodicalIF":4.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Diversity, Equity and Inclusion in Pragmatic Clinical Trials: Findings from the Pain Management Collaboratory.","authors":"Travis I Lovejoy, Amanda M Midboe, Diana M Higgins, Joseph Ali, Robert D Kerns, Alicia A Heapy, Ethel Kirabo Nalule, Natassja Pal","doi":"10.1016/j.jpain.2024.104727","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104727","url":null,"abstract":"<p><p>The National Institutes of Health, U.S. Department of Defense, and U.S. Department of Veterans Affairs established a Pain Management Collaboratory (PMC) in 2017, with the purpose of implementing and evaluating nonpharmacological approaches for management of pain and co-occurring conditions in military and veteran healthcare systems through the execution of pragmatic clinical trials. The purpose of the current study is to detail and critically examine recruitment and retention procedures across the PMC's large-scale multi-site pragmatic clinical trials, with attention to efforts made by trialists to diversify their study samples. Team members from 11 pragmatic clinical trials completed semi-structured interviews that focused on the meaning of diversity to the trial teams when planning the composition of their samples, methods used to recruit and retain diverse samples of patients, and planned analyses that take into consideration diverse subgroups of patients. Nearly 18,000 patients have been enrolled across trials, 22% of whom were assigned female sex at birth and 34% of whom identify with a marginalized race or ethnicity. Respondents highlighted study site selection, formation of partnerships with patient groups, and leveraging of data informatics as strategies that aided in the recruitment of patients diverse in terms of birth sex, race, and ethnicity. Notably, trialists adopted a narrow definition of diversity that did not take into consideration multiple intersecting identities of trial participants. Based on experiences of the PMC, we provide 14 recommendations on ways to diversify patient samples in clinical pain research. PERSPECTIVE: This article describes challenges posed, and opportunities provided, with pain pragmatic clinical trial designs, emphasizing approaches that optimize the inclusion of social identity groups that have historically been under-represented in pain research.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104727"},"PeriodicalIF":4.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Mobile app use among persons with fibromyalgia: a cross-sectional survey\" [J Pain, Volume 25, Issue 8, August 2024, 104515].","authors":"Jiaxin An, Wei Fan, Anant Mittal, Yan Zhang, Annie T Chen","doi":"10.1016/j.jpain.2024.104708","DOIUrl":"https://doi.org/10.1016/j.jpain.2024.104708","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"104708"},"PeriodicalIF":4.0,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}