Unraveling the secrets: Evolution of resistance mediated by membrane proteins

IF 15.8 1区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Resistance Updates Pub Date : 2024-08-16 DOI:10.1016/j.drup.2024.101140

Xue Yang , Min Li , Zi-Chang Jia , Yan Liu , Shun-Fan Wu , Mo-Xian Chen , Ge-Fei Hao , Qing Yang

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Abstract

Membrane protein-mediated resistance is a multidisciplinary challenge that spans fields such as medicine, agriculture, and environmental science. Understanding its complexity and devising innovative strategies are crucial for treating diseases like cancer and managing resistant pests in agriculture. This paper explores the dual nature of resistance mechanisms across different organisms: On one hand, animals, bacteria, fungi, plants, and insects exhibit convergent evolution, leading to the development of similar resistance mechanisms. On the other hand, influenced by diverse environmental pressures and structural differences among organisms, they also demonstrate divergent resistance characteristics. Membrane protein-mediated resistance mechanisms are prevalent across animals, bacteria, fungi, plants, and insects, reflecting their shared survival strategies evolved through convergent evolution to address similar survival challenges. However, variations in ecological environments and biological characteristics result in differing responses to resistance. Therefore, examining these differences not only enhances our understanding of adaptive resistance mechanisms but also provides crucial theoretical support and insights for addressing drug resistance and advancing pharmaceutical development.

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揭开秘密膜蛋白介导的抗药性进化

膜蛋白介导的抗药性是一个跨越医学、农业和环境科学等领域的多学科挑战。了解其复杂性并制定创新策略，对于治疗癌症等疾病和管理农业中的抗药性害虫至关重要。本文探讨了不同生物抗药性机制的双重性质：一方面，动物、细菌、真菌、植物和昆虫表现出趋同进化，从而发展出类似的抗性机制。另一方面，受不同环境压力和生物体结构差异的影响，它们也表现出不同的抗性特征。膜蛋白介导的抗性机制在动物、细菌、真菌、植物和昆虫中普遍存在，反映了它们为应对相似的生存挑战而通过趋同进化进化出的共同生存策略。然而，生态环境和生物特征的差异导致了对抗性的不同反应。因此，研究这些差异不仅能加深我们对适应性抗药性机制的理解，还能为解决抗药性问题和推动药物开发提供重要的理论支持和见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Resistance Updates 医学-药学

CiteScore

26.20

自引率

11.90%

发文量

审稿时长

29 days

期刊介绍： Drug Resistance Updates serves as a platform for publishing original research, commentary, and expert reviews on significant advancements in drug resistance related to infectious diseases and cancer. It encompasses diverse disciplines such as molecular biology, biochemistry, cell biology, pharmacology, microbiology, preclinical therapeutics, oncology, and clinical medicine. The journal addresses both basic research and clinical aspects of drug resistance, providing insights into novel drugs and strategies to overcome resistance. Original research articles are welcomed, and review articles are authored by leaders in the field by invitation. Articles are written by leaders in the field, in response to an invitation from the Editors, and are peer-reviewed prior to publication. Articles are clear, readable, and up-to-date, suitable for a multidisciplinary readership and include schematic diagrams and other illustrations conveying the major points of the article. The goal is to highlight recent areas of growth and put them in perspective. *Expert reviews in clinical and basic drug resistance research in oncology and infectious disease *Describes emerging technologies and therapies, particularly those that overcome drug resistance *Emphasises common themes in microbial and cancer research