Mechanism of staphylococcal resistance to clinically relevant antibiotics

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2024-08-31 DOI:10.1016/j.drup.2024.101147

Daniela Brdová, Tomáš Ruml, Jitka Viktorová

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Abstract

Staphylococcus aureus, a notorious pathogen with versatile virulence, poses a significant challenge to current antibiotic treatments due to its ability to develop resistance mechanisms against a variety of clinically relevant antibiotics. In this comprehensive review, we carefully dissect the resistance mechanisms employed by S. aureus against various antibiotics commonly used in clinical settings. The article navigates through intricate molecular pathways, elucidating the mechanisms by which S. aureus evades the therapeutic efficacy of antibiotics, such as β-lactams, vancomycin, daptomycin, linezolid, etc. Each antibiotic is scrutinised for its mechanism of action, impact on bacterial physiology, and the corresponding resistance strategies adopted by S. aureus. By synthesising the knowledge surrounding these resistance mechanisms, this review aims to serve as a comprehensive resource that provides a foundation for the development of innovative therapeutic strategies and alternative treatments for S. aureus infections. Understanding the evolving landscape of antibiotic resistance is imperative for devising effective countermeasures in the battle against this formidable pathogen.

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葡萄球菌对临床相关抗生素的耐药性机制

金黄色葡萄球菌是一种臭名昭著的病原体，具有多种毒力，由于它能对多种临床相关抗生素产生耐药机制，因此对目前的抗生素治疗方法构成了巨大挑战。在这篇综述中，我们仔细剖析了金黄色葡萄球菌对临床常用的各种抗生素的耐药机制。文章通过错综复杂的分子途径，阐明了金黄色葡萄球菌逃避β-内酰胺类、万古霉素、达托霉素、利奈唑胺等抗生素疗效的机制。对每种抗生素的作用机制、对细菌生理的影响以及金黄色葡萄球菌采取的相应抗药性策略都进行了仔细研究。本综述综合了与这些抗药性机制有关的知识，旨在提供一个全面的资源，为开发金黄色葡萄球菌感染的创新治疗策略和替代疗法奠定基础。了解抗生素耐药性不断演变的情况对于制定有效的对策来对抗这种可怕的病原体至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research