Marta Stelmach-Mardas, Jarosław Walkowiak, Paweł Zagrodzki, Bogna Grygiel-Górniak, Juliusz Przysławski
{"title":"Lipid profile and non-cholesterol sterols in obese women's serum after supplementing with plant stanol ester.","authors":"Marta Stelmach-Mardas, Jarosław Walkowiak, Paweł Zagrodzki, Bogna Grygiel-Górniak, Juliusz Przysławski","doi":"10.1159/000357464","DOIUrl":"10.1159/000357464","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the influence of increased plant stanol ester intake on lipid profile and serum ratio of non-cholesterol sterols to cholesterol in obese women (50 years of age) with dyslipidemia.</p><p><strong>Methods: </strong>90 females were assigned into 2 treatment groups: For a period of 4 weeks, group 1 was receiving a yoghurt, enriched with 2 g of plant stanol ester (PS group), and group 2 was receiving a yoghurt drink without extra stanols. Anthropometric measurements included body height and weight. Lipid profile was determined by commercially available enzymatic methods. Serum non-cholesterol sterols and stanols concentrations were quantitated by gas chromatography. The study was single-blind and placebo-controlled.</p><p><strong>Results: </strong>The yoghurt drink enriched with plant stanol ester significantly reduced serum total cholesterol, LDL cholesterol, and non-HDL cholesterol levels (p < 0.05). No changes were observed in HDL cholesterol and triacylglycerol levels. The highest drop of LDL cholesterol was noted in the upper quartile of total cholesterol concentrations. In the PS group the statistically significant (p < 0.0001) changes were also observed in serum ratios of non-cholesterol sterols to cholesterol: campesterol, sitosterol, sitostanol, and avenasterol.</p><p><strong>Conclusion: </strong>Plant stanol esters influence the concentration of total cholesterol, particularly LDL cholesterol. This effect seems to be related to the reduced dietary cholesterol absorption.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 3","pages":"178-83"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32531884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Franziska Matzer, Eva Nagele, Babak Bahadori, Karl Dam, Christian Fazekas
{"title":"Stress-relieving effects of short-term balneotherapy - a randomized controlled pilot study in healthy adults.","authors":"Franziska Matzer, Eva Nagele, Babak Bahadori, Karl Dam, Christian Fazekas","doi":"10.1159/000360966","DOIUrl":"https://doi.org/10.1159/000360966","url":null,"abstract":"<p><strong>Background: </strong>Stress-relieving effects of balneotherapy compared to progressive muscle relaxation (PMR) and to resting were investigated by measuring subjective relaxation and salivary cortisol. It was also examined whether participants with a high versus low stress level would have a different relaxation response.</p><p><strong>Methods: </strong>A sample of healthy volunteers was randomized to balneotherapy, PMR, or a resting control group, each intervention lasting for 25 min. Pre- and post-intervention salivary cortisol samples were collected, and participants rated their status of relaxation on a quantitative scale. In addition, 3 questionnaires were applied to detect participants' stress level and bodily complaints.</p><p><strong>Results: </strong>49 healthy participants were recruited (65.3% female). In a pre-post comparison, salivary cortisol decreased (F = 23.53, p < 0.001) and subjective relaxation ratings increased (F = 132.18, p < 0.001) in all 3 groups. Study participants in the balneotherapy group rated themselves as more relaxed after the intervention as compared to the other groups (F = 5.22, p < 0.009). Participants with a high versus low stress level differed in somatic symptoms and in morning cortisol levels, but showed a similar relaxation response.</p><p><strong>Conclusion: </strong>Findings suggest that compared to PMR and resting, balneotherapy seems to be more beneficial with regard to subjective relaxation effects and similarly beneficial with regard to a decrease in salivary cortisol.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 2","pages":"105-10"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000360966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32359309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reinhard Saller, Jörg Melzer, Günter Meng, Ursula von Mandach, Karin Fürer, Herbert Schwabl, Cecile Vennos
{"title":"[Efficacy in phytotherapy].","authors":"Reinhard Saller, Jörg Melzer, Günter Meng, Ursula von Mandach, Karin Fürer, Herbert Schwabl, Cecile Vennos","doi":"10.1159/000362394","DOIUrl":"https://doi.org/10.1159/000362394","url":null,"abstract":"ePerinatale Pharmakologie, UniversitatsSpital Zurich, f Padma AG, Hinwil, Schweiz Die moderne Phytotherapie ist im Rahmen ihrer materiellen Moglichkeiten ein durchaus forschungsaffiner Therapiebereich. Neben einem mehrdimensionalen Ansatz, anhand einer Heilpflanze beispielhaft ein potentiel les phytotherapeutisches Therapiespektrum auszuloten geht es vor allem um eine reflektierte wissenschaftliche Auseinandersetzung mit Methodologie, Aussagekraft und notwendigen Modifizierungen von Metaanalysen sowie mit Ansatzen aus der Versorgungsforschung. Beide Vorgehensweisen bilden derzeit auch in der Phytotherapie einen viel beachteten Fokus der klinischen und klinisch-epidemiologischen Forschung. Die Metaanalysen beschaftigen sich naturgemas mit bereits vorhandenen Studiendaten und treffen dabei jeweils eine begrundete wenngleich selektive und forscherbezogen durchaus subjektive Auswahl. Spezifische phytothera peutische Gesichtspunkte wie z.B. Besonderheiten von Extrakten oder Vergleichbarkeit von Phytotherapeutika werden bislang kaum wissenschaftlich angemessen berucksichtigt. In der Versorgungsforschung, die nicht durch fixe Studienvorgaben eingeschrankt ist, stehen Daten aus der flexiblen und variablen Praxis im Vorder grund. Dieser Ansatz kann es, bei allen Einschrankungen, ermoglichen, neue und therapierelevante Gesichtspunkte zu entdecken, z.B. im Hinblick auf Dosierungen. Der authentische Charakter von Phytotherapeutika als Vielstoffgemische in stofflicher und funktioneller Hin sicht mit genuinen pleiotropen Eigenschaften wird bislang in der Forschung, vor allem der pharmakologischen Forschung, nur selten adaquat aufgegriffen. Vergleichbar werden pflanzliche Arzneimittel noch im mer praferentiell unter dem eher realitatsfernen Grundsatz gesehen: «one drug, one indication». Die Betrachtung und Beforschung von Phytotherapeutika als Netzwerkarzneimittel mit pleiotropen Signaturen weist auf zukunfstrachtige Vorgehensweisen hin.","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 Suppl 1 ","pages":"19-28"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000362394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32494545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
You-Jung Kwon, Seunghoon Lee, Sangmin Park, Ungin Lee, Sung-Keun Lim, Dongwoo Nam, Sanghoon Lee
{"title":"Clinical effects of needle-pricking therapy on peripheral facial paralysis.","authors":"You-Jung Kwon, Seunghoon Lee, Sangmin Park, Ungin Lee, Sung-Keun Lim, Dongwoo Nam, Sanghoon Lee","doi":"10.1159/000358742","DOIUrl":"https://doi.org/10.1159/000358742","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the effects of needle-pricking therapy on peripheral facial paralysis.</p><p><strong>Methods: </strong>This study included 162 patients with peripheral facial paralysis, 107 of whom were treated with usual care (conventional and alternative treatments) and 55 of whom were additionally treated with needle-pricking therapy on 3 specific extra-meridian acupuncture points known as 'Samjoong' (Sānchóng in Chinese). We evaluated changes in facial motor functions and sequelae using the Yanagihara and gross House-Brackmann grading systems before and after treatments.</p><p><strong>Results: </strong>Yanagihara score and House-Brackmann grade significantly improved after treatments in both groups. However, the needle-pricking therapy group showed greater improvements in Yanagihara score and House-Brackmann grade than the usual care group.</p><p><strong>Conclusion: </strong>Our results suggest that Samjoong needle-pricking therapy could be applied as an adjunct therapy to usual care for patients with peripheral facial paralysis.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 1","pages":"14-8"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000358742","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40288676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Klaus Blaser, Milena Zlabinger, Thilo Hinterberger
{"title":"[Interpersonal attention management inventory: a new instrument to capture different self- and external perception skills].","authors":"Klaus Blaser, Milena Zlabinger, Thilo Hinterberger","doi":"10.1159/000358176","DOIUrl":"https://doi.org/10.1159/000358176","url":null,"abstract":"<p><strong>Background: </strong>The Interpersonal Attention Management Inventory (IAMI) represents a new instrument to capture self- and external perception skills. The underlying theoretical model assumes 3 mental locations of attention (the intrapersonal space, the extrapersonal space, and the external intrapersonal space) of the other.</p><p><strong>Methods: </strong>The IAMI was studied regarding its factor structure; it was shortened and statistical values as well as first reference values were calculated based on a larger sample (n = 1089).</p><p><strong>Results: </strong>By factor analysis, the superordinate scales could be widely validated. The shortened version with 31 items and 3 superordinate scales shows a high reliability of the global value (Cronbach's α = 0.81) and, regarding the convergent validity, a modest correlation (r = 0.41) of the global value and mindfulness, measured with the Freiburg Mindfulness Inventory (FMI).</p><p><strong>Conclusions: </strong>Further validation studies are invited so that the IAMI can be used as an instrument for (course) diagnosis in the therapy of psychiatric disorders as well as for research in social neuroscience, e.g., in investigations on mindfulness, compassion, empathy, theory of mind, and self-boundaries.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 1","pages":"34-41"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000358176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40288679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An open-label pilot study of homeopathic treatment of attention deficit hyperactivity disorder in children and youth.","authors":"David Brulé, Lauren Sule, Beth Landau-Halpern, Violeta Nastase, Umesh Jain, Sunita Vohra, Heather Boon","doi":"10.1159/000368137","DOIUrl":"https://doi.org/10.1159/000368137","url":null,"abstract":"<p><strong>Background: </strong>An open-label pilot study of individualized homeopathy for attention deficit hyperactivity disorder (ADHD) was conducted to assess the potential for future studies with a focus on the feasibility of the recruitment plan and outcome measure schedules; identification of any group characteristics of participants who respond significantly to the therapy; and establishing the length of time required for an improvement in ADHD symptoms.</p><p><strong>Patients and methods: </strong>Participants (aged 6-16) were recruited through community advertisement and outreach. Participants completed 1 screening and 9 individualized homeopathic follow-up consultations. ADHD symptoms were assessed using the Conners 3 - Parent Questionnaire administered at each consultation. The pre- and post-study difference in Conners Global Index - Parent (CGI-P) T-score was evaluated for each participant. Baseline data of those who showed a statistically significant improvement (responders) were compared to those who did not (non-responders).</p><p><strong>Results: </strong>35 participants were enrolled over 11 months. 80% completed all 10 consultations in a median of 12.1 months. 63% had a statistically significant improvement in the primary outcome, first occurring after a mean of 4.5 visits. Overall scores for participants completing at least 2 data points decreased from a baseline median of 85.5 to 74.0 (p < 0.001, CI 95%). There were no significant baseline differences between responders and non-responders. No serious adverse events related to the therapy were reported.</p><p><strong>Conclusion: </strong>The change in the median CGI-P T-score from baseline to the end of this open-label pilot study was statistically significant. The research methods are feasible. Future studies are warranted.</p><p><strong>Trial registration: </strong>NCT01141634.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 5","pages":"302-9"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000368137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32839413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using hospital data and routines to estimate costs and effects of integrative care programmes for chronic pain and stress disorders--a feasibility study.","authors":"Tobias Sundberg, Torkel Falkenberg","doi":"10.1159/000363635","DOIUrl":"https://doi.org/10.1159/000363635","url":null,"abstract":"<p><strong>Background: </strong>Evidence of cost and effects for comprehensive hospital-based integrative care (IC) is scarce. The aim of this study was to explore the feasibility of using local hospital data and routines to estimate costs and effects of anthroposophic IC programmes for chronic pain and stress disorders in Sweden.</p><p><strong>Methods: </strong>Retrospective analysis of one IC hospital's local administrative registry data. Main outcomes embraced patient demographics, programme duration and costs, patients' health status (EQ-5D index, 0-1) and self-rated health (EQ-5D VAS, 0-100), from hospital admittance to discharge. The use of postal questionnares for collecting follow-up data after hospital discharge was assessed.</p><p><strong>Results: </strong>The IC pain programme had 461 records, all with complete data on costs and duration: average programme cost, EUR 5,925 (95% CI 5,780-6,070), and duration, 17.8 (SD 4.7) days. The IC stress programme had 263 records, all with complete cost and duration data: programme cost, EUR 5,494 (95%CI 5,318-5,671); duration 18.0 (SD 4.7) days. From admittance to discharge, health status improved by 0.23 (95% CI 0.19-0.27) in the pain, and by 0.16 (95% CI 0.12-0.20) in the stress programme. Improvements in self-rated health were 20 (95% CI 18-22), and 21 (95% CI 18-23), respectively. There was a general decrease in questionnaire response rate after hospital discharge, whereby 27-32% of respondents had completed data after 9 months.</p><p><strong>Conclusions: </strong>It was feasible to use hospital registry data to estimate costs and show positive effects of anthroposophic IC programmes for pain and stress disorders in Sweden. Clinical implications and the need for long-term follow-up are discussed.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 3","pages":"164-70"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000363635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32532453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An earplug technique to reduce the gag reflex during dental procedures.","authors":"Yusuf Ozgur Cakmak, Omer Ozdogmus, Yumusan Günay, Bahadır Gürbüzer, Emre Tezulaş, Elif Ciğdem Kaspar, Hüsniye Hacıoglu","doi":"10.1159/000362140","DOIUrl":"https://doi.org/10.1159/000362140","url":null,"abstract":"<p><strong>Background: </strong>The gag reflex is a frequent problem occurring during dental treatment procedures, especially while making impressions of the maxillary teeth. The present study aims to evaluate the efficacy of a simple earplug as an external auditory canal stimulator to supress the profound gag reflex and as a second step, to map areas of the oropharynx suppressed by this technique.</p><p><strong>Methods: </strong>In the first step of the study, 90 patients who had a gag reflex during the impression procedure were allocated to a study group, a sham group, and a control group for evaluating the efficacy of the earplug technique. Second, 20 new patients with a gag reflex were included in order to map the oropharnygeal areas suppressed by this technique.</p><p><strong>Results: </strong>The severity of the gag reflex was reduced in the earplug group (but not in the sham or the control group). The affected area included the hard palate, uvula, and the tongue but not the posterior wall of oropharynx.</p><p><strong>Conclusion: </strong>An earplug technique can be a useful, practical, and effective tool to overcome the gag reflex during oral procedures, such as impression procedures of maxillary teeth.</p>","PeriodicalId":51049,"journal":{"name":"Forschende Komplementarmedizin","volume":"21 2","pages":"94-8"},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000362140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32359334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}