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DNA methylation modifications induced by hexavalent chromium. 六价铬诱导的DNA甲基化修饰。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2019-01-01 Epub Date: 2019-05-13 DOI: 10.1080/10590501.2019.1592640
Xinnian Guo, Lingfang Feng, Bernardo Lemos, Jianlin Lou
{"title":"DNA methylation modifications induced by hexavalent chromium.","authors":"Xinnian Guo,&nbsp;Lingfang Feng,&nbsp;Bernardo Lemos,&nbsp;Jianlin Lou","doi":"10.1080/10590501.2019.1592640","DOIUrl":"https://doi.org/10.1080/10590501.2019.1592640","url":null,"abstract":"<p><p>Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"37 3","pages":"133-145"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2019.1592640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37234256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis. 微rna和长链非编码rna对细胞色素P450表达的调控:环境毒理学和癌变的表观遗传机制。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2019-01-01 Epub Date: 2019-07-15 DOI: 10.1080/10590501.2019.1639481
Dongying Li, William H Tolleson, Dianke Yu, Si Chen, Lei Guo, Wenming Xiao, Weida Tong, Baitang Ning
{"title":"Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis.","authors":"Dongying Li,&nbsp;William H Tolleson,&nbsp;Dianke Yu,&nbsp;Si Chen,&nbsp;Lei Guo,&nbsp;Wenming Xiao,&nbsp;Weida Tong,&nbsp;Baitang Ning","doi":"10.1080/10590501.2019.1639481","DOIUrl":"https://doi.org/10.1080/10590501.2019.1639481","url":null,"abstract":"<p><p>Environmental exposures to hazardous chemicals are associated with a variety of human diseases and disorders, including cancers. Phase I metabolic activation and detoxification reactions catalyzed by cytochrome P450 enzymes (CYPs) affect the toxicities of many xenobiotic compounds. Proper regulation of CYP expression influences their biological effects. Noncoding RNAs (ncRNAs) are involved in regulating CYP expression, and ncRNA expression is regulated in response to environmental chemicals. The mechanistic interactions between ncRNAs and CYPs associated with the toxicity and carcinogenicity of environmental chemicals are described in this review, focusing on microRNA-dependent CYP regulation. The role of long noncoding RNAs in regulating CYP expression is also presented and new avenues of research concerning this regulatory mechanism are described.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"37 3","pages":"180-214"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2019.1639481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37145443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats. 急性吡咯利西啶生物碱中毒大鼠肝脏反应的毒性蛋白质组学评估。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-04-03 DOI: 10.1080/10590501.2018.1450186
Yan-Hong Li, William Chi-Shing Tai, Imran Khan, Cheng Lu, Yao Lu, Wing-Yan Wong, Wood-Yee Chan, Wen-Luan Wendy Hsiao, Ge Lin
{"title":"Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats.","authors":"Yan-Hong Li,&nbsp;William Chi-Shing Tai,&nbsp;Imran Khan,&nbsp;Cheng Lu,&nbsp;Yao Lu,&nbsp;Wing-Yan Wong,&nbsp;Wood-Yee Chan,&nbsp;Wen-Luan Wendy Hsiao,&nbsp;Ge Lin","doi":"10.1080/10590501.2018.1450186","DOIUrl":"https://doi.org/10.1080/10590501.2018.1450186","url":null,"abstract":"<p><p>A toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity. This toxicoproteomic study of acute pyrrolizidine alkaloid intoxication lays a foundation for future investigation to delineate molecular mechanisms of pyrrolizidine alkaloid-induced hepatotoxicity.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 2","pages":"65-83"},"PeriodicalIF":0.0,"publicationDate":"2018-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2018.1450186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36019628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Effects of noble metal nanoparticles on the hydroxyl radical scavenging ability of dietary antioxidants. 贵金属纳米颗粒对膳食抗氧化剂清除羟基自由基能力的影响。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-04-03 DOI: 10.1080/10590501.2018.1450194
Hui Zhang, Xiumei Jiang, Gaojuan Cao, Xiaowei Zhang, Timothy R Croley, Xiaochun Wu, Jun-Jie Yin
{"title":"Effects of noble metal nanoparticles on the hydroxyl radical scavenging ability of dietary antioxidants.","authors":"Hui Zhang,&nbsp;Xiumei Jiang,&nbsp;Gaojuan Cao,&nbsp;Xiaowei Zhang,&nbsp;Timothy R Croley,&nbsp;Xiaochun Wu,&nbsp;Jun-Jie Yin","doi":"10.1080/10590501.2018.1450194","DOIUrl":"https://doi.org/10.1080/10590501.2018.1450194","url":null,"abstract":"<p><p>Noble metal nanoparticles (NPs) have been widely used in many consumer products. Their effects on the antioxidant activity of commercial dietary supplements have not been well evaluated. In this study, we examined the effects of gold (Au NPs), silver (Ag NPs), platinum (Pt NPs), and palladium (Pd NPs) on the hydroxyl radical (·OH) scavenging ability of three dietary supplements vitamin C (L-ascorbic acid, AA), (-)-epigallocatechin gallate (EGCG), and gallic acid (GA). By electron spin resonance (ESR) spin-trapping measurement, the results show that these noble metal NPs can inhibit the hydroxyl radical scavenging ability of these dietary supplements.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 2","pages":"84-97"},"PeriodicalIF":0.0,"publicationDate":"2018-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2018.1450194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36019630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
A comprehensive screening shows that ergothioneine is the most abundant antioxidant in the wild macrofungus Phylloporia ribis Ryvarden. 综合筛选结果表明，麦角硫因是野生大型真菌根瘤菌中含量最丰富的抗氧化剂。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-04-03 DOI: 10.1080/10590501.2018.1450201
Hengqiang Zhao, Minmin Zhang, Qian Liu, Xiaoli Wang, Ruixuan Zhao, Yanling Geng, Tityee Wong, Shengbo Li, Xiao Wang
{"title":"A comprehensive screening shows that ergothioneine is the most abundant antioxidant in the wild macrofungus Phylloporia ribis Ryvarden.","authors":"Hengqiang Zhao,&nbsp;Minmin Zhang,&nbsp;Qian Liu,&nbsp;Xiaoli Wang,&nbsp;Ruixuan Zhao,&nbsp;Yanling Geng,&nbsp;Tityee Wong,&nbsp;Shengbo Li,&nbsp;Xiao Wang","doi":"10.1080/10590501.2018.1450201","DOIUrl":"https://doi.org/10.1080/10590501.2018.1450201","url":null,"abstract":"<p><p>The polar and non-polar extracts from the authenticated wild mushroom Phylloporia ribis were separated by hydrophilic interaction liquid chromatography (HILIC) and by reverse phase (RP)-HPLC, respectively. A split valve separated the eluents into two fractions for free-radical scavenging analysis and for structural identification. Forty-six compounds showed scavenging activity of the stable-free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The structures of 8 antioxidants (inosine, caffeic acid, ergothioneine, p-hydroxybenzoic acid, adenosine, 3,4-dihydroxybenzaldehyde, apigenin, and naringenin) are characterized by Mass Spectrometer. Among them, ergothioneine was the most abundant (>65%) and most active antioxidant in P. ribis.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 2","pages":"98-111"},"PeriodicalIF":0.0,"publicationDate":"2018-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2018.1450201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36019632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Mechanistic biomarkers of liver toxicity and carcinogenesis. 肝毒性和癌变的机制生物标志物。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-04-03 DOI: 10.1080/10590501.2018.1450205
William H Tolleson
{"title":"Mechanistic biomarkers of liver toxicity and carcinogenesis.","authors":"William H Tolleson","doi":"10.1080/10590501.2018.1450205","DOIUrl":"https://doi.org/10.1080/10590501.2018.1450205","url":null,"abstract":"In general, exposure to chemical agents that cause liver toxicity or carcinogenesis bring about their biological effects via a complex series of biochemical events. Biochemical mediators of chemica...","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 2","pages":"63-64"},"PeriodicalIF":0.0,"publicationDate":"2018-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2018.1450205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36019631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles considered as mixtures for toxicological research. 被认为是毒理学研究混合物的纳米颗粒。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-01-02 Epub Date: 2018-01-09 DOI: 10.1080/10590501.2018.1418792
Hua Deng, Ying Zhang, Hongtao Yu
{"title":"Nanoparticles considered as mixtures for toxicological research.","authors":"Hua Deng,&nbsp;Ying Zhang,&nbsp;Hongtao Yu","doi":"10.1080/10590501.2018.1418792","DOIUrl":"https://doi.org/10.1080/10590501.2018.1418792","url":null,"abstract":"<p><p>Nanoparticles are used widely in our lives, but the understanding of their impacts on human and environmental health is still limited, at least due in part to the fact that nanoparticles are mixtures. This review describes that \"nanotoxicity\" is actually a test of the overall effect of a nanoparticle mixture: starting materials for nanoparticle preparation, surface coating agents, surface reaction-generated species, and transformed byproducts of the nanoparticle in biological and environmental media, as well as variations of the intrinsic nanoparticle structures.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2018.1418792","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35719427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Toxicity of engineered nanomaterials mediated by nano-bio-eco interactions. 纳米-生物-生态相互作用介导的工程纳米材料的毒性。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-01-02 Epub Date: 2018-01-03 DOI: 10.1080/10590501.2017.1418793
Xiaojia He, Peter Fu, Winfred G Aker, Huey-Min Hwang
{"title":"Toxicity of engineered nanomaterials mediated by nano-bio-eco interactions.","authors":"Xiaojia He,&nbsp;Peter Fu,&nbsp;Winfred G Aker,&nbsp;Huey-Min Hwang","doi":"10.1080/10590501.2017.1418793","DOIUrl":"https://doi.org/10.1080/10590501.2017.1418793","url":null,"abstract":"<p><p>Engineered nanomaterials may adversely impact human health and environmental safety by nano-bio-eco interactions not fully understood. Their interaction with biotic and abiotic environments are varied and complicated, ranging from individual species to entire ecosystems. Their behavior, transport, fate, and toxicological profiles in these interactions, addressed in a pioneering study, are subsequently seldom reported. Biological, chemical, and physical dimension properties, the so-called multidimensional characterization, determine interactions. Intermediate species generated in the dynamic process of nanomaterial transformation increase the complexity of assessing nanotoxicity. We review recent progress in understanding these interactions, discuss the challenges of the study, and suggest future research directions.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 1","pages":"21-42"},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2017.1418793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35705462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
Chemical characterization and evaluation of the antioxidants in Chaenomeles fruits by an improved HPLC-TOF/MS coupled to an on-line DPPH-HPLC method. 改进的HPLC-TOF/MS联用在线dph - hplc法对木瓜果实中抗氧化剂的化学性质及评价
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-01-02 Epub Date: 2018-01-16 DOI: 10.1080/10590501.2017.1418814
Minmin Zhang, Ruixuan Zhao, Siduo Zhou, Wei Liu, Yan Liang, Zhiguo Zhao, Shengbo Li, Xiao Wang, Tityee Wong, Hengqiang Zhao
{"title":"Chemical characterization and evaluation of the antioxidants in Chaenomeles fruits by an improved HPLC-TOF/MS coupled to an on-line DPPH-HPLC method.","authors":"Minmin Zhang,&nbsp;Ruixuan Zhao,&nbsp;Siduo Zhou,&nbsp;Wei Liu,&nbsp;Yan Liang,&nbsp;Zhiguo Zhao,&nbsp;Shengbo Li,&nbsp;Xiao Wang,&nbsp;Tityee Wong,&nbsp;Hengqiang Zhao","doi":"10.1080/10590501.2017.1418814","DOIUrl":"https://doi.org/10.1080/10590501.2017.1418814","url":null,"abstract":"<p><p>An improved method based on HPLC-TOF/MS was developed to catalog the antioxidants in five species of Chaenomeles (Mugua). Forty-four fractions from the Mugua extracts show appreciable levels of antioxidative activity in scavenging the stable free-radical 2,2-diphenyl-1-picrylhydrazyl and the hydroxyl radicals. Twelve major antioxidant's chemical structures are identified. Antioxidant activities differ between species, but intra-species level of antioxidants, regardless of their ripeness, are similar. C. sinensis has the highest antioxidant level. A rigorous quality control procedure was implemented to ensure accuracy of antioxidant quantification. This improved procedure can be used for rapid discovery of antioxidants in other plant extracts.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 1","pages":"43-62"},"PeriodicalIF":0.0,"publicationDate":"2018-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2017.1418814","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35739387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
Quantum chemical simulations revealed the toxicokinetic mechanisms of organic phosphorus flame retardants catalyzed by P450 enzymes. 量子化学模拟揭示了P450酶催化的有机磷阻燃剂的毒性动力学机制。
Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2018-01-01 Epub Date: 2018-11-20 DOI: 10.1080/10590501.2018.1537564
Zhiqiang Fu, Jingwen Chen, Yong Wang, Huixiao Hong, Hongbin Xie
{"title":"Quantum chemical simulations revealed the toxicokinetic mechanisms of organic phosphorus flame retardants catalyzed by P450 enzymes.","authors":"Zhiqiang Fu,&nbsp;Jingwen Chen,&nbsp;Yong Wang,&nbsp;Huixiao Hong,&nbsp;Hongbin Xie","doi":"10.1080/10590501.2018.1537564","DOIUrl":"https://doi.org/10.1080/10590501.2018.1537564","url":null,"abstract":"<p><p>The metabolic fate and toxicokinetics of organic phosphorus flame retardants catalyzed by cytochrome P450 enzymes (CYPs) are here investigated by in silico simulations, leveraging an active center model to mimic the CYPs, triphenyl phosphate (TPHP), tris(2-butoxyethyl) phosphate and tris(1,3-dichloro-2-propyl) phosphate as substrates. Our calculations elucidated key main pathways and predicted products, which were corroborated by current in vitro data. Results showed that alkyl OPFRs are eliminated faster than aryl and halogenated alkyl-substituted OPFRs. In addition, we discovered a proton shuttle pathway for aryl hydroxylation of TPHP and P = O bond-assisted H-transfer mechanisms (rather than nonenzymatic hydrolysis) that lead to O-dealkylation/dearylation of phosphotriesters.</p>","PeriodicalId":51085,"journal":{"name":"Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews","volume":"36 4","pages":"272-291"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2018.1537564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36700739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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