Acta Endocrinologica-Bucharest最新文献_第2页

HORMONAL PROFILE IN SEVERE BURNS. 严重烧伤的激素水平。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.408

F V Hodea, V M Voiculescu, T G Manole, A Grosu-Bularda, C S Hariga

{"title":"HORMONAL PROFILE IN SEVERE BURNS.","authors":"F V Hodea, V M Voiculescu, T G Manole, A Grosu-Bularda, C S Hariga","doi":"10.4183/aeb.2024.408","DOIUrl":"10.4183/aeb.2024.408","url":null,"abstract":"Acute or chronic burn injuries require hormonal responses that significantly influence patient prognosis. Elevated cortisol, catecholamines, and glucagon levels, lead to important metabolic changes, such as hyperglycaemia, insulin resistance, protein catabolism, free fatty acids oxidation, and secondary metabolic acidosis. These alterations impair immune function and wound healing and trigger a systemic inflammatory response. A multidisciplinary approach is needed in order to correctly manage the aforementioned endocrine and metabolic changes. During the acute phase, glucose monitoring, corticosteroid administration for transient or iatrogenic adrenal insufficiency and electrolyte balance maintenance are critical. Chronic phase requires hormonal replacement, nutritional optimization, and anabolic agents administration to counteract catabolic states. Despite continuous advances in burn care, understanding the complex interplay between hormonal changes and immune dysfunction remains challenging. Managing burn-associated endocrine responses could lead to the development of new therapeutic strategies, including personalised and stage- adapted treatment.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"408-411"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SYNCHRONOUS ONCOCYTIC CARCINOMA, MEDULLARY CARCINOMA AND PAPILLARY MICROCARCINOMA OF THYROID. 甲状腺同步嗜癌、髓样癌和乳头状微癌。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.373

S Aksoy, N Gokkaya, A E Gul, H E Sıkar, S Özçelik, K Aydin

{"title":"SYNCHRONOUS ONCOCYTIC CARCINOMA, MEDULLARY CARCINOMA AND PAPILLARY MICROCARCINOMA OF THYROID.","authors":"S Aksoy, N Gokkaya, A E Gul, H E Sıkar, S Özçelik, K Aydin","doi":"10.4183/aeb.2024.373","DOIUrl":"10.4183/aeb.2024.373","url":null,"abstract":"Thyroid tumors are the most frequently reported endocrine malignancies. However thyroid collision tumors are rare pathological findings, representing less than 1% of thyroid cancers. In our case, a 50-year-old female patient presented with a complaint of neck swelling. During the exams, nodules were identified in both thyroid lobes. Pathologic analysis of a fine-needle aspiration biopsy(FNA) has been obtained from a 60×50 mm hypoechoic nodule raised suspicion of oncocytic carcinoma(OC). Another FNA was performed on a 17×11 mm hypoechoic solid nodule, revealing features of medullary thyroid carcinoma (MTC). Preoperative whole-body scans indicated no evidence of metastases. The patient subsequently underwent total thyroidectomy and central lymph node dissection. Pathological examination revealed OC, MTC, papillary microcarcinoma (PTMC), simultaneous metastasis of MTC and papillary thyroid carcinoma (PTC) to the same lymph node. The patient's calcitonin level was normalized postoperatively and I-131 ablation therapy was administered to the patient in the ATA high risk category. The patient was monitored under levothyroxine suppression. The simultaneous occurrence of OC, MTC and PTMC of the thyroid gland along with metastases of PTC and MTC in the same lymph node are reported in this case. To the best of our knowledge, this association had not been previously reported in the literature.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"373-377"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECTIVENESS OF MOBILE PHONE-BASED DISTANCE VIDEO EDUCATION ON METABOLIC VARIABLES AND COGNITIVE-SOCIAL FACTORS IN TYPE 2 DIABETES. 基于手机的远程视频教育对2型糖尿病代谢变量和认知社会因素的影响

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.261

A K Bayraktar, Ö Tekir, H Yildiz

{"title":"EFFECTIVENESS OF MOBILE PHONE-BASED DISTANCE VIDEO EDUCATION ON METABOLIC VARIABLES AND COGNITIVE-SOCIAL FACTORS IN TYPE 2 DIABETES.","authors":"A K Bayraktar, Ö Tekir, H Yildiz","doi":"10.4183/aeb.2024.261","DOIUrl":"10.4183/aeb.2024.261","url":null,"abstract":"Objective: Our research investigated the impact of mobile phone distance video education of patients with type II diabetes. This approach was delivered to 100 type 2 diabetes patients based on their cognitive-social factors and metabolic variables.Subjects and methods: A randomized controlled trial study design was employed. Diabetes education videos were designed and were streamed to the smartphones of the patients. Data were collected from the control (n=50) and experimental (n=50) groups in the first interview, and metabolic control data were recorded. The second interview was held three months after the education process was completed. During this meeting, the survey instrument and the Turkish version of the Multidimensional Diabetes Questionnaire was re-administered to both groups, and metabolic control data were recorded.Results: Following the distance video education, there was a significant decrease in the FPG (1.2 mmol/L) HbA1c (-1.04%), LDL (-0.4 mmol/L) and BMI (-0.7 kg/m2) values of the experimental group, and their cognitive-social factors were found to improve in terms of perceiving diabetes.Conclusions: In our study, distance education via mobile phones was an influential approach on cognitive-social factors and metabolic variables of type 2 diabetes patients.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"261-268"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PREMATURITY, SGA, OBESITY AND RAPID WEIGHT GAIN AS KEY FACTORS IN PREMATURE ADRENARCHE: A RETROSPECTIVE STUDY IN TURKISH GIRLS. 早产、sga、肥胖和体重迅速增加是早产的关键因素：土耳其女孩的回顾性研究。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.318

G Can Yılmaz, H N Peltek Kendirci, E Demir

{"title":"PREMATURITY, SGA, OBESITY AND RAPID WEIGHT GAIN AS KEY FACTORS IN PREMATURE ADRENARCHE: A RETROSPECTIVE STUDY IN TURKISH GIRLS.","authors":"G Can Yılmaz, H N Peltek Kendirci, E Demir","doi":"10.4183/aeb.2024.318","DOIUrl":"10.4183/aeb.2024.318","url":null,"abstract":"Context: Premature adrenarche (PA) is linked to prematurity, small for gestational age (SGA), and rapid weight gain. Understanding these factors is important for early identification and management of PA.Objective: To evaluate the impact of prematurity, SGA, obesity, and rapid weight gain on the development of PA in Turkish girls.Design: A retrospective review of medical records from girls diagnosed with PA between 2015 and 2020.Subjects and methods: A total of 104 girls diagnosed with PA were included. Clinical data, including birth weight, gestational age, body mass index (BMI), and hormone levels (DHEA-S), were analyzed. The relationships between PA and prematurity, SGA, obesity, and rapid weight gain (delta weight SDS) were assessed.Results: Of the 104 patients, 14.4% were born prematurely, 28.8% were SGA, and 30.5% were overweight or obese. A positive correlation was observed between delta weight SDS and DHEA-S levels (r=0.523, p<0.01). While obesity was not significantly associated with elevated DHEA-S levels, rapid weight gain was a key factor.Conclusions: Prematurity and SGA are significant risk factors for PA, with rapid weight gain playing a critical role. Monitoring weight gain in SGA and premature infants is essential to mitigate PA-related risks.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"318-323"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BREAST CANCER AND PROLACTIN: A LIFETIME RELATIONSHIP. 乳腺癌和催乳素：一生的关系。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.349

P Lempidaki, S Zervoudis, V Michou, P Eskitzis, G Iatrakis, G Mastorakos

引用次数: 0

ENDOCRINE AND GROWTH ABNORMALITIES IN CHILDREN WITH KIDNEY FAILURE ON MAINTENANCE HEMODIALYSIS - EXPERIENCE OF A SINGLE CENTER FROM WESTERN ROMANIA. 维护性血液透析治疗肾衰竭患儿的内分泌和生长异常——来自罗马尼亚西部单一中心的经验。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.393

R Steflea, R F Stroescu, M Gafencu, F Chisavu, E R Stoicescu, G Doros

{"title":"ENDOCRINE AND GROWTH ABNORMALITIES IN CHILDREN WITH KIDNEY FAILURE ON MAINTENANCE HEMODIALYSIS - EXPERIENCE OF A SINGLE CENTER FROM WESTERN ROMANIA.","authors":"R Steflea, R F Stroescu, M Gafencu, F Chisavu, E R Stoicescu, G Doros","doi":"10.4183/aeb.2024.393","DOIUrl":"10.4183/aeb.2024.393","url":null,"abstract":"The underlying mechanisms for endocrine disturbances in patients with kidney alterations are complex.Aim: To provide better longitudinal follow-up of children, especially to check their progress through puberty.Material and methods: A prospective study was conducted at the \"Louis Turcanu\" Emergency Hospital for Children in Timisoara, Romania during 01.01.2022- 31.12.2024. The study population included ten pediatric patients with end stage renal disease (ESRD) on hemodialysis. Data were collected from the electronic medical records and included demographic information and relevant laboratory parameters, which reflect the patients' anemia status, inflammation, mineral metabolism and other endocrine abnormalities.Results: Erythropoietin doses ranged from 87 to 176 units/kg once a week at the beginning of our study, higher than guidelines recommendations. Most patients presented with hemoglobin levels below the normal range which slightly increased over the 3 years period. Vitamin D levels ranged from 8.1 to 55.8 ng/mL. These resulted in a poor control of the mineral bone disease associated with kidney failure.Conclusions: The loss of kidney function is associated with an impaired control of phosphor-calcium balance, and anemia, growth and pubertal delay in children. This study highlights the need for individualized treatment plans and a multidisciplinary approach in pediatric patients with ESRD.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"393-400"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A NEW-FOUND ARMC5 GERMLINE VARIANT IN PRIMARY BILATERAL MACRONODULAR ADRENAL HYPERPLASIA USING WHOLE-EXOME SEQUENCING AND PROTEIN PREDICTIVE ANALYSIS. 利用全外显子组测序和蛋白质预测分析新发现的原发性双侧肾上腺大结节性增生的armc5种系变异。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.277

Y Zhang, Y Tao, Q Wu, X Liu, C Zou, H Geng

{"title":"A NEW-FOUND ARMC5 GERMLINE VARIANT IN PRIMARY BILATERAL MACRONODULAR ADRENAL HYPERPLASIA USING WHOLE-EXOME SEQUENCING AND PROTEIN PREDICTIVE ANALYSIS.","authors":"Y Zhang, Y Tao, Q Wu, X Liu, C Zou, H Geng","doi":"10.4183/aeb.2024.277","DOIUrl":"10.4183/aeb.2024.277","url":null,"abstract":"Objective: ARMC5 mutations are responsible for the development of primary bilateral macronodular adrenal hyperplasia (PBMAH). In this study, we aimed to report a novel ARMC5 germline variant in a PBMAH patient family.Method: CT examination and dexamethasone suppression test (DST) were used in the diagnosis of PBMAH. Sanger sequencing was used to validate the familial heredity. For the novel variant, protein predictive analysis was performed to study the changes of secondary and tertiary structures and hydrophobicity.Results: A 45 years old male (proband, III-1) was diagnosed as PBMAH. Whole-exome sequencing (WES) was performed, finding one mutation: c.719_ 724dup, p Arg240_ Pro241dup. Sanger sequencing showed the II-2, III-1, IV-1 with heterozygous gene, confirming the familial heredity. For protein predictive analysis, the predicted secondary structure of variants has one alpha-helix structure incomplete compared with normal ARMC5. The tertiary structure could draw the same conclusion, that hydrophobicity decreases after mutation.Conclusion: We reported a new-found ARMC5 germline variant in PBMAH using WES and protein predictive analysis. With the help of WES, early diagnosis of PBMAH could help variant carriers to prevent the occurrence of cancer by lifetime follow-up.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"277-285"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A STEPWISE APPROACH TO LOCALIZATION STUDIES IN PRIMARY HYPERPARATHYROIDISM. 原发性甲状旁腺功能亢进的分步定位研究。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.311

G Balci, A B Bahçecioğlu, F Avcı Merdin, M F Erdoğan

{"title":"A STEPWISE APPROACH TO LOCALIZATION STUDIES IN PRIMARY HYPERPARATHYROIDISM.","authors":"G Balci, A B Bahçecioğlu, F Avcı Merdin, M F Erdoğan","doi":"10.4183/aeb.2024.311","DOIUrl":"10.4183/aeb.2024.311","url":null,"abstract":"Purpose: Primary hyperparathyroidism (PHP) is a prevalent endocrine disorder requiring surgical treatment. The rise of minimally invasive parathyroidectomy as the favored surgical approach emphasizes the significance of localization studies. This study aims to explore clinical and laboratory profiles of PHP patients and evaluate the efficacy of diverse localization methods in a substantial patient cohort.Methods: We analyzed clinical features, biochemical parameters, and imaging outcomes for localization, as well as postoperative histopathological findings in 327 diagnosed PHP patients who underwent surgery. Initial localization methods, which included ultrasonography (US), US-guided Parathormone (PTH) washout analysis, and 99mTechnetium-Sestamibi/123Iodine Scintigraphy (MIBI-SPECT/CT), were applied to all patients. Advanced techniques like Four-Dimensional Computed Tomography (4D-CT) and 18F-Fluorocholine Positron Emission Tomography (18F-FCH PET/CT) were used for cases where initial methods failed and/or for secondary intervention.Results: Minimally invasive surgery accounted for 74% (n=241) of cases. Histopathological analysis revealed single adenoma in 94.5% (n=309) patients, hyperplasia in 5.2% (n=17), and cancer in 0.3% (n=1). Adenoma volume showed a significant positive correlation with serum calcium and parathyroid hormone (PTH) levels (p<0.001). 82 and 26 cases required 4D-CT and 18F-FCH PET/CT respectively, for localization. Positive predictive values (PPV) for imaging modalities were: US (84.56%), US-guided PTH-washout analysis (87.30%), MIBI-SPECT/CT (92.1%), 4D-CT (81.94%), and 18F-FCH PET/CT (95.83%).Conclusion: Serum calcium and PTH levels estimate adenoma size. Initial localization studies (i.e.US, PTH washout and, MIBI-SPECT/CT) effectively localized most adenomas. 4D-CT showed notable efficacy, and 18F-FCH PET/CT had the highest PPV for adenoma localization when the initial studies failed.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"311-317"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CLINICALLY SILENT SOMATOTROPH ADENOMA PRESENTING WITH ACUTE CARPAL TUNNEL SYNDROME: A CASE WITH 14-YEAR FOLLOW-UP AND REVIEW OF THE LITERATURE. 临床沉默的生长发育腺瘤表现为急性腕管综合征：1例14年随访和文献复习。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.403

N Kurtulmus, K Kayikci, S Yarman

{"title":"CLINICALLY SILENT SOMATOTROPH ADENOMA PRESENTING WITH ACUTE CARPAL TUNNEL SYNDROME: A CASE WITH 14-YEAR FOLLOW-UP AND REVIEW OF THE LITERATURE.","authors":"N Kurtulmus, K Kayikci, S Yarman","doi":"10.4183/aeb.2024.403","DOIUrl":"10.4183/aeb.2024.403","url":null,"abstract":"Objective: Carpal tunnel syndrome(CTS) is a neuropathy of the upper limb that is quite common in patients with active acromegaly, but the diagnosis of acromegaly is often made years after the diagnosis of CTS. But in the absence of the typical acral phenotype it is difficult to know when CTS will appear as the first symptom.Method: Here, we present a 27-year-old female patient with a history of numbness that first appeared in her right hand and 2 weeks later in her left hand. While the etiology of acute CTS was being investigated on cervical MRI, the hormonal evaluation of the incidentally detected mass in the sella turcica revealed that it was a clinically silent somatotroph adenoma.Results: Considering the patient's age, desire to have children, lack of typical acral features, the fact that these adenomas may cause phenotypic changes over time, their aggressive course and more recurrences, the decision for transsphenoidal surgery was made. The patient, who has been followed for 14 years, has two healthy children and does not have any complaints, acral phenotype or GH hormone excess.Conclusion: Awareness that acute unilateral/bilateral CTS without any risk factors may be the first sign of clinically silent somatotrophinoma may improve the prognosis of acromegaly by preventing diagnostic delay.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"403-407"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IODINATED CONTRAST MEDIA INDUCED THYROID STORM AND ACUTE CORONARY SYNDROME: A CASE REPORT. 碘造影剂致甲状腺风暴和急性冠状动脉综合征1例报告。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-07-01 Epub Date: 2025-05-23 DOI: 10.4183/aeb.2024.384

J Bjekic-Macut, T Baltic, T Petrovic Nikolic, M Brankovic, M Brajkovic, N Nikolic, N Ivanovic, M Zdravkovic

{"title":"IODINATED CONTRAST MEDIA INDUCED THYROID STORM AND ACUTE CORONARY SYNDROME: A CASE REPORT.","authors":"J Bjekic-Macut, T Baltic, T Petrovic Nikolic, M Brankovic, M Brajkovic, N Nikolic, N Ivanovic, M Zdravkovic","doi":"10.4183/aeb.2024.384","DOIUrl":"10.4183/aeb.2024.384","url":null,"abstract":"Background: A thyroid storm is an extreme disorder that occurs in severe thyrotoxicosis. This condition is life-threatening, with mortality rates up to 10-20%. A typical dose of iodinated contrast media (ICM) contains approximately 13,500 μg of free iodide and 15-60 g of bound iodine, representing an acute iodide load of 90 to several hundred thousand times the recommended daily intake of 150 μg. As a result of sudden exposure to high iodide loads, thyroid hormone regulation can be disrupted, leading to hypothyroidism (Wolff-Chaikoff effect) or hyperthyroidism (Jod-Basedow phenomenon), particularly in those with underlying nodular thyroid disease.Case description: A 37-year-old man presented to the emergency room (ER) with clinical and electrocardiographic signs of acute myocardial infarction. Primary PCI with iodinated contrast was performed. After the intervention, laboratory analyses revealed thyrotoxicosis, and the patient was administered initial thyrosuppressive therapy along with cardiac therapy and discharged from the hospital. One week later, he returned to the hospital with signs of a thyroid storm.Conclusion: This case report aimed to raise awareness regarding the routine evaluation of thyroid function in patients with and without previous signs and symptoms of thyrotoxicosis who had undergone acute myocardial infarction and coronary angiography.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 3","pages":"384-387"},"PeriodicalIF":0.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0