DNA methylation modifications induced by hexavalent chromium.

Q2 Biochemistry, Genetics and Molecular Biology

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews Pub Date : 2019-01-01 Epub Date: 2019-05-13 DOI:10.1080/10590501.2019.1592640

Xinnian Guo, Lingfang Feng, Bernardo Lemos, Jianlin Lou

引用次数: 8

Abstract

Hexavalent chromium [Cr (VI)] contributes a significant health risk and causes a number of chronic diseases and cancers. While the genotoxic and carcinogenic effects of hexavalent chromium exposure are explicit and better-characterized, the exact mechanism underlying the carcinogenic process of Cr (VI) is still a matter of debate. In recent years, studies have shown that epigenetic modifications, especially DNA methylation, may play a significant role in Cr (VI)-induced carcinogenesis. The aim of this review is to summarize our understanding regarding the effects of Cr (VI) on global and gene-specific DNA methylation.

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六价铬诱导的DNA甲基化修饰。

六价铬[Cr (VI)]造成重大的健康风险，并导致许多慢性疾病和癌症。虽然六价铬暴露的遗传毒性和致癌作用是明确的和更好的表征，但Cr (VI)致癌过程的确切机制仍然是一个有争议的问题。近年来的研究表明，表观遗传修饰，特别是DNA甲基化，可能在Cr (VI)诱导的癌变中起重要作用。这篇综述的目的是总结我们对Cr (VI)对整体和基因特异性DNA甲基化的影响的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Environmental Science and Health Part C-Environmental Carcinogenesis & Ecotoxicology Reviews 环境科学-毒理学

CiteScore

6.20

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews aims at rapid publication of reviews on important subjects in various areas of environmental toxicology, health and carcinogenesis. Among the subjects covered are risk assessments of chemicals including nanomaterials and physical agents of environmental significance, harmful organisms found in the environment and toxic agents they produce, and food and drugs as environmental factors. It includes basic research, methodology, host susceptibility, mechanistic studies, theoretical modeling, environmental and geotechnical engineering, and environmental protection. Submission to this journal is primarily on an invitational basis. All submissions should be made through the Editorial Manager site, and are subject to peer review by independent, anonymous expert referees. Please review the instructions for authors for manuscript submission guidance.