European Heart Journal - Imaging Methods and Practice最新文献

{"title":"Four-dimensional analysis of aortic root motion in normal population using retrospective multiphase computed tomography","authors":"X. Yuan, Xiaoxin Kan, Jianpeng Li, Yang Yan, Saeed Mirsadraee, Tarun Mittal, Andrew Shah, Debbie Saunders, Xiao Yun Xu, Christoph A Nienaber","doi":"10.1093/ehjimp/qyae007","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae007","url":null,"abstract":"\u0000 \u0000 \u0000 Aortic root motion is suspected to contribute to proximal aortic dissection. While motion of the aorta in 4 dimensions can be traced with real-time imaging, displacement and rotation in quantitative terms remain unknown.\u0000 \u0000 \u0000 \u0000 The hypothesis was to slow feasibility of quantification of 3-dimensional aortic root motion from dynamic CT imaging.\u0000 \u0000 \u0000 \u0000 Dynamic CT images of 40 patients for coronary assessment were acquired using a dynamic protocol. Scans were ECG-triggered and segmented in 10 time-stepped phases (0%-90%) per cardiac cycle. With identification of the sino-tubular junction (STJ) a patient-specific coordinate system was created with the Z-axis (out-of-plane) parallel to longitudinal direction. The left and right coronary ostia were traced at each time-step to quantify downward motion in reference to the STJ plane, motion within the STJ plane (in-plane), and the degree of rotation.\u0000 \u0000 \u0000 \u0000 Enrolled individuals had an age of 65 ± 12, and 14 were male (35%). The out-of-plane motion was recorded with the largest displacement of 10.26 ± 2.20 and 8.67 ± 1.69 mm referenced by left and right coronary ostium, respectively. The mean downward movement of aortic root was 9.13 ± 1.86 mm. The largest in-plane motion was recorded at 9.17 ± 2.33 mm and 6.51 ± 1.75 mm referenced to left and right coronary ostium, respectively. The largest sino-tubular junction in-plane motion was 7.37 ± 1.96 mm, and rotation of the aortic root was 11.8 ± 4.60⁰.\u0000 \u0000 \u0000 \u0000 In-vivo spatial and temporal displacement of the aortic root can be identified and quantified from multiphase ECG-gated contrast-enhanced CT images. Knowledge of normal 4D motion of the aortic root may help understand its biomechanical impact in patients with aortopathy and pre- and post-surgical or transcatheter aortic valve replacement.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"11 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139805655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four-dimensional analysis of aortic root motion in normal population using retrospective multiphase computed tomography","authors":"X. Yuan, Xiaoxin Kan, Jianpeng Li, Yang Yan, Saeed Mirsadraee, Tarun Mittal, Andrew Shah, Debbie Saunders, Xiao Yun Xu, Christoph A Nienaber","doi":"10.1093/ehjimp/qyae007","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae007","url":null,"abstract":"\u0000 \u0000 \u0000 Aortic root motion is suspected to contribute to proximal aortic dissection. While motion of the aorta in 4 dimensions can be traced with real-time imaging, displacement and rotation in quantitative terms remain unknown.\u0000 \u0000 \u0000 \u0000 The hypothesis was to slow feasibility of quantification of 3-dimensional aortic root motion from dynamic CT imaging.\u0000 \u0000 \u0000 \u0000 Dynamic CT images of 40 patients for coronary assessment were acquired using a dynamic protocol. Scans were ECG-triggered and segmented in 10 time-stepped phases (0%-90%) per cardiac cycle. With identification of the sino-tubular junction (STJ) a patient-specific coordinate system was created with the Z-axis (out-of-plane) parallel to longitudinal direction. The left and right coronary ostia were traced at each time-step to quantify downward motion in reference to the STJ plane, motion within the STJ plane (in-plane), and the degree of rotation.\u0000 \u0000 \u0000 \u0000 Enrolled individuals had an age of 65 ± 12, and 14 were male (35%). The out-of-plane motion was recorded with the largest displacement of 10.26 ± 2.20 and 8.67 ± 1.69 mm referenced by left and right coronary ostium, respectively. The mean downward movement of aortic root was 9.13 ± 1.86 mm. The largest in-plane motion was recorded at 9.17 ± 2.33 mm and 6.51 ± 1.75 mm referenced to left and right coronary ostium, respectively. The largest sino-tubular junction in-plane motion was 7.37 ± 1.96 mm, and rotation of the aortic root was 11.8 ± 4.60⁰.\u0000 \u0000 \u0000 \u0000 In-vivo spatial and temporal displacement of the aortic root can be identified and quantified from multiphase ECG-gated contrast-enhanced CT images. Knowledge of normal 4D motion of the aortic root may help understand its biomechanical impact in patients with aortopathy and pre- and post-surgical or transcatheter aortic valve replacement.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139865370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-cardiac arrest temporal evolution of left ventricular function in a rat model. Speckle tracking Echocardiography and cardiac circulating biomarkers","authors":"D. De Giorgio, D. Olivari, F. Fumagalli, D. Novelli, María Cerrato, Francesca Motta, G. Ristagno, Roberto Latini, L. Staszewsky","doi":"10.1093/ehjimp/qyae006","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae006","url":null,"abstract":"\u0000 \u0000 \u0000 There is little information from experimental studies regarding the evolution of post-resuscitation cardiac arrest (post-ROSC) myocardial dysfunction during mid-term follow-up. For this purpose, we assessed left ventricular (LV) function and circulating cardiac biomarkers at different time points in a rat model of cardiac arrest (CA).\u0000 \u0000 \u0000 \u0000 Rats were divided into two groups: control and post-ROSC rats. Eight min of untreated ventricular fibrillation were followed by 8 min of CPR. Conventional and speckle tracking (STE) echocardiographic parameters and cardiac circulating biomarkers concentrations were assessed, at 3-4-72-96h post-ROSC.\u0000 \u0000 \u0000 \u0000 At 3-and-4h post-ROSC LV systolic function resulted severely impaired and hs-cTnT and NT-pro ANP plasma concentrations were significantly increased, compared to control rats (p<0.0001 for all). At 72 and 96h post-ROSC left ventricular ejection fraction (LVEF) normalized. At 96h, the following variables were significantly different from control rats: early-trans-mitral-peak-velocity, 56.8 ± 3.1 vs. 87.8 ± 3.8 cm/sec, p<0.0001; late-trans-mitral-peak-velocity, 50.6±4.7 vs. 73.7±4.2 cm/sec, p<0.0001; mean s’ wave velocity, 4.6±0.3 vs. 5.9±0.3 cm/sec, p<0.0001, global longitudinal strain (GLS) -7.5±0.5 and vs. -11±1.2%, p<0.01, global longitudinal strain rate (GLSR): -0-9±0.4 and -2.3±0.2 1/sec, p<0.01 and NT-proANP concentration, 2.5[0.2; 6.0] vs 0.4 [0.01; 1.0] nmol/L, p<0.01.\u0000 \u0000 \u0000 \u0000 s’ velocity, GLS and GLSR, indicated that LV systolic function was still impaired 96h post-ROSC. These findings agree with NT-proANP concentrations which continue high. Normalization of LVEF supports the use of STE for its greater sensitivity for monitoring post-CA cardiac function. Further investigations are needed to provide evidence of the post-ROSC LV diastolic function pattern.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"320 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139828259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-cardiac arrest temporal evolution of left ventricular function in a rat model. Speckle tracking Echocardiography and cardiac circulating biomarkers","authors":"D. De Giorgio, D. Olivari, F. Fumagalli, D. Novelli, María Cerrato, Francesca Motta, G. Ristagno, Roberto Latini, L. Staszewsky","doi":"10.1093/ehjimp/qyae006","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae006","url":null,"abstract":"\u0000 \u0000 \u0000 There is little information from experimental studies regarding the evolution of post-resuscitation cardiac arrest (post-ROSC) myocardial dysfunction during mid-term follow-up. For this purpose, we assessed left ventricular (LV) function and circulating cardiac biomarkers at different time points in a rat model of cardiac arrest (CA).\u0000 \u0000 \u0000 \u0000 Rats were divided into two groups: control and post-ROSC rats. Eight min of untreated ventricular fibrillation were followed by 8 min of CPR. Conventional and speckle tracking (STE) echocardiographic parameters and cardiac circulating biomarkers concentrations were assessed, at 3-4-72-96h post-ROSC.\u0000 \u0000 \u0000 \u0000 At 3-and-4h post-ROSC LV systolic function resulted severely impaired and hs-cTnT and NT-pro ANP plasma concentrations were significantly increased, compared to control rats (p<0.0001 for all). At 72 and 96h post-ROSC left ventricular ejection fraction (LVEF) normalized. At 96h, the following variables were significantly different from control rats: early-trans-mitral-peak-velocity, 56.8 ± 3.1 vs. 87.8 ± 3.8 cm/sec, p<0.0001; late-trans-mitral-peak-velocity, 50.6±4.7 vs. 73.7±4.2 cm/sec, p<0.0001; mean s’ wave velocity, 4.6±0.3 vs. 5.9±0.3 cm/sec, p<0.0001, global longitudinal strain (GLS) -7.5±0.5 and vs. -11±1.2%, p<0.01, global longitudinal strain rate (GLSR): -0-9±0.4 and -2.3±0.2 1/sec, p<0.01 and NT-proANP concentration, 2.5[0.2; 6.0] vs 0.4 [0.01; 1.0] nmol/L, p<0.01.\u0000 \u0000 \u0000 \u0000 s’ velocity, GLS and GLSR, indicated that LV systolic function was still impaired 96h post-ROSC. These findings agree with NT-proANP concentrations which continue high. Normalization of LVEF supports the use of STE for its greater sensitivity for monitoring post-CA cardiac function. Further investigations are needed to provide evidence of the post-ROSC LV diastolic function pattern.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"54 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Magnetic Resonance Imaging of Myeloperoxidase Activity Identifies Culprit Lesions and Predicts Future Atherothrombosis","authors":"James Nadel, Xiaoying Wang, Prakash Saha, André Bongers, Sergey Tumanov, N. Giannotti, Weiyu Chen, Niv Vigder, Mohammed M. Chowdhury, G. J. Lima da Cruz, Carlos Velasco, Claudia Prieto, Andrew Jabbour, René M. Botnar, Roland Stocker, A. Phinikaridou","doi":"10.1093/ehjimp/qyae004","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae004","url":null,"abstract":"\u0000 \u0000 \u0000 Unstable atherosclerotic plaques have increased activity of myeloperoxidase (MPO). We examined whether molecular magnetic resonance imaging (MRI) of intraplaque MPO activity predicts future atherothrombosis in rabbits and correlates with ruptured human atheroma.\u0000 \u0000 \u0000 \u0000 Plaque MPO activity was assessed in vivo in rabbits (n=12) using the MPO-Gd (gadolinium) probe at 8 and 12 weeks after induction of atherosclerosis and before pharmacological triggering of atherothrombosis. Excised plaques were used to confirm MPO activity by liquid chromatography-tandem mass spectrometry (LC-MSMS) and to determine MPO distribution by histology. MPO activity was higher in plaques that caused post-trigger atherothrombosis than plaques which did not. Among the in vivo MRI metrics, the plaques’ R1 relaxation rate after administration of MPO-Gd was the best predictor of atherothrombosis. MPO activity measured in human carotid endarterectomy (CEA) specimens (n=30) by MPO-Gd enhanced MRI was correlated with in vivo patient MRI and histological plaque phenotyping, as well as LC-MSMS. MPO-Gd retention measured as the change in R1 relaxation from baseline was significantly greater in histologic and MRI-graded American Heart Association (AHA) type VI than types III-V plaques. This association was confirmed by comparing AHA grade to MPO activity determined by LC-MSMS.\u0000 \u0000 \u0000 \u0000 We show that elevated intraplaque MPO activity detected by molecular MRI employing MPO-Gd predicts future atherothrombosis in a rabbit model and detects ruptured human atheroma, strengthening the translational potential of this approach to prospectively detect high-risk atherosclerosis.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139601796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental discovery of a complex coronary anatomy with multiple rare anomalies","authors":"Davide Donelli, G. Niccoli, Diego Ardissino, E. Faragasso","doi":"10.1093/ehjimp/qyae003","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae003","url":null,"abstract":"","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"127 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huge pseudoaneurysm of the left ventricular outflow tract developed a few years after surgery for subvalvular mitral aneurysm. To plug or not to plug it is the question","authors":"Humberto Morais, Elsa Fernandes, M. Gonçalves","doi":"10.1093/ehjimp/qyae002","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae002","url":null,"abstract":"","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"79 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-resolution quantification of stress perfusion defects by cardiac magnetic resonance","authors":"C. Scannell, Richard Crawley, E. Alskaf, M. Breeuwer, Sven Plein, A. Chiribiri","doi":"10.1093/ehjimp/qyae001","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae001","url":null,"abstract":"\u0000 \u0000 \u0000 Quantitative stress perfusion cardiac magnetic resonance (CMR) is becoming more widely available, but it is still unclear how to integrate this information in clinical decision making. Typically, pixel-wise perfusion maps are generated but diagnostic and prognostic studies have summarised perfusion as just one value per-patient or in 16 myocardial segments. In this study, the reporting of quantitative perfusion maps is extended from the standard 16 segments to a high-resolution bullseye. Cut-off thresholds are established for the high-resolution bullseye and the identified perfusion defects are compared versus visual assessment.\u0000 \u0000 \u0000 \u0000 34 patients with known or suspected coronary artery disease were retrospectively analysed. Visual perfusion defects were contoured on the CMR images and pixel-wise quantitative perfusion maps were generated. Cut-off values were established on the high-resolution bullseye consisting of 1800 points and compared to the per-segment, per-coronary, and per-patient resolution thresholds.\u0000 Quantitative stress perfusion was significantly lower in visually abnormal pixels 1.11 (0.75-1.57) versus 2.35 (1.82-2.9) ml/min/g (Mann-Whitney U test p < 0.001), with an optimal cut-off of 1.72 ml/min/g. This was lower than the segment-wise optimal threshold of 1.92 ml/min/g. Bland-Altman analysis showed visual assessment underestimated large perfusion defects compared to the quantification with good agreement for smaller defect burdens. A Dice overlap of 0.68 (0.57-0.78) was found.\u0000 \u0000 \u0000 \u0000 This study introduces a high-resolution bullseye consisting of 1800 points, rather than 16, per patient for reporting quantitative stress perfusion which may improve sensitivity. Using this representation, the threshold required to identify areas of reduced perfusion is lower than for segmental analysis.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"59 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The promise and pitfalls of focused cardiac ultrasound among general practitioners","authors":"Zachary Rhinehart, L. E. Sade","doi":"10.1093/ehjimp/qyae018","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae018","url":null,"abstract":"","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"17 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transthoracic and transoesophageal echocardiography for tricuspid transcatheter edge-to-edge repair: a step-by-step protocol","authors":"Matteo Mazzola, C. Giannini, Alessandro Sticchi, P. Spontoni, N. Pugliese, L. Gargani, M. De Carlo","doi":"10.1093/ehjimp/qyae017","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae017","url":null,"abstract":"\u0000 Tricuspid regurgitation (TR) carries an unfavourable prognosis and often leads to progressive right ventricular (RV) failure. Secondary TR accounts for over 90% of cases and is caused by RV and/or tricuspid annulus dilation, in the setting of left heart disease or pulmonary hypertension. Surgical treatment for isolated TR entails a high operative risk and is seldom performed. Recently, transcatheter edge-to-edge repair (TEER) has emerged as a low-risk alternative treatment in selected patients. Although the experience gained from mitral TEER has paved the way for the technique’s adaptation to the tricuspid valve (TV), its anatomical complexity necessitates precise imaging. To this end, a comprehensive protocol integrating 2D and 3D imaging from both transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE) plays a crucial role. TTE allows for an initial morphological assessment of the TV, quantification of TR severity, evaluation of biventricular function, and non-invasive haemodynamic evaluation of pulmonary circulation. TOE, conversely, provides a detailed evaluation of TV morphology, enabling precise assessment of TR mechanism and severity, and represents the primary method for determining eligibility for TEER. Once a patient is considered eligible for TEER, TOE, alongside fluoroscopy, will guide the procedure in the catheterization lab. High-quality TOE imaging is crucial for patient selection and to achieve procedural success. The present review examines the roles of TTE and TOE in managing patients with severe TR eligible for TEER, proposing the step-by-step protocol successfully adopted in our centre.","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"26 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}