Acta Endocrinologica-Bucharest最新文献_第2页

SYSTEMIC INFLAMMATORY MARKERS - PROGNOSTIC VALUE IN OVARIAN CANCER.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.162

A L Dinca, A Diaconu, R D Birla, B I Coculescu, V G Dinca, I S Tudorache, L Stoica, C Marica, E C Coculescu, E Panaitescu, G Manole, S M Constantinoiu

{"title":"SYSTEMIC INFLAMMATORY MARKERS - PROGNOSTIC VALUE IN OVARIAN CANCER.","authors":"A L Dinca, A Diaconu, R D Birla, B I Coculescu, V G Dinca, I S Tudorache, L Stoica, C Marica, E C Coculescu, E Panaitescu, G Manole, S M Constantinoiu","doi":"10.4183/aeb.2024.162","DOIUrl":"10.4183/aeb.2024.162","url":null,"abstract":"Background: Chronic inflammation is associated with different cancers, and is identified as a key pathogenic mechanism in ovarian cancer. The purpose of our study was to evaluate systemic inflammation markers, as predictive and prognostic factors, in ovarian cancer patients with initial surgical treatment.Subjects and methods: We performed a retrospective study on 60 ovarian cancer patients with primary cytoreduction surgery, between 2010-2018, with a follow-up period of at least one year. We analyzed systemic inflammation markers and their correlations with the clinical, paraclinical, tumor characteristics, or treatment particularities, and evaluated them as prognostic factors for overall survival.Results: In the univariate analysis, no statistically significantly differences were observed, by correlating the systemic inflammation markers with age, reproductive status, FIGO stage, or type of cytoreduction. Higher neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were statistically significant associated with deceased patients, and lower lymphocyte-monocyte ratio (LMR) had statistical significance for living patients. For the patients in the group, the increase of NLR, as well as of PLR leads to the increased risk of death, and the increase of LMR leads to the decrease of this risk. In the multivariate regression analysis, the increase of NLR determined an increased risk of death by 9.7%, and for LMR a reduced risk of death by 46.9%.Conclusions: Systemic inflammation markers had no statistical significance correlated with age, reproductive status, FIGO stage, serous cancer type, or type of cytoreduction but only with overall survival. NLR is an independent risk factor, while LMR is an independent protection factor as well as optimal cytoreduction.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"162-169"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

URINARY BLADDER PARAGANGLIOMA- A NOTEWORTHY, RARE ENTITY.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.236

J N Bharti

{"title":"URINARY BLADDER PARAGANGLIOMA- A NOTEWORTHY, RARE ENTITY.","authors":"J N Bharti","doi":"10.4183/aeb.2024.236","DOIUrl":"10.4183/aeb.2024.236","url":null,"abstract":"Urinary Bladder paraganglioma accounts for 0.06% of all bladder tumors and 1% of all pheochromocytoma. Most tumors are localized at the dome or trigone and are unifocal. The presenting complaints are painless hematuria, micturition syncope. It may be sporadic or associated with hereditary predisposition syndromes such as Hereditary Paraganglioma-Pheochromocytoma Syndrome.Case report: A 70-year-old male presented with complaints of hematuria. The physical examination was unremarkable. The CT scan revealed an enhancing mass in the lateral wall of bladder. The mass was resected, and histopathological examination showed features of tumor cells arranged in Zell ballen pattern. Tumor cells show mild nuclear pleomorphism, round to oval vesicular nuclei, prominent nucleoli and moderate to abundant granular basophilic cytoplasm. Rare mitosis and no necrosis were noted. On immunohistochemistry, tumor cells were immunoreactive to Synaptophysin, S-100P and negative for CK7 suggesting Paraganglioma. The patient is doing fine after two years of follow up. Due to its rarity, there are no recommendations for treatment and monitoring but, their risk of malignancy forces a long-term follow up. Initial management included early reassessment by cystoscopy, transurethral bladder resection (TURB) and imaging.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"236-238"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CONGENITAL HYPOTHYROIDISM SCREENING RESULTS IN THE TURKISH PROVINCE OF ADIYAMAN IN 2015-2020.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.201

F Bolu, S Bolu

{"title":"CONGENITAL HYPOTHYROIDISM SCREENING RESULTS IN THE TURKISH PROVINCE OF ADIYAMAN IN 2015-2020.","authors":"F Bolu, S Bolu","doi":"10.4183/aeb.2024.201","DOIUrl":"10.4183/aeb.2024.201","url":null,"abstract":"Context: Congenital hypothyroidism (CH) is one of the most common preventable causes of intellectual disability, and can be diagnosed in the early period through neonatal screening programs.Objective: The purpose of this study was to determine the prevalence of CH and recall rates in the province of Adıyaman.Design: This retrospective study evaluated the data of newborn screening program in Adıyaman province between January 2015 and December 2020.Subjects and methods: The thyroid-stimulating hormone (TSH) cut-off value in the screening program is 5.5 mIU/L and TSH values lower than 5.5 mIU/L are regarded as normal. Babies with TSH levels exceeding 5.5 mIU/L were defined as 'recalled'. TSH measurements and clinical diagnoses of the recalled babies were evaluated.Results: TSH was <5.5 mIU/L in 62270 (90.08%) of the newborns, 5.5-20 mIU/L in 6114 (8.84%), and >20 mIU/L in 742 (1.07%). Venous T4-TSH values were normal in 673 of the 742 babies with TSH levels exceeding 20 mIU/L, while 63 babies were diagnosed with CH. Heel blood results were normal in 5880 of the 6114 babies with TSH levels of 5.5-20 mIU/L and for whom repeat heel blood was requested. TSH levels in repeat heel blood were >5.5 mIU/L in 184 babies and 93 of them were diagnosed with hypothyroidism. The recall rate among babies undergoing heel blood TSH measurement in the province of Adıyaman was 9.9%. 156 babies were started on thyroid replacement therapy with diagnoses of CH. The incidence of babies diagnosed with hypothyroidism was 1/443.Conclusion: According to the CH screening results, the recall rate and incidence of CH in the province of Adıyaman were higher than the global general figures. Both the low TSH threshold value employed in neonatal hypothyroidism screening and the province falling within the iodine deficiency region may account for this.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"201-206"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ENDOCRINOLOGICAL AND GYNECOLOGICAL PARAMETERS IN ASSESSING INFERTILITY AT REPRODUCTIVE AGE.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.256

A E Tanase, M Ciocoiu, G V Tanase

引用次数: 0

HETEROKARYOTIC MONOZYGOTIC TURNER TWINS: AN INTERESTING PRESENTATION.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.244

Y Denkboy Ongen, A Parlak, E Eren

引用次数: 0

ONCOCYTIC VARIANT OF MEDULLARY CARCINOMA THYROID - A RARE ENTITY.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.247

J N Bharti

引用次数: 0

THE IMPORTANCE OF EARLY DETECTING OF THYROID DYSFUNCTION DURING PREGNANCY AND ASSOCIATION WITH GESTATIONAL DIABETES MELLITUS.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.153

J Todorović, S Dugalić, M Jovandarić, M Stojiljković, I Pantić, M Macura, S Perkovic, M Milinčić, S Demet, S Ilker, M Gojnić

{"title":"THE IMPORTANCE OF EARLY DETECTING OF THYROID DYSFUNCTION DURING PREGNANCY AND ASSOCIATION WITH GESTATIONAL DIABETES MELLITUS.","authors":"J Todorović, S Dugalić, M Jovandarić, M Stojiljković, I Pantić, M Macura, S Perkovic, M Milinčić, S Demet, S Ilker, M Gojnić","doi":"10.4183/aeb.2024.153","DOIUrl":"10.4183/aeb.2024.153","url":null,"abstract":"Objective: Thyroid dysfunction represents common disorder occurring very frequently among women of reproductive age, including pregnancy. The aim of this literature review was to determine in which way thyroid function during pregnancy is associated with GDM.Design: We conducted review of the literature following the basic principles of literature search.Methods: Two researcher independently searched PubMed in the period of last five years (2018-2023) to identify eligible studies regarding thyroid function and GDM.Results: From 51 papers initially found after the inserting key words in PubMed search field 30 were excluded after the title and abstract review. After reading full text of 21 articles, 15 were included in the review.Conclusions: Our review of literature showed not only that two most common disorders during pregnancy were GDM and thyroid dysfunction, but also indicated that they were in positive correlation.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"153-161"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANALYSIS OF PUBLIC INTEREST ABOUT OSTEOPOROSIS USING GOOGLE TRENDS: ARE SEASON AND ECONOMY EFFECTIVE?

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.121

B T Dede, M Oğuz, B Alyanak, F Bağcıer

{"title":"ANALYSIS OF PUBLIC INTEREST ABOUT OSTEOPOROSIS USING GOOGLE TRENDS: ARE SEASON AND ECONOMY EFFECTIVE?","authors":"B T Dede, M Oğuz, B Alyanak, F Bağcıer","doi":"10.4183/aeb.2024.121","DOIUrl":"10.4183/aeb.2024.121","url":null,"abstract":"Background: The aim of this study was to assess the awareness of the USA and world population about osteoporosis, taking into account seasonal variations and economic conditions.Methods: The term \"osteoporosis\" was searched using Google Trends between January 1, 2004 and September 12, 2024. Cosinor analysis was used to test the effect of seasonality on relative search volumes (RSV) for osteoporosis searches in the USA and worldwide. LOESS (Locally Estimated Scatterplot Smoothing) was used to decompose a time series into its seasonal component, trend component, and residual component. We also analysed RSV values in US states according to income levels.Results: It is seen that RSV values in the USA and the world have been in a decreasing trend from 2004 to 2014, but after 2015, they have been in an increasing trend. According to the results of the cosinor analysis, RSV values in the US and worldwide are highest in the fall months and lowest in the summer months. Significant differences were found in search trends between seasons in both the US and the world (p<0.05). There is no statistically significant difference in RSV values by income level worldwide and in the USA (p>0.05).Conclusion: Osteoporosis appears to be a global health problem and a major focus of attention, both in the US and around the world. Health strategies to increase osteoporosis awareness can be planned to address different income groups, taking into account regional and seasonal effects.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"121-126"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SHORT HISTORY OF OBESITY.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.207

D Micic, S Polovina, D Micic, V D Yumuk

引用次数: 0

PREDICTORS OF TSH NORMALIZATION IN THYROTOXICOSIS PATIENTS AFTER TREATMENT.

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.193

C H Han, C H Yin, J S Chen, Y S Chen, C H Chu, W C Chuang, H C Hung

{"title":"PREDICTORS OF TSH NORMALIZATION IN THYROTOXICOSIS PATIENTS AFTER TREATMENT.","authors":"C H Han, C H Yin, J S Chen, Y S Chen, C H Chu, W C Chuang, H C Hung","doi":"10.4183/aeb.2024.193","DOIUrl":"10.4183/aeb.2024.193","url":null,"abstract":"Context: Understanding factors delaying recovery in thyrotoxicosis patients is crucial for optimizing treatment plan.Objective: This study aimed to identify predictive factors for the delayed thyroid function recovery in thyrotoxicosis patients.Design: The study is a retrospective review of medical records of adult thyrotoxicosis patients diagnosed at Kaohsiung Veterans General Hospital, Taiwan, from January 2014 to December 2021. The duration of follow-up for the main outcome was at least 18 months.Subjects and methods: Patients newly diagnosed with thyrotoxicosis who were age > 18 years old, had a TSH level <0.1 μIU/mL, received CBZ or PTU treatment, and demonstrated a subsequent TSH increase to above 0.4 μIU/mL, were included.Results: The study included 443 patients. The average time to achieve normalized TSH levels was 6.9 months. Key factors associated with delayed TSH normalization included higher body mass index (BMI) [odds ratio (OR) = 1.06, confidence interval (CI): 1.01-1.12], elevated serum free T4 levels (OR = 1.97; CI, 1.44-2.69), and treatment with propylthiouracil (OR = 2.66; CI, 1.33-5.32). In contrast, factors such as sex, age, season of diagnosis, and comorbidities did not significantly impact the rate of TSH normalization.Conclusion: The study highlights the importance of considering individual patient characteristics, such as BMI and initial free T4 levels, in thyrotoxicosis management. The findings suggest a potential preference for carbimazole over PTU in achieving faster TSH normalization. This research contributes to the understanding of thyrotoxicosis recovery and supports the need for personalized treatment approaches in clinical practice.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"193-200"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0