Journal of Pain最新文献

{"title":"From fragmented services to whole-person care: Rethinking youth pain-mental health management.","authors":"Erma Pratiwi Nufi","doi":"10.1016/j.jpain.2025.105542","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105542","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105542"},"PeriodicalIF":4.0,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of sleep-related issues with chronic pain and high-impact chronic pain incidence in U.S. adults: A 1-year representative cohort study","authors":"Alberto Herrero Babiloni ,&nbsp;Barbara Fonseca Alonso ,&nbsp;Marc O. Martel ,&nbsp;Ian A. Boggero ,&nbsp;Gilles J. Lavigne ,&nbsp;Adam P. Goode ,&nbsp;Flavia P. Kapos","doi":"10.1016/j.jpain.2025.105541","DOIUrl":"10.1016/j.jpain.2025.105541","url":null,"abstract":"<div><div>In this longitudinal cohort study, we used nationally representative data from the U.S. National Health Interview Survey (n = 7826 for chronic pain; n = 9195 for high-impact chronic pain [HICP]) to examine the association of trouble sleeping and tiredness with 1-year incidence of chronic pain and HICP in U.S. adults. We also evaluated group-specific estimates by age, sex, and race/ethnicity. The 1-year cumulative incidence of chronic pain was 10.6% (95% CI: 9.8–11.5%) and of HICP was 4.2% (95% CI: 3.7–4.8%). In adjusted models, individuals reporting trouble sleeping “more than half the days” had a 63% higher risk of chronic pain (RR = 1.63, 95% CI: 1.16–2.28) and a 101% higher risk of HICP (RR = 2.01, 95% CI: 1.29–3.13). Those reporting tiredness “nearly every day” had an 89% higher risk of chronic pain (RR = 1.89, 95% CI: 1.32–2.69) and 166% higher risk of HICP (RR = 2.66, 95% CI: 1.76–4.02). Stratified models revealed greater pain incidence in non-Hispanic/Latino (NH) Asian and NH Black or African American individuals with tiredness symptoms. Findings support addressing sleep and daily tiredness to prevent chronic pain, particularly in racially and ethnically minoritized populations.</div></div><div><h3>Perspective</h3><div>Sleep disturbances and tiredness predict the development of both chronic pain and high-impact chronic pain one year later, even after stratifying by sociodemographic characteristics. Stratified analyses revealed important racial/ethnic disparities, highlighting the potential of addressing sleep-related mechanisms to prevent pain-related disability and reduce inequities in chronic pain outcomes<strong>.</strong></div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"36 ","pages":"Article 105541"},"PeriodicalIF":4.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evidence for biomechanical and physiological parameters as biomarkers to discriminate between individuals with and without non-specific neck pain using sensor devices: A systematic review with meta-analysis.","authors":"Ali Cihan Dagli, Beyza Yazgan Dagli, Emad Al-Yahya, Lucas Fonseca, Praminda Caleb-Solly","doi":"10.1016/j.jpain.2025.105543","DOIUrl":"10.1016/j.jpain.2025.105543","url":null,"abstract":"<p><p>Neck pain is among the most prevalent musculoskeletal conditions worldwide. The underlying cause mostly remains unidentified, classified as non-specific neck pain. Pain can alter movement patterns and physiological responses, suggesting that certain biomechanical and physiological changes may serve as objective biomarkers for non-specific neck pain. In recent years, growing interest in sensor technologies has enabled accurate and objective measurement of these changes. This is the first review to systematically summarise current evidence on the capability of biomechanical and physiological parameters, measured via sensors, to differentiate individuals with non-specific neck pain from asymptomatic controls, and evaluate their discriminative performance. Comprehensive searches of six databases (CINAHL, MEDLINE, EMBASE, AMED, IEEE Xplore, PEDro), grey literature, and reference lists (inception to August 20, 2025) yielded 53 observational studies for qualitative synthesis, with meta-analysis on 27. Meta-analysis indicates robust evidence linking non-specific neck pain with reduced neck range of motion, impaired joint position error, decreased step length and gait speed, reduced sway area, increased electromyographic activity of the sternocleidomastoid muscle, and reduced heart rate variability. Narrative findings reported altered neck movement speed, acceleration, and smoothness during functional tasks (e.g., reach and lifting). Classification studies showed high discriminative performance using machine learning and statistical techniques, with accuracies of 71.9-90%, sensitivities of 76.3-100%, and specificities of 77.6-90%, especially for gait and electromyography parameters. The findings highlight biomechanical and physiological alterations in non-specific neck pain that can serve as objective biomarkers. Clinically, these insights could offer support to enhance assessment and inform rehabilitation strategies. PERSPECTIVE: This comprehensive review synthesises current evidence on physiological and biomechanical parameters as biomarkers in non-specific neck pain. While these parameters show promise for pain classification, their utility as biomarkers requires further evaluation and validation of their discriminative power for improved assessment and inform rehabilitation strategies.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105543"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"S100A12 correlates with inflammatory and pain symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome","authors":"Marc Manthey ,&nbsp;Temuujin Dansranjav ,&nbsp;Hang Yan ,&nbsp;Adrian Pilatz ,&nbsp;Hans-Christian Schuppe ,&nbsp;Jens Rosellen ,&nbsp;Heidrun H. Krämer ,&nbsp;Elena Neumann ,&nbsp;Florian Wagenlehner ,&nbsp;Undraga Schagdarsurengin","doi":"10.1016/j.jpain.2025.105536","DOIUrl":"10.1016/j.jpain.2025.105536","url":null,"abstract":"<div><div>Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most prevalent urological condition in men under 50, characterized by persistent or recurrent pelvic and perineal pain, and significantly reduced quality of life. Reliable biomarkers for assessment and mechanistic understanding of pain remain limited. This retrospective case-control study consisting of 90 CP/CPPS patients (median age 29.4 years) and 90 age-matched healthy controls investigated the alarmin S100A12 as a potential biomarker linking inflammation to neurogenic pain. Seminal plasma, serum, and post-prostatic massage (PPM) urine samples were analyzed. S100A12 levels were significantly elevated in patients in seminal plasma (median 47.8 vs. 2.5 ng/ml, p&lt;0.001) and serum (median 49.2 vs. 17.4 ng/ml, p&lt;0.001). Seminal S100A12 correlated with inflammatory markers (ρ=0.551–0.686), CPSI pain scores (ρ=0.451, p&lt;0.001), and IPSS (ρ=0.342, p=0.001). Receiver operating characteristic analysis demonstrated superior diagnostic performance for seminal S100A12 (AUC=0.90, 95% CI: 0.77–0.93) compared to leukocyte count (AUC=0.60), IL-8 (AUC=0.70), and granulocyte elastase (AUC=0.50). S100A12 also correlated with sperm tail defects (ρ=0.445, p&lt;0.001), and inversely with motility (ρ=–0.306, p=0.003) and vitality (ρ=–0.273, p=0.005). In silico analysis of prostate single-cell RNA sequencing data identified <em>S100A12</em>-expressing <em>CXCR1</em>+ myeloid cells, suggesting a link to IL-8–mediated inflammation. PPM urine-derived leukocytes from patients showed increased expression of <em>RAGE</em> (p=0.006) and <em>CALCA</em> (p&lt;0.001), correlating with pain severity (ρ=0.541, p&lt;0.001). These findings implicate S100A12 in leukocyte–nerve interactions underlying pelvic pain and dysfunction, and support its use as a diagnostic biomarker and potential therapeutic target in CP/CPPS.</div></div><div><h3>Perspective</h3><div>This study identifies S100A12 as a potential biomarker of inflammation and pain in young CP/CPPS patients. The findings suggest a neuroimmune interaction involving S100A12, RAGE, and CGRP/NGF signaling, which may guide future patient stratification and therapeutic development targeting pain chronicity, inflammation, and reproductive dysfunction in CP/CPPS.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"36 ","pages":"Article 105536"},"PeriodicalIF":4.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144996826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor regarding DNMT3a contributes to bone cancer pain by epigenetic silencing of Kcnq2/Kcnq3 in dorsal root ganglion neurons.","authors":"Parth Aphale, Himanshu Shekhar, Shashank Dokania","doi":"10.1016/j.jpain.2025.105537","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105537","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105537"},"PeriodicalIF":4.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Welfare policies, joint pain prevalence and educational gaps in 50 U.S. states from 2011 to 2021: A fixed effects analysis","authors":"Rui Huang ,&nbsp;Yuhang Li ,&nbsp;Feinuo Sun","doi":"10.1016/j.jpain.2025.105539","DOIUrl":"10.1016/j.jpain.2025.105539","url":null,"abstract":"<div><div>Research on geographic disparities in pain and arthritis-related outcomes is still in its infancy, with little attention to the developing trends over time and the role of state welfare policies in shaping pain disparities. This study examines 1) spatiotemporal trends of moderate/severe arthritis-related joint pain prevalence across 50 U.S. states, 2) educational disparities therein, and 3) the impact of welfare policies— i.e., Supplemental Nutrition Assistance Program, Earned Income Tax Credit, minimum wage, unemployment insurance, and Medicaid generosity. This study compiles 6-wave biennial state-level panel data using data from the Behavioral Risk Factor Surveillance System (BRFSS). Logistic regressions are conducted to estimate trends of joint pain prevalence, prevalence for different educational groups (i.e., less than high school, high school or some college, bachelor’s degree or above), and educational disparities. Incorporating policy data from the State Policy &amp; Politics Database (SPPD) and the Kaiser Family Foundation’s database (KFF), fixed effects regressions were used, with state- and year-fixed effects, to assess the impact of welfare policies. Results show that joint pain prevalence has risen in most states, with educational disparities in pain widening in over half, though both trends vary substantially across states. Colorado and North Dakota exhibit considerably sharper increases in both pain prevalence and educational inequalities. Generous Medicaid programs are associated with decreased joint pain prevalence for general population and the least-educated, and marginally linked to smaller educational inequalities therein. This study underscores the importance of state welfare policies in addressing pain disparities and calls for targeted interventions to support less-educated populations.</div></div><div><h3>Perspectives</h3><div>This article uses state-level panel data on arthritis-related pain and welfare policies to underscore the importance of studying macro-level policy determinants of pain and associated disparities.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"36 ","pages":"Article 105539"},"PeriodicalIF":4.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effect of pain history and experimental pain responses on adolescents' quality-of-life: a cohort study.","authors":"Catarina Pires, Makram Talih, Cláudia Filipa Gomes, Elsa Mateus, Nare Navasardyan, Christopher Sivert Nielsen, Maria José Santos, Raquel Lucas","doi":"10.1016/j.jpain.2025.105540","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105540","url":null,"abstract":"<p><p>Pain has been shown to impact quality-of-life, but less is known on whether adverse pediatric pain profiles predict long-term quality-of-life in non-clinical populations. We aimed to (1) assess the association of multisite and chronic musculoskeletal pain with quality-of-life at age 18, and (2) test whether experimental pain responses at age 13 predict future quality-of-life. We used data from the Generation XXI cohort. Reported pain was assessed using the Luebeck questionnaire at ages 13 and 18. At age 13, a subsample underwent quantitative sensory testing to assess pain sensitivity, and temporal summation of pain effects. At age 18, quality-of-life was assessed in six dimensions using the Kiddo-KINDL questionnaire. Associations were quantified using linear regression or analysis of covariance models, adjusted for adverse childhood experiences reported at age 13. No associations between multisite pain at 13 and scores in any quality-of-life dimensions at 18 were observed in either sex. Females with chronic musculoskeletal pain at 13 reported lower quality-of-life scores at 18 for self-esteem (linear regression coefficient: 12.73 [95% confidence interval: 4.18, 21.27]), friends (8.59 [1.76, 15.41]), school (6.05 [0.24, 11.86]) and overall quality-of-life (6.25 [1.47, 11.02]). Temporal summation of pain at 13 was associated with overall quality-of-life at 18 (-2.17 [-3.81, -0.54]). Participants who did not report multisite pain at either age showed higher quality-of-life scores at 18 across most dimensions. Quality-of-life scores were lower among participants reporting chronic musculoskeletal pain at both ages. Our findings underline the implications of pediatric pain management in shaping future psychosocial well-being. PERSPECTIVE: We found that: 1) experiencing pain throughout adolescence is associated with lower quality-of-life in late adolescence, particularly in females; 2) early enhanced temporal summation of pain may indicate future quality-of-life impairments; and 3) persistent pain from 13 to 18 seems to have a cumulative effect, especially for multisite pain.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105540"},"PeriodicalIF":4.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of stigma in Spanish people with chronic pain using the 8-item Stigma Scale for Chronic Illnesses (SSCI-8).","authors":"Juan P Sanabria-Mazo, Jaime Navarrete, Mayte Serrat, Juan R Castaño-Asins, Jordi Alonso, Lance M McCracken, Whitney Scott, Rubén Nieto, Juan V Luciano","doi":"10.1016/j.jpain.2025.105538","DOIUrl":"https://doi.org/10.1016/j.jpain.2025.105538","url":null,"abstract":"<p><p>Stigma is common in people with chronic pain. At present, however, the measurement of stigma in Spanish-speaking individuals remains a challenge due to a lack of validated measures in Spanish. The present study examines the psychometric properties of the Spanish version of the Stigma Scale for Chronic Illnesses 8-item version (SSCI-8) in people with chronic pain, focusing on dimensionality, factorial invariance, reliability (internal consistency and test-retest), and construct validity. Adults with chronic pain in Spain were recruited from patient associations and social networks to complete an online survey. The final sample comprised 530 individuals aged 18 to 70, predominantly women (> 90%). Half of the sample completed the SSCI-8 on a second occasion four weeks later. Data analyses supported a one-factor model with correlated errors as the most optimal solution for the SSCI-8 (CFI =.988; TLI =.983; WRMR =.938; RMSEA =.093; 95% CI [.076,.110]) and factorial invariance across different subgroups. SSCI-8 scores showed a normal distribution, good internal consistency, and adequate stability over time. Significant positive correlations were found, as expected, between stigma and depression, anxiety, pain intensity, pain interference, disability, and injustice experiences. Likewise, significant negative correlations were observed with psychological flexibility. The SSCI-8 accounted for incremental variance beyond injustice experiences in predicting the clinical outcomes. The Spanish version of the SSCI-8 appears psychometrically sound as a measure of stigma for use in people with chronic pain. PERSPECTIVE: The full invariance evidence across gender and pain type reported means that total score differences are due to real differences in perceived stigma, rather than observed differences in interpretations of item contents between men and women in pain or with different types of pain.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105538"},"PeriodicalIF":4.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The direction and magnitude of conditioned pain modulation is dependent on test stimulus intensity in healthy participants but not in those with fibromyalgia","authors":"Laila A. Chaudhry ,&nbsp;Isabel Aboud ,&nbsp;Mathilde Ferland ,&nbsp;Natasha Stonebanks Cuillerier ,&nbsp;Simon S. Carrier ,&nbsp;Elodie Nickner ,&nbsp;Marc O. Martel ,&nbsp;Jeffrey S. Mogil","doi":"10.1016/j.jpain.2025.105534","DOIUrl":"10.1016/j.jpain.2025.105534","url":null,"abstract":"<div><div>Conditioned pain modulation (CPM) is a psychophysical phenomenon considered to be a measure of endogenous descending pain modulatory mechanisms. Previous rodent data from our lab demonstrated that test stimulus intensity affects CPM’s direction, with higher-intensity stimuli leading to hypoalgesia (i.e., CPM) and lower-intensity stimuli leading to hyperalgesia (i.e., “anti-CPM”). Our primary aim was to see if we could replicate these findings in humans. Because deficits in CPM suggest low capacity to inhibit pain—a risk factor for chronic pain—the secondary aim of this study was to see how this “anti-CPM” phenomenon presented itself in chronic pain patients with fibromyalgia. Healthy controls (<em>n</em>=51) and participants with fibromyalgia (<em>n</em>=39) underwent an individual heat pain threshold assessment, followed by a single CPM trial, at –1, +1, or +3 °C below/above their threshold. The CPM trial consisted of two baseline sub/suprathreshold heat pain stimulations (the test stimulus), a 30-s cold pressor test (4 °C) as a conditioning stimulus, and a final heat pain stimulation at the same temperature, with pain ratings provided throughout. Healthy controls displayed statistically significant CPM analgesia at +3 °C, no change at +1 °C, and hyperalgesia (anti-CPM) at −1 °C. Further analyses revealed that subjective intensity of the test stimulus determined the direction and magnitude of CPM. We observed no significant evidence for either analgesic CPM or anti-CPM in participants with fibromyalgia, suggesting that the mechanism(s) subserving both phenomena are dysfunctional in them.</div></div><div><h3>Perspective</h3><div>Similar to previous work in rodents, we show here that the use of lower-intensity test stimuli leads to hyperalgesic, instead of analgesic, conditioned pain modulation (CPM). Neither form of CPM was observed in participants with fibromyalgia.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"36 ","pages":"Article 105534"},"PeriodicalIF":4.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nociceptive and neuropathic pain descriptors in adults with sickle cell disease are associated with overlap activity in the default, salience and somatosensory networks","authors":"Joel Dzidzorvi Kwame Disu ,&nbsp;Charles R. Jonassaint ,&nbsp;Tales Santini ,&nbsp;Tamer S. Ibrahim ,&nbsp;Enrico M. Novelli ,&nbsp;Sossena Wood","doi":"10.1016/j.jpain.2025.105532","DOIUrl":"10.1016/j.jpain.2025.105532","url":null,"abstract":"<div><div>Central sensitization plays a crucial role in chronic pain experienced by individuals with sickle cell disease, yet current pain assessment tools fail to capture the complex, multidimensional nature of this pain. Disrupted neural communication serves as a key marker of central sensitization. Thus, this study investigated whether Painimation, a novel electronic visualization tool for pain assessment, correlates with functional connectivity in brain networks using enhanced resolution 7-Tesla imaging, potentially offering a simpler method to identify CS in patients with SCD. Using 7-Tesla magnetic resonance imaging, resting-state functional connectivity was examined in the default mode, salience, and somatosensory networks in 27 patients with SCD compared to 30 pain-free controls. Patients used Painimation to select visual animations representing their pain qualities and assigned intensity values. The most selected pain descriptors were throbbing, cramping, stabbing, and shooting pain. Patients with sickle cell disease demonstrated significantly decreased connectivity in all three networks when compared to controls, particularly between prefrontal regions in the default mode network, between the insula and paracentral regions in the salience network. The Painimation data showed that specific pain descriptors had distinct connectivity patterns, with cramping and stabbing pain exhibiting the strongest correlations within the somatosensory network. Notably, higher pain intensity scores for cramping and stabbing pain were associated with decreased functional connectivity in key somatosensory network regions. Linking Painimation descriptions with neuroimaging findings advances the understanding of pain processing mechanisms in sickle cell disease.</div></div><div><h3>Perspective</h3><div>This study provides novel insights into the neural correlations of subjective pain experiences in SCD, revealing how specific pain qualities relate to distinct patterns of brain connectivity. Identifying brain biomarkers that link pain descriptions, experiences and perception could transform the way pain is understood and managed in SCD.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"36 ","pages":"Article 105532"},"PeriodicalIF":4.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}