Acta Endocrinologica-Bucharest最新文献

THE EFFECT OF THERAPY WITH INSULIN ANALOGUES (ASPART AND GLARGINE) ON OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH TYPE 1 DIABETES MELLITUS. 使用胰岛素类似物（阿斯巴甜和格列宁）治疗对 1 型糖尿病患者氧化应激参数的影响。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.463

S Radenković, M Velojić Golubović, D Dimić, D B Radojković, V Ćirić, Z Gluvić, J Bjekić-Macut, A Marković, L Radić, M Pešić

{"title":"THE EFFECT OF THERAPY WITH INSULIN ANALOGUES (ASPART AND GLARGINE) ON OXIDATIVE STRESS PARAMETERS IN PATIENTS WITH TYPE 1 DIABETES MELLITUS.","authors":"S Radenković, M Velojić Golubović, D Dimić, D B Radojković, V Ćirić, Z Gluvić, J Bjekić-Macut, A Marković, L Radić, M Pešić","doi":"10.4183/aeb.2023.463","DOIUrl":"10.4183/aeb.2023.463","url":null,"abstract":"Context: There are evidences that excessive production of reactive oxygen species is one of important abnormalities that contribute to development of chronic diabetic complications.Objective: To test the effect of intensive insulin therapy with analogues through the examining the level of oxidative stress parameters.Subjects and methods: Comparison of data obtained by prospective analysis in 49 patients with T1DM was used, before and after six months of intensive insulin analog therapy.Results: The values of all three investigated parameters of oxidative stress malondialdehyde (MDA); xanthine oxidase (XO) and nitrates and nitrites (NOx) in our population with T1DM compared to the control (group of 42 voluntary blood donors) are statistically higher. The levels of antioxidant protection parameters compared to the control group also differ; the activities of catalase and glutathione peroxidase (GPx) are statistically higher in our population of T1DM patients compared to the control and superoxide dismutase (SOD) activities are statistically lower.The values of all three examined parameters of oxidative stress decrease after six months of intensive insulin analog therapy and were statistically lower after the therapy: for MDA p<0.001, for XO p<0.01 and for NOx p<0.05. The activities of catalase (p<0.001) and GPx (p<0.01) both decrease with therapy, while the activity of SOD is highest after the sixth month of therapy (p<0.001).Conclusion: In our patients with T1DM compared to the control the level of oxidative stress is significantly higher. Intensive insulin analog therapy with aspart and glargine promotes predominantly the improvement of oxidative stress, and in a less degree antioxidant protection.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE PREVALENCE OF POLYNEUROPATHY IN THE PRE-DIABETES PERIOD. 糖尿病前期多发性神经病的发病率。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.497

S Kalyon, P Özkan Gümüşkaya, N Özsoy, A S Pala, A Basmakcı, M Ozcan, Y Arman, T Tukek

{"title":"THE PREVALENCE OF POLYNEUROPATHY IN THE PRE-DIABETES PERIOD.","authors":"S Kalyon, P Özkan Gümüşkaya, N Özsoy, A S Pala, A Basmakcı, M Ozcan, Y Arman, T Tukek","doi":"10.4183/aeb.2023.497","DOIUrl":"10.4183/aeb.2023.497","url":null,"abstract":"Objective: This study aims to determine the prevalence of neuropathy in the prediabetic period.Design subjects and method: Informed consent was attained from the patients who volunteered to participate in the study after ethics committee approval was obtained. Patients under the age of 18, having vitamin B12 or folic acid deficiency, history of collagen tissue-rheumatological disease, chronic kidney failure, cirrhosis, ethylism, thyroid disease, autoimmune disease, malignancy, tuberculosis, type 1 or 2 diabetes mellitus and pregnant women were excluded from the study. Patients diagnosed with prediabetes were evaluated by the DN4 neuropathy complaint questionnaire. Neuropathy was diagnosed in patients having a score of four or more. For the statistical analyses Student t-test, Pearson chi-square test, and Fisher's exact test were performed using the NCSS program.Results: A total of 224 volunteers, 167 women and 57 men, were included in the study. The mean age of the participants was 51 and the mean level of hemoglobin A1C was 5.9. Neuropathy was detected in 45% of the cases. Especially in women, there was a significant increase in the frequency of neuropathy compared to men. The most common complaints found in our study were burning sensation and numbness in the extremities.Conclusions: Similar to diabetic patients, prediabetic patients also have a high rate of neuropathy. For the early diagnosis of neuropathy and to be treated promptly, screening tests such as DN4 should be performed for all prediabetic patients. According to the test results, advanced examinations such as EMG or biopsy should be performed earlier.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MT2 INHIBITS OSTEOCLASTOGENESIS BY SCAVENGING ROS. mt2 通过清除 ros 抑制破骨细胞生成。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.447

S Wei, K Liu, H Wu, J Hu, J He, G Li, B Liu, W Yang

{"title":"MT2 INHIBITS OSTEOCLASTOGENESIS BY SCAVENGING ROS.","authors":"S Wei, K Liu, H Wu, J Hu, J He, G Li, B Liu, W Yang","doi":"10.4183/aeb.2023.447","DOIUrl":"10.4183/aeb.2023.447","url":null,"abstract":"Context and objective: Reactive oxygen species (ROS) produced under oxidative stress is important for osteoclastogenesis. As a major member of the metallothionein (MT) family, metallothionein2 (MT2) can scavenge ROS in osteoblasts. However, the role of MT2 in osteoclastogenesis and ROS production in osteoclast precursors (OCPs) is unknown.Material and methods: In this study, we first investigated MT2 expression level in osteoporotic model mice. Next, we explored the roles of MT2 in osteoclastic differentiation and ROS production in OCPs. Ultimately, via rescue assays based on hydrogen peroxide (H2O2), the significance of ROS in MT-2-regulated osteoclastic differentiation was further elucidated.Results: Compared with sham operated (Sham) mice, ovariectomized (OVX) mice displayed bone marrow primary OCPs (Ly6C+CD11b-) having higher ROS levels and lower MT2 expression. MT2 overexpression inhibited the formation of mature osteoclasts, while MT2 knockdown was contrary. Moreover, MT2 overexpression inhibited ROS production in OCPs, while MT2 knockdown exhibited the opposite effects. Notably, the inhibitory effect of MT2 overexpression on osteoclastogenesis and ROS production was blocked by the addition of H2O2.Conclusion: MT2 inhibits osteoclastogenesis through repressing ROS production in OCPs, which indicates that the strategy of upregulating MT2 in OCPs may be applied to the clinical treatment of osteoclastic bone loss.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MYOFIBROBLASTS HINDER RECOVERY OF HASHIMOTO THYROIDITIS IN THE ULTRASTRUCTURAL LEVEL. 在超微结构层面，肌成纤维细胞阻碍了桥本氏甲状腺炎的康复。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.415

P Theotokis, A Gkantaras, E Avramidou, S Meditskou, M E Manthou

{"title":"MYOFIBROBLASTS HINDER RECOVERY OF HASHIMOTO THYROIDITIS IN THE ULTRASTRUCTURAL LEVEL.","authors":"P Theotokis, A Gkantaras, E Avramidou, S Meditskou, M E Manthou","doi":"10.4183/aeb.2023.415","DOIUrl":"10.4183/aeb.2023.415","url":null,"abstract":"Background: Hashimoto thyroiditis (HT) is an autoimmune disorder associated with hypothyroidism. Lymphocyte infiltration leading to thyroid follicular cell destruction is counteracted by increased collagen production, deposition and scarring. However, only recently a specific subpopulation of modified fibroblasts with contractile properties, namely \"myofibroblasts\" (MFBs) have been linked to HT.Aim: Our ultrastructural study aims to delineate the presence and contribution of MFBs to the fibrotic milieu of HT.Material and methods: Tissue biopsies were obtained from 5 HT-diagnosed patients and specimens were examined using a Transmission Electron Microscope (TEM).Results: Histopathological examination indicated extensive microvilli atrophy and atypical vacuolations of the thyroid follicular cells in the HT samples. In addition to interstitial extravasated lymphocytes, capillaries were encircled by MFBs (mean distance from lumen 1.248± 0.43µm) with the characteristic electron-dense α-smooth muscle actin (α-SMA), confirmable in higher magnifications. Myofibroblastic projections were found to have significantly higher representation near the capillary lumen compared to the impaired endothelial lining (P < 0.01).Conclusion: Our TEM findings suggest that the intrusion of endothelia by myofibroblastic projections can be a significant factor towards the malfunction of follicular cells in HT patients and offer a paradigmal understanding of the ultrastructural interactions that may underlie the HT pathology.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PARATHYROID ADENOMA PRESENTING AS MULTIPLE BROWN TUMORS AND SEVERE ASYMPTOMATIC HYPERCALCEMIA. 甲状旁腺腺瘤表现为多发性棕色肿瘤和严重的无症状高钙血症。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.508

D V Wasnik, R S Khot, P P Joshi, B D Rathod, U Narang, C Ratnaparkhi

{"title":"PARATHYROID ADENOMA PRESENTING AS MULTIPLE BROWN TUMORS AND SEVERE ASYMPTOMATIC HYPERCALCEMIA.","authors":"D V Wasnik, R S Khot, P P Joshi, B D Rathod, U Narang, C Ratnaparkhi","doi":"10.4183/aeb.2023.508","DOIUrl":"10.4183/aeb.2023.508","url":null,"abstract":"Introduction: Primary hyperparathyroidism may have several presentations, varying from an incidental asymptomatic biochemical finding to gastrointestinal, psychiatric, renal and bone manifestations. Brown tumors are rare non-neoplastic lesions because of abnormal bone metabolism. Herein, we describe a patient who presented with lytic bony lesions and severe asymptomatic hypercalcemia due to parathyroid adenoma.Case presentation: A 38-year-old male presented with multiple painful bony lesions over upper and lower limbs. Radiographs of long bones showed multiple lytic lesions with cortical thinning. Investigations revealed hypercalcemia and hyperparathyroidism. A radionuclide scan showed parathyroid adenoma. The patient was treated for hypercalcemia and a parathyroidectomy was performed.Conclusions: In a patient presenting with multiple bony swellings and asymptomatic hypercalcemia, hyperparathyroidism should be suspected. Parathyroid adenoma is a treatable cause of primary hyperparathyroidism.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CASE OF HYPONATREMIA DUE TO PITUITARY METASTASIS OF LUNG CANCER. 一例肺癌垂体转移导致的低钠血症。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.501

I Taskaldiran, P Gokbulut, G Koc, S Fırat, T Omma, S M Kuşkonmaz, C Culha

{"title":"A CASE OF HYPONATREMIA DUE TO PITUITARY METASTASIS OF LUNG CANCER.","authors":"I Taskaldiran, P Gokbulut, G Koc, S Fırat, T Omma, S M Kuşkonmaz, C Culha","doi":"10.4183/aeb.2023.501","DOIUrl":"10.4183/aeb.2023.501","url":null,"abstract":"Context: Hyponatremia is a common electrolyte abnormality.Objective: We report a patient who presented with hyponatremia and diagnosed as small cell lung cancer metastatic to hypothalamus and pituitary.Case report: A 68 year old male patient was admitted with fever and cough and pneumonia was considered. Serum sodium level was 113 mmol/L. Syndrome of inappropriate ADH (SIADH) is considered. Thyroid function tests and cortisol levels pointed out a central deficiency in both axes. Pituitary MRI was performed and a hypothalamic and pituitary mass were observed. Prednisolone therapy was started followed by L thyroxine replacement. A chest computer tomography (CT) was taken 2 weeks later revealed a mass lesion. Bronchoscopic biopsy was performed and histopathological diagnosis of the tumor was reported as small cell lung cancer.Result: Many mechanisms were considered as the cause of hyponatremia in our patient. SIADH, secondary adrenal insufficiency and secondary hypothyroidism due to pituitary metastasis are possible causes.Conclusion: The reason of hyponatremia is sometimes complex. When the underlying causes of hyponatremia are not evaluated in detail, many diagnoses can be missed.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A MODEL TO PREDICT DIAGNOSIS OF PANCREATIC NEUROENDOCRINE TUMORS BASED ON EUS IMAGING FEATURES. 根据 EUS 成像特征预测胰腺神经内分泌肿瘤诊断的模型。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.407

I Saizu, B Cotruta, R A Iacob, S Bunduc, R E Saizu, M Dumbrava, C Pietrareanu, G Becheanu, D Grigorie, C Gheorghe

{"title":"A MODEL TO PREDICT DIAGNOSIS OF PANCREATIC NEUROENDOCRINE TUMORS BASED ON EUS IMAGING FEATURES.","authors":"I Saizu, B Cotruta, R A Iacob, S Bunduc, R E Saizu, M Dumbrava, C Pietrareanu, G Becheanu, D Grigorie, C Gheorghe","doi":"10.4183/aeb.2023.407","DOIUrl":"10.4183/aeb.2023.407","url":null,"abstract":"Background: This study aimed to determine predictive clinical and endoscopic ultrasound (EUS) features for pancreatic neuroendocrine tumor (PNET) diagnosis, utilizing EUS-guided tissue acquisition.Methods: A prospective study from 2018-2022 included patients with pancreatic masses undergoing EUS with elastography. Univariate binomial logistic regression followed by multiple logistic regression with significant predictors was employed. A forward selection algorithm identified optimal models based on predictor numbers. Variables encompassed EUS tumor characteristics (e.g., location, size, margins, echogenicity, vascularity on Doppler, main pancreatic duct dilation, elastography appearance, vascular invasion, and hypoechoic rim), alongside demographic and risk factors (smoking, alcohol, diabetes).Results: We evaluated 165 patients (24 PNETs). EUS features significantly linked with PNET diagnosis were well-defined margins (79% vs. 26%, p < 0.001), blue elastography appearance (46% vs. 9.9%, p < 0.001), vascularization (67% vs. 25%, p < 0.001), hypoechoic rim (46% vs. 10%, p < 0.001). The top-performing model, with 89.1% accuracy, included two predictors: a homogeneous lesion (OR, 95% CI) and a hypoechoic rim (OR, 95% CI).Conclusions: EUS appearance can differentiate PNETs from non-PNETs, with the hypoechoic rim being an independent predictor of PNET diagnosis. The most effective predictive model for PNETs combined the homogeneous lesion and presence of the hypoechoic rim.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OCCURRENCE OF METFORMIN IN ENVIRONMENTAL WATER SAMPLES AND COMPARISON WITH CONSUMPTION DATA FROM A SURROUNDING HOSPITAL OVER 5 YEARS: A RETROSPECTIVE CASE STUDY. 环境水样中二甲双胍的含量以及与周边一家医院五年来的消耗量数据的比较：一项回顾性案例研究。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.532

L L Bai, J Gao, H Zhang, J Wang

{"title":"OCCURRENCE OF METFORMIN IN ENVIRONMENTAL WATER SAMPLES AND COMPARISON WITH CONSUMPTION DATA FROM A SURROUNDING HOSPITAL OVER 5 YEARS: A RETROSPECTIVE CASE STUDY.","authors":"L L Bai, J Gao, H Zhang, J Wang","doi":"10.4183/aeb.2023.532","DOIUrl":"10.4183/aeb.2023.532","url":null,"abstract":"Context: The environmental occurrence of metformin has been frequently world-widely reported. Despite the diabetes susceptibility in the Chinese population, the studies on occurrence of metformin as environment disruptor in China are insufficient.Objective: To determine the occurrence trends and possible environmental pollution sources of metformin as an emerging micropollutant.Methods: High-performance liquid chromatography-electrospray ionization-tandem mass spectrometry system was used to detect the metformin levels in water samples collected from the Xi'an city Moat, China once a year from 2017 to 2021. Correlations among the metformin levels in moat water, in surrounding hospital wastewater, and hospital metformin consumption data were assessed using Pearson, Spearman and Kendall's tau-b correlation coefficients.Results: Occurrence of metformin was found in Xi'an city Moat water with levels in the range of 304-793 ng/L. Significant correlations were found between the metformin levels in city moat water and the total (or outpatient) metformin utilization data of the hospital.Conclusion: Data suggested the potential environmental issues posed by metformin in Xi'an city in China. The metformin consumption volume in the surrounding hospitals, especially at the outpatient services, could be used to predict the metformin concentrations in the moat water.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PANCREATIC FAT CONTENT PLAYS AN IMPORTANT ROLE IN THE DEVELOPMENT OF TYPE 2 DIABETES MELLITUS SIMILAR TO THAT OF LIVER FAT CONTENT. 胰腺脂肪含量与肝脏脂肪含量一样，在 2 型糖尿病的发病过程中发挥着重要作用。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.421

L Ting, W Liyun, W Zheng, Z Cao

{"title":"PANCREATIC FAT CONTENT PLAYS AN IMPORTANT ROLE IN THE DEVELOPMENT OF TYPE 2 DIABETES MELLITUS SIMILAR TO THAT OF LIVER FAT CONTENT.","authors":"L Ting, W Liyun, W Zheng, Z Cao","doi":"10.4183/aeb.2023.421","DOIUrl":"10.4183/aeb.2023.421","url":null,"abstract":"Objective: Type 2 diabetes mellitus (T2DM) is a major health problem worldwide. Earlier studies have reported that pancreatic fat content (PFC) and liver fat content (LFC) are risk factors for T2DM. The aim of the present study was to demonstrate the relationship between PFC, LFC and T2DM.Methods: A total of 70 T2DM subjects and 30 non-diabetic volunteers who underwent Dixon-based magnetic resonance imaging (MRI) method at Yixing People's Hospital between December 2018 to December 2020 were included in the study. The three-point Dixon (3p-Dixon) method was used to measure the fat content in the pancreas and liver. Clinical indices including gender, age, body mass index (BMI), total cholesterol, triglyceride, glucose and C peptide levels were collected. The association between PFC, LFC, and OGTT-derived parameters was examined by Pearson and Spearman correlation analyses.Results: T2DM subjects had higher PFC and LFC than those measured in the non-diabetic subjects (p <0.05). PFC and LFC were associated positively with OGTT-derived parameters such as insulin secretion, insulin resistance, and early- and late-phase insulin secretion in the male T2DM subjects(p <0.05), but not in the non-diabetic and female T2DM subjects. The relationship between PFC and OGTT-derived parameters was also more obvious than that for LFC in overweight and obese male patients with T2DM whose BMI was >24 kg/m2.Conclusion: PFC and LFC were both associated with β-cell dysfunction and insulin resistance in males with T2DM. The relationship between PFC and β-cell dysfunction and insulin resistance was more obvious than that observed for LFC in overweight and obese male T2DM patients. More attention should therefore be paid to PFC in clinical settings.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RISK FACTORS FOR ACUTE KIDNEY INJURY ASSOCIATED WITH SEVERE HYPOTHYROIDISM. 与严重甲状腺功能减退症相关的急性肾损伤的风险因素。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.456

A Batman, M M Canat, E S Saygili, E Besler, D Yildiz, F Yener Ozturk, Y Altuntas

{"title":"RISK FACTORS FOR ACUTE KIDNEY INJURY ASSOCIATED WITH SEVERE HYPOTHYROIDISM.","authors":"A Batman, M M Canat, E S Saygili, E Besler, D Yildiz, F Yener Ozturk, Y Altuntas","doi":"10.4183/aeb.2023.456","DOIUrl":"10.4183/aeb.2023.456","url":null,"abstract":"Objective: This study aims to investigate the factors affecting development of acute kidney injury (AKI) in patients with severe hypothyroidism.Methods: This retrospective observational study involved patients with primary hypothyroidism and thyroid stimulating hormone (TSH) levels of more than 50 mIU/L at their review in the endocrinology outpatient clinic, between January 2015 and April 2021. Factors affecting the development of AKI were examined by logistic regression analysis.Results: A total of 100 patients, 20 (11 male (M), 9 female (F)) in the AKI (case) group and 80 (23 M, 57 F) patients in control group, were included in our study. The median age of the case group (56 years, interquartile range (IQR) 44.3-68.5) was significantly higher than the control group (49 years, IQR 32.3-60; p = 0.027), and the ratio of males to females was significantly higher in the case group (p = 0.001). Multivariate logistic regression analyses showed that hypothyroidism diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95% confidence intervals (CI) 5.955-598.031; p = 0.001), free triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI 2.491-118.089; p = 0.004) and creatine kinase (CK) > 1000 U/L (OR 1.522, 95% CI 1.602-82.848; p = 0.015) were predictors for the development of AKI in patients with severe hypothyroidism.Conclusion: We recommend close follow-up and monitoring of patients with AKI caused by severe hypothyroidism if patients who are diagnosed at age > 60 years, CK > 1000 U/L or FT3 < 1.3 pg/mL.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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