Acta Endocrinologica-Bucharest最新文献

LEVOTHYROXINE-SIMETHICONE DRUG INTERACTION AND PRESENCE OF MACRO-TSH IN AN INFANT WITH CONGENITAL HYPOTHYROIDISM. 先天性甲状腺功能减退婴儿左旋甲状腺素-西甲硅氧烷药物相互作用及巨量tsh的存在。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.127

K Çetin, Z Donbaloğlu, B Singin, Y F Bahar, S Özdem, M Parlak, H Tuhan

{"title":"LEVOTHYROXINE-SIMETHICONE DRUG INTERACTION AND PRESENCE OF MACRO-TSH IN AN INFANT WITH CONGENITAL HYPOTHYROIDISM.","authors":"K Çetin, Z Donbaloğlu, B Singin, Y F Bahar, S Özdem, M Parlak, H Tuhan","doi":"10.4183/aeb.2025.127","DOIUrl":"https://doi.org/10.4183/aeb.2025.127","url":null,"abstract":"Introduction: Congenital hypothyroidism (CH) is a prevalent cause of intellectual disability, preventable with early detection and treatment. Levothyroxine (LT4) is the standard treatment, but its efficacy can be compromised by drug interactions.Case description: We present an 18-day-old boy diagnosed with CH, who exhibited elevated thyroid-stimulating hormone (TSH) levels despite LT4 treatment. Upon increasing the LT4 dose and observing persistent TSH elevation, further investigation revealed the concurrent use of simethicone-containing colic drops. Literature suggests that simethicone can interfere with LT4 absorption. The colic drops were discontinued, leading to normalized TSH levels. Additionally, macro-TSH, indicated by a polyethylene glycol (PEG) precipitation test, was considered to contribute to the elevated TSH levels.Discussion: This case underscores the necessity of thorough medication history reviews in patients with CH. Drug interactions, such as those with simethicone, can significantly impact LT4 efficacy. Moreover, the presence of macro-TSH should be considered when TSH levels are disproportionately elevated.Conclusion: Clinicians should be vigilant about over-the-counter medication use and potential interactions in managing CH. Comprehensive patient history and careful monitoring are critical to optimizing treatment outcomes.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"127-130"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALYSIS OF SHORT-CHAIN FATTY ACIDS AND ASSOCIATION WITH GLUCAGON-LIKE PEPTIDE-1 IN HEALTHY, OBESE, PREDIABETES AND TYPE 2 DIABETES INDIVIDUALS. 健康、肥胖、糖尿病前期和2型糖尿病患者短链脂肪酸及其与胰高血糖素样肽-1的关系分析

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.10

S Dede, E Karakuş, M Yaman, Ö Bilen

{"title":"ANALYSIS OF SHORT-CHAIN FATTY ACIDS AND ASSOCIATION WITH GLUCAGON-LIKE PEPTIDE-1 IN HEALTHY, OBESE, PREDIABETES AND TYPE 2 DIABETES INDIVIDUALS.","authors":"S Dede, E Karakuş, M Yaman, Ö Bilen","doi":"10.4183/aeb.2025.10","DOIUrl":"https://doi.org/10.4183/aeb.2025.10","url":null,"abstract":"Context: Short-chain fatty acids (SCFAs) play a critical role in host metabolism, both directly and through specific G protein-coupled receptors, and may provide a link between glucose and lipid metabolism. This study aimed to compare fecal SCFA concentrations and to evaluate associations between SCFAs and glucagon-like peptide 1 (GLP-1) in individuals with type 2 diabetes (T2DM), prediabetes, obesity, and health.Subjects and methods: The study included 60 volunteers in four groups: T2DM (n= 15), prediabetes (n= 15), obesity (n= 15), and healthy individuals (n= 15). We analyzed fecal SCFA and GLP-1 concentrations by HPLC-UV and ELISA method, respectively.Results: In comparison to healthy individuals, obese, prediabetic and T2DM exhibited notably elevated total SCFA levels respectively (p=0.019, p=0.017, p=0.024). Acetic acid concentration showed an increase in both obese and prediabetic groups compared to the healthy group (p=0.02, p=0.017). Butyric acid concentration was elevated in T2DM and prediabetic groups in comparison to both healthy and obese groups (p=0.024, p=0.017, p=0.07, p=0.56). The GLP-1 levels significantly decreased in the obese and prediabetic groups compared to the healthy and T2DM groups (p=0.00, p=0.021, p=0.000, p=0.005). GLP-1 was correlated with acetic acid, butyric acid, and the total SCFA concentrations in the T2DM and obese groups (r= 0.479, p= 0.098; r= 0.441, p= 0.099; r= 0.654, p= 0.015, respectively) while there was no correlation in the prediabetic group.Conclusion: Our results extend the knowledge on the alteration of SCFA levels in the states of obesity, prediabetes, and T2DM and enrich the understanding of the relationship between SCFAs and GLP-1.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"10-16"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECT OF PIOGLITAZONE TREATMENT ON ASPROSIN LEVELS IN PATIENTS WITH DIABETES AND METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MAFLD). 吡格列酮治疗对糖尿病和代谢功能障碍相关脂肪变性肝病（mld）患者asprosin水平的影响

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.74

S Bahçebaşı, H Sipahioğlu, A Karabulut, S Kuzugüden, A Savranlar

{"title":"EFFECT OF PIOGLITAZONE TREATMENT ON ASPROSIN LEVELS IN PATIENTS WITH DIABETES AND METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MAFLD).","authors":"S Bahçebaşı, H Sipahioğlu, A Karabulut, S Kuzugüden, A Savranlar","doi":"10.4183/aeb.2025.74","DOIUrl":"https://doi.org/10.4183/aeb.2025.74","url":null,"abstract":"Introduction: Blood asprosin levels have been found to be elevated in patients with type 2 diabetes and those with Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD). MAFLD is common in individuals with diabetes. We investigated the relationship between pioglitazone treatment and asprosin levels in patients with diabetes and MAFLD.Materials and methods: Blood samples were collected from 25 patients diagnosed with diabetes and MAFLD at the time of diagnosis and 6 months after pioglitazone treatment. Additionally, blood samples were collected from 15 healthy volunteers as controls.Results: Compared to the 6-month control after pioglitazone treatment, significant reductions were observed in glucose, HbA1c, AST, ALT, GGT, ALP, and Fib-4 scores. However, no significant difference was detected in asprosin levels.Discussion: The significant decrease in glucose, HbA1c, AST, ALT, GGT, ALP, and Fib-4 scores after pioglitazone treatment indicates that pioglitazone is effective in the treatment of both diabetes and MAFLD. The fact that asprosin levels were not different in patients with diabetes and MAFLD compared to healthy controls suggests that diabetic fatty liver occurs through mechanisms independent of asprosin.Conclusion: These results imply that while pioglitazone is effective in treating both diabetes and MAFLD, its action does not involve modulating asprosin levels.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"74-79"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ENDOCRINE DISTURBANCES IN PARASELLAR MENINGIOMAS AND THE EFFECT OF TRANSSPHENOIDAL DECOMPRESSION OPERATIONS. 鞍旁脑膜瘤的内分泌紊乱及经蝶窦减压手术的影响。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.67

M Repschlaeger, V Binder, Y Zhao, R Fahlbusch, M Buchfelder

{"title":"ENDOCRINE DISTURBANCES IN PARASELLAR MENINGIOMAS AND THE EFFECT OF TRANSSPHENOIDAL DECOMPRESSION OPERATIONS.","authors":"M Repschlaeger, V Binder, Y Zhao, R Fahlbusch, M Buchfelder","doi":"10.4183/aeb.2025.67","DOIUrl":"https://doi.org/10.4183/aeb.2025.67","url":null,"abstract":"Objective: To assess the outcome of clinical and endocrinological dysfunctions after transsphenoidal decompression in parasellar meningioma.Methods: Retrospective pre- and postoperative evaluation of 40 patients (30 women, 10 men; mean age, 55.9±11.9) who underwent decompressive transsphenoidal microsurgeries. The preoperative investigation took place one month prior surgery, the first follow-up within one week, the second follow-up within three months postoperatively.Results: The most common symptom in our study was diplopia (47.5%, n=19) which showed improvement in 21.1% (n=4) of cases. Preoperative hyperprolactinemia, presented in 52.5% of patients (n=21) with hyperprolactinemia remaining in just 20% of patients (n=8) in the first follow-up. Other endocrine axes were affected less frequently, but also majorly showed improvements. The corticotropic axis was affected in 8.8% (n=3) and remained unchanged. Female gonadotropic axis irritation decreased from 34.5% (n=10) to 31.0% (n=9), male axis deterioration improved in two cases from 50% (n=5) to 30% (n=3). The somatotropic and thyrotropic axes were never negatively affected. Adjuvant radiotherapy was carried out in 60% (n=24) of patients and not yet commenced in an additional nine (22.5%).Conclusion: Experience shows that transsphenoidal decompression is a useful and low complication associated procedure in the initial management of cavernous sinus meningioma.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"67-73"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LIPOHYPERTHROPHY: NEW TECHNOLOGY, OLD PROBLEMS. 肥胖：新技术，老问题。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.141

J V Rocha, M Vaz Lopes, M de Griné Severino, C Peixe, C I Lopes, M A Duarte, A C Gomes, E Lacerda Nobre

引用次数: 0

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.148

G V Tănase, A E Tănase, M Ciocoiu

引用次数: 0

INDEPENDENT AND COMBINED EFFECTS OF HYPERGLYCEMIA AND CHRONIC KIDNEY DISEASE ON BONE MINERAL DENSITY AND MICROARCHITECTURE. 高血糖和慢性肾脏疾病对骨密度和微结构的独立和联合影响。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.59

I C Mogos, D A Niculescu, R Dusceac, C Poiana

{"title":"INDEPENDENT AND COMBINED EFFECTS OF HYPERGLYCEMIA AND CHRONIC KIDNEY DISEASE ON BONE MINERAL DENSITY AND MICROARCHITECTURE.","authors":"I C Mogos, D A Niculescu, R Dusceac, C Poiana","doi":"10.4183/aeb.2025.59","DOIUrl":"https://doi.org/10.4183/aeb.2025.59","url":null,"abstract":"Introduction: Abnormal glucose metabolism (prediabetes and type 2 diabetes mellitus [T2DM]) and chronic kidney disease (CKD) are two conditions that frequently coexist and affect bone mass and microarchitecture. We investigated both independent and combined effects of abnormal glucose metabolism and chronic kidney disease (CKD) on bone mineral density (BMD) and microarchitecture.Methods: This observational, single center, prospective study recruited 604 men and postmenopausal women with prediabetes or T2DM and normal kidney function (n=365) or CKD (n=113) or with normal glucose tolerance (NGT) and normal kidney function (n=105) or CKD (n=21). We measured lumbar spine, femoral neck, 33% radius BMD and trabecular bone score (TBS). 25- hydroxyhydroxy-vitamin-D was sufficient in most patients (64.9%). Patients with T2DM were controlled on therapy (glycated hemoglobin 6.3% [5.8-6.6]).Results: Absolute BMD and T-score were significantly higher in prediabetes and T2DM than in NGT patients at all three sites. Irrespective of glycemic status, patients with CKD had similar BMD with patients with normal kidney function at all sites, even if they were 4-7 years older. TBS was similar in all groups. There was no association between HbA1c and BMD at any site or TBS.Conclusions: In conclusion, our study showed that impaired glucose metabolism (prediabetes or T2DM) and CKD have independent but no additive effects on bone mineral density and microarchitecture in patients with well-controlled diabetes and vitamin D sufficiency. This suggests that independent intensive treatment and screening could prevent bone loss and architectural damage in these 2 conditions that frequently coexist.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"59-66"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CONCURRENT OCCURRENCE OF NEUROFIBROMATOSIS TYPE 1 AND TURNER SYNDROME: A PEDIATRIC CASE REPORT WITH COMPREHENSIVE LITERATURE REVIEW. 1型神经纤维瘤病和特纳综合征同时发生：一个儿科病例报告并综合文献复习。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.110

B Singin, Z Donbaloğlu, E Barsal Çetiner, B Aydın Behram, M Parlak, H Tuhan

{"title":"CONCURRENT OCCURRENCE OF NEUROFIBROMATOSIS TYPE 1 AND TURNER SYNDROME: A PEDIATRIC CASE REPORT WITH COMPREHENSIVE LITERATURE REVIEW.","authors":"B Singin, Z Donbaloğlu, E Barsal Çetiner, B Aydın Behram, M Parlak, H Tuhan","doi":"10.4183/aeb.2025.110","DOIUrl":"https://doi.org/10.4183/aeb.2025.110","url":null,"abstract":"Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder that typically presents in childhood and involves multiple organ systems. Turner syndrome (TS) is a chromosomal condition resulting from complete or partial loss of one X chromosome. Both disorders can independently cause short stature and pubertal delay.Case report: We present a 9-year-old girl diagnosed with NF1 at age 6, based on widespread café-au-lait macules and a positive family history. She was referred to our pediatric endocrinology clinic for evaluation of severe short stature. Physical examination revealed TS stigmata, including height SDS: -4.07, cubitus valgus, webbed neck, low posterior hairline, and widely spaced nipples. Karyotype analysis confirmed mosaic TS: 45,X[12]/46,X,del(X)(p11.2)[18]. Cranial magnetic resonance imaging revealed hamartomatous lesions, an empty sella, and an optic pathway glioma, for which she had received chemotherapy. Laboratory findings were consistent with hypergonadotropic hypogonadism. Estrogen replacement therapy was initiated; however, recombinant human growth hormone treatment was declined by the family after counseling.Conclusions: This co-occurrence is exceedingly rare, with only a few pediatric cases having been reported in the literature. This dual diagnosis poses diagnostic and therapeutic challenges and necessitates a personalized approach to growth assessment, pubertal induction, and long-term tumor surveillance in pediatric endocrine care.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"110-115"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147378979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FROM 'NULL CELL ADENOMA' TO REFINED DIAGNOSIS: PITFALLS IN PITUITARY MASS EVALUATION. 从“无细胞腺瘤”到精细化诊断：垂体肿块评估的陷阱。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.131

M Korkmaz Yilmaz, M Karagulle, H Karatay, B Erkan, M Niyazoglu, E Hatipoglu

{"title":"FROM 'NULL CELL ADENOMA' TO REFINED DIAGNOSIS: PITFALLS IN PITUITARY MASS EVALUATION.","authors":"M Korkmaz Yilmaz, M Karagulle, H Karatay, B Erkan, M Niyazoglu, E Hatipoglu","doi":"10.4183/aeb.2025.131","DOIUrl":"https://doi.org/10.4183/aeb.2025.131","url":null,"abstract":"Background: Null cell adenoma (NCA) of the pituitary gland, once considered a distinct subtype of non-functioning pituitary tumors, has been substantially redefined with the advent of transcription factor (TF) immunostaining. The updated WHO classifications emphasize cell lineage differentiation, significantly narrowing the true spectrum of NCAs.Objective: To underscore the diagnostic challenges and potential misclassification of NCAs by presenting two illustrative cases and reviewing the evolving diagnostic approach.Methods: We describe two diagnostically complex cases initially classified as NCAs due to negative anterior pituitary hormone and TF immunostaining. Both demonstrated atypical clinical features, such as rapid progression and elevated Ki-67 indices, prompting further pathological reassessment.Results: In the first case, follow-up surgeries and additional immunohistochemistry revealed a posterior pituitary tumor-spindle cell oncocytoma. In the second, reevaluation identified hepatocellular carcinoma (HCC) metastasis to the pituitary. These findings highlight the necessity of considering posterior pituitary tumors and metastases in the differential diagnosis of NCAs, especially when clinical or imaging findings suggest alternative etiologies.Conclusion: NCAs must be regarded as a diagnosis of exclusion. Accurate classification depends on thorough clinicopathological correlation, multidisciplinary collaboration, and the use of expanded immunohistochemical panels. Recognition of rare mimickers is crucial for guiding appropriate treatment and improving outcomes.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"131-140"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DIAGNOSIS OF ACROMEGALY IN BILATERAL CARPAL TUNNEL SYNDROME AND FOLLOW-UP WITH ULTRASONOGRAPHY: A CASE REPORT. 双侧腕管综合征肢端肥大症的诊断及超声随访1例。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2025-01-01 DOI: 10.4183/aeb.2025.122

D Ferahman

引用次数: 0