Comparative Immunology Microbiology and Infectious Diseases最新文献

{"title":"Beta-lactamase genes in bacteria from food animals, retail meat, and human surveillance programs in the United States from 2002 to 2021","authors":"Md. Kaisar Rahman,&nbsp;Howard Rodriguez-Mori,&nbsp;Guy H. Loneragan,&nbsp;Babafela Awosile","doi":"10.1016/j.cimid.2024.102139","DOIUrl":"10.1016/j.cimid.2024.102139","url":null,"abstract":"<div><p>The spread of beta-lactamase-producing bacteria is a global public-health concern. This study aimed to explore the distribution of beta-lactamases reported in three sampling sources (cecal, retail meat, and human) collected as part of integrated surveillance in the United States. We retrieved and analyzed data from the United States National Antimicrobial Resistance Monitoring Systems (NARMS) from 2002 to 2021. A total of 115 beta-lactamase genes were detected in <em>E. coli</em>, <em>Salmonella enterica</em>, <em>Campylobacter</em>, <em>Shigella</em> and <em>Vibrio</em>: including 35 genes from cecal isolates, 32 genes from the retail meat isolates, and 104 genes from the human isolates. Three genes in <em>E. coli</em> (<em>bla</em>_CMY-2, <em>bla</em>_TEM-1A, and <em>bla</em>_TEM-1B), 6 genes in Salmonella enterica (<em>bla</em>_CARB-2, <em>bla</em>_CMY-2, <em>bla</em>_CTXM-65, <em>bla</em>_TEM-1A, <em>bla</em>_TEM-1B, and <em>bla</em>_HERA-3), and 2 genes in <em>Campylobacter</em> spp. (<em>bla</em>_OXA-61 and <em>bla</em>_OXA-449) have been detected across food animals (cattle, chicken, swine, and turkey) and humans over the study period. <em>bla</em>_CTXM-55 has been detected in <em>E. coli</em> isolates from the four food animal sources while <em>bla</em>_CTXM-15 and <em>bla</em>_CTXM-27 were found only in cattle and swine. In <em>Salmonella enterica</em>, <em>bla</em>_CTXM-2, <em>bla</em>_CTXM-9, <em>bla</em>_CTXM-14, <em>bla</em>_CTXM-15, <em>bla</em>_CTXM-27, <em>bla</em>_CTXM-55, and <em>bla</em>_NDM-1 were only detected among human isolates. <em>bla</em>_OXAs and <em>bla</em>_CARB were bacteria-specific and the only beta-lactamase genes detected in <em>Campylobacter</em> spp. and <em>Vibrio</em> spp respectively. The proportions of beta-lactamase genes detected varies from bacteria to bacteria. This study provided insights on the beta-lactamase genes detected in bacteria in food animals and humans in the United States. This is necessary for better understanding the molecular epidemiology of clinically important beta-lactamases in one health interface.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102139"},"PeriodicalIF":2.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139666937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular prevalence of vector borne bacterial pathogens in the blood samples of wild rodent species trapped from Saudi Arabia","authors":"Abdul Ghafar ,&nbsp;Samia Q. Alghamdi ,&nbsp;Abdullah D. Alanazi ,&nbsp;Syed Muhammad Zukhruf Qousain ,&nbsp;Maryam Ijaz ,&nbsp;Muhammad Naeem ,&nbsp;Muhammad Ali ,&nbsp;Hira Muqaddas ,&nbsp;Adil Khan ,&nbsp;Furhan Iqbal","doi":"10.1016/j.cimid.2024.102129","DOIUrl":"10.1016/j.cimid.2024.102129","url":null,"abstract":"<div><p>Order Rodentia is the most speciose among mammals and the members of this order are known to host more than 60 zoonotic diseases and rodents are a potential health threat to humans. This study was designed to report the molecular prevalence and phylogenetic evaluation of various blood borne bacterial pathogens (<em>Anaplasma ovis, Anaplasma phagocytophilum</em>, <em>Anaplasma marginale</em> and <em>Bartonella</em> spp<em>.</em>) in the blood samples of four wild rodent species [<em>Meriones rex</em> (N = 27), <em>Acomys dimidiatus</em> (N = 18), <em>Myomys yemeni</em> (N = 6) and <em>Rattus rattus</em> (N = 3)] that were trapped during August till October 2020 from Al Makhwah governorate in Saudi Arabia. Results revealed by 9/54 (16.6%) rodents amplified <em>Msp4</em> gene and 2/54 (3.7%) rodents amplified <em>rpoB</em> gene of <em>Anaplasma ovis</em> and <em>Bartonella</em> spp<em>.</em> respectively. <em>Anaplasma phagocytophilum</em> and <em>Anaplasma marginale</em> were not detected among enrolled rodent species. <em>Meriones rex</em> was the most highly infected rodent species. DNA sequencing and BLAST analysis confirmed the presence of <em>Anaplasma ovis</em> and the <em>Bartonella koehlerae</em> in rodent blood samples. Phylogenetic analysis of both pathogens showed that Saudi isolates were clustered together and were closely related to isolates that were reported from worldwide countries. Risk factor analysis revealed that prevalence of both bacterial pathogens was not restricted to a particular rodent species or a rodent sex (P &gt; 0.05). In conclusion, we are reporting for the very first time that Saudi rodents are infected with <em>Anaplasma ovis</em> and rodents can be infected with <em>Bartonella koehlerae</em>. Similar studies at large scale are recommended in all those areas of Saudi Arabia that are unexplored for the incidence and prevalence of bacterial pathogens among the rodents that are living near human dwellings in order to prevent bacterial infections in local people as well as in livestock<em>.</em></p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102129"},"PeriodicalIF":2.0,"publicationDate":"2024-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139580279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular detection and MST genotyping of Coxiella burnetii in ruminants and stray dogs and cats in Northern Algeria","authors":"H. Ghaoui ,&nbsp;I. Bitam ,&nbsp;S. Zaidi ,&nbsp;N. Achour ,&nbsp;S. Zenia ,&nbsp;T. Idres ,&nbsp;P.E. Fournier","doi":"10.1016/j.cimid.2024.102126","DOIUrl":"10.1016/j.cimid.2024.102126","url":null,"abstract":"<div><p>Aiming at identifying the reservoir and contamination sources of <em>Coxiella burnetii</em> in Northern Algeria, we investigated the molecular presence of the bacterium in 599 samples (blood, placenta, liver, spleen, and uterus) collected from cattle, sheep, dogs and cats. Our qPCR results showed that <strong>15/344 (4.36%)</strong> blood samples and <strong>six/255 (2.35%)</strong> organ specimens were positive for <em>C. burnetii</em>. In cattle, <strong>three (4%)</strong> blood and liver samples were positive. In sheep, one blood <strong>(1.19%)</strong> and <strong>3 (8.57%)</strong> placenta samples were positive. At the Algiers dog pound, <strong>8 (10%)</strong> and <strong>3 (5%)</strong> blood samples were qPCR positivein dogs and cats, respectively. In addition, <strong>MST</strong> genotyping showed that <strong>MST 33</strong> was present in cattle and sheep, <strong>MST 20</strong> in cattle,and<strong>MST 21</strong> in dogs and cats.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102126"},"PeriodicalIF":2.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139558738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular survey of hemoplasmas and Coxiella burnetii in vampire bats from northern Brazil","authors":"Victória Valente Califre de Mello ,&nbsp;Laryssa Borges de Oliveira ,&nbsp;Taciana Fernandes Souza Barbosa Coelho ,&nbsp;Daniel Antonio Braga Lee ,&nbsp;Eliz Oliveira Franco ,&nbsp;Rosangela Zacarias Machado ,&nbsp;Marcos Rogério André","doi":"10.1016/j.cimid.2024.102127","DOIUrl":"10.1016/j.cimid.2024.102127","url":null,"abstract":"<div><p><span>In addition to zoonotic viral pathogens, bats can also harbor bacterial pathogens, including hemoplasmas (hemotropic mycoplasmas) and </span><span><em>Coxiella burnetii</em></span>. The present study aimed to investigate, using molecular techniques, the presence of hemoplasmas and <em>C. burnetii</em> in spleen samples from vampire bats in northern Brazil. For this purpose, between 2017 and 2019, spleen samples were collected from <span><em>Desmodus rotundus</em></span> (n = 228) and <em>Diaemus youngii</em> (n = 1) captured in the states of Pará (n = 207), Amazonas (n = 1), Roraima (n = 18) and Amapá (n = 3). DNA samples extracted from the bat spleen and positive in PCR for the endogenous <span><em>gapdh</em></span> gene were subjected to conventional PCR assays for the 16S rRNA, 23S rRNA and RNAse P genes from hemoplasmas and to qPCR based on the <em>IS1111</em> gene element for <em>C. burnetii</em>. All spleen samples from vampire bats were negative in the qPCR for <em>C. burnetii</em><span>. Hemoplasmas were detected in 10 % (23/229) of spleen samples using a PCR based on the 16S rRNA gene. Of these, 21.73 % (5/23) were positive for the 23S rRNA gene and none for the RNAseP gene. The seven hemoplasma 16S rRNA sequences obtained were closely related to sequences previously identified in vampire bats from Belize, Peru and Brazil. The 23S rRNA sequence obtained revealed genetic proximity to hemoplasmas from non-hematophagous bats from Brazil and Belize. The analysis revealed different circulating genotypes among Brazilian vampire bats, in addition to a trend towards genera-specific hemoplasma genotypes. The present study contributes to the knowledge of the wide diversity of hemoplasmas in vampire bats.</span></p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102127"},"PeriodicalIF":2.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139510283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidences of Helicobacter infection in pigs and tracing occupational hazard in pig farmers","authors":"Seema Rani Pegu ,&nbsp;Joyshikh Sonowal ,&nbsp;Swaraj Rajkhowa ,&nbsp;Pranab Jyoti Das ,&nbsp;Gyanendra Singh Sengar ,&nbsp;Rajib Deb ,&nbsp;Manjisa Choudhury ,&nbsp;Naba Jyoti Deka ,&nbsp;Souvik Paul ,&nbsp;Juwar Doley ,&nbsp;Dilip Kumar Sarma ,&nbsp;Samir Das ,&nbsp;N.H. Mohan ,&nbsp;Rajendran Thomas ,&nbsp;Vivek Kumar Gupta","doi":"10.1016/j.cimid.2024.102128","DOIUrl":"10.1016/j.cimid.2024.102128","url":null,"abstract":"<div><p><span><em>Helicobacter</em><em> species</em></span> (spp<em>.</em><span>) is a gram-negative spiral-shaped motile bacterium that causes gastritis in pigs and also colonizes in the human stomach. The present study assessed the prevalence of </span><em>Helicobacter</em><span><span> spp. in pig gastric mucosa and the stool of pig farmers in Assam, India. A total of 403 stomach samples from pig slaughter points, 74 </span>necropsy<span> samples of pigs from pig farms, and 97 stool samples from pig farmers were collected. Among the pig stomach samples, 43 (20.09%) of those with gastritis showed the presence of Gram-negative, spiral-shaped organisms, while only 3.04% of stomach samples without lesions had these organisms. Scanning Electron Microscopy (SEM) of urease-positive stomach samples revealed tightly coiled </span></span><em>Helicobacter</em><span> bacteria in the mucus lining. Histopathological examination showed chronic gastritis with hemorrhagic necrosis, leucocytic infiltration<span>, and lymphoid aggregates. PCR confirmed the presence of </span></span><em>Helicobacter suis</em> in 19.63% of pig stomach samples and 2.08% of pig farmer stool samples. Additionally, 3.12% of the stool samples from pig farmers were positive for <span><em>Helicobacter </em><em>pylori</em></span><span>. Phylogenetic analysis revealed distinct clusters of </span><em>Helicobacter suis</em> with other <em>Helicobacter</em> spp. These findings highlight the prevalence of <em>Helicobacter</em> in both pig gastric mucosa and pig farmer stool. The findings highlight the need for improved sanitation and hygiene practices among pig farmers to minimize the risk of <em>Helicobacter</em> infection in humans.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102128"},"PeriodicalIF":2.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139470469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative molecular epidemiology, subtype distribution, and zoonotic potential of Blastocystis sp. in Equus animals (horses, donkeys, and mules) in northwestern Iran","authors":"Ali Asghari ,&nbsp;Amirhosein Yousefi ,&nbsp;Mohammad Reza Mohammadi ,&nbsp;Roya Badali ,&nbsp;Laya Shamsi ,&nbsp;Ahmet Efe Köseoğlu ,&nbsp;Amir Abbaszadeh ,&nbsp;Morteza Shams ,&nbsp;Behnam Mohammadi-Ghalehbin","doi":"10.1016/j.cimid.2024.102124","DOIUrl":"10.1016/j.cimid.2024.102124","url":null,"abstract":"<div><p>A total of 500 fecal samples were collected from Equus animals in six different cities (Ardabil, Namin, Nir, Meshginshahr, Germi, and Khalkhal) of Ardabil Province, northwestern Iran, with 200 samples from horses, 200 from donkeys, and 100 from mules. Of the horse samples, 100 were from racing horses under special monitoring and care, while the remaining 100 were from non-racing horses, including those used for herding or in rural areas. All fecal samples were examined for the presence of <em>Blastocystis</em><span><span> sp. using PCR amplification of the SSU rRNA gene's barcode region after </span>DNA extraction. The molecular prevalence of </span><em>Blastocystis</em> infection in Equus animals was 7.6% (38/500). <em>Blastocystis</em> was more common in horses [11.5% (23/200)] than in donkeys [5.5% (11/200)] and mules [4% (4/100)] (P &gt; 0.05). Compared to racing horses [3% (3/100)], non-racing/rural horses [20% (20/100)] exhibited a substantially higher prevalence of <em>Blastocystis</em> (P &lt; 0.05). The prevalence of <em>Blastocystis</em> in diarrheal samples and younger animals was remarkably higher than in formed samples and older animals, respectively (P &lt; 0.05). No significant difference in <em>Blastocystis</em> infection prevalence was found between the genders of examined animals (P &gt; 0.05). In Equus animals, 38 <em>Blastocystis</em> isolates included eight STs: ST10 [31.6% (12/38)], ST1 [21.1% (8/38)], ST2 [15.8% (6/38)], ST3 [10.5% (4/38)], ST4 [7.9% (3/38)], ST7 [5.2% (2/38)], ST14 [5.2% (2/38)], and ST6 [2.6% (1/38)]. These results suggest that Equus animals act as a proper reservoir for numerous <em>Blastocystis</em><span> STs, consequently playing a crucial part in the spread of this protozoan<span> infection to humans, animals, and water reservoirs.</span></span></p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"106 ","pages":"Article 102124"},"PeriodicalIF":2.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139375724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic detection and phylogenetic analysis of Bartonella quintana in pet cats from Urmia City, Northwest Iran","authors":"Sima Alempour Rajabi ,&nbsp;Abdolghaffar Ownagh ,&nbsp;Mojtaba Hadian","doi":"10.1016/j.cimid.2024.102125","DOIUrl":"10.1016/j.cimid.2024.102125","url":null,"abstract":"<div><p>The aim of this study was to investigate the presence and genetic characteristics of <span><em>Bartonella quintana</em></span><span> in pet cats from Urmia City, located in the northwest of Iran. Blood samples were collected from 200 cats, and their age, gender, and breed were noted. Nested-PCR and sequencing were used to identify </span><em>B. quintana</em> in positive samples, and the <em>ftsZ</em><span> gene sequences were analyzed using BioEdit software. The gene sequence obtained in this study exhibited 100.00 % similarity to reference sequences in the GenBank® database, and a phylogenetic tree was constructed using MEGA11. The results revealed that 15 % of the cats (30 out of 200 blood samples) tested positive for the </span><em>B. quintana</em> gene, with a 95 % confidence interval of 10.71 % to 20.61 %.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"105 ","pages":"Article 102125"},"PeriodicalIF":2.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139375697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilm-forming ability, antibiotic resistance and phylogeny of Escherichia coli isolated from extra intestinal infections of humans, dogs, and chickens.","authors":"G A D K K Gunathilaka ,&nbsp;W A P M Dewasmika ,&nbsp;U M Sandaruwan ,&nbsp;N G D A K Neelawala ,&nbsp;G E D Madhumali ,&nbsp;N Dissanayake ,&nbsp;M A R Priynatha ,&nbsp;D V P Prasada ,&nbsp;D R A Dissanayake","doi":"10.1016/j.cimid.2023.102123","DOIUrl":"10.1016/j.cimid.2023.102123","url":null,"abstract":"<div><p><em>Escherichia coli</em> (<em>E. coli</em>) causes various infections in humans and animals. The biofilm-forming ability of <em>E. coli</em><span> has increased antimicrobial resistance and capacity to cause recurrent and chronic infections. This study determined the biofilm-forming ability of </span><em>E. coli</em><span> isolated from extraintestinal infections of humans, chickens, and dogs in relation to the phylogroup, type of infection, and antibiotic resistance. Isolates from chickens showed significantly higher biofilm-forming ability compared to those causing urinary tract infections in humans (</span><em>p</em><span> = 0.0001). Further, isolates belonging to phylogroup B1 displayed a higher likelihood to form biofilms. Resistance to ciprofloxacin<span> and trimethoprim-sulfamethoxazole was positively correlated with biofilm-forming ability. Harbouring plasmid-mediated quinolone resistance gene, </span></span><em>qnrS</em> was also positively correlated with biofilm formation. This study provides insight into factors such as phylogroup and the type of infections that could enhance biofilm formation, as well as genotypic and phenotypic antibiotic resistance that could correlate with the ability to form biofilms</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"105 ","pages":"Article 102123"},"PeriodicalIF":2.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spread analysis of glanders in the state of Piauí, northeastern Brazil","authors":"Roselma de Carvalho Moura ,&nbsp;Francisco Alyson de Oliveira ,&nbsp;Dayseanny de Oliveira Bezerra ,&nbsp;Raizza Eveline Escórcio Pinheiro ,&nbsp;Ricardo Antônio Pilegi Sfaciotte ,&nbsp;Joandes Henrique Fonteque ,&nbsp;Sandra Maria Ferraz ,&nbsp;Raylson Pereira de Oliveira ,&nbsp;Verônica Flores da Cunha Scheeren ,&nbsp;David Germano Gonçalves Schwarz","doi":"10.1016/j.cimid.2023.102122","DOIUrl":"10.1016/j.cimid.2023.102122","url":null,"abstract":"<div><p>Brazil is strategic in controlling neglected zoonoses<span>, such as glanders, in its territory. Among the Brazilian states, Piauí is a strategic state for the spread of the disease in the country. The present study aimed to evaluate the spatial and temporal distribution of official cases of glanders in Piauí between 2015 and 2022. The glanders cases were located in the municipalities of the north and central-north mesoregions, mainly in Campo Maior, Teresina and Altos. The highest incidence risk (IR) occurred in of Altos (IR = 257.9), Sussuapara (IR = 158.4), and Teresina (IR = 157.7). A primary cluster was formed with a relative risk of 14.88 between 2019 and 2022, encompassing 34 municipalities in the north and central-north regions. In Piauí, glanders is well localized, with the potential for spread across borders. This is the first study demonstrating the distribution of reported cases of glanders in the state of Piauí.</span></p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"105 ","pages":"Article 102122"},"PeriodicalIF":2.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139080090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-vaccinal distemper-like disease in two dog litters with confirmed infection of vaccine virus strain","authors":"Henna M. Pekkarinen ,&nbsp;Veera K. Karkamo ,&nbsp;Katri J. Vainio-Siukola ,&nbsp;Maria K. Hautaniemi ,&nbsp;Paula M. Kinnunen ,&nbsp;Tuija K. Gadd ,&nbsp;Riikka H. Holopainen","doi":"10.1016/j.cimid.2023.102114","DOIUrl":"10.1016/j.cimid.2023.102114","url":null,"abstract":"<div><p>Modified live canine distemper virus (CDV) vaccines are widely used and considered both safe and effective. Although there are occasional literature reports of suspected vaccine-induced disease, there are none where the vaccine strain has been identified in affected tissues. Here we describe two such cases in different litters. In litter A, five of ten puppies presented with fever, anorexia, vomiting, and diarrhea a few days post-vaccination. Four puppies died or were euthanized, and autopsy revealed atypical necrosis of the lymphoid tissue. In litter B, two of five puppies developed typical neurological signs some months post-vaccination and autopsy revealed encephalitis. In all cases, affected organs tested positive for CDV on immunohistochemistry, and CDV RNA extracted from the lesions confirmed the presence of vaccine strain. Since multiple puppies from each litter were affected, it cannot be excluded without further studies that some undiagnosed inherited immunodeficiency disorder may have been involved.</p></div>","PeriodicalId":50999,"journal":{"name":"Comparative Immunology Microbiology and Infectious Diseases","volume":"105 ","pages":"Article 102114"},"PeriodicalIF":2.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0147957123001728/pdfft?md5=97bba2f9abe043950704799c6b7b545b&pid=1-s2.0-S0147957123001728-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139030364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}