Drug Resistance Updates最新文献_第8页

Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness 抑制成纤维细胞生长因子受体 1 可抑制胰腺癌的化疗耐药性和化疗驱动的侵袭性

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-02-04 DOI: 10.1016/j.drup.2024.101064

Qingxiang Lin , Andrea Serratore , Jin Niu , Shichen Shen , Tista Roy Chaudhuri , Wen Wee Ma , Jun Qu , Eugene S. Kandel , Robert M. Straubinger

{"title":"Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness","authors":"Qingxiang Lin , Andrea Serratore , Jin Niu , Shichen Shen , Tista Roy Chaudhuri , Wen Wee Ma , Jun Qu , Eugene S. Kandel , Robert M. Straubinger","doi":"10.1016/j.drup.2024.101064","DOIUrl":"10.1016/j.drup.2024.101064","url":null,"abstract":"<div><h3>Aims</h3><p>Pancreatic ductal adenocarcinoma (PDAC) is often intrinsically-resistant to standard-of-care chemotherapies such as gemcitabine. Acquired gemcitabine resistance (GemR) can arise from treatment of initially-sensitive tumors, and chemotherapy can increase tumor aggressiveness. We investigated the molecular mechanisms of chemoresistance and chemotherapy-driven tumor aggressiveness, which are understood incompletely.</p></div><div><h3>Methods</h3><p>Differential proteomic analysis was employed to investigate chemotherapy-driven chemoresistance drivers and responses of PDAC cells and patient-derived tumor xenografts (PDX) having different chemosensitivities. We also investigated the prognostic value of FGFR1 expression in the efficacy of selective pan-FGFR inhibitor (FGFRi)-gemcitabine combinations.</p></div><div><h3>Results</h3><p>Quantitative proteomic analysis of a highly-GemR cell line revealed fibroblast growth factor receptor 1 (FGFR1) as the highest-expressed receptor tyrosine kinase. FGFR1 knockdown or FGFRi co-treatment enhanced gemcitabine efficacy and decreased GemR marker expression, implicating FGFR1 in augmentation of GemR. FGFRi treatment reduced PDX tumor progression and prolonged survival significantly, even in highly-resistant tumors in which neither single-agent showed efficacy. Gemcitabine exacerbated aggressiveness of highly-GemR tumors, based upon proliferation and metastatic markers. Combining FGFRi with gemcitabine or gemcitabine+nab-paclitaxel reversed tumor aggressiveness and progression, and prolonged survival significantly. In multiple PDAC PDXs, FGFR1 expression correlated with intrinsic tumor gemcitabine sensitivity.</p></div><div><h3>Conclusion</h3><p>FGFR1 drives chemoresistance and tumor aggressiveness, which FGFRi can reverse.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness 抑制成纤维细胞生长因子受体 1 可抑制胰腺癌的化疗耐药性和化疗驱动的侵袭性

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-02-01 DOI: 10.1016/j.drup.2024.101064

Q. Lin, Andrea Serratore, Jin Niu, S. Shen, T. R. Chaudhuri, Wen Wee Ma, Jun Qu, Eugene Kandel, R. Straubinger

引用次数: 0

AI in Infectious Diseases: The Role of Datasets 传染病中的人工智能：数据集的作用

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-02-01 DOI: 10.1016/j.drup.2024.101067

Cesar de la Fuente-Nunez

引用次数: 0

Development and evaluation of a human CD47/HER2 bispecific antibody for Trastuzumab-resistant breast cancer immunotherapy 开发和评估用于抗曲妥珠单抗乳腺癌免疫疗法的人类 CD47/HER2 双特异性抗体

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-02-01 DOI: 10.1016/j.drup.2024.101068

Binglei Zhang, Jianxiang Shi, Xiaojing Shi, Xiaolu Xu, Le Gao, Song Li, Mengmeng Liu, Mengya Gao, Shuiling Jin, Jian Zhou, Dandan Fan, Fang Wang, Zhenyu Ji, Zhilei Bian, Yongping Song, Wenzhi Tian, Yichao Zheng, Linping Xu, Wei Li

引用次数: 0

Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer GPRC5A 的甲基化通过激活 mTOR 信号通路促进三阴性乳腺癌的肝转移和多西他赛耐药性

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-02-01 DOI: 10.1016/j.drup.2024.101063

Xueqi Ou , Yeru Tan , Jindong Xie , Jingping Yuan , Xinpei Deng , Ruonan Shao , Cailu Song , Xi Cao , Xiaoming Xie , Rongfang He , Yuehua Li , Hailin Tang

{"title":"Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer","authors":"Xueqi Ou , Yeru Tan , Jindong Xie , Jingping Yuan , Xinpei Deng , Ruonan Shao , Cailu Song , Xi Cao , Xiaoming Xie , Rongfang He , Yuehua Li , Hailin Tang","doi":"10.1016/j.drup.2024.101063","DOIUrl":"10.1016/j.drup.2024.101063","url":null,"abstract":"<div><h3>Aims</h3><p>This study aims to explore the function and mechanism of G Protein-coupled receptor class C group 5 member A (GPRC5A) in docetaxel-resistance and liver metastasis of breast cancer.</p></div><div><h3>Methods</h3><p>Single-cell RNA transcriptomic analysis and bioinformatic analysis are used to screen relevant genes in breast cancer metastatic hepatic specimens. MeRIP, dual-luciferase analysis and bioinformation were used to detect m6A modulation. Mass spectrometry (MS), co-inmunoprecipitation (co-IP) and immunofluorescence colocalization were executed to explore the mechanism of GPRC5A in breast cancer cells.</p></div><div><h3>Result</h3><p>GPRC5A was upregulated in triple-negative breast cancer (TNBC) and was associated with a poor prognosis. In vitro and in vivo experiments demonstrated that knockdown of GPRC5A alleviated metastasis and resistance to docetaxel in TNBC. Overexpression of GPRC5A had the opposite effects. The m6A methylation of GPRC5A mRNA was modulated by METTL3 and YTHDF1, which facilitates its translation. GPRC5A inhibited the ubiquitination-dependent degradation of LAMTOR1, resulting in the recruitment of mTORC1 to lysosomes and activating the mTORC1/p70s6k signaling pathway.</p></div><div><h3>Conclusion</h3><p>METTL3/YTHDF1 axis up-regulates GPRC5A expression by m6A methylation. GPRC5A activates mTORC1/p70s6k signaling pathway by recruiting mTORC1 to lysosomes, consequently promotes docetaxel-resistance and liver metastasis.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368764624000219/pdfft?md5=bf4c6ebbb0ee5c7db7592e6ce4fb4306&pid=1-s2.0-S1368764624000219-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139655960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond ABCC10 / MRP7 在抗癌药物耐药性及其他方面的作用

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-01-29 DOI: 10.1016/j.drup.2024.101062

Da-Qian Chen , Yuhao Xie , Lu-Qi Cao , Joshua S. Fleishman , Yang Chen , Tiesong Wu , Dong-Hua Yang

{"title":"The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond","authors":"Da-Qian Chen , Yuhao Xie , Lu-Qi Cao , Joshua S. Fleishman , Yang Chen , Tiesong Wu , Dong-Hua Yang","doi":"10.1016/j.drup.2024.101062","DOIUrl":"10.1016/j.drup.2024.101062","url":null,"abstract":"<div><p>Multidrug resistance protein 7 (MRP7), also known as ATP-binding cassette (ABC) transporter subfamily C10 (ABCC10), is an ABC transporter that was first identified in 2001. ABCC10/MRP7 is a 171 kDa protein located on the basolateral membrane of cells. ABCC10/MRP7 consists of three transmembrane domains and two nucleotide binding domains. It mediates multidrug resistance of tumor cells to a variety of anticancer drugs by increasing drug efflux and results in reducing intracellular drug accumulation. The transport substrates of ABCC10/MRP7 include antineoplastic drugs such as taxanes, vinca alkaloids, and epothilone B, as well as endobiotics such as leukotriene C4 (LTC<sub>4</sub>) and estradiol 17 β-D-glucuronide. A variety of ABCC10/MRP7 inhibitors, including cepharanthine, imatinib, erlotinib, tariquidar, and sildenafil, can reverse ABCC10/MRP7-mediated MDR. Additionally, the presence or absence of ABCC10/MRP7 is also closely related to renal tubular dysfunction, obesity, and other diseases. In this review, we discuss: 1) Structure and functions of ABCC10/MRP7; 2) Known substrates and inhibitors of ABCC10/MRP7 and their potential therapeutic applications in cancer; and 3) Role of ABCC10/MRP7 in non-cancerous diseases.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phage-mediated colistin resistance in Acinetobacter baumannii 噬菌体介导的鲍曼不动杆菌对可乐定的耐药性

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-01-28 DOI: 10.1016/j.drup.2024.101061

Massimiliano Lucidi , Francesco Imperi , Irene Artuso , Giulia Capecchi , Cinzia Spagnoli , Daniela Visaggio , Giordano Rampioni , Livia Leoni , Paolo Visca

{"title":"Phage-mediated colistin resistance in Acinetobacter baumannii","authors":"Massimiliano Lucidi , Francesco Imperi , Irene Artuso , Giulia Capecchi , Cinzia Spagnoli , Daniela Visaggio , Giordano Rampioni , Livia Leoni , Paolo Visca","doi":"10.1016/j.drup.2024.101061","DOIUrl":"10.1016/j.drup.2024.101061","url":null,"abstract":"<div><h3><em>Aims</em></h3><p>Antimicrobial resistance is a global threat to human health, and <em>Acinetobacter baumannii</em> is a paradigmatic example of how rapidly bacteria become resistant to clinically relevant antimicrobials. The emergence of multidrug-resistant <em>A</em>. <em>baumannii</em> strains has forced the revival of colistin as a last-resort drug, suddenly leading to the emergence of colistin resistance. We investigated the genetic and molecular basis of colistin resistance in <em>A. baumannii</em>, and the mechanisms implicated in its regulation and dissemination.</p></div><div><h3><em>Methods</em></h3><p>Comparative genomic analysis was combined with genetic, biochemical, and phenotypic assays to characterize Φ19606, an <em>A</em>. <em>baumannii</em> temperate bacteriophage that carries a colistin resistance gene.</p></div><div><h3><em>Results</em></h3><p>Ф19606 was detected in 41% of 523 <em>A</em>. <em>baumannii</em> complete genomes and demonstrated to act as a mobile vehicle of the colistin resistance gene <em>eptA1</em>, encoding a functional lipid A phosphoethanolamine transferase<em>.</em> The <em>eptA1</em> gene is coregulated with its chromosomal homolog <em>pmrC</em> via the PmrAB two-component system and confers colistin resistance when induced by low calcium and magnesium levels. Resistance selection assays showed that the <em>eptA1</em>-harbouring phage Ф19606 promotes the emergence of spontaneous colistin-resistant mutants.</p></div><div><h3><em>Conclusions</em></h3><p>Φ19606 is an unprecedented example of a self-transmissible phage vector implicated in the dissemination of colistin resistance.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368764624000190/pdfft?md5=e2e2dfa626e3a5985be906d1dbff90e9&pid=1-s2.0-S1368764624000190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139568611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges 克服抗病毒药物耐药性的靶向药物设计策略：机遇与挑战

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-01-26 DOI: 10.1016/j.drup.2024.101053

Shaoqing Du , Xueping Hu , Luis Menéndez-Arias , Peng Zhan , Xinyong Liu

{"title":"Target-based drug design strategies to overcome resistance to antiviral agents: opportunities and challenges","authors":"Shaoqing Du , Xueping Hu , Luis Menéndez-Arias , Peng Zhan , Xinyong Liu","doi":"10.1016/j.drup.2024.101053","DOIUrl":"10.1016/j.drup.2024.101053","url":null,"abstract":"<div><p>Viral infections have a major impact in human health. Ongoing viral transmission and escalating selective pressure have the potential to favor the emergence of vaccine- and antiviral drug-resistant viruses. Target-based approaches for the design of antiviral drugs can play a pivotal role in combating drug-resistant challenges. Drug design computational tools facilitate the discovery of novel drugs. This review provides a comprehensive overview of current drug design strategies employed in the field of antiviral drug resistance, illustrated through the description of a series of successful applications. These strategies include technologies that enhance compound-target affinity while minimizing interactions with mutated binding pockets. Furthermore, emerging approaches such as virtual screening, targeted protein/RNA degradation, and resistance analysis during drug design have been harnessed to curtail the emergence of drug resistance. Additionally, host targeting antiviral drugs offer a promising avenue for circumventing viral mutation. The widespread adoption of these refined drug design strategies will effectively address the prevailing challenge posed by antiviral drug resistance.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139568490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyphenol nanocomplex modulates lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect 多酚纳米复合物可调节乳酸代谢重编程并激发免疫反应，从而增强癌症治疗效果

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-01-20 DOI: 10.1016/j.drup.2024.101060

Zhan Zhang , Xinnan Li , Weiqiang Liu , Guanglei Chen , Jinchi Liu , Qingtian Ma , Pengjie Hou , Lu Liang , Caigang Liu

{"title":"Polyphenol nanocomplex modulates lactate metabolic reprogramming and elicits immune responses to enhance cancer therapeutic effect","authors":"Zhan Zhang , Xinnan Li , Weiqiang Liu , Guanglei Chen , Jinchi Liu , Qingtian Ma , Pengjie Hou , Lu Liang , Caigang Liu","doi":"10.1016/j.drup.2024.101060","DOIUrl":"10.1016/j.drup.2024.101060","url":null,"abstract":"<div><p>Cancer lactate metabolic reprogramming induces an elevated level of extracellular lactate and H<sup>+</sup>, leading to an acidic immunosuppressive tumor microenvironment (TEM). High lactic acid level may affect the metabolic programs of various cells that comprise an antitumor immune response, therefore, restricting immune-mediated tumor destruction, and leading to therapeutic resistance and unsatisfactory prognosis. Here, we report a metal-phenolic coordination-based nanocomplex loaded with a natural polyphenol galloflavin, which inhibits the function of lactate dehydrogenase, reducing the production of lactic acid, and alleviating the acidic immunosuppressive TME. Besides, the co-entrapped natural polyphenol carnosic acid and the synthetic PEG-Ce6 polyphenol derivative (serving as a photosensitizer) could induce immunogenic cancer cell death upon laser irradiation, which further activates immune system and promotes immune cell recruitment and infiltration in tumor tissues. We demonstrated that this nanocomplex-based combinational therapy could reshape the TME and elicit immune responses in a murine breast cancer model, which provides a promising strategy to enhance the therapeutic efficiency of drug-resistant breast cancer.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368764624000189/pdfft?md5=c1adb273fb999561d308f0725bebd41e&pid=1-s2.0-S1368764624000189-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139505985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy 利用非编码 RNA 介导的 ATP 结合盒 (ABC) 转运体调控克服癌症化疗的多药耐药性

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-01-20 DOI: 10.1016/j.drup.2024.101058

Kenneth K.W. To , Zoufang Huang , Hang Zhang , Charles R. Ashby Jr. , Liwu Fu

{"title":"Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy","authors":"Kenneth K.W. To , Zoufang Huang , Hang Zhang , Charles R. Ashby Jr. , Liwu Fu","doi":"10.1016/j.drup.2024.101058","DOIUrl":"10.1016/j.drup.2024.101058","url":null,"abstract":"<div><p><span>Multidrug resistance (MDR) is one of the primary factors that produces </span>treatment<span><span><span> failure in patients receiving </span>cancer chemotherapy<span><span>. MDR is a complex multifactorial phenomenon, characterized by a decrease or abrogation of the efficacy of a wide spectrum of anticancer drugs that are structurally and mechanistically distinct. The overexpression of the ATP-binding cassette (ABC) transporters, notably </span>ABCG2<span> and ABCB1, are one of the primary mediators of MDR in cancer cells<span>, which promotes the efflux of certain chemotherapeutic drugs from cancer cells, thereby decreasing or abolishing their therapeutic efficacy. A number of studies have suggested that non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and </span></span></span></span>circular RNAs<span> (circRNAs), play a pivotal role in mediating the upregulation of ABC transporters in certain MDR cancer cells. This review will provide updated information about the induction of ABC transporters due to the aberrant regulation of ncRNAs in cancer cells. We will also discuss the measurement and biological profile of circulating ncRNAs in various body fluids as potential biomarkers for predicting the response of cancer patients to chemotherapy. Sequence variations, such as alternative polyadenylation<span> of mRNA and single nucleotide polymorphism (SNPs) at miRNA target sites, which may indicate the interaction of miRNA-mediated gene regulation with genetic variations to modulate the MDR phenotype, will be reviewed. Finally, we will highlight novel strategies that could be used to modulate ncRNAs and circumvent ABC transporter-mediated MDR.</span></span></span></p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":24.3,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139505866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0