Dm Disease-A-Month最新文献_第10页

The role of biomarkers in the prognosis and risk stratification in heart failure: A systematic review 生物标志物在心衰预后和风险分层中的作用：系统综述。

IF 3.8 3区医学

Dm Disease-A-Month Pub Date : 2024-07-02 DOI: 10.1016/j.disamonth.2024.101782

{"title":"The role of biomarkers in the prognosis and risk stratification in heart failure: A systematic review","authors":"","doi":"10.1016/j.disamonth.2024.101782","DOIUrl":"10.1016/j.disamonth.2024.101782","url":null,"abstract":"<div><p><span><span><span><span>Acute heart failure (AHF) episodes are marked by high rates of morbidity and mortality during the episode and minimal advancements in its care. Multiple biomarker monitoring is now a crucial supplementary technique in the therapy of AHF. A scientific literature search was conducted by assessing and evaluating the most pertinent research that has been published, including original papers and review papers with the use of </span>PubMed, Medline, and </span>Cochrane databases<span><span>. Established biomarkers like natriuretic peptides (BNP, NT-proBNP) and </span>cardiac troponins<span> play crucial roles in diagnostic and prognostic evaluation. Emerging biomarkers such as microRNAs, </span></span></span>osteopontin<span>, galectin-3, ST2<span>, and GDF-15 show promise in enhancing risk stratification and predicting </span></span></span>adverse outcomes in HF. However, while these biomarkers offer valuable insights, their clinical utility requires further validation and integration into practice. Continued research into novel biomarkers holds promise for early HF detection and risk assessment, potentially mitigating the global burden of HF. Understanding the nuances of biomarker utilization is crucial for their effective incorporation into clinical practice, ultimately improving HF management and patient care.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":"70 10","pages":"Article 101782"},"PeriodicalIF":3.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of exercise training and dietary sodium restriction in heart failure rehabilitation: A systematic review 运动训练和饮食限钠在心力衰竭康复中的作用：系统综述。

IF 3.8 3区医学

Dm Disease-A-Month Pub Date : 2024-07-02 DOI: 10.1016/j.disamonth.2024.101781

{"title":"The role of exercise training and dietary sodium restriction in heart failure rehabilitation: A systematic review","authors":"","doi":"10.1016/j.disamonth.2024.101781","DOIUrl":"10.1016/j.disamonth.2024.101781","url":null,"abstract":"<div><p><span>Heart failure (HF) rehabilitation seeks to enhance the entire well-being and quality of life of those with HF by focusing on both physical and mental health. Non-pharmacological measures, particularly exercise training, and dietary salt reduction, are essential components of heart failure rehabilitation. This study examines the impact of these components on the recovery of patients with heart failure. By conducting a comprehensive analysis of research articles published from 2010 to 2024, we examined seven relevant studies collected from sources that include PubMed and Cochrane reviews. Our findings indicate that engaging in physical activity leads to favorable modifications in the heart, including improved </span>heart contractility<span>, vasodilation<span>, and cardiac output. These alterations enhance the delivery of oxygen to the peripheral tissues and reduce symptoms of heart failure, such as fatigue and difficulty breathing. Nevertheless, decreasing the consumption of salt in one's diet to less than 1500 mg per day did not have a substantial impact on the frequency of hospitalizations, visits to the emergency room, or overall mortality when compared to conventional treatment. The combination of sodium restriction and exercise training can have synergistic effects due to their complementary modes of action. Exercise improves cardiovascular health and skeletal muscle metabolism, while sodium restriction increases fluid balance and activates neurohormonal pathways. Therefore, the simultaneous usage of both applications may result in more significant enhancements in HF symptoms and clinical outcomes compared to using each program alone.</span></span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":"70 10","pages":"Article 101781"},"PeriodicalIF":3.8,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forword: Heart failure and other selected issues in cardiac pathology 前言：心力衰竭及其他心脏病理学选题。

IF 3.8 3区医学

Dm Disease-A-Month Pub Date : 2024-06-29 DOI: 10.1016/j.disamonth.2024.101779

引用次数: 0

Cardiovascular complications during pregnancy: Advancing cardio-obstetrics 孕期心血管并发症：推进心血管产科的发展。

IF 3.8 3区医学

Dm Disease-A-Month Pub Date : 2024-06-22 DOI: 10.1016/j.disamonth.2024.101780

{"title":"Cardiovascular complications during pregnancy: Advancing cardio-obstetrics","authors":"","doi":"10.1016/j.disamonth.2024.101780","DOIUrl":"10.1016/j.disamonth.2024.101780","url":null,"abstract":"<div><p>As the incidence of cardiovascular diseases (CVDs) continues to rise among women of childbearing age, the pregnant population with pre-existing heart conditions presents a complex and heterogeneous profile. These women face varying degrees of risk concerning maternal cardiovascular, obstetric, and fetal complications. Effectively managing adverse cardiovascular events during pregnancy presents substantial clinical challenges. The uncertainties surrounding diagnostic and therapeutic approaches create a dynamic landscape with potential implications for maternal and fetal health. Cardio-obstetrics has become increasingly recognized as a vital multidisciplinary field necessitating a collaborative approach to managing cardiovascular conditions during pregnancy. In this review, we aim to provide a thorough and up-to-date examination of the existing evidence, offering a comprehensive overview of strategies and considerations in the management of cardiovascular complications during pregnancy. Special emphasis is placed on the safety assessment of diagnostic procedures and the exploration of treatment options designed to prioritize the well-being of the mother and fetus. We also explore the significance of a multidisciplinary cardio-obstetrics team in providing comprehensive care for women of childbearing age with or at risk for CVD.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":"70 10","pages":"Article 101780"},"PeriodicalIF":3.8,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0011502924001068/pdfft?md5=2c5a8efac69431932bd56b793af16aab&pid=1-s2.0-S0011502924001068-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141443690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Title Page 标题页

IF 4 3区医学

Dm Disease-A-Month Pub Date : 2024-06-20 DOI: 10.1016/S0011-5029(24)00095-6

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Information for Readers 读者信息

IF 4 3区医学

Dm Disease-A-Month Pub Date : 2024-06-20 DOI: 10.1016/S0011-5029(24)00096-8

引用次数: 0

C2: Editorial Board C2：编辑委员会

IF 4 3区医学

Dm Disease-A-Month Pub Date : 2024-06-20 DOI: 10.1016/S0011-5029(24)00094-4

引用次数: 0

The efficacy and safety of gene therapy approaches in Parkinson's disease: A systematic review 帕金森病基因治疗方法的有效性和安全性：系统综述。

IF 4 3区医学

Dm Disease-A-Month Pub Date : 2024-06-06 DOI: 10.1016/j.disamonth.2024.101754

Chiranjeevee R. Saravanan MBBS , Reem Faiz Hussein Eisa MBBS , Elizabeth Gaviria MD , Amani Algubari MD , Kiran Kishor Chandrasekar MBBS , Pugazhendi Inban MD , Priyadarshi Prajjwal MBBS , Hyma Bamba MBBS , Gurmehar Singh MBBS , Mohammed Dheyaa Marsool Marsool MBChB , Srikanth Gadam MD

{"title":"The efficacy and safety of gene therapy approaches in Parkinson's disease: A systematic review","authors":"Chiranjeevee R. Saravanan MBBS , Reem Faiz Hussein Eisa MBBS , Elizabeth Gaviria MD , Amani Algubari MD , Kiran Kishor Chandrasekar MBBS , Pugazhendi Inban MD , Priyadarshi Prajjwal MBBS , Hyma Bamba MBBS , Gurmehar Singh MBBS , Mohammed Dheyaa Marsool Marsool MBChB , Srikanth Gadam MD","doi":"10.1016/j.disamonth.2024.101754","DOIUrl":"10.1016/j.disamonth.2024.101754","url":null,"abstract":"<div><h3>Background</h3><p>Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the brain. Despite existing treatments, there remains an unmet need for therapies that can halt or reverse disease progression. Gene therapy has been tried and tested for a variety of illnesses, including PD. The goal of this systematic review is to assess gene therapy techniques' safety and effectiveness in PD clinical trials.</p></div><div><h3>Methods</h3><p>Online databases PubMed/Medline, and Cochrane were used to screen the studies for this systematic review. The risk of bias of the included studies was assessed using standard tools.</p></div><div><h3>Results</h3><p>Gene therapy can repair damaged dopaminergic neurons from the illness or deal with circuit anomalies in the basal ganglia connected to Parkinson's disease symptoms. Rather than only treating symptoms, this neuroprotective approach alters the illness itself. Medication for gene therapy is currently administered at the patient's bedside. It can hyperactivate specific brain circuits associated with motor dysfunction. PD therapies are developing quickly, and there aren't enough head-to-head trials evaluating the safety and effectiveness of available treatments. When choosing an advanced therapy, patient-specific factors should be considered in addition to the effectiveness and safety of each treatment option.</p></div><div><h3>Conclusion</h3><p>In comparison to conventional therapies, gene therapy may be advantageous for PD. It may minimize side effects, relieve symptoms, and offer dependable dopamine replacement.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":"70 7","pages":"Article 101754"},"PeriodicalIF":4.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141288870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Title Page 标题页

IF 4 3区医学

Dm Disease-A-Month Pub Date : 2024-06-01 DOI: 10.1016/S0011-5029(24)00083-X

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Information for Readers 读者信息

IF 4 3区医学

Dm Disease-A-Month Pub Date : 2024-06-01 DOI: 10.1016/S0011-5029(24)00084-1

引用次数: 0