PAGET'S DISEASE OF THE BONE FOUND INCIDENTALLY ON F-18 FDG PET/CT: CLINICAL SIGNIFICANCE AND DIFFERENTIAL DIAGNOSTIC CRITERIA.

IF 0.7 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Acta Endocrinologica-Bucharest Pub Date : 2023-07-01 Epub Date: 2024-02-01 DOI:10.4183/aeb.2023.292
F Üstün, F E Ustabaşıoğlu, B Tokuç, B Yımaz Bülbül, M Çelik, S Aytürk
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引用次数: 0

Abstract

Background: Paget Disease (PD) is usually asymptomatic and discovered incidentally, it is known that it is exhibited low to high grade increased F-18 FDG uptake.

Aim: In this study, we investigated the distinguishability of FDG PET/CT in incidental PD cases from other bone diseases and at different stages of the disease.

Patients and methods: In this cross-sectional, descriptive study, "Paget" identification associated with PET/CT reports was found in 69 of 18,119 studies (~3.8%). Of the 45 patients (33 males and 12 females) eligible for inclusion in the study, 35.6% had monostotic and 64.4% had polyostotic disease (p>0.5). There was no statistically significant difference in biochemical parameters between groups.

Results: According to the radiological appearance of the patients, 36 were in the mixed stage and 9 were in the blastic stage. Only the difference in ALP and creatinine values between the groups was statistically significant. SUVmax, SUVmean and HU values were found to be statistically significantly higher in pagetoid bones compared to control bone lesions. For SUVmax for PD bone lesion we found the 2.55 cutoff point with a sensitivity of 91% and a specificity of 84%.

Conclusion: The specific radiological appearance of bone lesions and the evaluation of metabolic activity compared to normal bone seem to help differentiate PD from other lesions. Prospective studies are needed in the differentiation of FDG's disease stage and treatment response evaluation. The ability to differentiate between benign and malignant FDG avid bone lesions in oncological patients' enables appropriate patient management, including avoiding unnecessary additional invasive procedures such as bone biopsy.

在 F-18 FDG PET/CT 上偶然发现的骨的帕吉特氏病:临床意义和鉴别诊断标准。
背景:目的:在这项研究中,我们调查了FDG PET/CT在偶发PD病例中与其他骨病和疾病不同阶段的可区分性:在这项横断面描述性研究中,18119 项研究中有 69 项(约占 3.8%)发现了与 PET/CT 报告相关的 "Paget "鉴定。在符合研究条件的 45 名患者(33 名男性和 12 名女性)中,35.6% 患有单发性疾病,64.4% 患有多发性疾病(P>0.5)。各组间的生化指标差异无统计学意义:结果:根据患者的放射学表现,36 例为混合型,9 例为疱疹型。只有ALP和肌酐值在组间差异有统计学意义。与对照组骨病变相比,髓样骨的 SUVmax、SUVmean 和 HU 值在统计学上明显更高。我们发现,PD 骨病变的 SUVmax 临界点为 2.55,敏感性为 91%,特异性为 84%:结论:与正常骨相比,骨病变的特异性放射学外观和代谢活动评估似乎有助于区分帕金森病和其他病变。在区分 FDG 的疾病分期和治疗反应评估方面需要进行前瞻性研究。区分肿瘤患者良性和恶性FDG阳性骨病变的能力有助于对患者进行适当的管理,包括避免不必要的额外侵入性程序,如骨活检。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Endocrinologica-Bucharest
Acta Endocrinologica-Bucharest 医学-内分泌学与代谢
CiteScore
1.30
自引率
20.00%
发文量
53
审稿时长
6-12 weeks
期刊介绍: Acta Endocrinologica (Buc) is an international journal covering the fields of basic and clinical Endocrinology, Neuroendocrinology, Reproductive Medicine, Chronobiology, Human Ethology published quarterly Acta Endocrinologica (Buc) is the official international journal of the Romanian Society for Endocrinology. It continues the former Romanian Journal of Endocrinology
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