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Study of the epithelial state of the oral mucosa in patients with recurrent aphthous stomatitis 复发性口腔炎患者口腔黏膜上皮状态研究
Parodontologiya Pub Date : 2024-07-01 DOI: 10.33925/1683-3759-2024-900
O. V. Tarasova, O. N. Pavlova, O. Gulenko
{"title":"Study of the epithelial state of the oral mucosa in patients with recurrent aphthous stomatitis","authors":"O. V. Tarasova, O. N. Pavlova, O. Gulenko","doi":"10.33925/1683-3759-2024-900","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-900","url":null,"abstract":"Relevance. Recurrent aphthous stomatitis (RAS) is one of the most common diseases affecting the oral mucosa. It is characterized by the recurrent appearance of ulcers (aphthae) and a prolonged course with periodic exacerbations.Purpose. To study the condition of the oral mucosa epithelium in patients with recurrent aphthous stomatitis undergoing treatment with antiseptics and reparative agents.This study examined samples of buccal epithelium from 64 patients, who were randomly divided into two equal groups: the first group used chlorhexidine as a mouthwash (control group); the second group used octenidine + phenoxyethanol for 7 days. For pain relief, patients in both groups applied a gel containing lidocaine + chamomile extract. After 7 days, the therapy continued with reparative agents (a hydrogel-based material with sodium alginate, Derinat, and lidocaine, deproteinized calf blood extract, and sea buckthorn oil). Each group was further divided into three subgroups for this part of the therapy. The condition of the buccal epithelium was assessed three times: before treatment, on the 7th day, and on the 21st day of therapy. Buccal epithelium preparations were prepared and analyzed using standard methods.Results. The analysis of cytogenetic and karyological indicators of buccal epithelial cells in patients with CRAS revealed that, at the peak of the inflammatory process, cells with micronuclei and various forms of nuclear protrusions were more frequently observed. During therapy, there was a notable reduction in buccal epithelial cells exhibiting these pathological features.Conclusion. Before therapy, patients with RAS exhibited cytogenetic instability and various karyological anomalies in the buccal epithelial cells of the oral mucosa. These anomalies included significantly higher occurrences of micronuclei, karyopyknosis, karyolysis, nuclear vacuolization, intercellular bridges, and chromatin condensation. During the different therapy regimens for RAS, normalization of the epithelial state of the oral mucosa was observed, with the most pronounced improvements seen with the use of octenidine + phenoxyethanol in combination with a hydrogel-based material containing sodium alginate, Derinat, and lidocaine.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141707590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of thigh fascia autograft for repairing a through-and-through soft tissue defect in the alveolar process: a clinical case 使用大腿筋膜自体移植修复牙槽突软组织穿通缺损:一个临床病例
Parodontologiya Pub Date : 2024-06-11 DOI: 10.33925/1683-3759-2024-917
S. A. Alishlalov, S. P. Sysolyatin, T. V. Serebrov, A. S. Handzratsyan
{"title":"Use of thigh fascia autograft for repairing a through-and-through soft tissue defect in the alveolar process: a clinical case","authors":"S. A. Alishlalov, S. P. Sysolyatin, T. V. Serebrov, A. S. Handzratsyan","doi":"10.33925/1683-3759-2024-917","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-917","url":null,"abstract":"Relevance. In most cases, soft tissue defects can be addressed using standard local flap transposition methods. However, large defects and/or those with scar tissue changes, through-and-through defects involving destruction of both vestibular and palatal cortical plates, defects penetrating into the nasal cavity, and similar situations necessitate unconventional solutions utilizing external graft materials.Clinical case description. This clinical case details the use of an autograft from the wide fascia of the thigh (Fascia lata) to repair an atypical defect of the alveolar process in the maxilla, specifically in the area of teeth 1.2 and 1.1. This defect exhibited through penetration between the vestibule of the oral cavity and the oral cavity proper, along with a significant deficiency of local tissues required for defect closure. The results of clinical, instrumental, and CT examinations conducted before and after the surgical intervention are presented.Results. Objective clinical studies conducted three months post-operation showed complete closure of the defect in the alveolar process of the maxilla, with full epithelization in the postoperative intervention area.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141358030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management strategy of a periodontist in treating a patient with bisphosphonate-related jaw osteonecrosis: a clinical case 牙周病医生治疗双膦酸盐相关颌骨骨坏死患者的管理策略:一个临床病例
Parodontologiya Pub Date : 2024-06-10 DOI: 10.33925/1683-3759-2024-894
D. D. Teremov, V. A. Rumyantsev
{"title":"Management strategy of a periodontist in treating a patient with bisphosphonate-related jaw osteonecrosis: a clinical case","authors":"D. D. Teremov, V. A. Rumyantsev","doi":"10.33925/1683-3759-2024-894","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-894","url":null,"abstract":"Relevance. Drug-related osteonecrosis of the jaws is a serious complication of antiresorptive therapy in patients with cancer, systemic osteoporosis, and Paget's disease, significantly impacting the patients' quality of life.Clinical case description. This article analyzes the progressive oral manifestations of a complication of antiresorptive therapy—drug-related osteonecrosis of the jaws—in a patient with breast cancer. The osteonecrosis was characterized by an exposed bone area in the upper jaw, periodontal inflammation, and a malodorous discharge from the mouth. The paper details the appropriate management strategy by the periodontist, tailored to the patient's individual characteristics.Conclusion. Early initiation of a conservative, comprehensive, and gentle treatment regimen can reduce inflammation in periodontal tissues, including the necrotic area, thus avoiding the need for high-risk surgical procedures.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141363012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementation of a predictive strategy in the diagnosis of inflammatory periodontal diseases 在牙周炎症性疾病诊断中实施预测策略
Parodontologiya Pub Date : 2024-06-07 DOI: 10.33925/1683-3759-2024-853
O. V. Eremin, L. Ostrovskaya, N. Zakharova, L. S. Kathanova, V. M. Morgunova, J. Kobzeva, M. Barulina, V. A. Tsitronov, D. Domenyuk
{"title":"Implementation of a predictive strategy in the diagnosis of inflammatory periodontal diseases","authors":"O. V. Eremin, L. Ostrovskaya, N. Zakharova, L. S. Kathanova, V. M. Morgunova, J. Kobzeva, M. Barulina, V. A. Tsitronov, D. Domenyuk","doi":"10.33925/1683-3759-2024-853","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-853","url":null,"abstract":"Relevance. The diagnosis of periodontal diseases, considering their severity, prevalence, progression, and staging, can be achieved by determining the levels of biomarkers or molecular imaging biomarkers in biofluids such as crevicular or sulcular fluid (GCF or GSF), saliva, and oral fluid. GCF is currently regarded as one of the diagnostically significant biological fluids for assessing the condition of periodontal tissues, not only in clinical diagnostic laboratories but also in dental offices. The implementation of sensitive, highly accurate, non-invasive, and specific methods for rapid GCF diagnosis, based on the qualitative analysis of biomarkers of cytokine imbalance, immunological disorders, changes in non-specific defence factors, and biophysical indicators, will allow for an objective assessment of the condition of periodontal tissues.Purpose. To improve the efficiency of periodontitis prevention using a developed mathematical model for personalized prediction of the course of inflammatory periodontal diseases based on the investigated biomarkers in GCF.Material and methods. The study included 101 patients: Group I consisted of 22 patients diagnosed with K05.10 (gingivitis), Group II included 31 patients diagnosed with K05.31 (mild periodontitis), and Group III comprised 18 patients diagnosed with K05.31 (moderate periodontitis). The comparison group consisted of 30 individuals with clinically healthy periodontium. All subjects underwent clinical and instrumental examination, determination of periodontal indices, GCF collection, and quantitative analysis of immune regulatory mediators (IL-1β, IL-6, TNF-α, IL-8, MCP-1, IL-17, VEGF, IL-1RA).Results. The study of immune regulatory mediators confirmed the significance of increased levels of pro- and anti-inflammatory cytokines/chemokines, as well as the reduction of the anti-inflammatory biomarker IL-1RA in GCF at the early stages of inflammatory changes in periodontal tissues. This is accompanied by the appearance of signs indicating the destruction of the dentogingival junction. Using logistic regression and training a multiclass classifier based on the support vector machine method, a model was developed to predict the risk of dentogingival junction loss in patients, potentially leading to periodontitis.Conclusion. The results of logistic regression modelling and training a multiclass classifier based on the support vector machine method demonstrate that in diagnosing the initial stages of periodontal tissue damage with the loss of the dentogingival junction (DGJ), the most effective approach is the comprehensive use of inflammatory process biomarkers and the development of multi-marker algorithms based on a computer program.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141373566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of palatally positioned mini-screws together with the Herbst appliance for rehabilitating adult patients with skeletal types of distal dental arch relationships: a clinical case 将腭侧定位微型螺钉与赫氏矫治器一起应用于远端牙弓关系骨骼类型的成年患者的康复:一个临床病例
Parodontologiya Pub Date : 2024-06-07 DOI: 10.33925/1683-3759-2024-863
R. Fadeev, N. D. Pirskii
{"title":"Application of palatally positioned mini-screws together with the Herbst appliance for rehabilitating adult patients with skeletal types of distal dental arch relationships: a clinical case","authors":"R. Fadeev, N. D. Pirskii","doi":"10.33925/1683-3759-2024-863","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-863","url":null,"abstract":"Relevance. Utilizing the Herbst appliance for managing distal occlusal relationships in patients with completed facial growth serves as an alternative to surgico-orthodontic methods. This approach, however, extends the treatment duration and necessitates stabilization of the upper molars following removal of the appliance when moving the anterior segment of the upper dentition distally.Objective. To clinically substantiate the feasibility of combining the Herbst appliance with palatally positioned mini-screws for treating distal dental occlusal relationships in adult patients.Description of сlinical сases. Clinical photographic documentation and diagnostic modeling of facial and dentition were conducted for two patients. This was complemented by the computation and analysis of jaw CT scans and profile cephalometric radiographs. The AMORF method was employed for a quantitative evaluation of dentomaxillofacial anomalies. Hypotheses were drawn based on the employment of a 6.0 mm micro-implant at the median suture in projection with teeth 1.6-2.6, alongside the Herbst appliance, suggesting potential stability of the upper molars during the distal repositioning of the anterior segment of the upper dentition.Conclusion. The outcomes from the documented clinical cases suggest that integrating palatally positioned mini-screws with the Herbst appliance facilitates stable positioning of the upper jaw’s first molars during the distal movement of the anterior segment, attributed to the solid support provided by the mini-screw implant.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141374836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of conventional cigarettes, e-cigarettes, and tobacco heating systems on the oral mucosa 传统香烟、电子烟和烟草加热系统对口腔黏膜的影响
Parodontologiya Pub Date : 2024-04-16 DOI: 10.33925/1683-3759-2024-877
S. V. Miklyaev, N. A. Blokhina, N. S. Chuprikov
{"title":"The impact of conventional cigarettes, e-cigarettes, and tobacco heating systems on the oral mucosa","authors":"S. V. Miklyaev, N. A. Blokhina, N. S. Chuprikov","doi":"10.33925/1683-3759-2024-877","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-877","url":null,"abstract":"Relevance. Over the past few years, the popularity of nicotine-containing substances and tobacco heating systems has continued to grow, while the demand for conventional tobacco leaf cigarettes has been falling. Electronic cigarettes consist of a heating system and a liquid with various flavorings. During the operation of the heating stick, the liquid is converted into an aerosol, which the user needs to inhale. First of all, the hot steam comes into contact with the oral cavity. The aerosol components settle on the oral mucosa, the approximal surfaces of the teeth, penetrating the body with a saliva current, expose the oral cavity to prolonged exposure, causing various changes in the oral cavity and causing discomfort to the smoker. This problem is urgent and based on the above, it is necessary to study all possible effects of cigarettes and electronic nicotine delivery systems on the human body.Purpose. To assess the impact of nicotine-containing products and smokeless tobacco on the oral mucosa.Materials and methods. A cohort of 98 patients, aged 20 to 60, was recruited for the study. Participants were divided into four groups: Group 1 consisted of conventional cigarette smokers; Group 2, users of vapes; Group 3, users of IQOS; and Group 4 included patients who used all three device types interchangeably.Results. The investigation identified a direct correlation between the participant's age, the device used, and their level of oral hygiene. The poorest oral hygiene was seen in Group 4, where individuals used a combination of conventional cigarettes, vapes, and IQOS. Although a majority acknowledged the harmful effects of tobacco products, only 33 participants were aware of the negative impacts associated with vapes and IQOS.Conclusion. The lack of regulation and awareness of the health risks associated with IQOS and vaping pose substantial challenges for healthcare, indicating a need for more research into these issues.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioelectrical activity in temporalis and masseter muscles across different gnathic types 不同咬肌类型的颞肌和颌下肌的生物电活动
Parodontologiya Pub Date : 2024-04-10 DOI: 10.33925/1683-3759-2024-884
E. V. Istomina, N. S. Grishina, N. Tsalikova, M. G. Grishkina
{"title":"Bioelectrical activity in temporalis and masseter muscles across different gnathic types","authors":"E. V. Istomina, N. S. Grishina, N. Tsalikova, M. G. Grishkina","doi":"10.33925/1683-3759-2024-884","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-884","url":null,"abstract":"Relevance. Discrepancies in the bioelectrical activity of the masseter muscle were observed through surface electromyography analysis. Despite the availability of scientific literature on the morphological and anatomical variances in the mastication muscles and subcutaneous adipose tissue across different gnathic types, these differences are often overlooked in the interpretation of surface electromyography absolute values.Materials and methods. A clinical evaluation, including the measurement of craniofacial parameters and an electromyography study of the right and left temporalis (RTA and LTA) and masseter muscles (RM and LM), was conducted on 73 individuals aged 21 to 24. Subjects were categorized based on upper and lower face gnathic type indices into three groups of 10: Group 1 (brachyfacial type), Group 2 (mesofacial type), and Group 3 (dolichofacial type). The study compared the surface electromyography-derived IMPACT index and average amplitude values of the muscles across groups, alongside analyzing the correlation between electromyographic values and gnathic type indices (GPDu.f./t-t and GPDl.f./ko-ko), with statistically significant differences noted at p ≤ 0.017.Results. Differences in RM and LM parameters, and the IMPACT index during the \"Maximal Voluntary Gnathic Clenching of the Jaws\" (MVC) test were statistically significant among the groups. An increase in both the IMPACT index and average masseter muscle values was noted in dolichofacial subjects. Significant variations in LM values during the MVC test were observed between dolichofacial and mesofacial subjects. In the MVC test, groups 1 and 3 demonstrated a moderately strong positive correlation between the IMPACT index and GPDu.f./t-t and GPDl.f./ko-ko, while a strong positive correlation was identified between the RM parameter and GPDu.f./t-t and GPDl.f./ko-ko.Conclusion. In the MVC test, the RM and LM parameters, as well as the average IMPACT index, were notably higher in dolichofacial subjects compared to other groups. A direct correlation between the mean right masseter bioelectrical activity and the average IMPACT index with the upper and lower facial gnathic indices was observed in brachyfacial and dolichofacial subjects in the MVC test.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140720490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Individualized management of chronic periodontitis in patients with orthodontic abnormalities: a clinical case report 正畸异常患者慢性牙周炎的个性化治疗:临床病例报告
Parodontologiya Pub Date : 2024-04-10 DOI: 10.33925/1683-3759-2024-913
S. L. Blashkova, Y. V. Fazylova, I. M. Shaidullin, I. Z. Urdyakov
{"title":"Individualized management of chronic periodontitis in patients with orthodontic abnormalities: a clinical case report","authors":"S. L. Blashkova, Y. V. Fazylova, I. M. Shaidullin, I. Z. Urdyakov","doi":"10.33925/1683-3759-2024-913","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-913","url":null,"abstract":"Relevance. Chronic periodontitis is a multifactorial disease influenced by a variety of factors. Beyond periodontal pathogens and systemic conditions, important contributing factors include malocclusion, dental misalignment, and tooth loss. These conditions can compromise the tissue blood flow hemodynamics and precipitate occlusal trauma with signs of functional overload. Subsequently, this may intensify the inflammation and degradation of the alveolar bone, often leading to premature tooth loss.Correction of malocclusion is paramount in the effective management of periodontal diseases, requiring orthodontic treatment to resolve malocclusion and mitigate signs of functional overload. This treatment aims to redistribute occlusal forces uniformly, thus creating a conducive environment for successful prosthodontic rehabilitation and promoting optimal personal oral hygiene.Clinical case description. This article outlines a personalized approach to managing periodontal inflammation in individuals with orthodontic anomalies. Patient Z., born in 2002, was diagnosed with moderate severity chronic periodontitis (K05.31), presenting with a Class I molar and canine relationship on both sides, constricted dental arches, individual tooth macrodontia, and retrusion and torsiversion of the incisors. The assessment of the patient's periodontal status and overall health was conducted using standard clinical, radiographic, and laboratory diagnostics, whereas the orthodontic assessment involved anthropometric analysis of dental casts and lateral cephalometric radiographs. The periodontal intervention included foundational non-surgical treatments such as ultrasonic scaling both supra- and subgingivally, biofilm disruption using the Vector Paro system, and specific pharmacotherapy. The orthodontic treatment aimed to widen both dental arches and correct the inclination of the upper and lower incisors, achieving a normal occlusion with fixed orthodontic appliances (Damon Q brackets) in accordance with the treatment plan. The effectiveness of the treatment was measured by examining the improvement in gingival conditions, periodontal parameters, and radiographic evidence before and after the intervention.Conclusion. The research demonstrated that an individualized treatment protocol integrating periodontal and orthodontic care can substantially improve the overall health of the dentofacial complex, masticatory efficiency, and aesthetic aspects.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140717649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive assessment of dental implant procedures: a comparative study on different antibiotic prophylaxis regimens 牙科植入手术的综合评估:不同抗生素预防方案的比较研究
Parodontologiya Pub Date : 2024-04-08 DOI: 10.33925/1683-3759-2024-889
V. R. Gabidullina, A. Tsitsiashvili, A. V. Volkov, N. Stankova, A. V. Zaborovsky, V. Tsarev, A. Panin, V. V. Podporina
{"title":"Comprehensive assessment of dental implant procedures: a comparative study on different antibiotic prophylaxis regimens","authors":"V. R. Gabidullina, A. Tsitsiashvili, A. V. Volkov, N. Stankova, A. V. Zaborovsky, V. Tsarev, A. Panin, V. V. Podporina","doi":"10.33925/1683-3759-2024-889","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-889","url":null,"abstract":"Relevance. The administration of antibiotics in implantology is indicated to prevent suppurative inflammation conditions. Two regimens are commonly used: a single preoperative dose or prolonged postoperative antibiotic administration. Due to ethical constraints, certain parameters of antibiotic efficacy cannot be directly evaluated within clinical trials. These include the status of the implant-mandibular segment microbiome and the histological parameters of the tissue's inflammatory response at the implant site.Materials and methods. This study employed a miniature pig model comprising 10 males. The cohort was equally divided into two groups of five animals each. Group 1 received a single preoperative dose of amoxicillin/clavulanic acid 2 ml per 20 kg body weight. Group 2 received the same initial dose prior to implantation, followed by a daily postoperative dose of amoxicillin/clavulanic acid at 1 ml per 20 kg body weight for five days. Each animal received six dental implants. An implant site microbiological test was performed pre-surgery, on Day 1, 3, 7 and 14 post-surgery. Core needle biopsies for histological examination of the tissues were performed on the same postoperative days.Results. Microbiological testing revealed that Group 2 exhibited lower levels of Streptococcus spp. on Day 3 (p = 0.04) and Porphyromonas spp. on Day 7 (p = 0.04). Group 1 demonstrated reduced levels of Fusobacterium spp. on Day 1 (p = 0.02) and Porphyromonas spp. both pre-surgery (p = 0.04) and on Day 1 (p = 0.012). Comparative analysis of histological assays from the implant sites indicated identical tissue inflammatory responses, regardless of the antibiotic prophylaxis regimen.Conclusion. Both the single-dose and the prolonged antibiotic prophylaxis regimens, using amoxicillin/clavulanic acid for dental implantation, demonstrated similar histological patterns of tissue inflammation at the implant site, along with comparable microbiota profiles within the implant site. The oral mucosa exhibited an increased population of Staphylococcus spp. and Streptococcus spp., which might contribute to the development of resistant strains, as well as Candida spp., potentially increasing the risk of candidiasis infection onset.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vacuum laser therapy as part of combined treatment for plaque-induced gingivitis 真空激光疗法作为斑块引起的牙龈炎综合疗法的一部分
Parodontologiya Pub Date : 2024-04-02 DOI: 10.33925/1683-3759-2024-875
S. N. Ermoliev, I. S. Agafonova, Sh. L. Shimanskiy, V. Atrushkevich
{"title":"Vacuum laser therapy as part of combined treatment for plaque-induced gingivitis","authors":"S. N. Ermoliev, I. S. Agafonova, Sh. L. Shimanskiy, V. Atrushkevich","doi":"10.33925/1683-3759-2024-875","DOIUrl":"https://doi.org/10.33925/1683-3759-2024-875","url":null,"abstract":"Relevance. The increasing prevalence of plaque-induced gingivitis among the working-age population worldwide is leading to more cases of tooth loss and diminished quality of life, highlighting the need for early intervention in periodontal inflammation. Given the rising resistance of periodontal flora to pharmacological treatments and the potential for macroorganism sensitization, exploring the efficacy of non-pharmacological interventions that stimulate adaptive mechanisms in periodontal tissues becomes crucial for managing plaque-induced gingivitis effectively.Materials and Methods. This investigation details the findings from young adults who consented to participate after being informed about the study's protocol. The focus was on evaluating the clinical and functional health of intact periodontal tissues showing early signs of inflammation at the beginning of the treatment, upon completion, and one month after treatment. In addition to standard periodontal treatment, subjects in the experimental cohort underwent daily vacuum laser therapy sessions using a 650 nm wavelength red laser at a pulse rate of up to 10 Hz. Functional monitoring was performed utilizing vital computer capillaroscopy and dynamic vacuum sampling to evaluate capillary resistance in the microcirculation of periodontal tissues.Results. Vacuum laser therapy demonstrated significant therapeutic benefits in treating plaque-induced gingivitis, notably reducing the diameter of capillaries by approximately 14.5%. This reduction was attributed to enhanced capillary resistance and normalized microvascular wall permeability. Notably, the time to petechial formation doubled following dosed vacuum application to periodontal tissues, indicating enhanced reticuloendothelial system activity and capillary network regeneration. Patient assessments using the oral health index showed notable improvements in oral hygiene and the absence of inflammation signs.Conclusion. The study's results affirm the effectiveness of combining vacuum laser therapy with conventional treatment modalities for plaque-induced gingivitis, highlighting its benefits in improving periodontal health without relying on pharmacological interventions.","PeriodicalId":509759,"journal":{"name":"Parodontologiya","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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