Acta Endocrinologica-Bucharest最新文献_第8页

PHEOCHROMOCYTOMA, THE GREAT MASQUERADER, PRESENTING AS REVERSIBLE CARDIOMYOPATHY: PRIMUM NON NOCERE. 嗜铬细胞瘤--大伪装者，表现为可逆性心肌病：不可忽视。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.370

H Boro, H Sharma, D Mittal, R S Kaswan, D P Saran, N Nagar, M S Jakhar, L Goyal, S Saini, V Joshi, S Chugh, V Bundela, V Mannar, L Nagendra, S Agstam

{"title":"PHEOCHROMOCYTOMA, THE GREAT MASQUERADER, PRESENTING AS REVERSIBLE CARDIOMYOPATHY: PRIMUM NON NOCERE.","authors":"H Boro, H Sharma, D Mittal, R S Kaswan, D P Saran, N Nagar, M S Jakhar, L Goyal, S Saini, V Joshi, S Chugh, V Bundela, V Mannar, L Nagendra, S Agstam","doi":"10.4183/aeb.2023.370","DOIUrl":"10.4183/aeb.2023.370","url":null,"abstract":"Background: Pheochromocytoma, the great masquerader, can have a varied spectrum of clinical manifestations. It can often cause a diagnostic challenge despite the availability of modern investigation modalities.Case: We present the case of a 38-year-old male who presented with uncontrolled hypertension for the past 10 years and heart failure for one year. The diagnosis of pheochromocytoma was missed in the initial setting, leading to a biopsy of the retroperitoneal mass. Fortunately, the patient survived the procedure. Subsequently, with the involvement of a multi-disciplinary team, he was optimized for surgery under strict cardiac monitoring. After the complete excision of the tumour, he showed significant improvement not only in his clinical symptoms but also in his cardiac status.Conclusions: This case emphasizes the age-old medical phrase of 'Primum non nocere or first, do no harm'. Any invasive procedure in a pheochromocytoma can lead to a massive release of catecholamines causing a hypertensive crisis, pulmonary oedema, and even cardiac arrest. Any young patient presenting with hypertension or heart failure should be investigated for secondary causes. Cardiomyopathy due to pheochromocytoma is because of catecholamine overload and usually reverses or improves after curative surgery.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"370-375"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARISON OF C-PEPTIDE LEVELS IN MONOGENIC FORMS OF DIABETES WITH OTHER TYPES OF DIABETES: A SINGLE-CENTER STUDY. 单基因糖尿病与其他类型糖尿病的 c 肽水平比较：单中心研究。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.281

D Geneş, Z Pekkolay, M Şimşek, H Saraçoğlu, M Turgut, S Tekeş, A K Tuzcu

{"title":"COMPARISON OF C-PEPTIDE LEVELS IN MONOGENIC FORMS OF DIABETES WITH OTHER TYPES OF DIABETES: A SINGLE-CENTER STUDY.","authors":"D Geneş, Z Pekkolay, M Şimşek, H Saraçoğlu, M Turgut, S Tekeş, A K Tuzcu","doi":"10.4183/aeb.2023.281","DOIUrl":"10.4183/aeb.2023.281","url":null,"abstract":"Objective: This study aimed to evaluate the utility of C-peptide levels in the differentiation of monogenic forms of diabetes from type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in clinical practice.Subjects and methods: A total of 104 patients aged >16 who visited the Dicle University's Faculty of Medicine between April 2011 and December 2020 and were diagnosed with monogenic diabetes by genetic analysis or with T1DM and T2DM were randomly selected for retrospective evaluation. The C-peptide levels of these patients at the time of diagnosis of diabetes were compared.Results: Of the 104 patients, 24 (23%) were diagnosed with maturity-onset diabetes of the young (MODY), 40 (38.5%) with T1DM, and 40 (38.5%) with T2DM. Median C-peptide levels (ng/mL) (interquartile range) were 1.78 (1.24-2.88) in MODY group, 0.86 (0.34-1.22) in T1DM group, and 2.38 (1.58-4.27) in T2DM group.Conclusions: There was a difference in C-peptide levels between MODY and T1DM groups but not between MODY and T2DM groups. As per clinical evaluations, although C-peptide levels of patients with MODY are similar to those of patients with T2DM patients, the possibility of C-peptide levels being similar to those required for T1DM diagnosis should also be considered.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"281-285"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PITUITARY FUNCTIONS AFTER RECOVERY FROM COVID-19. 从covid-19中恢复后的垂体功能。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.314

M G Kaya, R Alanli, M B Kucukay, F B Ulukaya, F Bakir

{"title":"PITUITARY FUNCTIONS AFTER RECOVERY FROM COVID-19.","authors":"M G Kaya, R Alanli, M B Kucukay, F B Ulukaya, F Bakir","doi":"10.4183/aeb.2023.314","DOIUrl":"10.4183/aeb.2023.314","url":null,"abstract":"Context: Injury and functional disorders in pituitary gland after COVID-19 still need elucidation.Objective: To investigate pituitary functions, particularly hypothalamic pituitary adrenal (HPA) axis after COVID-19 infection.Methods: This study was conducted at a university hospital between May and October 2021. Patients who had COVID-19, were enrolled as study group, three months after recovery. Participants who do not have COVID-19 diagnosis, with similar characteristics were included as control group. Blood samples were taken on the morning at 08 AM. Adrenal stimulation test was performed with 1 µg of ACTH (Synacthen).Results: The study group included 50 patients and control group was 49 cases. One (2%) out of the 50 patients with 8 a.m. serum cortisol below 5 µg/dL. Low serum ACTH levels were detected in 7 (14%) participants in patient group. Stimulation with 1 µg of ACTH (Synacthen) test was performed for 2 (4%) of 50 patients with serum cortisol below 10 µg/dL. Both patients achieved a peak cortisol of over 12.5 µg/dL after stimulation. Standard deviation (SD) score for insulin like growh factor-1 (IGF-1) was lower than -2 SD for age and gender in 7 (14%) patients. TSH levels was mildly increased in five (10%) patients. There was no significant difference in baseline pituitary hormone levels in study and control groups.Conclusion: Basal pituitary hormone levels and HPA axes were found to be preserved and competently functioning in patients who experienced mild/moderate COVID-19. However, symptoms observed after COVID-19 episode were evident in substantial amount of patients in this study and these symptoms were not associated with changes in pituitary gland function.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"314-318"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CASE REPORT OF HAND AND FOOT SKIN CHANGES RESEMBLING PTU-INDUCED VASCULITIS IN A YOUNG MALE WITH DIFFUSE TOXIC GOITRE. 一名患有弥漫性毒性甲状腺肿的年轻男性手足皮肤变化类似于 ptu 引起的血管炎的病例报告。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.380

M Tomasovic, M Sinik, Z Gluvic, S Zafirovic, Esma R Isenovic

{"title":"A CASE REPORT OF HAND AND FOOT SKIN CHANGES RESEMBLING PTU-INDUCED VASCULITIS IN A YOUNG MALE WITH DIFFUSE TOXIC GOITRE.","authors":"M Tomasovic, M Sinik, Z Gluvic, S Zafirovic, Esma R Isenovic","doi":"10.4183/aeb.2023.380","DOIUrl":"10.4183/aeb.2023.380","url":null,"abstract":"Context: Propylthiouracil (PTU) could cause lupus or vasculitis-like hypersensitivities thus interfering with some other concomitant diseases.Objective: Clinicians must be aware of the side effects of medications, particularly after their introduction and long-term use. Some clinical manifestations may be similar to well-known drug side effects or hypersensitivity. Every unusual clinical scenario related to drug use must be evaluated individually and thoroughly.Subjects and methods: Hands and feet skin changes were observed several days after PTU administration in a male patient with severe diffuse toxic goitre. A complete blood count, biochemistry analyses, thyroid function tests and antibodies, and immunology analyses were performed.Results: As the skin changes were distributed regionally, liver function tests were normal, and there were no signs of clinical deterioration, it was decided to continue PTU treatment and monitor the patient. The initial maculopapular rash quickly turned vesicular, then scaly. After two weeks, the skin changes were wholly restored, with no scarring. Hand, Foot, and Mouth disease (HFMD) was diagnosed after a thorough epidemiological survey and clinical workout.Conclusions: Our case study demonstrates that skin changes associated with HFMD may resemble those associated with PTU-induced vasculitis.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"380-385"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

INSULIN RESISTANCE AND PATHOGENESIS OF POSTMENOPAUSAL OSTEOPOROSIS. 胰岛素抵抗和绝经后骨质疏松症的发病机制。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.349

D I I Greere, F Grigorescu, D Manda, C Lautier, C Poianã

{"title":"INSULIN RESISTANCE AND PATHOGENESIS OF POSTMENOPAUSAL OSTEOPOROSIS.","authors":"D I I Greere, F Grigorescu, D Manda, C Lautier, C Poianã","doi":"10.4183/aeb.2023.349","DOIUrl":"10.4183/aeb.2023.349","url":null,"abstract":"Osteoporosis (OP) is a disease predisposing postmenopausal women to fractures, and often accompanied by insulin resistance (IR) and metabolic syndrome (MetS). Previous studies provided contradictory results concerning prevalence of MetS in postmenopausal OP. To better understand the pathogenesis of IR, we reviewed cellular and molecular aspects and systematically reviewed studies providing homeostasis model assessment (HOMA) index. Bone is an active endocrine organ maintaining its integrity by orchestrated balance between bone formation and resorption. Both osteoblasts and osteoclasts contain receptors for insulin and insulin-like growth factor-1 (IGF-1) operating in skeletal development and in the adult life. Defects in this system generate systemic IR and bone-specific IR, which in turn regulates glucose homeostasis and energy metabolism through osteocalcin. Examination of genetic syndromes of extreme IR revealed intriguing features namely high bone mineral density (BMD) or accelerated growth. Studies of moderate forms of IR in postmenopausal women reveal positive correlations between HOMA index and BMD while correlations with osteocalcin were rather negative. The relation with obesity remains complex involving regulatory factors such as leptin and adiponectin to which the contribution of potential genetic factors and in particular, the correlation with the degree of obesity or body composition should be added.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"349-363"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PAGET'S DISEASE OF THE BONE FOUND INCIDENTALLY ON F-18 FDG PET/CT: CLINICAL SIGNIFICANCE AND DIFFERENTIAL DIAGNOSTIC CRITERIA. 在 F-18 FDG PET/CT 上偶然发现的骨的帕吉特氏病：临床意义和鉴别诊断标准。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.292

F Üstün, F E Ustabaşıoğlu, B Tokuç, B Yımaz Bülbül, M Çelik, S Aytürk

{"title":"PAGET'S DISEASE OF THE BONE FOUND INCIDENTALLY ON F-18 FDG PET/CT: CLINICAL SIGNIFICANCE AND DIFFERENTIAL DIAGNOSTIC CRITERIA.","authors":"F Üstün, F E Ustabaşıoğlu, B Tokuç, B Yımaz Bülbül, M Çelik, S Aytürk","doi":"10.4183/aeb.2023.292","DOIUrl":"10.4183/aeb.2023.292","url":null,"abstract":"Background: Paget Disease (PD) is usually asymptomatic and discovered incidentally, it is known that it is exhibited low to high grade increased F-18 FDG uptake.Aim: In this study, we investigated the distinguishability of FDG PET/CT in incidental PD cases from other bone diseases and at different stages of the disease.Patients and methods: In this cross-sectional, descriptive study, \"Paget\" identification associated with PET/CT reports was found in 69 of 18,119 studies (~3.8%). Of the 45 patients (33 males and 12 females) eligible for inclusion in the study, 35.6% had monostotic and 64.4% had polyostotic disease (p>0.5). There was no statistically significant difference in biochemical parameters between groups.Results: According to the radiological appearance of the patients, 36 were in the mixed stage and 9 were in the blastic stage. Only the difference in ALP and creatinine values between the groups was statistically significant. SUVmax, SUVmean and HU values were found to be statistically significantly higher in pagetoid bones compared to control bone lesions. For SUVmax for PD bone lesion we found the 2.55 cutoff point with a sensitivity of 91% and a specificity of 84%.Conclusion: The specific radiological appearance of bone lesions and the evaluation of metabolic activity compared to normal bone seem to help differentiate PD from other lesions. Prospective studies are needed in the differentiation of FDG's disease stage and treatment response evaluation. The ability to differentiate between benign and malignant FDG avid bone lesions in oncological patients' enables appropriate patient management, including avoiding unnecessary additional invasive procedures such as bone biopsy.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"292-300"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETROPERITONEAL PARAGANGLIOMA MANIFESTED AS ACUTE ABDOMEN DUE TO INTRATUMOR HEMORRHAGE. 腹膜后副神经节瘤因瘤内出血而表现为急腹症。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.396

M P Calderón, E Ruiz-Carazo, A J Láinez Ramos-Bossini

引用次数: 0

EVALUATION OF FETUIN-A LEVELS IN THE EARLY STAGE OF AUTOIMMUNE THYROIDITIS. 评估自身免疫性甲状腺炎早期的胎儿素-a水平。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.301

E Söbü, Z Yildiz, A Karaaslan, C Çetin, B Berk Akbeyaz, G D Kaya Özçora, B Yilmaz

{"title":"EVALUATION OF FETUIN-A LEVELS IN THE EARLY STAGE OF AUTOIMMUNE THYROIDITIS.","authors":"E Söbü, Z Yildiz, A Karaaslan, C Çetin, B Berk Akbeyaz, G D Kaya Özçora, B Yilmaz","doi":"10.4183/aeb.2023.301","DOIUrl":"10.4183/aeb.2023.301","url":null,"abstract":"Context: Fetuin-A is a multifunctional protein and is known to be related to metabolic syndrome, vascular calcification, and inflammation.Objective: The purpose of this study was to determine the effects of serum fetuin-A levels on autoimmune thyroiditis without thyroid dysfunction.Subjects and methods: This prospective case-control study was performed at the pediatric endocrinology outpatient clinic of a tertiary health institution in Istanbul, Turkey between July 2022 and October 2022. Serum fetuin-A levels were assessed using a human fetuin-A enzyme-linked immunosorbent assay (ELISA) kit (Elabscience Biotechnology, Houston, TX, USA).Results: The study included 86 participants, of which 42 were patients with Hashimoto's thyroiditis (HT) and 44 were controls. Autoimmune thyroiditis without thyroid dysfunction was found to be related to lower plasma fetuin-A levels. There were no statistically significant differences in the neutrophil-to-lymphocyte ratio, fasting blood glucose level, insulin level, or HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) value between the groups. A fetuin-A level of ≤162.22 µg/mL (80.95% sensitivity and 70.45% specificity) was found to support the identification of autoimmune thyroiditis.Conclusions: The findings of our study suggest that autoimmune thyroiditis without thyroid dysfunction is related to lower fetuin-A levels. Low fetuin-A levels are known to be associated with an increased risk of cardiovascular disease, suggesting that careful monitoring is required in patients with low fetuin-A levels.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"301-306"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PAPILLARY THYROID CARCINOMA FOLLOWING ADALIMUMAB TREATMENT IN ANKYLOSING SPONDYLITIS: A CAUSAL OR COINCIDENTAL ASSOCIATION? 强直性脊柱炎患者接受阿达木单抗治疗后发生甲状腺乳头状癌：是因果关系还是巧合？

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.376

S Uslu

{"title":"PAPILLARY THYROID CARCINOMA FOLLOWING ADALIMUMAB TREATMENT IN ANKYLOSING SPONDYLITIS: A CAUSAL OR COINCIDENTAL ASSOCIATION?","authors":"S Uslu","doi":"10.4183/aeb.2023.376","DOIUrl":"10.4183/aeb.2023.376","url":null,"abstract":"The introduction of tumor necrosis factor-alpha (TNF-α) targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of ankylosing spondylitis (AS). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects, ranging from common ones, including infections, to uncommon thyroid neoplasms. Adalimumab (ADA), a fully human monoclonal antibody targeted against TNF-α, is indicated for AS. We describe the case of a patient with AS who developed a papillary thyroid carcinoma (PTC) while on therapy with ADA. Cervical lymphadenopathy and a heterogeneous nodule in the right thyroid lobe were detected in the 48-year-old female patient who had been using ADA (40 mg subcutaneously every 2 weeks) for 2 years with the diagnosis of AS. Fine-needle aspiration cytology confirmed PTC. ADA treatment was discontinued, and a total thyroidectomy surgery was performed. We believe that the thyroid gland should also be taken into consideration while screening for malignancy before and during TNF inhibitors (TNFi).","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"376-379"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139737097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VITAMIN D DEFICIENCY AS AN INDEPENDENT PREDICTOR OF CARDIOVASCULAR DISEASE. 维生素 d 缺乏症是心血管疾病的独立预测因素。

IF 1 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI: 10.4183/aeb.2023.319

C F Frentusca, K Babes, D I Galusca

{"title":"VITAMIN D DEFICIENCY AS AN INDEPENDENT PREDICTOR OF CARDIOVASCULAR DISEASE.","authors":"C F Frentusca, K Babes, D I Galusca","doi":"10.4183/aeb.2023.319","DOIUrl":"10.4183/aeb.2023.319","url":null,"abstract":"Context: In addition to traditional risk factors for cardiovascular diseases, there are new risk factors with potentially relevant prognostic, such as vitamin D deficiency.Objective: The study aims to analyze the relationship between vitamin D deficiency and the occurrence of cardiovascular disease, in patients who already have at least one cardiovascular risk factor.Design: It is a prospective, observational study. Follow- up time was 24 months.Subjects and methods: A total of 77 patients were included in the study, aged over 18 years, who had at least one cardiovascular risk factor. Their vitamin D levels were measured and they were monitored for a period of 2 years, in order to see which one developed cardiovascular diseases.Results: Of the 77 patients, 56 (72.7%) had serum deficient levels of vitamin D and the mean serum level was 16 ng/mL (± 8.6 ng/mL). Statistically significant differences were observed only in the case of dyslipidemia (p=0.0334). The evolution to cardiovascular disease occurred in 39 of the cases (50.6%). The only independent risk factors for progression to cardiovascular disease demonstrated in this study were serum vitamin D (OR = 0.9024, 95% CI: 0.83-0.97 and age (OR = 1.1313, 95% CI: 1.05-1.21).Conclusion: The results shows that patients with cardiovascular risk factors and advanced age are at a higher risk of developing cardiovascular disease, if they also have vitamin D deficiency.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"19 3","pages":"319-325"},"PeriodicalIF":1.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10863965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139736600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0