Acta Endocrinologica-Bucharest最新文献_第10页

EFFICACY AND PROGNOSIS IN PATIENTS WITH PAPILLARY THYROID CANCER WITH POSTOPERATIVE PREABLATIVE STIMULATED THYROGLOBULIN ABOVE 10 NG/ML AFTER INITIAL THERAPY WITH RADIOIODINE. 甲状腺乳头状癌术后放射碘初始治疗促甲状腺球蛋白高于10 ng / ml患者的疗效及预后

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.186

L Luo, J Xia, R Zhang, X Yao

{"title":"EFFICACY AND PROGNOSIS IN PATIENTS WITH PAPILLARY THYROID CANCER WITH POSTOPERATIVE PREABLATIVE STIMULATED THYROGLOBULIN ABOVE 10 NG/ML AFTER INITIAL THERAPY WITH RADIOIODINE.","authors":"L Luo, J Xia, R Zhang, X Yao","doi":"10.4183/aeb.2024.186","DOIUrl":"10.4183/aeb.2024.186","url":null,"abstract":"Objective: Few prognostic analyses have been conducted for papillary thyroid cancer (PTC) patients with preablative stimulated Tg >10 ng/mL. We investigated the therapeutic responses and prognosis of these patients after the initial radioiodine (RAI) therapy.Methods: We retrospectively assessed 256 patients with PTC who underwent RAI remnant ablation after total thyroidectomy, and all presTg levels were >10 ng/mL. We assessed therapeutic responses and influencing factors 6-12 months after the initial RAI therapy. The Kaplan-Meier method was used to analyze progression-free survival (PFS).Results: After initial RAI therapy, excellent (ER), indeterminate (IDR), biochemically incomplete (BIR), and structurally incomplete (SIR) responses were identified in 5.1% (13/256), 22.6% (58/256), 46.9% (120/256), and 25.4% (65/256) of the patients, respectively. Among them, incomplete response (IR [BIR+SIR]), accounting for 72.3% of the responses. Univariate and multivariate analyses showed that presTg (OR=1.047, 95% CI 1.027-1.066, p=0.000), sex (OR=3.356, 95% CI 1.613-6.986, p=0.001), and tumor size (OR=1.431, 95% CI 1.050-1.951, p=0.023) were independent risk factors for IR. ROC analysis identified presTg levels and tumor size cutoffs of 24.4 mg/mL and 2.3 cm, respectively, for predicting IR. The PFS was significantly shorter in the SIR group than in the ER, IDR, and BIR groups (p=0.020). At the last follow-up, the number of patients with SIR decreased significantly (65 to 44 cases).Conclusions: PresTg level, tumor size, and male sex were predictive of IR, and patients with initial SIR showed the poorest prognosis. Individualized interventions can improve the prognosis of patients with an initial SIR.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"186-192"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE MUSCULOSKELETAL DISORDERS IN DIABETIC PATIENTS AND THE EVALUATION OF THEIR RELATIONSHIP WITH METABOLIC PARAMETERS AND MICROVASCULAR COMPLICATIONS. 糖尿病患者肌肉骨骼疾病及其与代谢参数和微血管并发症关系的评价。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.136

P Edis, N Ozdemir, Z Hekimsoy

{"title":"THE MUSCULOSKELETAL DISORDERS IN DIABETIC PATIENTS AND THE EVALUATION OF THEIR RELATIONSHIP WITH METABOLIC PARAMETERS AND MICROVASCULAR COMPLICATIONS.","authors":"P Edis, N Ozdemir, Z Hekimsoy","doi":"10.4183/aeb.2024.136","DOIUrl":"10.4183/aeb.2024.136","url":null,"abstract":"Background: Diabetes mellitus has been associated with many different musculoskeletal system problems.Objective: This study aims to show the prevalence of musculoskeletal disorders in patients with diabetes and to reveal their relationship to the metabolic parameters and microvascular complications.Methods: Seven hundred two diabetic patients who consecutively applied to our clinic between March 2017 and February 2018 were included in this prospective cross-sectional study. The relationship of the musculoskeletal disorders including carpal tunnel syndrome, Dupuytren's contracture, adhesive capsulitis, flexor tenosynovitis, limited joint mobility syndrome, Charcot arthropathy, diabetic foot and gout to the patients' age, gender, type of diabetes, duration of diabetes, metabolic parameters, and microvascular complications were evaluated.Results: Musculoskeletal system disorders were detected in 45.9% (n = 322) of the 702 diabetic patients evaluated in our study. The most common disorders were carpal tunnel syndrome 17.7% (n = 124), Dupuytren's contracture 14.4% (n = 101), and adhesive capsulitis 13.8% (n = 97). A statistically significant relationship of the HbA1c level with Dupuytren's contracture, carpal tunnel syndrome, and adhesive capsulitis was detected (p<0.05).Conclusions: Patients' age, duration of diabetes, HbA1c level, and presence of microvascular complications are associated with musculoskeletal disorders in this population.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"136-142"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PARATHYROID CANCER: REVIEW OF UNCOMMON DISEASE. 甲状旁腺癌：罕见疾病综述。

IF 0.8 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.212

H Yabanoglu, I M Arer, F Ozarslan

引用次数: 0

OUTCOME OF FOUR PATIENTS WITH OSTEONECROSIS AFTER ONE-YEAR PAMIDRONATE TREATMENT. 4例骨坏死患者帕米膦酸治疗1年后的结果。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.239

K Yüksek Acinikli, Ö Besci, E Yaşar, Ö Tüfekçi, Z Karadağ, G Yıldız, R Torun, G Akın Kağızmanlı, M Torun Bayram, Ş Yılmaz, H Güleryüz, A Abacı, E Böber, K Demir

{"title":"OUTCOME OF FOUR PATIENTS WITH OSTEONECROSIS AFTER ONE-YEAR PAMIDRONATE TREATMENT.","authors":"K Yüksek Acinikli, Ö Besci, E Yaşar, Ö Tüfekçi, Z Karadağ, G Yıldız, R Torun, G Akın Kağızmanlı, M Torun Bayram, Ş Yılmaz, H Güleryüz, A Abacı, E Böber, K Demir","doi":"10.4183/aeb.2024.239","DOIUrl":"10.4183/aeb.2024.239","url":null,"abstract":"Context: Osteonecrosis (ON) is bone death caused by inadequate blood supply and its optimal management remains uncertain.Objective: We describe the outcomes of BP (pamidronate) treatment in our patients.Design: Data regarding clinical, laboratory, magnetic resonance imaging (MRI) studies, and bone mineral density measurements (BMD) were recorded before and one year after treatment (reevaluation). The severity of the clinical picture was assessed using the criteria of the common terminology criteria for adverse events (CTCAE).Subjects and methods: There were four female patients (patient 1, acute lymphoblastic leukemia; patient 2, immune thrombocytopenic purpura; patients 3 and 4, systemic lupus erythematosus) .All of them had been treated with high-dose prednisolone. Clinical picture of all patients were consistent with grade 3 according to CTCAE(: severe symptoms, limiting self-care ).Results: ON lesions were multifocal in the lower limbs in all of them and none of them had any fractures. All of them had been treated with high-dose glucocorticoid. Patients were treated with pamidronate (1 mg/kg/day, with maximum dose of 60 mg/day, for two days, quarterly). At the time of re-evaluation(one year after treatment), the lesions were stable on MRI, and their clinical condition was consistent with grade 1 according to CTCAE(asymptomatic). No side effects related to the use of bisphosphonates were observed except for increased BMD (SD score of 2.9) in one of the patients.Conclusions: Pamidronate may be an effective treatment for the improvement of functional impairment and pain among patients with severe osteonecrosis (ON) lesions.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"239-243"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SYSTEMIC INFLAMMATORY MARKERS - PROGNOSTIC VALUE IN OVARIAN CANCER. 系统性炎症标志物-卵巢癌的预后价值。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.162

A L Dinca, A Diaconu, R D Birla, B I Coculescu, V G Dinca, I S Tudorache, L Stoica, C Marica, E C Coculescu, E Panaitescu, G Manole, S M Constantinoiu

{"title":"SYSTEMIC INFLAMMATORY MARKERS - PROGNOSTIC VALUE IN OVARIAN CANCER.","authors":"A L Dinca, A Diaconu, R D Birla, B I Coculescu, V G Dinca, I S Tudorache, L Stoica, C Marica, E C Coculescu, E Panaitescu, G Manole, S M Constantinoiu","doi":"10.4183/aeb.2024.162","DOIUrl":"10.4183/aeb.2024.162","url":null,"abstract":"Background: Chronic inflammation is associated with different cancers, and is identified as a key pathogenic mechanism in ovarian cancer. The purpose of our study was to evaluate systemic inflammation markers, as predictive and prognostic factors, in ovarian cancer patients with initial surgical treatment.Subjects and methods: We performed a retrospective study on 60 ovarian cancer patients with primary cytoreduction surgery, between 2010-2018, with a follow-up period of at least one year. We analyzed systemic inflammation markers and their correlations with the clinical, paraclinical, tumor characteristics, or treatment particularities, and evaluated them as prognostic factors for overall survival.Results: In the univariate analysis, no statistically significantly differences were observed, by correlating the systemic inflammation markers with age, reproductive status, FIGO stage, or type of cytoreduction. Higher neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) were statistically significant associated with deceased patients, and lower lymphocyte-monocyte ratio (LMR) had statistical significance for living patients. For the patients in the group, the increase of NLR, as well as of PLR leads to the increased risk of death, and the increase of LMR leads to the decrease of this risk. In the multivariate regression analysis, the increase of NLR determined an increased risk of death by 9.7%, and for LMR a reduced risk of death by 46.9%.Conclusions: Systemic inflammation markers had no statistical significance correlated with age, reproductive status, FIGO stage, serous cancer type, or type of cytoreduction but only with overall survival. NLR is an independent risk factor, while LMR is an independent protection factor as well as optimal cytoreduction.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"162-169"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

URINARY BLADDER PARAGANGLIOMA- A NOTEWORTHY, RARE ENTITY. 膀胱副神经节瘤-一个值得注意的，罕见的实体。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.236

J N Bharti

{"title":"URINARY BLADDER PARAGANGLIOMA- A NOTEWORTHY, RARE ENTITY.","authors":"J N Bharti","doi":"10.4183/aeb.2024.236","DOIUrl":"10.4183/aeb.2024.236","url":null,"abstract":"Urinary Bladder paraganglioma accounts for 0.06% of all bladder tumors and 1% of all pheochromocytoma. Most tumors are localized at the dome or trigone and are unifocal. The presenting complaints are painless hematuria, micturition syncope. It may be sporadic or associated with hereditary predisposition syndromes such as Hereditary Paraganglioma-Pheochromocytoma Syndrome.Case report: A 70-year-old male presented with complaints of hematuria. The physical examination was unremarkable. The CT scan revealed an enhancing mass in the lateral wall of bladder. The mass was resected, and histopathological examination showed features of tumor cells arranged in Zell ballen pattern. Tumor cells show mild nuclear pleomorphism, round to oval vesicular nuclei, prominent nucleoli and moderate to abundant granular basophilic cytoplasm. Rare mitosis and no necrosis were noted. On immunohistochemistry, tumor cells were immunoreactive to Synaptophysin, S-100P and negative for CK7 suggesting Paraganglioma. The patient is doing fine after two years of follow up. Due to its rarity, there are no recommendations for treatment and monitoring but, their risk of malignancy forces a long-term follow up. Initial management included early reassessment by cystoscopy, transurethral bladder resection (TURB) and imaging.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"236-238"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ENDOCRINOLOGICAL AND GYNECOLOGICAL PARAMETERS IN ASSESSING INFERTILITY AT REPRODUCTIVE AGE. 评估育龄不孕症的内分泌和妇科参数。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.256

A E Tanase, M Ciocoiu, G V Tanase

引用次数: 0

CONGENITAL HYPOTHYROIDISM SCREENING RESULTS IN THE TURKISH PROVINCE OF ADIYAMAN IN 2015-2020. 2015-2020年土耳其阿迪亚曼省先天性甲状腺功能减退筛查结果

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.201

F Bolu, S Bolu

{"title":"CONGENITAL HYPOTHYROIDISM SCREENING RESULTS IN THE TURKISH PROVINCE OF ADIYAMAN IN 2015-2020.","authors":"F Bolu, S Bolu","doi":"10.4183/aeb.2024.201","DOIUrl":"10.4183/aeb.2024.201","url":null,"abstract":"Context: Congenital hypothyroidism (CH) is one of the most common preventable causes of intellectual disability, and can be diagnosed in the early period through neonatal screening programs.Objective: The purpose of this study was to determine the prevalence of CH and recall rates in the province of Adıyaman.Design: This retrospective study evaluated the data of newborn screening program in Adıyaman province between January 2015 and December 2020.Subjects and methods: The thyroid-stimulating hormone (TSH) cut-off value in the screening program is 5.5 mIU/L and TSH values lower than 5.5 mIU/L are regarded as normal. Babies with TSH levels exceeding 5.5 mIU/L were defined as 'recalled'. TSH measurements and clinical diagnoses of the recalled babies were evaluated.Results: TSH was <5.5 mIU/L in 62270 (90.08%) of the newborns, 5.5-20 mIU/L in 6114 (8.84%), and >20 mIU/L in 742 (1.07%). Venous T4-TSH values were normal in 673 of the 742 babies with TSH levels exceeding 20 mIU/L, while 63 babies were diagnosed with CH. Heel blood results were normal in 5880 of the 6114 babies with TSH levels of 5.5-20 mIU/L and for whom repeat heel blood was requested. TSH levels in repeat heel blood were >5.5 mIU/L in 184 babies and 93 of them were diagnosed with hypothyroidism. The recall rate among babies undergoing heel blood TSH measurement in the province of Adıyaman was 9.9%. 156 babies were started on thyroid replacement therapy with diagnoses of CH. The incidence of babies diagnosed with hypothyroidism was 1/443.Conclusion: According to the CH screening results, the recall rate and incidence of CH in the province of Adıyaman were higher than the global general figures. Both the low TSH threshold value employed in neonatal hypothyroidism screening and the province falling within the iodine deficiency region may account for this.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"201-206"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE IMPORTANCE OF EARLY DETECTING OF THYROID DYSFUNCTION DURING PREGNANCY AND ASSOCIATION WITH GESTATIONAL DIABETES MELLITUS. 早期发现妊娠期甲状腺功能障碍的重要性及其与妊娠期糖尿病的关系。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.153

J Todorović, S Dugalić, M Jovandarić, M Stojiljković, I Pantić, M Macura, S Perkovic, M Milinčić, D Sengul, I Sengul, M Gojnić

{"title":"THE IMPORTANCE OF EARLY DETECTING OF THYROID DYSFUNCTION DURING PREGNANCY AND ASSOCIATION WITH GESTATIONAL DIABETES MELLITUS.","authors":"J Todorović, S Dugalić, M Jovandarić, M Stojiljković, I Pantić, M Macura, S Perkovic, M Milinčić, D Sengul, I Sengul, M Gojnić","doi":"10.4183/aeb.2024.153","DOIUrl":"10.4183/aeb.2024.153","url":null,"abstract":"Objective: Thyroid dysfunction represents common disorder occurring very frequently among women of reproductive age, including pregnancy. The aim of this literature review was to determine in which way thyroid function during pregnancy is associated with GDM.Design: We conducted review of the literature following the basic principles of literature search.Methods: Two researcher independently searched PubMed in the period of last five years (2018-2023) to identify eligible studies regarding thyroid function and GDM.Results: From 51 papers initially found after the inserting key words in PubMed search field 30 were excluded after the title and abstract review. After reading full text of 21 articles, 15 were included in the review.Conclusions: Our review of literature showed not only that two most common disorders during pregnancy were GDM and thyroid dysfunction, but also indicated that they were in positive correlation.","PeriodicalId":50902,"journal":{"name":"Acta Endocrinologica-Bucharest","volume":"20 2","pages":"153-161"},"PeriodicalIF":0.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HETEROKARYOTIC MONOZYGOTIC TURNER TWINS: AN INTERESTING PRESENTATION. 异核同卵特纳双胞胎：一个有趣的报告。

IF 0.7 4区医学

Acta Endocrinologica-Bucharest Pub Date : 2024-04-01 Epub Date: 2025-01-18 DOI: 10.4183/aeb.2024.244

Y Denkboy Ongen, A Parlak, E Eren

引用次数: 0