Drug Resistance Updates最新文献

O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma O-GlcNAcylation 对 RIPK1 依赖性细胞凋亡的调控决定了肾细胞癌对舒尼替尼的敏感性

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-09-12 DOI: 10.1016/j.drup.2024.101150

{"title":"O-GlcNAcylation regulation of RIPK1-dependent apoptosis dictates sensitivity to sunitinib in renal cell carcinoma","authors":"","doi":"10.1016/j.drup.2024.101150","DOIUrl":"10.1016/j.drup.2024.101150","url":null,"abstract":"<div><p>Receptor interacting protein kinase 1 (RIPK1) has emerged as a key regulatory molecule that influences the balance between cell death and cell survival. Under external stress, RIPK1 determines whether a cell undergoes RIPK-dependent apoptosis (RDA) or survives by activating NF-κB signaling. However, the role and mechanisms of RIPK1 on sunitinib sensitivity in renal cell carcinoma (RCC) remain elusive. In this study, we demonstrated that the O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) of RIPK1 induces sunitinib resistance in RCC by inhibiting RDA. O-GlcNAc transferase (OGT) specifically interacts with RIPK1 through its tetratricopeptide repeats (TPR) domain and facilitates RIPK1 O-GlcNAcylation. The O-GlcNAcylation of RIPK1 at Ser<sup>331</sup>, Ser<sup>440</sup> and Ser<sup>669</sup> regulates RIPK1 ubiquitination and the formation of the RIPK1/FADD/Caspase-8 complex, thereby inhibiting sunitinib-induced RDA in RCC. Site-specific depletion of O-GlcNAcylation on RIPK1 affects the formation of the RIPK1/FADD/Caspase 8 complex, leading to increased sunitinib sensitivity in RCC.</p><p>Our data highlight the significance of aberrant RIPK1 O-GlcNAcylation in the development of sunitinib resistance and indicate that targeting RIPK1 O-GlcNAcylation could be a promising therapeutic strategy for RCC.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":15.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142228809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance 乳化作用在调节 DNA 损伤修复和肿瘤化疗耐药性方面的重要作用

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-09-06 DOI: 10.1016/j.drup.2024.101148

Jia Li, Zhe-Sheng Chen, Yihang Pan, Leli Zeng

引用次数: 0

Plasmid-borne tigecycline resistance gene tet(X4) in Salmonella enterica and Escherichia coli isolates from a pediatric patient with diarrhea 从一名腹泻儿科患者体内分离出的肠炎沙门氏菌和大肠埃希氏菌中发现质粒携带的替加环素抗性基因 tet(X4)

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-09-02 DOI: 10.1016/j.drup.2024.101145

引用次数: 0

Mechanism of staphylococcal resistance to clinically relevant antibiotics 葡萄球菌对临床相关抗生素的耐药性机制

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-08-31 DOI: 10.1016/j.drup.2024.101147

{"title":"Mechanism of staphylococcal resistance to clinically relevant antibiotics","authors":"","doi":"10.1016/j.drup.2024.101147","DOIUrl":"10.1016/j.drup.2024.101147","url":null,"abstract":"<div><p><em>Staphylococcus aureus</em>, a notorious pathogen with versatile virulence, poses a significant challenge to current antibiotic treatments due to its ability to develop resistance mechanisms against a variety of clinically relevant antibiotics. In this comprehensive review, we carefully dissect the resistance mechanisms employed by <em>S. aureus</em> against various antibiotics commonly used in clinical settings. The article navigates through intricate molecular pathways, elucidating the mechanisms by which <em>S. aureus</em> evades the therapeutic efficacy of antibiotics, such as β-lactams, vancomycin, daptomycin, linezolid, <em>etc</em>. Each antibiotic is scrutinised for its mechanism of action, impact on bacterial physiology, and the corresponding resistance strategies adopted by <em>S. aureus</em>. By synthesising the knowledge surrounding these resistance mechanisms, this review aims to serve as a comprehensive resource that provides a foundation for the development of innovative therapeutic strategies and alternative treatments for <em>S. aureus</em> infections. Understanding the evolving landscape of antibiotic resistance is imperative for devising effective countermeasures in the battle against this formidable pathogen.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":15.8,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368764624001055/pdfft?md5=12f715097caabdafe7529ca70e6a87b4&pid=1-s2.0-S1368764624001055-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the resistance to therapies in pancreatic ductal adenocarcinoma 揭示胰腺导管腺癌的抗药性。

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-08-30 DOI: 10.1016/j.drup.2024.101146

引用次数: 0

Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer NUDT21 的非甲基化抑制了二十二碳六烯酸的生物合成，导致前列腺癌对恩杂鲁胺产生耐药性

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-08-24 DOI: 10.1016/j.drup.2024.101144

{"title":"Un-methylation of NUDT21 represses docosahexaenoic acid biosynthesis contributing to enzalutamide resistance in prostate cancer","authors":"","doi":"10.1016/j.drup.2024.101144","DOIUrl":"10.1016/j.drup.2024.101144","url":null,"abstract":"<div><h3>Aims</h3><p>The recent approval of enzalutamide for metastatic castration-sensitive prostate cancer underscores its growing clinical significance, raising concerns about emerging resistance and limited treatment options. While the reactivation of the androgen receptor (AR) and other genes plays a role in enzalutamide resistance, identifications of novel underlying mechanism with therapeutic potential in enzalutamide-resistant (EnzaR) cells remain largely elusive.</p></div><div><h3>Methods</h3><p>Drug-resistant prostate cancer cell lines, animal models, and organoids were utilized to examine NUDT21 function by transcriptomic and metabolomic analyses through loss-of-function and gain-of-function assays. Notably, a mono-methylation monoclonal antibody and conditional-knockin transgenic mouse model of NUDT21 were generated for evaluating its function.</p></div><div><h3>Results</h3><p>NUDT21 overexpression acts as a crucial alternative polyadenylation (APA) mediator, supported by its oncogenic role in prostate cancer. PRMT7-mediated mono-methylation of NUDT21 induces a shift in 3’UTR usage, reducing oncogenicity. In contrast, its un-methylation promotes cancer growth and cuproptosis insensitivity in EnzaR cells by exporting toxic copper and suppressing docosahexaenoic acid (DHA) biosynthesis. Crucially, NUDT21 inhibition or DHA supplementation with copper ionophore holds therapeutic promise for EnzaR cells.</p></div><div><h3>Conclusions</h3><p>The un-methylation of NUDT21-mediated 3’UTR shortening unveils a novel mechanism for enzalutamide resistance, and our findings offer innovative strategies for advancing the treatment of prostate cancer patients experiencing enzalutamide resistance.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":15.8,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S136876462400102X/pdfft?md5=8d5415fa3df7d10f5e75ab1ffb7c812f&pid=1-s2.0-S136876462400102X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR-AMRtracker: A novel toolkit to monitor the antimicrobial resistance gene transfer in fecal microbiota CRISPR-AMRtracker：监测粪便微生物群中抗菌药耐药性基因转移的新型工具包

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-08-24 DOI: 10.1016/j.drup.2024.101142

引用次数: 0

Revolutionising infection control: building the next generation of phage banks 彻底改变感染控制：建立下一代噬菌体库

IF 24.3 1区医学

Drug Resistance Updates Pub Date : 2024-08-22 DOI: 10.1016/j.drup.2024.101143

Braira Wahid, Muhammad Salman Tiwana, Akhtar Ali

引用次数: 0

Fusion event mediated by IS903B between chromosome and plasmid in two MCR-9- and KPC-2-co-producing Klebsiella pneumoniae isolates 由 IS903B 介导的两种 MCR-9 和 KPC-2 共同产生的肺炎克雷伯菌分离株染色体与质粒之间的融合事件

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-08-17 DOI: 10.1016/j.drup.2024.101139

引用次数: 0

Unraveling the secrets: Evolution of resistance mediated by membrane proteins 揭开秘密膜蛋白介导的抗药性进化

IF 15.8 1区医学

Drug Resistance Updates Pub Date : 2024-08-16 DOI: 10.1016/j.drup.2024.101140

{"title":"Unraveling the secrets: Evolution of resistance mediated by membrane proteins","authors":"","doi":"10.1016/j.drup.2024.101140","DOIUrl":"10.1016/j.drup.2024.101140","url":null,"abstract":"<div><p>Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields such as medicine, agriculture, and environmental science. Understanding its complexity and devising innovative strategies are crucial for treating diseases like cancer and managing resistant pests in agriculture. This paper explores the dual nature of resistance mechanisms across different organisms: On one hand, animals, bacteria, fungi, plants, and insects exhibit convergent evolution, leading to the development of similar resistance mechanisms. On the other hand, influenced by diverse environmental pressures and structural differences among organisms, they also demonstrate divergent resistance characteristics. Membrane protein-mediated resistance mechanisms are prevalent across animals, bacteria, fungi, plants, and insects, reflecting their shared survival strategies evolved through convergent evolution to address similar survival challenges. However, variations in ecological environments and biological characteristics result in differing responses to resistance. Therefore, examining these differences not only enhances our understanding of adaptive resistance mechanisms but also provides crucial theoretical support and insights for addressing drug resistance and advancing pharmaceutical development.</p></div>","PeriodicalId":51022,"journal":{"name":"Drug Resistance Updates","volume":null,"pages":null},"PeriodicalIF":15.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1368764624000980/pdfft?md5=f32ad03042bf67bda91992e6b1153808&pid=1-s2.0-S1368764624000980-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142148766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0