Journal of Pain最新文献

{"title":"Editorial commitment to trust and integrity in science: Implications for pain and anesthesiology research","authors":"Tonya M. Palermo PhD , Didier Bouhassira MD, PhD , Karen D. Davis PhD, FCAHS, FRSC , Hugh C. Hemmings Jr, MD, PhD, FRCA , Robert W. Hurley MD, PhD , Joel Katz PhD , Jaideep J. Pandit FRCA, DPhil, DM, MBA , Theodore J. Price PhD , Michael E. Schatman PhD , Stephan K.W. Schwarz MD, PhD, FRCPC , Dennis C. Turk PhD , Marc Van de Velde MD, PhD, EDRA, FESAIC , Matthew D. Wiles MRCP, FCRA, FFICM , Tony L. Yaksh PhD , David Yarnitsky MD","doi":"10.1016/j.jpain.2025.105397","DOIUrl":"10.1016/j.jpain.2025.105397","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105397"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What are the consequences of musculoskeletal pain in adolescents? A critical qualitative systematic review and meta-synthesis","authors":"Nichole Phillips ,&nbsp;Benjamin T. Brown ,&nbsp;Lise Hestbaek ,&nbsp;Henrik Hein Lauridsen ,&nbsp;Amy Miller ,&nbsp;Natasha Magson ,&nbsp;Michael S. Swain","doi":"10.1016/j.jpain.2025.105418","DOIUrl":"10.1016/j.jpain.2025.105418","url":null,"abstract":"<div><div>There is a paucity of research into the lived experiences of adolescents with musculoskeletal pain. This study synthesised the available qualitative research on musculoskeletal pain consequences in adolescents. CINAHL, EMBASE, MEDLINE, PsycINFO and Research Rabbit were searched, and a critical qualitative systematic review and meta-synthesis was performed (Prospero ID=476626). Screening and data extraction were completed in duplicate. Critical appraisal of included studies and level of confidence in the findings were assessed. A thematic synthesis approach was used to derive analytical themes. Twelve studies were included (n=213). Adolescents (age range 8–22 years) reported functional impediments that impacted daily living, mobility, school, socializing, and sleep. Distress and concern regarding movement, health, isolation, autonomy, support, healthcare experiences, and their future were also reported. Adolescents report complex and burdensome consequences of musculoskeletal pain. The functional impediments and the psychosocial impacts lead adolescents to feel distressed, isolated, and unsupported. Confidence in the findings according to the GRADE-CERQual assessment showed high, moderate and low confidence across the results. This knowledge can be used to develop meaningful communication and understanding in clinical encounters with adolescents, and provide focus for more impactful research, addressing the consequences reported by adolescents.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105418"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient partnership is essential to the advancement of pain research","authors":"Kathryn A. Birnie ,&nbsp;Alexandra Neville","doi":"10.1016/j.jpain.2025.105438","DOIUrl":"10.1016/j.jpain.2025.105438","url":null,"abstract":"<div><div>Patient partnership is becoming a cornerstone of pain research advancement. It is a key strategy in promoting inclusive research practices and is now a requirement of many funding bodies. The involvement of people with lived experience as partners in research not only enhances research quality, relevance, and impact, but also embodies the principles of health equity and social justice. Indeed, patient partnership is fundamentally about the democratization of science. Historically, patient involvement and advocacy have been key drivers of change in health research, including in the field of pain. This commentary highlights key areas where patient partners are actively shaping the pain research ecosystem and the leading practices being implemented to guide the pain research community. As patient partnership rapidly evolves both within pain research and beyond, it is imperative to stay aware of and educate ourselves on advancements occurring in the broader patient partnership sphere. The integration of patient partnership in research calls for reflexivity, cultural responsiveness, and trauma-informed approaches to ensure diverse experiences are included and respected. Ultimately, patient partnership has the potential to advance pain research, leading to better understanding, prevention, and management of pain across diverse populations and improved health outcomes.</div></div><div><h3>Perspective</h3><div>Concerted efforts are needed to expand patient partnership in pain research. In addition to enhancing research quality and impact, patient partnership is also fundamentally about the democratization of science, health equity, and an act of social justice that is essential to the advancement of pain research, practice, and policy.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105438"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of an EEG neurofeedback intervention for corneal neuropathic pain: A single-case experimental design with multiple baselines","authors":"Negin Hesam-Shariati ,&nbsp;Lara Alexander ,&nbsp;Fiona Stapleton ,&nbsp;Toby Newton-John ,&nbsp;Chin-Teng Lin ,&nbsp;Pauline Zahara ,&nbsp;Kevin Yi Chen ,&nbsp;Sebastian Restrepo ,&nbsp;Ian W. Skinner ,&nbsp;James H. McAuley ,&nbsp;G. Lorimer Moseley ,&nbsp;Mark P. Jensen ,&nbsp;Sylvia M. Gustin","doi":"10.1016/j.jpain.2025.105394","DOIUrl":"10.1016/j.jpain.2025.105394","url":null,"abstract":"<div><div>Corneal neuropathic pain is a complex condition, rarely responsive to current treatments. This trial investigated the potential effect of a novel home-based self-directed EEG neurofeedback intervention on corneal neuropathic pain using a multiple-baseline single-case experimental design. Four Participants completed a predetermined baseline of 7, 10, 14, and 17 days, randomly assigned to each participant, followed by 20 intervention sessions over four weeks. Two one-week follow-ups occurred immediately and five weeks post-intervention during which participants were encouraged to practice mental strategies. Daily pain severity and pain interference observations were the outcome measures, while anxiety, depression, or sleep problems were the generalisation measures. The results showed a medium effect on pain severity and interference across participants when comparing baseline to five-week post-intervention according to Tau-<em>U</em> effect sizes. At the individual level, both <em>Tau-U</em> and NAP effect sizes indicated significant reductions in pain severity and interference for three participants when comparing baseline to five-week post-intervention. However, the reductions indicated by the visual inspection were not considered clinically meaningful. This single-case experimental design study raises the possibility that the intervention may improve pain severity and interference for some individuals; variability in outcomes highlights the need for future research to better understand individual responses and optimize the intervention effect.</div></div><div><h3>Registration</h3><div>Australian New Zealand Clinical Trial Registry ACTRN12623000173695</div></div><div><h3>Perspective</h3><div>This trial demonstrates the potential of EEG neurofeedback to reduce pain severity and interference in individuals with corneal neuropathic pain. It also highlights user preferences for technology-based interventions, emphasizing ease of use, accessibility, and self-administration to enhance adherence, especially for individuals with limited mobility or restricted healthcare access.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105394"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Future research directions on neuroplasticity in manual therapy and exercise for chronic neck pain","authors":"Jinghua Hou ,&nbsp;Jiawei Du","doi":"10.1016/j.jpain.2025.105443","DOIUrl":"10.1016/j.jpain.2025.105443","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105443"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes toward patient engagement in clinical pain research: Insights from individuals with chronic pain in the United States","authors":"Katherine J. Holzer ,&nbsp;Haley E. Bernstein ,&nbsp;Christin Veasley ,&nbsp;Simon Haroutounian ,&nbsp;Dagmar Amtmann ,&nbsp;Aderonke Bamgbose Pederson ,&nbsp;Bryce B. Reeve ,&nbsp;Dennis C. Turk ,&nbsp;Robert H. Dworkin ,&nbsp;Dale J. Langford","doi":"10.1016/j.jpain.2025.105358","DOIUrl":"10.1016/j.jpain.2025.105358","url":null,"abstract":"<div><div>The value of engaging people with lived experience into chronic pain research is becoming increasingly recognized, yet the perspectives of individuals with chronic pain who have not previously participated in research are underexplored. This study aims to fill this gap by assessing the attitudes, preferences, and barriers related to patient engagement among adults living with chronic pain in the United States (US). An online survey was developed in collaboration with an advisory board and community engagement studio and distributed through Qualtrics panels from December 2023-January 2024. Quotas for age, gender, and race were employed to reach a representative sample for each of these variables based on the 2020 US census.^1,2 Of the 505 participants, 267 reported chronic low back pain (53%) and 144 had headaches or migraines (22%). A majority (65%−79%) were familiar with medical research, and 64% (n = 327) expressed interest in engaging as patient partners. Key facilitators for engagement included the desire to help others and learn about their condition, while compensation was also an important motivator. Barriers were time constraints, lack of payment, and worry about privacy. Younger participants (Chi-square p = 0.04) and those with higher education (Chi-square p = 0.01) were more likely to express interest in research partnerships. Strategies to enhance patient engagement should focus on reducing barriers and providing clear, meaningful opportunities for engagement, potentially increasing both recruitment and retention in chronic pain research. Future research should explore these dynamics further and consider international perspectives to develop comprehensive patient engagement strategies.</div></div><div><h3>Perspective</h3><div>This study surveys over 500 individuals with chronic pain to understand their attitudes towards engagement in clinical pain research. It identifies key facilitators and barriers, such as time constraints and low compensation, and aims to refine strategies to enhance patient partner engagement and representation in clinical pain research.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105358"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to experimentally induce fear of movement-related pain and measure psychophysiological and behavioral reactions as a proxy – A scoping review","authors":"Larissa Pagels ,&nbsp;Ann Meulders ,&nbsp;Tibor M. Szikszay ,&nbsp;Waclaw M. Adamczyk ,&nbsp;Marvin Barnekow ,&nbsp;Kerstin Luedtke","doi":"10.1016/j.jpain.2025.105410","DOIUrl":"10.1016/j.jpain.2025.105410","url":null,"abstract":"<div><div>Fear can significantly increase the experienced pain intensity in individuals with chronic musculoskeletal pain and limit their ability to engage in daily activities. Fear of movement-related pain (FMRP) is commonly assessed via self-report, but research suggests measuring psychophysiological or behavioral parameters as an alternative. The objective of this scoping review was to identify and evaluate existing paradigms to induce FMRP, as well as the psychophysiological, behavioral and neural measurements used for its assessment. Experimental studies, with adult participants (≥18 years, healthy and chronic pain) observing or performing movements, were included if they used a FMRP induction paradigm or measured psychophysiological and behavioral proxies of FMRP. A total of 1883 studies were screened; 34 eligible studies were included. Paradigms inducing FMRP involved anticipated pain paired with movement (via classical or operant conditioning) or elicited pre-existing FMRP through the observation of movements potentially associated with pain. The identified studies employed various psychophysiological and behavioral measures indicating FMRP, such as response latency/duration, decision-making behavior, eyeblink startle response, and autonomic nervous system responses (e.g., skin conductance, heart rate, respiratory rate), as well as neural correlates (fMRI). fMRI studies revealed activation in fear- and pain-processing brain areas that correlated with patient-reported measurements (e.g., amygdala, hippocampus, lateral orbitofrontal cortex). Among the psychophysiological and behavioral measures displaying significant differences between fear-evoking, and neutral conditions, heart rate, respiratory response, skin conductance, and eyeblink-startle response demonstrated the largest effect sizes. In conclusion, physiological reactions can be measured during imagined, observed, or performed movements as a proxy for FMRP.</div></div><div><h3>Perspective</h3><div>This review provides an overview of existing paradigms to induce or elicit already conditioned FMRP in participants with chronic pain and in healthy participants. Therefore, the results of this review can inform future research projects that aim to further analyze the learning mechanisms behind and the processing of FMRP at brain level. Furthermore, measuring psychophysiological or behavioral proxies of FMRP can be beneficial not only in research settings, but also in clinical settings, to complement patient-reported outcome measures or to measure the FMRP of people with communicating issues, that are not able to complete a self-reported questionnaire.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105410"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Future research directions on neuroplasticity in manual therapy and exercise for chronic neck pain","authors":"Rungtawan Chaikla ,&nbsp;Munlika Sremakaew ,&nbsp;Suwit Saekho ,&nbsp;Suchart Kothan ,&nbsp;Sureeporn Uthaikhup","doi":"10.1016/j.jpain.2025.105444","DOIUrl":"10.1016/j.jpain.2025.105444","url":null,"abstract":"","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"32 ","pages":"Article 105444"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain phenotype trajectories and links to family relationship quality among black older adults","authors":"Sarah B. Woods PhD ,&nbsp;Patricia N.E. Roberson PhD ,&nbsp;Bhaskar Thakur PhD ,&nbsp;Zureyat Sola-Odeseye BS ,&nbsp;Victoria Udezi MD, MPH ,&nbsp;Beatrice Wood PhD ,&nbsp;Staja Booker PhD, RN, FAAN","doi":"10.1016/j.jpain.2025.105484","DOIUrl":"10.1016/j.jpain.2025.105484","url":null,"abstract":"<div><div>Given persistent pain disparities experienced by older Black adults, understanding associations between family relationships and how chronic pain unfolds during aging has important clinical implications. This study aims to identify distinct longitudinal pain phenotype trajectories and whether these are associated with family relationship quality among older Black Americans. We included Black participants (<em>N</em>=2586; 64% women; mean age=66.65) from eight biennial waves (2006–2020) of the nationally representative Health and Retirement Study who reported on pain incidence at baseline. Latent class analyses (LCA) of pain incidence, severity, interference, and prescription pain medication use identified three cross-sectional pain phenotypes, consistently, at each wave: no pain; mild-to-moderate chronic pain; and severe high-impact chronic pain. Second-order LCA determined each participant’s probability of experiencing each pain phenotype at each wave, simultaneously, and identified five 14-year pain phenotype trajectories: No Chronic Pain; Persistent Mild-to-Moderate Chronic Pain; Persistent Severe High-Impact Chronic Pain; Chronic Pain Recovery; Chronic Pain Worsening. Compared to pain-free adults, the odds of persistent mild-to-moderate pain were lower with greater intimate partner support and higher with greater intimate partner strain. The odds of persistent severe high-impact chronic pain were lower with greater intimate partner, family, and parent-child support, each, and higher with greater family and parent-child strain. Greater parent-child strain was also linked to higher odds of pain worsening over time. Ameliorating strained relationships and leveraging supportive relationship benefits may provide a culturally-attuned biopsychosocial approach to improving older Black Americans’ pain. Research is needed to determine mediating mechanisms for identification of precise intervention targets.</div></div><div><h3>Perspective</h3><div>This article describes trajectories of pain phenotypes (clusters of distinct pain indicators) for older Black Americans. Identified links between supportive and strained family relationships and ways in which aging Black adults’ pain unfolds over time may provide apt intervention targets in biopsychosocial pain management approaches.</div></div>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":"34 ","pages":"Article 105484"},"PeriodicalIF":4.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144535699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronal dual brain stimulation over the somatosensory cortex modulated social touch-induced analgesia depending on empathy.","authors":"Naoyuki Takeuchi, Yoshino Terui","doi":"10.1016/j.jpain.2025.105483","DOIUrl":"10.1016/j.jpain.2025.105483","url":null,"abstract":"<p><p>Social touch, when provided as emotional support, can induce pain relief. Alpha inter-brain synchrony in the somatosensory cortex may be a neural factor contributing to the pain relief induced by social touch. This study investigated whether artificial manipulation of inter-brain communication in the pain-receiver and touch-giver could modulate touch-induced analgesia using transcranial alternating current stimulation. Sixteen same-sex pairs of participants were assigned the roles of pain-receiver and touch-giver during alpha-band transcranial alternating current stimulation applied to the somatosensory cortex. Three transcranial alternating current stimulation conditions were randomized, and the participant roles changed between sessions: (1) the pain-receiver received transcranial alternating current stimulation and the touch-giver received sham stimulation; (2) both received transcranial alternating current stimulation (hyper-transcranial alternating current stimulation); and (3) both received sham stimulation. Social touch reduced pain, although there were no significant differences in pain perception among the three conditions. Analgesia by social touch during hyper-transcranial alternating current stimulation, compared with sham transcranial alternating current stimulation, was negatively correlated with the empathy level of the pain-receiver. No relationship was observed between pain relief and empathy levels when transcranial alternating current stimulation was administered only to the pain-receiver. Hyper-transcranial alternating current stimulation aimed to enhance alpha-band synchrony between dyads could promote touch-induced analgesia, especially in pain-receivers with low emotional empathy. These findings indicate a possible association between synchrony of somatosensory alpha activity and pain relief through social interactions. Manipulating brain synchrony by considering a patient's empathy level may support therapeutic analgesia influenced by the clinician-patient relationship. PERSPECTIVE: This study provides preliminary evidence for a possible association between alpha inter-brain synchrony in the somatosensory cortex and touch-induced analgesia from temporarily altering brain oscillations using hyper-transcranial alternating current stimulation. Manipulating inter-brain synchrony while considering a patient's empathy level may enhance therapeutic analgesia influenced by the clinician-patient relationship.</p>","PeriodicalId":51095,"journal":{"name":"Journal of Pain","volume":" ","pages":"105483"},"PeriodicalIF":4.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}