Journal of Aging and Physical Activity最新文献_第7页

Bioinformatics Analysis Identifies Key Genes in the Effect of Resistance Training on Female Skeletal Muscle Aging. 生物信息学分析确定了阻力训练对女性骨骼肌衰老影响的关键基因

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-04-29 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0178

Jiacheng Ma, Xiaoli Pang, Ismail Laher, Shunchang Li

{"title":"Bioinformatics Analysis Identifies Key Genes in the Effect of Resistance Training on Female Skeletal Muscle Aging.","authors":"Jiacheng Ma, Xiaoli Pang, Ismail Laher, Shunchang Li","doi":"10.1123/japa.2023-0178","DOIUrl":"10.1123/japa.2023-0178","url":null,"abstract":"Resistance training is used to combat skeletal muscle function decline in older adults. Few studies have been designed specific for females, resulting in very limited treatment options for skeletal muscle atrophy in aging women. Here, we analyzed the gene expression profiles of skeletal muscle samples from sedentary young women, sedentary older women, and resistance-trained older women, using microarray data from public database. A total of 45 genes that were differentially expressed during female muscle aging and reversed by resistance training were identified. Functional and pathway enrichment analysis, protein-protein interaction network analysis, and receiver operating characteristic analysis were performed to reveal the key genes and pathways involved in the effects of resistance training on female muscle aging. The collagen genes COL1A1, COL3A1, and COL4A1 were identified important regulators of female muscle aging and resistance training, by modulating multiple signaling pathways, such as PI3 kinase-Akt signaling, focal adhesions, extracellular matrix-receptor interactions, and relaxin signaling. Interestingly, the expression of CDKN1A and TP63 were increased during aging, and further upregulated by resistance training in older women, suggesting they may negatively affect resistance training outcomes. Our findings provide novel insights into the molecular mechanisms of resistance training on female muscle aging and identify potential biomarkers and targets for clinical intervention.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"531-540"},"PeriodicalIF":1.4,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Activity Levels and Sedentary Behavior of People Living With Mild Cognitive Impairment: A Cross-Sectional Study Using Thigh-Worn Accelerometers. 轻度认知障碍患者的体力活动水平和久坐行为：使用大腿佩戴式加速度计的横断面研究

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-04-29 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0176

Jane Hopkins, Joanne A McVeigh, Keith D Hill, Elissa Burton

{"title":"Physical Activity Levels and Sedentary Behavior of People Living With Mild Cognitive Impairment: A Cross-Sectional Study Using Thigh-Worn Accelerometers.","authors":"Jane Hopkins, Joanne A McVeigh, Keith D Hill, Elissa Burton","doi":"10.1123/japa.2023-0176","DOIUrl":"10.1123/japa.2023-0176","url":null,"abstract":"Community-dwelling people with Mild Cognitive Impairment self-reporting not to be meeting recommended physical activity levels participated in this study to (a) determine compliance of wearing (thigh-worn) accelerometers, (b) describe physical activity levels and sedentary behavior, and (c) determine the validity of the Physical Activity Scale for the Elderly (PASE) compared with activPAL accelerometers. A total of 79 people had valid accelerometer data (median [interquartile range]: age, 71 [54-75] years). Compliance was 86.81%. Participants were sedentary for 10.6 hr per day and engaged in a median of 9 min per day of moderate-intensity physical activity. Fair correlations were found between the PASE and total stepping time per day (r = .35, p < .01), total number of steps per day (r = .36, p < .01), and number of steps in stepping activities completed for ≤1 min (r = .42, p < .01). The PASE and Standing time (r = .04, p = .724) and PASE and Sitting time (r = .04, p = .699) had little to no relationship. The use of thigh-worn accelerometers for this population is achievable. People with Mild Cognitive Impairment have high levels of sedentary behavior and minimal engagement in moderate-intensity physical activity. The PASE has fair, positive criterion validity with activity-based outcomes measured by activPAL accelerometers but not with sedentary behavior, which is high for this population.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"520-530"},"PeriodicalIF":1.4,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Aerobic Exercise on Executive and Memory Functions in Patients With Alzheimer's Disease: A Systematic Review. 有氧运动对阿尔茨海默病患者执行和记忆功能的影响：系统回顾

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-03-23 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0292

Qiaoyou Luo, Zuguo Tian, Yuting Hu, Chaochao Wang

{"title":"Effects of Aerobic Exercise on Executive and Memory Functions in Patients With Alzheimer's Disease: A Systematic Review.","authors":"Qiaoyou Luo, Zuguo Tian, Yuting Hu, Chaochao Wang","doi":"10.1123/japa.2023-0292","DOIUrl":"10.1123/japa.2023-0292","url":null,"abstract":"Background: Alzheimer's disease threatens the health of older adults, particularly by disrupting executive and memory functions, and many studies have shown that aerobic exercise prevents and improves the symptoms associated with the disease.Objective: The objective was to systematically review the effects of aerobic exercise on executive and memory functions in patients with Alzheimer's disease and to determine the effect factors and mechanisms of the design of aerobic exercise intervention programs.Method: Relevant literature was searched in three databases (PubMed, Web of Science, and EBSCO) from January 1, 2014 to March 1, 2023, using a subject-word search method. Data on 10 items, including author and country, were extracted from the literature after screening. The quality of the literature was evaluated using the Physiotherapy Evidence Database scale, and a systematic review was performed.Results: Twelve papers from seven countries were ultimately included, embodying 11 randomized controlled trials and one study with a repeated-measures design. The overall quality of the studies was good as 657 study participants, aged 45 years and older who had varying degrees of Alzheimer's disease and significant symptoms, were included. Aerobic exercise was found to have a significant positive impact on executive and memory functions in people with Alzheimer's disease.Conclusion: The effects of aerobic exercise on aspects of executive function were mainly characterized by improvements in inhibitory control, working memory, and cognitive flexibility, whereas the effects on aspects of memory function were mainly characterized by improvements in logical memory, situational memory, and short-term memory.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"541-553"},"PeriodicalIF":1.4,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140195026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily Pain Severity but Not Vertebral Fractures Is Associated With Lower Physical Activity in Postmenopausal Women With Back Pain. 患有背痛的绝经后妇女的日常疼痛严重程度与减少体育锻炼有关，但与椎骨骨折无关。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-03-23 Print Date: 2024-06-01 DOI: 10.1123/japa.2023-0035

Gallin Montgomery, Jon H Tobias, Zoe Paskins, Tarnjit K Khera, Cameron J Huggins, Sarah J Allison, Daniel Abasolo, Emma M Clark, Alex Ireland

{"title":"Daily Pain Severity but Not Vertebral Fractures Is Associated With Lower Physical Activity in Postmenopausal Women With Back Pain.","authors":"Gallin Montgomery, Jon H Tobias, Zoe Paskins, Tarnjit K Khera, Cameron J Huggins, Sarah J Allison, Daniel Abasolo, Emma M Clark, Alex Ireland","doi":"10.1123/japa.2023-0035","DOIUrl":"10.1123/japa.2023-0035","url":null,"abstract":"Back pain lifetime incidence is 60%-70%, while 12%-20% of older women have vertebral fractures (VFs), often with back pain. We aimed to provide objective evidence, currently lacking, regarding whether back pain and VFs affect physical activity (PA). We recruited 69 women with recent back pain (age 74.5 ± 5.4 years). Low- (0.5 < g < 1.0), medium- (1.0 ≤ g < 1.5), and high-impact (g ≥ 1.5) PA and walking time were measured (100 Hz for 7 days, hip-worn accelerometer). Linear mixed-effects models assessed associations between self-reported pain and PA, and group differences (VFs from spine radiographs/no-VF) in PA. Higher daily pain was associated with reduced low (β = -0.12, 95% confidence interval, [-0.22, -0.03], p = .013) and medium-impact PA (β = -0.11, 95% confidence interval, [-0.21, -0.01], p = .041), but not high-impact PA or walking time (p > .11). VFs were not associated with PA (all p > .2). Higher daily pain levels but not VFs were associated with reduced low- and medium-impact PA, which could increase sarcopenia and falls risk in older women with back pain.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"428-437"},"PeriodicalIF":1.4,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140289551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual- and Single-Task Training in Older Adults With Age-Related Hearing Loss: A Randomized Controlled Study. 老年性听力损失老年人的双任务和单任务训练：随机对照研究。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-03-23 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0082

Hande Usta Ozdemir, Ali Kitis, Fazıl Necdet Ardıc

引用次数: 0

Physical Activity Patterns Within Dementia Care Dyads. 痴呆症护理二人组的体育活动模式。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-03-04 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0078

Nicolas Farina, Ríona McArdle, Ruth G Lowry, Sube Banerjee

{"title":"Physical Activity Patterns Within Dementia Care Dyads.","authors":"Nicolas Farina, Ríona McArdle, Ruth G Lowry, Sube Banerjee","doi":"10.1123/japa.2023-0078","DOIUrl":"10.1123/japa.2023-0078","url":null,"abstract":"Previous research has explored the physical activity habits of people with dementia and their family carers separately, with little consideration of how physical habits are associated within dyads. In this observational study, we sought to explore the relationship between people with dementia and their carers' physical activity, at a group level and at a dyadic level. Twenty-six participant dyads (persons with dementia and their carer spouses) were asked to wear an accelerometer for 30 days continuously. Comparisons were made at a group level and a dyadic level. People with dementia did not participate in significantly more moderate to vigorous physical activity (M = 15.44 min/day; SD = 14.40) compared with carers (M = 17.95 min/day; SD = 17.01). Within dyads, there were moderately strong associations between daily moderate to vigorous physical activity (r = .48-.54), but not with overall activity levels (r = .24). Despite physical activity habits remaining relatively low within people with dementia and carers, respectively, moderate to vigorous physical activity levels appear to be correlated within dyads. Understanding mutual influence on physical activity levels within dyads is an important pathway to promote an active lifestyle.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"480-487"},"PeriodicalIF":1.4,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Framing Physical Literacy for Adults Through a Rehabilitation Lens: An Expert Consensus Study. 通过康复视角构建成人体育素养：专家共识研究。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-02-28 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0095

Celeste Petrusevski, Joy C MacDermid, Michael G Wilson, Julie Richardson

引用次数: 0

Systemic Sirtuin 1 as a Potential Target to Mediate Interactions Between Body Fat and Testosterone Concentration in Master Athletes. 系统性 Sirtuin 1 是调节运动员体内脂肪与睾酮浓度之间相互作用的潜在靶点。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-02-28 Print Date: 2024-06-01 DOI: 10.1123/japa.2023-0193

Patricio Lopes de Araújo Leite, Larissa Alves Maciel, Samuel da Silva Aguiar, Caio Victor Sousa, Rodrigo Vanerson Passos Neves, Ivo Vieira de Sousa Neto, Lucca Campbell Simões, Thiago Dos Santos Rosa, Herbert Gustavo Simões

{"title":"Systemic Sirtuin 1 as a Potential Target to Mediate Interactions Between Body Fat and Testosterone Concentration in Master Athletes.","authors":"Patricio Lopes de Araújo Leite, Larissa Alves Maciel, Samuel da Silva Aguiar, Caio Victor Sousa, Rodrigo Vanerson Passos Neves, Ivo Vieira de Sousa Neto, Lucca Campbell Simões, Thiago Dos Santos Rosa, Herbert Gustavo Simões","doi":"10.1123/japa.2023-0193","DOIUrl":"10.1123/japa.2023-0193","url":null,"abstract":"Evidence indicates that master athletes have higher concentration of Sirtuin 1 (Sirt1), lower body fat (BF), and greater activity of the hypothalamic-pituitary-gonadal axis in comparison to untrained peers. However, no published data have demonstrated possible mediation effect of Sirt1 in the interaction of BF and testosterone in this population. Therefore, this study compared and verified possible associations between Sirt1, BF, fat mass index (FMI), testosterone, luteinizing hormone (LH), and testosterone/luteinizing hormone (T/LH) ratio in middle-aged master athletes (n = 54; 51.22 ± 7.76 years) and control middle-aged peers (n = 21; 47.76 ± 8.47 years). Venous blood was collected for testosterone, LH, and Sirt1. BF was assessed through skinfold protocol. Although LH concentration did not differ between groups, master athletes presented higher concentration of Sirt1, testosterone, and T/LH ratio, and lower BF and FMI in relation to age-matched nonathletes. Moreover, Sirt1 correlated positively with testosterone and T/LH ratio, negatively with BF, and was not significantly correlated with LH (mediation analysis revealed the effect of BF on testosterone is mediated by Sirt1 and vice versa; R2 = .1776; p = .032). In conclusion, master athletes have higher testosterone, T/LH ratio, and Sirt1, and lower BF and FMI in relation to untrained peers. Furthermore, Sirt1 was negatively associated with BF and positively associated with testosterone and T/LH ratio. These findings suggest that increased circulating Sirt1, possibly due to the master athlete's training regimens and lifestyle, exhibits a potential mediation effect on the interaction between endocrine function and body composition.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"438-445"},"PeriodicalIF":1.4,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139991758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Behavior Profiles Among Older Adults and Their Associations With Physical Capacity and Life-Space Mobility. 老年人的体育行为特征及其与体能和生命空间流动性的关系。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-02-16 Print Date: 2024-08-01 DOI: 10.1123/japa.2023-0225

Lotta Palmberg, Antti Löppönen, Matti Hyvärinen, Erja Portegijs, Taina Rantanen, Timo Rantalainen, Laura Karavirta

{"title":"Physical Behavior Profiles Among Older Adults and Their Associations With Physical Capacity and Life-Space Mobility.","authors":"Lotta Palmberg, Antti Löppönen, Matti Hyvärinen, Erja Portegijs, Taina Rantanen, Timo Rantalainen, Laura Karavirta","doi":"10.1123/japa.2023-0225","DOIUrl":"10.1123/japa.2023-0225","url":null,"abstract":"We identified data-driven multidimensional physical activity (PA) profiles using several novel accelerometer-derived metrics. Participants aged 75, 80, and 85 (n = 441) wore triaxial accelerometers for 3-7 days. PA profiles were formed with k-means cluster analysis based on PA minutes, intensity, fragmentation, sit-to-stand transitions, and gait bouts for men and women. Associations with physical capacity and life-space mobility were examined using age-adjusted general linear models. Three profiles emerged: \"Exercisers\" and \"actives\" accumulated relatively high PA minutes, with actives engaging in lighter intensity PA. \"Inactives\" had the highest activity fragmentation and lowest PA volume, intensity, and gait bouts. Inactives showed lower scores in physical capacity and life-space mobility compared with exercisers and actives. Exercisers and actives had similar physical capacity and life-space mobility, except female exercisers had higher walking speed in the 6-min walk test. Our findings demonstrate the importance of assessing PA as multidimensional behavior rather than focusing on a single metric.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"472-479"},"PeriodicalIF":1.4,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single- Versus Double-Leg Cycling: Small Muscle Mass Exercise Improves Exercise Capacity to a Greater Extent in Older Compared With Younger Population. 单腿骑车与双腿骑车：与年轻人相比，小肌肉锻炼能更大程度地提高老年人的运动能力。

IF 1.4 4区医学

Journal of Aging and Physical Activity Pub Date : 2024-02-13 Print Date: 2024-06-01 DOI: 10.1123/japa.2023-0234

Toni Haddad, Angela L Spence, Jeremiah J Peiffer, Gregory M Blain, Jeanick Brisswalter, Chris R Abbiss

{"title":"Single- Versus Double-Leg Cycling: Small Muscle Mass Exercise Improves Exercise Capacity to a Greater Extent in Older Compared With Younger Population.","authors":"Toni Haddad, Angela L Spence, Jeremiah J Peiffer, Gregory M Blain, Jeanick Brisswalter, Chris R Abbiss","doi":"10.1123/japa.2023-0234","DOIUrl":"10.1123/japa.2023-0234","url":null,"abstract":"Manipulating the amount of muscle mass engaged during exercise can noninvasively inform the contribution of central cardiovascular and peripheral vascular-oxidative functions to endurance performance. To better understand the factors contributing to exercise limitation in older and younger individuals, exercise performance was assessed during single-leg and double-leg cycling. 16 older (67 ± 5 years) and 14 younger (35 ± 5 years) individuals performed a maximal exercise using single-leg and double-leg cycling. The ratio of single-leg to double-leg cycling power (RatioPower SL/DL) was compared between age groups. The association between fitness (peak oxygen consumption, peak power output, and physical activity levels) and RatioPower SL/DL was explored. The RatioPower SL/DL was greater in older compared with younger individuals (1.14 ± 0.11 vs. 1.06 ± 0.08, p = .041). The RatioPower SL/DL was correlated with peak oxygen consumption (r = .886, p < .001), peak power output relative to body mass (r = .854, p < .001), and levels of physical activity (r = .728, p = .003) in the younger but not older subgroup. Reducing the amount of muscle mass engaged during exercise improved exercise capacity to a greater extent in older versus younger population and may reflect a greater reduction in central cardiovascular function compared with peripheral vascular-oxidative function with aging.","PeriodicalId":51073,"journal":{"name":"Journal of Aging and Physical Activity","volume":" ","pages":"408-415"},"PeriodicalIF":1.4,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139730965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0