Acta Endocrinologica-Bucharest最新文献_第2页

THE CLINICAL SIGNIFICANCE OF COMPLETE BLOOD COUNT, NEUTROPHIL-TO-LYMPHOCYTE RATIO, AND MONOCYTE-TO-LYMPHOCYTE RATIO IN GESTATIONAL DIABETES MELLITUS. 妊娠糖尿病患者全血细胞计数、中性粒细胞与淋巴细胞比率以及单核细胞与淋巴细胞比率的临床意义。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.441

G Liu, J Geng, R Jin, N Zhang, L Mei

{"title":"THE CLINICAL SIGNIFICANCE OF COMPLETE BLOOD COUNT, NEUTROPHIL-TO-LYMPHOCYTE RATIO, AND MONOCYTE-TO-LYMPHOCYTE RATIO IN GESTATIONAL DIABETES MELLITUS.","authors":"G Liu, J Geng, R Jin, N Zhang, L Mei","doi":"10.4183/aeb.2023.441","DOIUrl":"10.4183/aeb.2023.441","url":null,"abstract":"Background: To investigate the association between inflammatory factors, such as complete blood count (CBC) components, neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and gestational diabetes mellitus (GDM).Methods: A total of 635 pregnant women with GDM and 296 with normal pregnancies at 7-13 weeks of gestation who underwent prenatal examinations in the obstetrics department were enrolled (June 2020-December 2020). CBC parameters, including WBC, neutrophil, lymphocyte (LYM), monocyte (MON), red blood cell (RBC), hemoglobin (HGB), mean corpuscular volume (MCV), platelet (PLT), platelet accumulation (PCT), mean platelet volume (MPV), NLR, MLR, PLR, alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transferase (GGT), and other parameters were assessed. The receiver operating characteristic (ROC) curve was used to analyze the screening effects of the variables on the development of GDM.Results: There were significant differences in the blood levels of WBC, NEU, LYM, MON, RBC, HGB, PCT, ALT, AST, GGT, NLR, and MLR between the GDM and control groups (P<0.05). The diagnostic level of MON was the highest among all factors.Conclusion: Inflammatory factors (WBC, NEU, LYM, MON, NLR, and MLR counts) were correlated with GDM.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VON RECKLINGHAUSEN'S DISEASE OF THE BONE. 冯-林格豪森氏骨病。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.529

H S Arun, A K Kattepur

引用次数: 0

EXPRESSION PROFILES OF MIR-155-5P AND MIR-518B MICRORNAS IN CIRCULATING LEUKOCYTES OF THE PREGNANT PATIENTS WITH PREECLAMPSIA AND POLYCYSTIC OVARY SYNDROME. 子痫前期和多囊卵巢综合征孕妇循环白细胞中 mir-155-5p 和 mir-518b 小鼠的表达谱。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.426

M Hocaoglu, S Demirer, I Loclar Karaalp, E Kaynak, E Attar, A Turgut, E Komurcu Bayrak

{"title":"EXPRESSION PROFILES OF MIR-155-5P AND MIR-518B MICRORNAS IN CIRCULATING LEUKOCYTES OF THE PREGNANT PATIENTS WITH PREECLAMPSIA AND POLYCYSTIC OVARY SYNDROME.","authors":"M Hocaoglu, S Demirer, I Loclar Karaalp, E Kaynak, E Attar, A Turgut, E Komurcu Bayrak","doi":"10.4183/aeb.2023.426","DOIUrl":"10.4183/aeb.2023.426","url":null,"abstract":"Context: Polycystic ovary syndrome (PCOS) is associated with increased prevalence of preeclampsia (PE); microRNAs (miRs) could play an important role in the pathogenesis of PE and PCOS.Objective: To investigate the expression levels of miRs 155-5p and 518b in blood leukocytes of patients with PE and PCOS.Design: Using real-time quantitative PCR method, miR-155-5p and miR-518b were examined from PE, PCOS, PE+PCOS, and controls.Subjects and methods: The relative expression of the target miRs in patient samples was compared to control samples. The results were calculated as relative quantification values.Results: Confounding variables were controlled using analyses for covariance. Significant differences were observed in miR-155-5p (p=0.008) and miRNA-518 (p=0.016) expression levels among the groups. miR-155-5p (p=0.014) and miR-518b (p=0.036) were upregulated in PCOS patients and miR-518b (p=0.028) were increased in cases with PCOS+PE. Near significant difference was found (p=0.06) in miR-518b expression levels in cases with PE, compared to controls. miR-518b was observed to be positively correlated with alanine transaminase in cases with PE (r=0.80; P=0.017) and PE+PCOS (r=0.80, p=0.017).Conclusions: Our preliminary findings suggested that expression profiling of miR-155-5p and miR-518b in blood leukocytes were upregulated in pregnant women with PCOS. Moreover, miR-518b was found to be related to PE in cases with PCOS.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SPONTANEOUS CONCEPTION AFTER CYCLE PROGRAMMING WITH DROSPIRENONE - A NEW OPTION FOR FERTILITY TREATMENTS. 使用屈螺酮进行周期编程后自然受孕--生育治疗的新选择。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.505

S Findeklee, R M Sima

引用次数: 0

A 10-YEAR STUDY OF CHILDREN WITH GONADAL TUMORS AND DISORDERS OF SEX DIFFERENTIATION, IN ROMANIA. 罗马尼亚对患有性腺肿瘤和性分化障碍的儿童进行了为期 10 年的研究。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.487

U Ataikiru, R Iacob, A Chirita-Emandi, M Galinescu, I Miron, C Popoiu, E Boia

{"title":"A 10-YEAR STUDY OF CHILDREN WITH GONADAL TUMORS AND DISORDERS OF SEX DIFFERENTIATION, IN ROMANIA.","authors":"U Ataikiru, R Iacob, A Chirita-Emandi, M Galinescu, I Miron, C Popoiu, E Boia","doi":"10.4183/aeb.2023.487","DOIUrl":"10.4183/aeb.2023.487","url":null,"abstract":"Context: Children having gonadal tumors and disorder of sex differentiation (DSD) are rare.Objective: To investigate the presentation of DSD children with malignant gonadal tumors.Methods: A retrospective study from 2010-2020, that evaluated 17 children with DSD, including 13 females, eight months to 16 years, with congenital adrenal hyperplasia, 5-alpha reductase deficiency, androgen insensitivity syndrome, Turner, Sywer, and Klinefelter syndromes.Results: Ten children had malignant gonadal tumor; nine had germ cell tumors and one person granulosa cell tumors, while seven children with non-malignant tumor had gonadoblastoma, cystadenoma (five children), and cysts. Systemic malformations, obesity, elevated tumor markers, and psychosocial issues were observed in 90%, 90%, 70%, and 50% of children with malignancy unlike 28.6%, 42.9%, 14.35%, and 57.1% children without malignancy respectively. Most (9/10) children >12 years, had psychosocial issues, unlike 0/7 children ≤12 years. From 8/17 children presenting with symptoms suggestive of tumor, 75% had malignancy, while from 9/17 children with DSD presentation, 44% had malignant tumors. Malignancy was observed in 3/10 children between eight months to age six, while 7/10 children had stage 1-2 tumors. We reported a child, identified as female, aged 13 years, with partial androgen insensivity syndrome (PAIS) 46,XY, and testicular papillary serous cystadenoma with genomic variant AR NM_000044.4:c.2750del. p.(F917Sfs*27) chromosome Xq12, never published in people with PAIS nor population databases (GnomAD).Conclusion: DSD diagnosis raises numerous challenges. People with DSD have increased risk of malignancy, especially when obesity and, systemic malformations are present; also, psychosocial issues in these children are associated with postpubertal age.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BURNOUT PREVALENCE IN INTENSIVE CARE UNIT, GENERAL SURGERY UNIT AND EMERGENCY UNIT. A ROMANIAN STUDY. 重症监护室、普通外科和急诊室的职业倦怠流行率。罗马尼亚研究。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.523

A C Cotigă, A Gorbănescu, A Luca, E O Vladislav, M Zivari, D Ionescu, S Nica

{"title":"BURNOUT PREVALENCE IN INTENSIVE CARE UNIT, GENERAL SURGERY UNIT AND EMERGENCY UNIT. A ROMANIAN STUDY.","authors":"A C Cotigă, A Gorbănescu, A Luca, E O Vladislav, M Zivari, D Ionescu, S Nica","doi":"10.4183/aeb.2023.523","DOIUrl":"10.4183/aeb.2023.523","url":null,"abstract":"Objective: This study aims to investigate the effect of job characteristics and protective factors on burnout, one of the common medical staff issues. So far, little attention has been paid to testing protective factors' role on medical staff exhaustion.Design: Using a correlation design, these constructs were tested on a sample of 221 participants, doctors, and nurses.Main outcome: The present study revealed protective factors power in predicting burnout, over job characteristics, and the moderation effect of role-playing in the medical care unit and clinical department.Measures: For assessing burnout were used a Romanian translated version of the Maslach Burnout Inventory - General Survey (MBI).Results: Protective factors like physical activities, vacation, and hours spent with family introduced an explanatory model and had a predictive validity over job characteristics in predicting medical staff's burnout. Finally, the effect of physical activities on burnout was moderated both by the role played in the medical care unit and clinical department, while the effect of time served in other medical institutions was moderated only by the role played in the medical care unit.Conclusion: These results provide guidance for better burnout programs interventions, which are addressed to medical healthcare experts.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of thyroiditis in the context of Covid-19: cause-effect and beyond. Covid-19背景下的甲状腺炎管理：因果关系及其他。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.471

G S Gherlan, M L Gheorghiu, C Constantin, M Enyedi, N Baloseanu, D I Tanasie, I Gherlan

{"title":"Management of thyroiditis in the context of Covid-19: cause-effect and beyond.","authors":"G S Gherlan, M L Gheorghiu, C Constantin, M Enyedi, N Baloseanu, D I Tanasie, I Gherlan","doi":"10.4183/aeb.2023.471","DOIUrl":"10.4183/aeb.2023.471","url":null,"abstract":"Background: The COVID-19 pandemic hit the world in late 2019, and by 2020, everyone was affected. Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) belongs to the beta-coronavirus genre and uses the angiotensin-converting enzyme 2 (ACE2) receptor to penetrate cells. Thyroid cells are rich in such receptors. Therefore, this gland is frequently involved alongside other organs in the COVID-19 disease.Aim: To describe COVID-19 inflammation and, eventually, dysregulations of normal thyroid function in a case series of patients diagnosed in a tertiary endocrinology care centre.Patients and methods: We described subacute thyroiditis cases related to COVID-19 infection or vaccination against SARS-CoV2 infection (clinical manifestations and evolution). We also reviewed the literature data regarding COVID-19 infection or vaccination implications in thyroid pathology.Results: The literature describes two types of thyroid involvement in SARS-CoV2 infection or vaccination: subacute thyroiditis (SAT) and non-thyroidal illness syndrome (NTIS). In our case series, 5 patients (3 males), aged 41-54 years, developed the classical clinical manifestation of SAT related to COVID-19 infection (3 patients, concomitantly to upper respiratory infection or a few weeks apart) or anti-SARS-CoV2 ARNm vaccination (1-2 weeks after the vaccine administration). Clinical, laboratory and imaging findings and the evolution (steroid anti-inflammatory treatment used in 4/5 cases) were unremarkable compared to other SAT etiologies.Conclusion: We found no differences between the \"typical\" viral and post-COVID-19 SAT regarding clinical presentation, severity, response to treatment, and thyroid function alteration. The only remarkable difference is the association of SAT with anti-SARS-CoV2 ARNm vaccination.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A COVID-19 PATIENT WITH COMBINED BILATERAL ADRENAL HEMORRHAGE. 一名合并双侧肾上腺出血的 covid-19 患者。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.530

G Chai, Y Wang, Q Ji

引用次数: 0

VARIATIONS IN MONOGENIC DIABETES AND DIABETES SUSCEPTIBILITY GENES IN PEDIATRIC CASES: SINGLE CENTER EXPERIENCE. 儿科病例中单基因糖尿病和糖尿病易感基因的变异：单中心经验。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.512

I Arslanoğlu, R Eröz, F Yavuzyılmaz, M Doğan, S Bolu, S Karaca

{"title":"VARIATIONS IN MONOGENIC DIABETES AND DIABETES SUSCEPTIBILITY GENES IN PEDIATRIC CASES: SINGLE CENTER EXPERIENCE.","authors":"I Arslanoğlu, R Eröz, F Yavuzyılmaz, M Doğan, S Bolu, S Karaca","doi":"10.4183/aeb.2023.512","DOIUrl":"10.4183/aeb.2023.512","url":null,"abstract":"Context: Diabetes is a chronic disorder with a complex pathogenetic background including monogenic, polygenic, and environmental causes.Objective: The aim of the present paper is to share the information related to genetic and clinical data of large pediatric diabetes cohort.Design: The present study retrospectively analyzes genetic and clinical findings of subjects diagnosed with diabetes under the age of 18 year and are in follow-up in a pediatric diabetes referral center.Subjects and methods: Out of 1205 children with diabetes (902 treated with insulin) 246 underwent genetic tests on the basis of clinical selection criteria since 2007.Results: One hundred and ten variants related to diabetes were found in 89 of them. Age at presentation was 9.5±4.02 years (F/M 44/45). In total 49 pathogenic and likely pathogenic, 11 \"hot and warm\" of unknown significance variants were found in fourteen MODY and fifteen non-MODY genes according to criteria developed by American College of Medical Genetics. Thirty novel mutations were found. GCK (26.6%) and ABCC8 (10%) were two most frequently affected genes. Antibody testing revealed negative results in 80% of cases.Conclusions: Genetic interpretation in selected cases is important to understand the nature of the disease better. Improvement in testing opportunity and awareness might increase the prevalence of genetically explained diabetes cases. The distribution of subtypes differs between countries and even regions of the same country.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A COMPREHENSIVE EVALUATION OF HEMOGRAM-DERIVED INFLAMMATORY INDICES IN HASHIMOTO THYROIDITIS AND NON-IMMUNOGENIC HYPOTHYROIDISM. 全面评估桥本氏甲状腺炎和非免疫性甲状腺功能减退症的血细胞衍生炎症指数。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2023-10-01 Epub Date: 2024-06-24 DOI: 10.4183/aeb.2023.435

O Erinc, S Yesilyurt, A Senat

{"title":"A COMPREHENSIVE EVALUATION OF HEMOGRAM-DERIVED INFLAMMATORY INDICES IN HASHIMOTO THYROIDITIS AND NON-IMMUNOGENIC HYPOTHYROIDISM.","authors":"O Erinc, S Yesilyurt, A Senat","doi":"10.4183/aeb.2023.435","DOIUrl":"10.4183/aeb.2023.435","url":null,"abstract":"Objectives: The objective of this study was to evaluate the Systemic Inflammation Index (SII), Platelet to Lymphocyte Ratio (PLR), and Neutrophil to Lymphocyte Ratio (NLR) in HT and NIH, as well as their diagnostic value to predict the presence of inflammation.Subjects and methods: The study included 505 patients, including 190 healthy controls, 166 euthyroid Hashimoto's thyroiditis (HT), 91 hypothyroid HT, and 58 non- immunogenic hypothyroidism (NIH) patients. The records of the patients in each group were reviewed retrospectively.Results: In terms of SII, there was a significant difference between the control and patient groups (p<0.001). PLR and NLR values were also found to be significantly higher in the patient group (p<0.001 and p=0.007, respectively). When euthyroid HT, hypothyroid HT, and NIH subgroups were compared to the control group, there was a significant difference in SII, PLR (for all p<0.001), but not in NLR (p=0.059). SII, PLR, and NLR were not different between the subgroups (p=0.595, p=0.861, and p=0.777, respectively).Conclusions: It was found that the PLR, NLR, and SII indices were higher in Hashimoto's thyroiditis and non-immunogenic hypothyroidism. Of these indices, SII was the most powerful marker to predict the presence of inflammation.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11197836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0