Acta Endocrinologica-Bucharest最新文献

FROM "INFANTILE" TO ELDERLY: A RARE CAUSE OF HYPERCALCEMIA NOT TO BE MISSED IN THE GERIATRIC POPULATION. 从“婴儿”到老年人：在老年人群中不可错过的高钙血症的罕见原因。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.272

Ö Baş Aksu, H Güngör, C B Leblebici, N Kutlay, M F Erdoğan

{"title":"FROM \"INFANTILE\" TO ELDERLY: A RARE CAUSE OF HYPERCALCEMIA NOT TO BE MISSED IN THE GERIATRIC POPULATION.","authors":"Ö Baş Aksu, H Güngör, C B Leblebici, N Kutlay, M F Erdoğan","doi":"10.4183/aeb.2025.272","DOIUrl":"10.4183/aeb.2025.272","url":null,"abstract":"Idiopathic infantile hypercalcemia (IIH) is a rare, parathyroid hormone (PTH)-independent disorder of calcium metabolism. It is most often caused by mutations in the CYP24A1 gene that impair vitamin D catabolism. We report a 70-year-old male with persistent hypercalcemia (Ca 13.2 mg/dL) and low-normal PTH levels. Extensive evaluation excluded malignancy, granulomatous disease, and vitamin D intoxication. Genetic analysis revealed a homozygous CYP24A1 variant (c.233G>T; p.Gly78Val), consistent with CYP24A1 deficiency. Bisphosphonate therapy with zoledronic acid rapidly and sustainably normalized calcium levels for 10 months. The patient's daughter was a heterozygous carrier. This confirmed autosomal-recessive inheritance. This case illustrates an atypical late-onset presentation of CYP24A1 deficiency. It emphasizes the importance of considering this diagnosis in adults with PTH-independent hypercalcemia, especially when seasonal variation and family history are present. Recognition of CYP24A1 deficiency at all ages highlights the need for genotype-based terminology rather than the misleading label \"infantile\" hypercalcemia.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"272-276"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACROMEGALY AND MYBPC3 MUTATION: A SYNERGISTIC IMPACT ON CARDIOMYOPATHY DEVELOPMENT. 肢端肥大症和mybpc3突变：对心肌病发展的协同影响。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.256

I Tekin, I Büber, S Topsakal

{"title":"ACROMEGALY AND MYBPC3 MUTATION: A SYNERGISTIC IMPACT ON CARDIOMYOPATHY DEVELOPMENT.","authors":"I Tekin, I Büber, S Topsakal","doi":"10.4183/aeb.2025.256","DOIUrl":"10.4183/aeb.2025.256","url":null,"abstract":"Acromegaly is commonly associated with cardiomyopathy due to chronic overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), leading to biventricular hypertrophy, diastolic dysfunction, and in advanced cases, systolic dysfunction and heart failure. This case report presents a 42-year-old male diagnosed with acromegaly, who underwent successful resection of a pituitary macroadenoma. At diagnosis, GH was 12.0 [ng/mL] and IGF-1 was 670 [ng/mL] (age-adjusted ULN: 218). An oral glucose tolerance test was performed; GH failed to suppress below 7.20 [ng/mL]. Despite surgical intervention, the patient experienced persistent cardiac symptoms including exertional dyspnea and breathlessness, which prompted further cardiovascular evaluation. Cardiac examinations revealed significant hypertrophy of the interventricular septum and the left ventricular anterior wall, findings confirmed by echocardiography and cardiac magnetic resonance. Remarkably, genetic analysis identified a heterozygous mutation in the MYBPC3 gene, known to cause hypertrophic cardiomyopathy. This mutation likely exacerbated the patient's cardiac condition, suggesting a compounded effect of acromegaly and a genetic predisposition to cardiomyopathy. This case underscores the importance of considering genetic factors in acromegalic patients presenting with cardiomyopathy to tailor personalized management strategies. Further research is warranted to explore the interplay between hormonal excess and genetic mutations in cardiomyopathy development.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"256-260"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STRONG IMPLICATION OF TNF-α AND IL8 GENES POLYMORPHISMS WITH AUTOIMMUNE THYROID DISEASES IN TUNISIAN POPULATION. tnf -α和il8基因多态性与突尼斯人群自身免疫性甲状腺疾病的强烈含义

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.192

I Zaaber, H Marmouch, B Bel Hadj Jrad Tensaout, S Mestiri

{"title":"STRONG IMPLICATION OF TNF-α AND IL8 GENES POLYMORPHISMS WITH AUTOIMMUNE THYROID DISEASES IN TUNISIAN POPULATION.","authors":"I Zaaber, H Marmouch, B Bel Hadj Jrad Tensaout, S Mestiri","doi":"10.4183/aeb.2025.192","DOIUrl":"10.4183/aeb.2025.192","url":null,"abstract":"Background: Autoimmune thyroiditis, such as Graves' disease (GD) and Hashimoto's thyroiditis (HT), is a complex, genetically linked condition. IL-8 and TNF-α play a crucial role in these pathologies.Methods: This research was conducted on Tunisian patients with autoimmune thyroiditis (AITD) to examine the link between genetic variations in the IL-8 and TNF-α genes, their protein expression, and the likelihood of developing GD or HT. A total of 319 healthy controls, 230 patients with HT, and 75 patients with GD underwent genotyping via PCR-RFLP for the TNF-α-238 G/A and IL-8+781C>T polymorphisms. Plasma levels of IL-1β and TNF-α were also quantified.Results: The IL-8-781 T/T genotype and the IL-8-781 T allele were detected more frequently in HT and GD patients than in control participants. Patients with hypertension exhibited a higher frequency of the TNFA-238 G/A genotype and the TNFA-238 A allele compared to control individuals. However, no significant variation was observed in IL-8 and TNFA protein expression between patients and controls.Conclusions: The strong association between the IL-8-781C/T and TNFA-238 G/A polymorphisms and HT and GD suggests that these polymorphisms may play a crucial role in susceptibility to AITD within the Tunisian population.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"192-200"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A RARE DETERMINATION OF SMALL LYMPHOCYTIC LYMPHOMA ASSOCIATED WITH UNFAVORABLE EVOLUTION AND REVIEW OF THE LITERATURE. 一个罕见的小淋巴细胞性淋巴瘤与不利的演变和文献回顾。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.261

M Andreescu, V M Popov, A S Ionescu, I Bengulescu, B Diaconescu, M C Voicu, C Dobrea, I Dumitru, M Jianu, H Bumbea

{"title":"A RARE DETERMINATION OF SMALL LYMPHOCYTIC LYMPHOMA ASSOCIATED WITH UNFAVORABLE EVOLUTION AND REVIEW OF THE LITERATURE.","authors":"M Andreescu, V M Popov, A S Ionescu, I Bengulescu, B Diaconescu, M C Voicu, C Dobrea, I Dumitru, M Jianu, H Bumbea","doi":"10.4183/aeb.2025.261","DOIUrl":"10.4183/aeb.2025.261","url":null,"abstract":"Small lymphocytic lymphoma (SLL) is an indolent lymphoma. Hypercalcemia is rarely associated with this type of lymphoma and was reported as a Richter`s transformation sign of SLL in the literature. We report a case of a 64-year-old man, with many comorbidities, including cardiac and renal pathologies, known with hepatitis B. Small lymphocytic B lymphoma with genetic risk factors, such as TP53, 17p and unmutated IGHV was diagnosed by laterocervical node biopsy. During chemotherapy, the patient initially presented sciatic pain, leading to the suspicion of a new associated malignancy, but the lumbar MRI excluded osteolysis. A few weeks later, the patient presented with neurological symptoms and dangerous hypercalcemia and high levels of iPTH were discovered. Parathyroid determination was discovered and the second line therapy with Venetoclax- Rituximab was chosen, but unfavorable evolution was noted, with activated macrophage syndrome, disseminated intravascular coagulation and multiple organ dysfunction syndrome. The genetic risk factors and the presence of hypercalcemia are markers of negative prognosis and unfavorable evolution of the disease.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"261-264"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VALUE OF THE INDOCYANINE GREEN FLUORESCENCE SCORE IN PREDICTING POSTOPERATIVE HYPOPARATHYROIDISM IN THYROID SURGERY - A PROSPECTIVE OBSERVATIONAL STUDY. 吲哚菁绿荧光评分预测甲状腺手术后甲状旁腺功能减退的价值——一项前瞻性观察研究。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.153

R Boanta, M Misca, I Sabaru, V Grigorean, R Smarandache, V Strambu, I Brezean

{"title":"VALUE OF THE INDOCYANINE GREEN FLUORESCENCE SCORE IN PREDICTING POSTOPERATIVE HYPOPARATHYROIDISM IN THYROID SURGERY - A PROSPECTIVE OBSERVATIONAL STUDY.","authors":"R Boanta, M Misca, I Sabaru, V Grigorean, R Smarandache, V Strambu, I Brezean","doi":"10.4183/aeb.2025.153","DOIUrl":"10.4183/aeb.2025.153","url":null,"abstract":"Context: Postoperative hypoparathyroidism is the most frequent complication of total thyroidectomy (transient form, 19-38%). Indocyanine green (ICG) fluorescence imaging is validated for parathyroid perfusion assessment; its predictive value combined with strict in situ preservation has not been reported in Romania.Objective: To evaluate the predictive performance of the Vidal Fortuny ICG score for transient postoperative hypoparathyroidism.Design: Prospective observational single-centre study (February 2024 - February 2025) at the National Institute of Endocrinology \"C.I. Parhon\", Bucharest.Subjects and methods: Twenty-four consecutive adults received intraoperative ICG (5 mg IV; Karl Storz IMAGE1 S™ Rubina®) during thyroid surgery. Each parathyroid gland (PG) was assigned an ICG score (0/1/2) and a signal-to-background ratio versus the common carotid artery. Primary endpoint: biochemical hypoparathyroidism at 24 hours (PTH < 15 pg/mL or total Ca < 8.0 mg/dL).Results: Twenty-one women and 3 men; mean age 55.2 ± 14.1 years. All four PGs were identified in every patient (96/96, 100%). Score distribution (score 2/ 1/ 0): 63.5%/ 32.3%/ 4.2%. Transient hypoparathyroidism: 25.0%; dysphonia at 6 weeks: 0%. Sensitivity 66.7%, specificity 100%, PPV 100%, NPV 90%; LR- 0.33 (LR+ undefined: specificity 100%).Conclusions: As an adjunct to careful anatomical dissection, the ICG score reliably identifies devascularized parathyroid glands (specificity and PPV both 100%). In situ preservation without autotransplantation was safe. ICG complements anatomical dissection and warrants routine integration.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"153-163"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COMPARATIVE GROWTH OUTCOMES OF LONG-ACTING AND SHORT-ACTING GROWTH HORMONE THERAPY IN PEDIATRIC PATIENTS: A 12-MONTH RETROSPECTIVE ANALYSIS. 儿科患者长效和短效生长激素治疗的比较生长结局：一项12个月的回顾性分析

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.219

X Ji, L Shen, Z Lin, R Lv

{"title":"COMPARATIVE GROWTH OUTCOMES OF LONG-ACTING AND SHORT-ACTING GROWTH HORMONE THERAPY IN PEDIATRIC PATIENTS: A 12-MONTH RETROSPECTIVE ANALYSIS.","authors":"X Ji, L Shen, Z Lin, R Lv","doi":"10.4183/aeb.2025.219","DOIUrl":"10.4183/aeb.2025.219","url":null,"abstract":"Background: Growth hormone (GH) therapy is widely used for pediatric growth disorders, with short-acting (Saizen) and long-acting (Jintropin) formulations available. This study assesses height, weight, and bone age outcomes in children treated with Jintropin, Saizen, or a combination of both.Methods: This retrospective cohort study (N=108) compared Jintropin (n=31), Saizen (n=50), and Combination Therapy (n=27). To control for baseline heterogeneity (age, puberty) and repeated measures, analyses used ANCOVA and LMM. Post-hoc comparisons used Bonferroni correction. Safety was evaluated by ΔBA/ΔCA ratio.Results: Following multivariable LMM adjustment, the estimated marginal means for annualized GV were 9.30 cm/year (95% CI: 8.46-10.15) for Jintropin, 8.55 cm/year (95% CI: 7.90-9.20) for Saizen, and 9.56 cm/year (95% CI: 8.77-10.34) for Combination Therapy. Adjusted pairwise comparisons showed no significant efficacy differences between groups (Jintropin vs. Saizen: p=0.501; Combination vs. Saizen: p=0.160). Skeletal safety was confirmed across cohorts (ΔBA/ΔCA: 0.34, 0.46, 0.68), indicating no premature epiphyseal fusion.Conclusion: Long-acting Jintropin monotherapy provides growth outcomes comparable and non-inferior to daily Saizen, offering a convenient, effective alternative that reduces injection burden. The non-standard combination of long- and short-acting GH showed no statistically superior benefits, suggesting such complex regimens are unnecessary in clinical practice.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"219-226"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLINICAL AND HISTORICAL PREDICTORS OF GLYCEMIC CONTROL IN TYPE 1 DIABETES PATIENTS USING AUTOMATED INSULIN DELIVERY (AID) SYSTEMS: A RETROSPECTIVE ANALYSIS. 使用自动胰岛素输送系统的1型糖尿病患者血糖控制的临床和历史预测因素：回顾性分析

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.234

K Alfares

{"title":"CLINICAL AND HISTORICAL PREDICTORS OF GLYCEMIC CONTROL IN TYPE 1 DIABETES PATIENTS USING AUTOMATED INSULIN DELIVERY (AID) SYSTEMS: A RETROSPECTIVE ANALYSIS.","authors":"K Alfares","doi":"10.4183/aeb.2025.234","DOIUrl":"10.4183/aeb.2025.234","url":null,"abstract":"Background and objectives: Achieving optimal glycemic control in type 1 diabetes mellitus (T1DM) remains challenging despite the use of automated insulin delivery (AID) systems. This study evaluated glycemic outcomes and factors associated with poor control among T1DM patients using AID.Patients and methods: A descriptive cross-sectional study was conducted among 23 patients with T1DM. Data included demographics, age at diagnosis, duration of AID use, hospitalization, and HbA1c levels. Glycemic control was classified as good (<7%) or poor (≥7%) according to ADA guidelines.Results: Participants were predominantly adults (82.6%), with a mean age of 23.9 ± 7.6 years, and mostly female (73.9%). The mean age at diagnosis was 10.3 ± 6.0 years. Poor glycemic control was observed in 78.3% of patients, with a mean HbA1c of 8.0 ± 1.7%. Better control was significantly associated with older age at diagnosis and AID use for 6-12 months (p < 0.05). HbA1c showed no significant correlations with age, age at diagnosis, or AID duration. Logistic regression identified younger age at diagnosis as the only independent predictor of poor glycemic control.Conclusion: Suboptimal glycemic control remains common among T1DM patients using AID systems. Early age at diagnosis is a key risk factor for poor outcomes.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"234-238"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ASSOCIATION BETWEEN SARCOPENIA AND INSULIN RESISTANCE IN MIDDLE-AGED AND OLDER PEOPLE WITH TYPE 2 DIABETES MELLITUS. 中老年2型糖尿病患者肌肉减少症与胰岛素抵抗的关系

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.164

D Shan, W Xu, L Wu, J Jiang

{"title":"ASSOCIATION BETWEEN SARCOPENIA AND INSULIN RESISTANCE IN MIDDLE-AGED AND OLDER PEOPLE WITH TYPE 2 DIABETES MELLITUS.","authors":"D Shan, W Xu, L Wu, J Jiang","doi":"10.4183/aeb.2025.164","DOIUrl":"10.4183/aeb.2025.164","url":null,"abstract":"Objective: To probe into the potential connection between sarcopenia and insulin resistance in middle-aged and older cases with type 2 diabetes mellitus (T2DM).Methods: Ninety-six middle-aged and older patients with T2DM were selected. Bioelectrical impedance analysis was applied to take the appendicular muscle mass into measurement. Appendicular skeletal muscle mass index (ASMI) was calculated. By utilizing HOMA-IR and determining fasting C-peptide levels, insulin resistance (IR) was assessed.Results: According to the median value of ASMI (9.32 kg/m2), there were statistically significant differences in gender, height, weight, BMI, fasting C-peptide level, fasting glucose content in blood as well as in HOMA-IR among different ASMI groups. The correlated analysis unlocked that there were evidently negative correlations between ASMI and age, fasting blood glucose level (ρ=-0.214), lnHOMA-IR, and high-density lipoprotein dividly in middle-aged and older T2DM patients, while ASMI owned significantly positive correlation with fasting C-peptide level. In this population, male patients had a higher ASMI than females. After adjusting physical parameters and biochemical indicators, the multiple linear regression model demonstrated that ASMI was independently negatively correlated with lnHOMA-IR and fasting C-peptide level.Conclusion: ASMI associates with sarcopenia in middle-aged and older patients with T2DM is tightly linked with IR and pancreatic functionality.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"164-171"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECTS OF LIRAGLUTIDE ON BONE TURNOVER MARKERS AND BONE MINERAL DENSITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. 利拉鲁肽对2型糖尿病患者骨转换标志物及骨密度的影响。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.207

Y Wang, J Shen, J Wang, J Wang, L Lou

{"title":"EFFECTS OF LIRAGLUTIDE ON BONE TURNOVER MARKERS AND BONE MINERAL DENSITY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.","authors":"Y Wang, J Shen, J Wang, J Wang, L Lou","doi":"10.4183/aeb.2025.207","DOIUrl":"10.4183/aeb.2025.207","url":null,"abstract":"Aim: This study examines the impact of liraglutide on bone turnover markers and bone mineral density (BMD) in individuals diagnosed with type 2 diabetes mellitus (T2DM).Patients and methods: A randomized controlled trial included 100 participants who were assigned to receive either liraglutide in combination with metformin (n=50) or metformin alone (n=50) for a duration of 48 weeks.Results: Analysis revealed statistically significant improvements in metabolic parameters, including glucose and lipid metabolism, in the liraglutide group compared to controls (P < 0.001). Notably, male participants exhibited enhanced bone turnover markers, evidenced by increases in N-terminal mid-region osteocalcin (N-MID) and total type I collagen amino-terminal propeptide (TPINP), alongside decreases in the C-terminal telopeptide of type I collagen (β-CTX). Conversely, female participants did not demonstrate significant changes in these markers. Additionally, liraglutide effectively mitigated BMD loss observed at the femoral neck and lumbar spine in the treatment group. These findings underscore liraglutide's potential benefits in metabolic regulation and its role in supporting bone health, particularly in male patients. Further research is essential to conclusively define these effects and elucidate the underlying mechanisms.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"207-218"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SERUM 25-HYDROXY VITAMIN D AND BONE MINERAL DENSITY IN MULTIPLE CANAL INVOLVEMENT OF BENIGN PAROXYSMAL POSITIONAL VERTIGO. 良性阵发性位置性眩晕多管受累时血清25-羟基维生素d和骨密度的变化。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-04-01 Epub Date: 2026-07-28 DOI: 10.4183/aeb.2025.201

K E Choi, S H Kim, D W Bae

{"title":"SERUM 25-HYDROXY VITAMIN D AND BONE MINERAL DENSITY IN MULTIPLE CANAL INVOLVEMENT OF BENIGN PAROXYSMAL POSITIONAL VERTIGO.","authors":"K E Choi, S H Kim, D W Bae","doi":"10.4183/aeb.2025.201","DOIUrl":"10.4183/aeb.2025.201","url":null,"abstract":"Background and objective: Benign paroxysmal positional vertigo (BPPV) has been associated with low serum 25-hydroxyvitamin D levels and reduced bone mineral density (BMD), but it remains unclear whether these factors contribute to involvement of multiple semicircular canals. This study aimed to evaluate whether decreased BMD or vitamin D concentrations are associated with multi-canal BPPV.Methods: In this single-center retrospective study, 102 consecutive patients with idiopathic BPPV confirmed by video-oculography (VOG) were analyzed. All patients had serum 25-hydroxyvitamin D measurements and BMD T-scores assessed.Results: Among 102 patients (29 men, 73 women; mean age 62.3 ± 14.5 years), 70 had single-canal BPPV and 32 had multi-canal involvement. Mean vitamin D concentrations did not differ significantly between single-canal (24.52 ± 13.9 ng/mL) and multi-canal groups (19.55 ± 11.5 ng/mL; p = 0.0821). BMD T-scores were likewise similar (-1.93 ± 1.23 vs. -1.85 ± 1.34; p = 0.7639). Logistic regression showed that vitamin D insufficiency, vitamin D deficiency, osteopenia, and osteoporosis were not independent predictors of multi-canal BPPV.Conclusion: Low serum vitamin D levels and reduced BMD T-scores were not independently associated with multi-canal involvement in BPPV as confirmed by VOG diagnostics.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 2","pages":"201-206"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0