Acta Endocrinologica-Bucharest最新文献

{"title":"EVALUATION OF NON-ALCOHOLIC FATTY LIVER DISEASE AND BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN.","authors":"M Aslan, H Ş Aktaş, S Basat","doi":"10.4183/aeb.2025.31","DOIUrl":"https://doi.org/10.4183/aeb.2025.31","url":null,"abstract":"<p><strong>Background: </strong>In recent years, it has been claimed that non-alcoholoic fatty liver disease (NAFLD) has a negative effect on bone mineral density (BMD) and causes osteoporosis. This study was designed to investigate the relationship between non-alcoholic fatty liver disease and BMD in postmenopausal women.</p><p><strong>Patients and methods: </strong>This study was designed prospectively: 118 postmenopausal women were included in the study. The study participants were divided into two groups as 59 people with NAFLD and 59 people without NAFLD. The groups were compared in terms of bone mineral density.</p><p><strong>Results: </strong>The mean age of the participants in the study was 59.09 ± 9.22 years. According to the degree of NAFLD adiposity of the participants, 59 people were non-NAFLD (50%), 21 people were grade 1 (17.8%), 34 people were grade 2 (28.8%), and 4 people were grade 3 (3.4%). According to the Femur T score of the participants, 2 (1.7%) were osteoporosis, 34 (28.8%) osteopenia, 82 (69.5%) were normal. According to the L1-L4 T score of the participants, 18 (15.3%) were osteoporosis, 44 (37.3%) osteopenia, 56 (47.5%) normal. There was no statistical difference between the two groups in terms of femoral T score and L1-L4 T score. Age, BMI, GGT negatively affect the femoral T score.</p><p><strong>Conclusion: </strong>We found that there was no difference in BMD between groups with and without NAFLD ultrasonographically, but there was a negative correlation between GGT and Femur T score in the subjects.This data suggest that NAFLD may cause osteoporosis\".</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"31-36"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EARLY REASSURANCE OR FALSE SAFETY? THE FETAL HOME DOPPLER USE IN ACTIVE MONITORING IN THE FIRST TRIMESTER OF PREGNANCY - FROM THE ENDOCRINE PERSPECTIVE.","authors":"M Piron-Dumitrascu, V N Varlas, D Cretoiu, N Copca, N Suciu","doi":"10.4183/aeb.2025.142","DOIUrl":"https://doi.org/10.4183/aeb.2025.142","url":null,"abstract":"<p><strong>Context: </strong>The growing use of home monitoring devices during pregnancy has raised concerns about their reliability and psychological impact. From an endocrine perspective, early modulation of maternal stress through the hypothalamic-pituitary-adrenal (HPA) axis may influence fetal neuroendocrine programming. Identifying safe, reassuring tools that stabilize maternal emotional state in early gestation may support healthier endocrine adaptation for both mother and fetus.</p><p><strong>Objective: </strong>To evaluate the feasibility and psychological effects of handheld Doppler use for fetal cardiac monitoring in early pregnancy and to explore correlations between maternal-fetal cardiac coupling and maternal anxiety.</p><p><strong>Design: </strong>Prospective, observational, single-center study conducted between January 2019 and December 2023 at Polizu Clinical Hospital, Bucharest.</p><p><strong>Subjects and methods: </strong>One hundred women ≤14 weeks' gestation completed questionnaires evaluating handheld Doppler and pulse oximeter use. 54 received the DASS-21 anxiety subscale online; 26 provided valid responses. Comparative and correlational analyses were performed using IBM SPSS v29.</p><p><strong>Results: </strong>Fetal heart rate was detected in 67% of cases, with higher detection at increasing gestational ages. Women who detected the heartbeat had higher gestational age (10.4 ± 1.8 vs. 8.6 ± 1.9 weeks, p < 0.01). Anxiety scores inversely correlated with gestational age (p = 0.019). Most participants (68%) found the Doppler reassuring.</p><p><strong>Conclusions: </strong>Handheld Doppler monitoring during early pregnancy is feasible and provides emotional reassurance, potentially stabilizing maternal stress responses and supporting maternal-fetal endocrine adaptation.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"142-147"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIFFERENTIAL METABOLIC AND INFLAMMATORY RESPONSES TO ACUTE HYPERGLYCAEMIA IN ISCHAEMIC STROKE: IMPLICATIONS FOR DIABETES STRATIFICATION AND EARLY PROGNOSTICATION.","authors":"K Alali, O Albitar, S F Ismail, K A Baharuddin, S A Halim, W M Izani Wan Mohamed, C T Chow, N K Keong, T S Tuan Ismail, F S Mohd Zain, M J Mat Salleh, I Looi, P D Suppiah, S M Sheikh Ghadzi, S N Harun","doi":"10.4183/aeb.2025.91","DOIUrl":"https://doi.org/10.4183/aeb.2025.91","url":null,"abstract":"<p><strong>Background: </strong>Hyperglycaemia during acute ischaemic stroke (AIS) has been associated with poorer outcomes yet attempts to normalise glucose have not demonstrated clinical benefit. One proposed explanation is that the participants are not routinely stratified by the pre-stroke glycaemic status (diabetic hyperglycaemia [DHG], non-diabetic hyperglycaemia [NDHG]), which may contribute to heterogeneity in metabolic responses and dilute treatment effects. We compared early endocrine and inflammatory responses (insulin, C-peptide, cortisol, and cytokines) between DHG and NDHG and examined exploratory associations with stroke severity and 90-day functional outcomes.</p><p><strong>Methods: </strong>In this prospective multicentre cohort, 80 patients with AIS and hyperglycaemia (DHG or NDHG) were enrolled within 72 hours of admission. Biomarkers were measured on admission. Group comparisons were performed by diabetes status and stroke severity. Exploratory associations with 90-day functional outcome were assessed with LASSO regression.</p><p><strong>Results: </strong>Compared with DHG, NDHG was associated with higher insulin (142 vs 75 pmol/L;p<0.05), C-peptide (1.15 vs 0.87 nmol/L;p<0.05), IL-8 (23 vs 13 pg/mL;p<0.01), and IL-6 (8 vs 3 pg/mL;p=0.094). Cortisol was numerically higher in DHG than NDHG (352 vs 271 nmol/L;p=0.32). Within NDHG, endocrine and inflammatory measures varied by stroke severity, while remaining generally higher than DHG.</p><p><strong>Conclusion: </strong>Diabetes status was associated with differences in early endocrine and inflammatory profiles during AIS-associated hyperglycaemia. Given the observational design, single-time-point sampling, and modest sample size, these findings should be interpreted as hypothesis-generating. Future adequately powered studies with standardised sampling and detailed diabetes phenotyping are needed to determine whether diabetes-stratified approaches to hyperglycaemia management and prognostic modelling improve clinical utility.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"91-102"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRIGLYCERIDE GLUCOSE (TYG) INDEX AS A CONNECTION BETWEEN INSULIN RESISTANCE AND MICRO- AND MACROALBUMINURIA IN TYPE 2 DIABETES MELLITUS.","authors":"E Imre, H G Gunhan, P Erel, O Ustay","doi":"10.4183/aeb.2025.23","DOIUrl":"https://doi.org/10.4183/aeb.2025.23","url":null,"abstract":"<p><strong>Objective: </strong>The association between the development of diabetic kidney disease (DKD) and the Triglyceride-glucose (TyG) index, a surrogate marker of IR was barely investigated. We studied the role of TyG index in determining the risk of microalbuminuria before grade 3 chronic kidney disease in type 2 diabetes.</p><p><strong>Subjects and methods: </strong>This is a cross-sectional study including 365 patients with type 2 diabetes evaluated in the outpatient clinics of a tertiary center. Patients with febrile illness, obstructive uropathy, severe heart failure, stroke, non-diabetic renal disease, liver disease, malignant disease, autoimmune disease, patients with e-GFR < 60 mL/min/1.73 m², and pregnant patients were excluded.</p><p><strong>Results: </strong>There was more severe insulin resistance in patients with microalbuminuria, as indicated by the TyG index (P = 0.004). Patients with microalbuminuria had a higher mean TyG index than normoalbuminuric patients (p = 0.035). The TyG index positively correlated with the urine albumin/creatinine ratio (r = 0.223, P < 0.001) and was independently associated with DKD in regression analyses. The optimal cut-off point of the TyG index was defined as > 9.66.</p><p><strong>Conclusion: </strong>The present study showed that higher TyG index levels were associated with increased risk of micro-and macroalbuminuria in type 2 diabetic patients.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"23-30"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PITUITARY STALK INTERRUPTION SYNDROME CAUSED BY NOVEL COMPOUND HETEROZYGOUS MUTATIONS IN THE <i>KATNIP</i> GENE.","authors":"S Bahar Akin, I Tolga Ozgen, B Uyanik","doi":"10.4183/aeb.2025.116","DOIUrl":"https://doi.org/10.4183/aeb.2025.116","url":null,"abstract":"<p><p>Pituitary stalk interruption syndrome (PSIS) is characterized by the coexistence of an absent or thin pituitary stalk, an ectopic posterior pituitary (EPP) lobe, and an absent or hypoplastic anterior pituitary lobe. A 1-year-old boy presented with micropenis, and undescended testis associated with growth hormone, thyroid stimulating hormone, and gonadotropin deficiencies. Pituitary hypoplasia, EPP, and a missing pituitary stalk were seen on magnetic resonance imaging (MRI). Whole-exome sequencing (WES) revealed compound heterozygous variants in the <i>KATNIP</i> gene (NM_0.15202.5: c1461G>A / c.4035delC) in the recruited individual, and subsequent familial segregation showed that family established the trans position for c.1461G>A and c.4035delC variants.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"116-121"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PROGNOSTIC IMPLICATIONS OF HOBNAIL CELL MORPHOLOGY IN PAPILLARY THYROID CARCINOMA: A CLINICOPATHOLOGICAL ANALYSIS.","authors":"Y Kayhan, L Azizova, B Gündüz, M Kefeli, E K Kan, A Atmaca, R Çolak","doi":"10.4183/aeb.2025.80","DOIUrl":"https://doi.org/10.4183/aeb.2025.80","url":null,"abstract":"<p><strong>Context: </strong>Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, generally associated with a favorable prognosis. However, variants such as the hobnail subtype exhibit more aggressive pathological and clinical features.</p><p><strong>Objective: </strong>The 2022 WHO classification defines hobnail PTC (HPTC) as tumors with at least 30% hobnail cell morphology, yet the prognostic impact of varying hobnail cell proportions remains unclear.</p><p><strong>Design: </strong>This study aimed to evaluate the clinicopathological characteristics and prognostic significance of PTC with different degrees of hobnail features, contributing to improved risk stratification and management strategies.</p><p><strong>Subjects and methods: </strong>A comprehensive analysis was conducted on PTC cases exhibiting hobnail features at varying proportions. Pathological characteristics, including vascular and lymphatic invasion, calcification, lymph node metastasis, and capsule involvement, were assessed. Logistic regression analysis was performed to determine associations between hobnail morphology and aggressive disease behavior.</p><p><strong>Results: </strong>Tumors with ≥30% hobnail features exhibited significantly (p< 0.05) higher rates of vascular invasion, lymphatic invasion, calcification, and lymph node metastasis compared to tumors with fewer hobnail features and classic PTC. Logistic regression confirmed a strong association between hobnail morphology and lymphatic invasion/metastatic lymph nodes (p = 0.026). However, no significant correlation (p>0.05) was observed with extrathyroidal invasion, bilaterality, or the necessity of radioactive iodine (RAI) treatment.</p><p><strong>Conclusion: </strong>The findings emphasize the aggressive nature of PTC with prominent hobnail features, underscoring the need for tailored therapeutic strategies and close monitoring in affected patients. Further research is warranted to refine prognostic models and optimize treatment approaches.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"80-90"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASSESSMENT OF NON-ENDOCRINOLOGIST PHYSICIANS' AWARENESS OF DIABETES TECHNOLOGIES: A NATIONWIDE SURVEY IN TURKEY.","authors":"E Barsal Çetiner, Z Donbaloğlu","doi":"10.4183/aeb.2025.1","DOIUrl":"https://doi.org/10.4183/aeb.2025.1","url":null,"abstract":"<p><strong>Context: </strong>Continuous glucose monitoring (CGM) and insulin pump technologies have improved the management of type 1 diabetes mellitus, particularly in childhood. Physicians' knowledge and awareness of these devices are essential for their effective use.</p><p><strong>Objective: </strong>To assess physicians' knowledge and awareness regarding CGM and insulin pump systems.</p><p><strong>Design: </strong>This study was designed as a descriptive cross-sectional study.</p><p><strong>Subjects and methods: </strong>A total of 203 non-endocrinologist physicians from different regions and healthcare levels in Turkey participated. A 33-item questionnaire based on the ISPAD guidelines was used to evaluate knowledge.</p><p><strong>Results: </strong>Although 95.6% of participants had heard of CGM devices, only 14.8% correctly identified interstitial fluid as the medium of glucose measurement. While 34.5% knew that 6-10 daily fingerstick measurements are recommended, only half were aware that CGMs record 288 readings per day. Some mistakenly believed CGMs deliver insulin or require insertion in an operating room. Knowledge regarding insulin pump indications and age suitability was also insufficient. Knowledge levels did not significantly differ by specialty, academic title, or institution type.</p><p><strong>Conclusions: </strong>Non-endocrinologist physicians show limited knowledge of diabetes technologies, which may hinder patient education and management. Structured continuing medical education programs are needed to strengthen physicians' competencies in this rapidly advancing field.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"1-9"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECTS OF IRISIN ON REPRODUCTIVE HORMONES, LIPID PROFILES, AND OXIDATIVE STRESS BIOMARKERS IN MALE RATS.","authors":"B Shokrollahi, M Ibrahim Kwekha Zandi, A Palani, M Y Won, H J Lee, S S Kang","doi":"10.4183/aeb.2025.37","DOIUrl":"https://doi.org/10.4183/aeb.2025.37","url":null,"abstract":"<p><strong>Context: </strong>Irisin, a cleaved product of fibronectin type III domain-containing protein 5 (FNDC5), has been proposed as a key molecular link between energy metabolism and reproductive regulation. Emerging evidence suggests that it modulates hypothalamic-pituitary-gonadal (HPG) activity and oxidative balance, but its reproductive effects in males remain insufficiently defined.</p><p><strong>Objective: </strong>To evaluate the endocrine, antioxidant, and reproductive responses to exogenous irisin administration in healthy male Wistar rats.</p><p><strong>Design: </strong>A controlled, time-course experimental study was conducted to assess hormonal, biochemical, and sperm-related outcomes following irisin treatment.</p><p><strong>Subjects and methods: </strong>Twenty-four adult male Wistar rats were randomly allocated to Control (saline) or Treated (irisin, 200 ng/kg, subcutaneous) groups, with sample collection on days 10, 20, and 30. Serum levels of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, lipid profiles, and oxidative stress biomarkers [malondialdehyde (MDA), reactive oxygen species (ROS), total antioxidant capacity (TAC)] were analyzed. Sperm count, motility, and morphology were also evaluated.</p><p><strong>Results: </strong>Irisin administration significantly increased serum GnRH, LH, FSH, and testosterone concentrations (p < 0.001), indicating activation of the HPG axis. Lipid parameters remained unchanged. Oxidative stress markers were favorably modulated, with reduced MDA and ROS (p < 0.05) and a progressive increase in TAC over time (p < 0.05, group × day interaction). Sperm count was higher in the Treated group (p < 0.05), while motility and morphology were not significantly affected.</p><p><strong>Conclusions: </strong>Subcutaneous irisin administration enhances reproductive hormone secretion, improves antioxidant capacity, and increases sperm production in male rats without altering lipid metabolism. These findings suggest that irisin may serve as a potential therapeutic modulator of male reproductive function, particularly under conditions involving oxidative stress or endocrine disruption.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"37-46"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IMPACT OF HIGH-RISK HPV INFECTION AND MATERNAL THYROID FUNCTION ON ADVERSE OBSTETRIC OUTCOMES.","authors":"C E Condrat, D Cretoiu, S R Iacoban, N Copca, S C Voinea, V N Varlas, N Suciu","doi":"10.4183/aeb.2025.47","DOIUrl":"https://doi.org/10.4183/aeb.2025.47","url":null,"abstract":"<p><strong>Background: </strong>High-risk-HPV, metabolic disorders, and prior cesarean scar have been linked with adverse obstetric outcomes, but their combined effects are unclear.</p><p><strong>Methods: </strong>Retrospective cohort of 185 pregnancies at a Romanian tertiary center (2021-2024) with high-risk HPV DNA testing ≤24 weeks and thyroid profiling. Exposures: HPV status and comorbidities (gestational hypertension, gestational diabetes, prior cesarean scar). Primary outcome: cesarean delivery; secondary: preterm birth <37 weeks, major placental pathology, NICU admission. Multilevel logistic regression adjusted for age, BMI, parity, smoking, and twin gestation; interaction terms assessed HPV×comorbidity.</p><p><strong>Results: </strong>41/185 (22.2%) HPV-positive. Cesarean odds were higher for HPV-negative with any comorbidity (aOR 2.9, 95% CI 1.5-5.6) and highest for HPV-positive with comorbidity (aOR 4.3, 1.8-10.2) versus HPV-negative without comorbidity. HPV-positive status was associated with a modest TSH increase (max Δ+0.25 mIU/L in T3, 95% CI 0.05-0.44; p = 0.013), with similar FT4/FT3 and values largely within pregnancy-specific ranges. A significant interaction was observed for HPV × prior cesarean scar on preterm birth (p_interaction = 0.008; aOR 2.9, 1.2-7.2); interactions with gestational hypertension or diabetes were non-significant.</p><p><strong>Conclusions: </strong>High-risk HPV combined with maternal comorbidity was associated with increased cesarean and preterm-birth risk. Findings support incorporating HPV status into antenatal risk assessment and warrant larger prospective studies.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"47-58"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LEVELS OF COPEPTIN AND BETA-HYDROXY BUTYRATE IN DIABETIC KETOACIDOSIS.","authors":"Ç Yücel, Y Yüzbaşıoğlu, Y Katırcı, M S Ertuğrul, E Cömertpay","doi":"10.4183/aeb.2025.17","DOIUrl":"https://doi.org/10.4183/aeb.2025.17","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetic ketoacidosis (DKA) is an acute complication of diabetes mellitus, characterized by hyperglycemia, ketosis, and metabolic acidosis. This study aimed to evaluate blood and urine levels of copeptin and β-OHB in patients with DKA.</p><p><strong>Patients and methods: </strong>49 patients with DKA and 30 healthy controls were included in the study. Serum and urine β-OHB and copeptin levels were measured using ELISA. Statistical analysis included Mann-Whitney U test, t-test, and ROC curve analysis to assess diagnostic performance.</p><p><strong>Results: </strong>Compared with controls, patients with DKA demonstrated significantly higher serum and urine β-OHB levels (p < 0.001) and lower serum copeptin levels (p < 0.001), while urine copeptin did not differ significantly (p = 0.456). Serum copeptin showed high sensitivity (98.0%) but limited specificity, whereas urine copeptin had low diagnostic value.</p><p><strong>Discussion: </strong>This study confirms β-OHB as a reliable biomarker for diagnosing DKA, with urine β-OHB offering a rapid and non-invasive alternative. Copeptin did not demonstrate diagnostic discrimination between DKA and healthy subjects.</p><p><strong>Conclusion: </strong>Quantitative measurement of serum and urine β-OHB provides superior diagnostic accuracy in DKA and should be incorporated into emergency diagnostic pathways. Copeptin may complement β-OHB in monitoring fluid status.</p>","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"21 1","pages":"17-22"},"PeriodicalIF":0.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12966836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}