Dm Disease-A-Month最新文献

{"title":"Health equity in pediatrics: Current concepts for the care of children in the 21st century (Dis Mon)","authors":"Cheryl A. Dickson MD, MPH ,&nbsp;Berrin Ergun-Longmire MD ,&nbsp;Donald E. Greydanus MD, DrHC (Athens) ,&nbsp;Ransome Eke MD, PhD ,&nbsp;Bethany Giedeman BS ,&nbsp;Nikoli M. Nickson BA ,&nbsp;Linh-Nhu Hoang MA ,&nbsp;Uzochukwu Adabanya MD, MPH ,&nbsp;Daniela V. Pinto Payares BS, MS ,&nbsp;Summer Chahin PhD ,&nbsp;Jerica McCrary BS, MPA ,&nbsp;Katie White MA ,&nbsp;Jin Hyung Moon BS ,&nbsp;Nizoramo Haitova PhD ,&nbsp;Jocelyn Deleon MD ,&nbsp;Roger W. Apple PhD","doi":"10.1016/j.disamonth.2023.101631","DOIUrl":"10.1016/j.disamonth.2023.101631","url":null,"abstract":"<div><p><span><span>This is an analysis of important aspects of health equity in caring for children and adolescents written by a multidisciplinary team from different medical centers. In this discussion for clinicians, we look at definitions of pediatric health equity and the enormous impact of </span>social determinants of health in this area. Factors involved with pediatric healthcare disparities that are considered include race, ethnicity, gender, age, poverty, socioeconomic status, LGBT status, living in rural communities, housing instability, food insecurity, access to transportation, availability of healthcare professionals, the status of education, and employment as well as immigration. Additional issues involved with health equity in pediatrics that are reviewed will include the impact of the COVID-19 pandemic, behavioral health concepts, and the negative health effects of climate change. Recommendations that are presented include reflection of one's own attitudes on as well as an understanding of these topics, consideration of the role of various healthcare providers (i.e., </span>community health workers, peer health navigators, others), the impact of behavioral health integration, and the need for well-conceived curricula as well as multi-faceted training programs in pediatric health equity at the undergraduate and postgraduate medical education levels. Furthermore, ongoing research in pediatric health equity is needed to scrutinize current concepts and stimulate the development of ideas with an ever-greater positive influence on the health of our beloved children. Clinicians caring for children can serve as champions for the optimal health of children and their families; in addition, these healthcare professionals are uniquely positioned in their daily work to understand the drivers of health inequities and to be advocates for optimal health equity in the 21st century for all children and adolescents.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41169044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Information for Readers","authors":"","doi":"10.1016/S0011-5029(24)00046-4","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00046-4","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C2: Editorial Board","authors":"","doi":"10.1016/S0011-5029(24)00044-0","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00044-0","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0011502924000440/pdfft?md5=0f90a5cc20d5d2d09ceced8e63e69990&pid=1-s2.0-S0011502924000440-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S0011-5029(24)00045-2","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00045-2","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140134831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of gene therapy in sickle cell disease","authors":"Aishwarya Raghuraman MBBS ,&nbsp;Rebecca Lawrence MD ,&nbsp;Rudrakshi Shetty MBBS ,&nbsp;Chaithanya Avanthika MD ,&nbsp;Sharan Jhaveri MBBS ,&nbsp;Brinela Vivas Pichardo MBBS ,&nbsp;Amulya Mujakari MBBS","doi":"10.1016/j.disamonth.2024.101689","DOIUrl":"10.1016/j.disamonth.2024.101689","url":null,"abstract":"<div><h3>Background</h3><p>Gene therapy is an emerging treatment for sickle cell disease that works by replacing a defective gene with a healthy gene, allowing the body to produce normal red blood cells. This form of treatment has shown promising results in clinical trials, and is a promising alternative to traditional treatments. Gene therapy involves introducing a healthy gene into the body to replace a defective gene. The new gene can be delivered using a viral vector, which is a modified virus that carries the gene. The vector, carrying the healthy gene, is injected into the bloodstream. The healthy gene then enters the patient's cells and begins to produce normal hemoglobin, the protein in red blood cells that carries oxygen throughout the body.</p></div><div><h3>Methodology</h3><p>We conducted an all-language literature search on Medline, Cochrane, Embase, and Google Scholar until December 2022. The following search strings and Medical Subject Heading (MeSH) terms were used: “Sickle Cell,” “Gene Therapy” and “Stem Cell Transplantation”. We explored the literature on Sickle Cell Disease for its epidemiology, etiopathogenesis, the role of various treatment modalities and the risk-benefit ratio of gene therapy over conventional stem cell transplant.</p></div><div><h3>Results</h3><p>Gene therapy can reduce or eliminate painful episodes, prevent organ damage, and raise the quality of life for those living with the disease. Additionally, gene therapy may reduce the need for blood transfusions and other traditional treatments. Gene therapy has the potential to improve the lives of those living with sickle cell disease, as well as reduce the burden of the disease on society.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tachy-brady syndrome: Electrophysiology and evolving principles of management","authors":"Inderbir Padda MD ,&nbsp;Sneha Annie Sebastian MD ,&nbsp;Nimrat Khehra MD ,&nbsp;Arun Mahtani MD ,&nbsp;Yashendra Sethi MBBS ,&nbsp;Venkatesh Panthangi MD ,&nbsp;Matthew Fulton MD ,&nbsp;Dhrubajyoti Bandyopadhyay MD ,&nbsp;Gurpreet Johal MD, FACC, FASN, FRCPC","doi":"10.1016/j.disamonth.2023.101637","DOIUrl":"10.1016/j.disamonth.2023.101637","url":null,"abstract":"<div><p><span>Sudden alterations in the heart rate may be associated with diverse symptoms. Sinus node dysfunction (SND), also known as </span>sick sinus syndrome<span>, is a sinoatrial (SA) node disorder. SND is primarily caused by the dysfunction of the pacemaker, as well as impaired impulse transmission resulting in a multitude of abnormalities in the heart rhythms, such as bradycardia-tachycardia, atrial bradyarrhythmias<span>, and atrial tachyarrhythmias<span><span><span><span>. The transition from bradycardia to tachycardia is generally referred to as “tachy-brady syndrome” (TBS). Although TBS is etiologically variable, the manifestations remain consistent throughout. Abnormal heart rhythms have the propensity to limit tissue perfusion resulting in </span>palpitations, fatigue, </span>lightheadedness, </span>presyncope, and syncope. In this review, we examine the physiology of tachy-brady syndrome, the practical approach to its diagnosis and management, and the role of adenosine in treating SND.</span></span></span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10202595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C2: Editorial Board","authors":"","doi":"10.1016/S0011-5029(24)00026-9","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00026-9","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0011502924000269/pdfft?md5=bea16fa928205d57776c1dc27ff74538&pid=1-s2.0-S0011502924000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates in the management of atrial fibrillation: Emerging therapies and treatment","authors":"Saud Muthanna Shakir Al-Ezzi M.D. ,&nbsp;Isha Bista M.D. ,&nbsp;Mohammed Muthanna Al-Ezzi M.B.B.Ch ,&nbsp;Priyadarshi Prajjwal M.B.B.S. ,&nbsp;Safa Muthanna Shakir Al-Ezzi M.D. ,&nbsp;Himani Harshad Pattani M.B.B.S. ,&nbsp;Bita Amiri M.D., MPH ,&nbsp;Mohammed Dheyaa Marsool Marsool","doi":"10.1016/j.disamonth.2023.101633","DOIUrl":"10.1016/j.disamonth.2023.101633","url":null,"abstract":"<div><h3>Objective</h3><p>The most common and clinically important cardiac arrhythmia is atrial fibrillation (AF), which has a large negative impact on public health due to higher fatalities, morbidity, and healthcare expenditure rates. This study aims to provide valuable insights into the effectiveness and outcomes of various treatment approaches and interventions for AF.</p></div><div><h3>Study design</h3><p>Systematic review.</p></div><div><h3>Method</h3><p>The most pertinent published research (original papers and reviews) in the scientific literature were searched for and critically assessed using the online, internationally indexed databases PubMed, Medline, and Cochrane Reviews. These studies are summarised in this review. Keywords like “Atrial Fibrillation”, “emerging therapies”, “treatment”, “catheter ablation”, and “atrial appendage” were used to search the papers. The papers were researched and examined to be relevant to the topic.</p></div><div><h3>Conclusion</h3><p>A lot of work has gone into enhancing AF management to deal with this expanding public health concern. Significant developments and advances in the treatment of AF during the past few years have aided clinicians in giving AF patients better care. The most recent treatments for AF include medication, catheter ablation, cryo-balloon ablation, and left atrial appendage closure.</p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10322342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the path of TOF- A Literature review unveiling maternal-fetal dynamics, treatment strategies and psychological dimensions","authors":"Poulami Roy MBBS ,&nbsp;Viraj Sah MBBS ,&nbsp;Novonil Deb MBBS ,&nbsp;Vikash Jaiswal MD","doi":"10.1016/j.disamonth.2023.101659","DOIUrl":"10.1016/j.disamonth.2023.101659","url":null,"abstract":"<div><p><span>Tetralogy of Fallot (TOF) is a complex </span>congenital heart defect<span><span><span><span><span> that poses unique challenges for both mothers and their unborn children. This comprehensive review, aims to provide a holistic exploration of the maternal-fetal dynamics, treatment<span> strategies, and psychological dimensions involved in navigating the path of TOF during pregnancy. It delves into the physiological changes that occur during pregnancy in TOF patients, including pulmonary regurgitation, </span></span>right ventricular hypertrophy, and the </span>overriding aorta. By understanding these dynamics, healthcare professionals can tailor treatment strategies to optimize maternal and fetal outcomes. The review further investigates the treatment strategies employed in managing TOF during pregnancy, encompassing medical interventions, cardiac monitoring, and multidisciplinary care. It explores the role of advanced </span>imaging techniques, such as </span>echocardiography<span><span> and cardiac magnetic resonance imaging, in assessing TOF severity and guiding treatment decisions. The psychological factors influencing maternal adaptation, coping strategies, and the long-term implications on the child's psychological development are also examined. The integration of multidisciplinary approaches, including cardiac care, </span>psychosocial support, and mental health interventions, can orchestrate a harmonious symphony of maternal-fetal well-being in the challenging journey of TOF pregnancies. Future research endeavours should continue to explore these dimensions, further refining treatment strategies and enhancing the understanding of TOF pregnancies for improved outcomes.</span></span></p></div>","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89720460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page","authors":"","doi":"10.1016/S0011-5029(24)00027-0","DOIUrl":"https://doi.org/10.1016/S0011-5029(24)00027-0","url":null,"abstract":"","PeriodicalId":51017,"journal":{"name":"Dm Disease-A-Month","volume":null,"pages":null},"PeriodicalIF":4.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}