Lipid profile and non-cholesterol sterols in obese women's serum after supplementing with plant stanol ester.

Forschende Komplementarmedizin Pub Date : 2014-01-01 Epub Date: 2014-06-16 DOI:10.1159/000357464

Marta Stelmach-Mardas, Jarosław Walkowiak, Paweł Zagrodzki, Bogna Grygiel-Górniak, Juliusz Przysławski

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引用次数: 4

Abstract

Background: The aim of this study was to assess the influence of increased plant stanol ester intake on lipid profile and serum ratio of non-cholesterol sterols to cholesterol in obese women (50 years of age) with dyslipidemia.

Methods: 90 females were assigned into 2 treatment groups: For a period of 4 weeks, group 1 was receiving a yoghurt, enriched with 2 g of plant stanol ester (PS group), and group 2 was receiving a yoghurt drink without extra stanols. Anthropometric measurements included body height and weight. Lipid profile was determined by commercially available enzymatic methods. Serum non-cholesterol sterols and stanols concentrations were quantitated by gas chromatography. The study was single-blind and placebo-controlled.

Results: The yoghurt drink enriched with plant stanol ester significantly reduced serum total cholesterol, LDL cholesterol, and non-HDL cholesterol levels (p < 0.05). No changes were observed in HDL cholesterol and triacylglycerol levels. The highest drop of LDL cholesterol was noted in the upper quartile of total cholesterol concentrations. In the PS group the statistically significant (p < 0.0001) changes were also observed in serum ratios of non-cholesterol sterols to cholesterol: campesterol, sitosterol, sitostanol, and avenasterol.

Conclusion: Plant stanol esters influence the concentration of total cholesterol, particularly LDL cholesterol. This effect seems to be related to the reduced dietary cholesterol absorption.

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肥胖妇女补充植物甾醇酯后血清脂质和非胆固醇固醇的变化。

背景:本研究的目的是评估植物甾醇酯摄入量增加对50岁伴有血脂异常的肥胖妇女血脂和血清非胆固醇胆固醇比的影响。方法:将90只雌性大鼠分为2个治疗组，第1组喂食添加2 g植物甾醇酯的酸奶(PS组)，第2组喂食不添加甾醇的酸奶饮料，疗程4周。人体测量包括身高和体重。脂质谱由市售酶法测定。采用气相色谱法测定血清非胆固醇固醇和甾醇浓度。该研究采用单盲和安慰剂对照。结果:添加植物甾醇酯的酸奶饮料可显著降低血清总胆固醇、低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇水平(p < 0.05)。高密度脂蛋白胆固醇和甘油三酯水平未见变化。低密度脂蛋白胆固醇下降幅度最大的是总胆固醇浓度的上四分位数。在PS组中，血清中非胆固醇固醇与胆固醇的比值也有统计学意义(p < 0.0001)的变化:油菜甾醇、谷甾醇、谷甾醇和阿芬那甾醇。结论:植物甾醇酯影响总胆固醇浓度，尤其是低密度脂蛋白胆固醇。这种效果似乎与减少饮食中胆固醇的吸收有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Forschende Komplementarmedizin 医学-全科医学与补充医学

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