Dm Disease-A-Month最新文献

{"title":"Information for Readers","authors":"","doi":"10.1016/S0011-5029(24)00028-2","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00028-2","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy for heart failure: A novel treatment for the age old disease","authors":"Neel Vora M.B.B.S ,&nbsp;Parth Patel M.B.B.S ,&nbsp;Aarsh Gajjar M.B.B.S ,&nbsp;Parva Ladani M.B.B.S ,&nbsp;Ashwati Konat PhD ,&nbsp;Devanshi Bhanderi M.B.B.S ,&nbsp;Srikanth Gadam M.B.B.S ,&nbsp;Priyadarshi Prajjwal M.B.B.S ,&nbsp;Kamal Sharma (Associate Professor) ,&nbsp;Shivaram Poigai Arunachalam PhD (Professor of Medicine and Radiology)","doi":"10.1016/j.disamonth.2023.101636","DOIUrl":"10.1016/j.disamonth.2023.101636","url":null,"abstract":"<div><p><span><span><span><span>Across the globe, cardiovascular disease (CVD) is the leading cause of mortality. According to reports, around 6.2 million people in the United states have heart failure. Current standards of care for heart failure can delay but not prevent progression of disease. Gene therapy is one of the novel treatment modalities that promises to fill this limitation in the current standard of care for Heart Failure. In this paper we performed an extensive search of the literature on various advances made in gene therapy for heart failure till date. We review the delivery methods, targets, current applications, trials, limitations and feasibility of gene therapy for heart failure. Various methods have been employed till date for administering gene therapies including but not limited to arterial and </span>venous infusion, direct myocardial injection and pericardial injection. Various strategies such as AC6 expression, S100A1 protein upregulation, VEGF-B and SDF-1 gene therapy have shown promise in recent preclinical trials. Furthermore, few studies even show that stimulation of </span>cardiomyocyte<span> proliferation such as through cyclin A2 overexpression is a realistic avenue. However, a considerable number of obstacles need to be overcome for gene therapy to be part of standard treatment of care such as definitive choice of gene, </span></span>gene delivery systems and a suitable method for preclinical trials and </span>clinical trials on patients. Considering the challenges and taking into account the recent advances in gene therapy research, there are encouraging signs to indicate gene therapy for heart failure to be a promising treatment modality for the future. However, the time and feasibility of this option remains in a situation of balance.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of Pulmonary Hypertension and right ventricular systolic function – updates in diagnosis and treatment","authors":"Shubhadarshini G. Pawar MBBS MPH ,&nbsp;Nida Khan MBBS ,&nbsp;Ajal Salam MBBS Medical student ,&nbsp;Muskan Joshi MBBS Medical student ,&nbsp;Praveen Bharath Saravanan MBBS Medical student ,&nbsp;Shreya Pandey MD medical student","doi":"10.1016/j.disamonth.2023.101635","DOIUrl":"10.1016/j.disamonth.2023.101635","url":null,"abstract":"<div><p><span>Right ventricular (RV) systolic function<span> is an essential but neglected component in cardiac evaluation, and its importance to the contribution to overall cardiac function is undermined. It is not only sensitive to the effect of left heart valve disease but is also more sensitive to changes in pressure overload than the left ventricle. Pulmonary Hypertension is the common and well-recognized complication of RV </span></span>systolic dysfunction<span>. It is also the leading cause of pulmonary valve disease<span><span> and right ventricular dysfunction. Patients with a high </span>pulmonary artery pressure (PAP) and a low RV ejection fraction have a seven-fold higher risk of death than heart failure patients with a normal PAP and RV ejection fraction. Furthermore, it is an independent predictor of survival in these patients. In this review, we examine the association of right ventricular systolic function with Pulmonary Hypertension by focusing on various pathological and clinical manifestations while assessing their impact. We also explore new 2022 ESC/ERS guidelines for diagnosing and treating right ventricular dysfunction in Pulmonary Hypertension.</span></span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41173325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart Failure: Recent Advances and Breakthroughs","authors":"Sneha Annie Sebastian MD ,&nbsp;Edzel Lorraine Co MD, DMD ,&nbsp;Arun Mahtani MD ,&nbsp;Inderbir Padda MD, MPH ,&nbsp;Mahvish Anam MD ,&nbsp;Swapna Susan Mathew MD ,&nbsp;Ayesha Shahzadi MD ,&nbsp;Maha Niazi MD ,&nbsp;Shubhadarshini Pawar MD ,&nbsp;Gurpreet Johal MD, FACC, FASN, FRCPC","doi":"10.1016/j.disamonth.2023.101634","DOIUrl":"10.1016/j.disamonth.2023.101634","url":null,"abstract":"<div><p><span>Heart failure (HF) is a common clinical condition encountered in various healthcare settings with a vast socioeconomic impact. Recent advancements in pharmacotherapy have led to the evolution of novel therapeutic agents with a decrease in hospitalization and mortality rates in HF with reduced left ventricular ejection fraction (HFrEF). Lately, the introduction of artificial intelligence (AI) to construct decision-making models for the early detection of HF has played a vital role in optimizing cardiovascular disease outcomes. In this review, we examine the newer therapies and evidence behind goal-directed medical therapy (GDMT) for managing HF. We also explore the application of AI and machine learning (ML) in HF, including early diagnosis and </span>risk stratification<span> for HFrEF.</span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10231466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study the relationship between left atrial (LA) volume and left ventricular (LV) diastolic dysfunction and LV hypertrophy: Correlate LA volume with cardiovascular risk factors","authors":"Shubhadarshini G. Pawar MBBS, MPH ,&nbsp;Praveen Bharath Saravanan MBBS ,&nbsp;Shipra Gulati MD ,&nbsp;Shefali Pati MD ,&nbsp;Muskan Joshi ,&nbsp;Ajal Salam ,&nbsp;Nida Khan MBBS","doi":"10.1016/j.disamonth.2024.101675","DOIUrl":"10.1016/j.disamonth.2024.101675","url":null,"abstract":"<div><p>Heart failure (HF) with normal ejection fraction<span><span> - the isolated diastolic heart failure<span>, depicts increasing prevalence and health care burden in recent times. Having less mortality rate compared to </span></span>systolic heart failure<span> but high morbidity, it is evolving as a major cardiac concern. With increasing clinical use of Left atrial volume (LAV) quantitation in clinical settings, LAV has emerged as an important independent predictor of cardiovascular outcome in HF with normal ejection fraction. This article is intended to review the diastolic and systolic heart failure, their association with left atrial volume, in depth study of Left atrial function dynamics with determinants of various functional and structural changes.</span></span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreword: Clinical issues in cardiology","authors":"Jerrold B. Leikin MD (Senior Editor: Disease-A-Month)","doi":"10.1016/j.disamonth.2023.101632","DOIUrl":"10.1016/j.disamonth.2023.101632","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10278944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreword for The Role of Gene Therapy in Sickle Cell Disease and Parkinson’s Disease","authors":"Jerrold B. Leikin MD (Senior EditorDisease-A-Month)","doi":"10.1016/j.disamonth.2024.101688","DOIUrl":"10.1016/j.disamonth.2024.101688","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139556606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myopathies of endocrine origin: A review for physicians","authors":"Devarsh N. Shah ,&nbsp;Harshal Prakash Chorya ,&nbsp;N. Nishitha Ramesh ,&nbsp;Sulochana Gnanasekaram ,&nbsp;Neil Patel ,&nbsp;Yashendra Sethi ,&nbsp;Nirja Kaka","doi":"10.1016/j.disamonth.2023.101628","DOIUrl":"10.1016/j.disamonth.2023.101628","url":null,"abstract":"<div><p><span><span><span>Myopathies<span> are a common manifestation of endocrine disorders. Endocrine myopathies are often overlooked while considering differential diagnoses </span></span>in patients<span> with musculoskeletal symptoms. The hindrance to mobility and the musculoskeletal discomfort owing to these myopathies are important causes of disability and depreciated </span></span>quality of life in these patients. Endocrine myopathies occur due to the effects of endogenous or iatrogenic hormonal imbalance on </span>skeletal muscle<span> protein and glucose metabolism, disrupting the excitation-contraction coupling. Abnormalities of the pituitary, thyroid, parathyroid, adrenal, and gonadal hormones have all been associated with myopathies and musculoskeletal symptoms. Endocrine myopathies can either be the complication of a secondary endocrine disorder or a presenting symptom of a missed underlying disorder. Therefore, an underlying endocrine abnormality must always be excluded in all patients with musculoskeletal symptoms. This review presents a compilation of various endocrine myopathies, their etiopathogenesis, clinical presentation, diagnostic modalities, and treatment protocols.</span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10278941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0011-5029(24)00023-3","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00023-3","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139738759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreword: Musculoskeletal disorders in elite athletes and endocrine – induced myopathies","authors":"Jerrold B. Leikin MD FACP, FACEP, FACMT, FAACT, FASAM, FACOEM (Senior Editor: Disease-A-Month)","doi":"10.1016/j.disamonth.2023.101627","DOIUrl":"10.1016/j.disamonth.2023.101627","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}