Alberto Aimo, G. Panichella, I. Fabiani, Manuel Garofalo, Angela Ilaria Fanizzi, Maddalena Ragagnin, A. Milazzo, C. Zocchi, A. Del Franco, G. Pedrizzetti, I. Olivotto, M. Emdin
{"title":"Assessing Cardiac Mechanics through Left Ventricular Hemodynamic Forces","authors":"Alberto Aimo, G. Panichella, I. Fabiani, Manuel Garofalo, Angela Ilaria Fanizzi, Maddalena Ragagnin, A. Milazzo, C. Zocchi, A. Del Franco, G. Pedrizzetti, I. Olivotto, M. Emdin","doi":"10.1093/ehjimp/qyae077","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae077","url":null,"abstract":"\u0000 Hemodynamic forces (HDFs), which represent the forces exchanged between blood and surrounding tissues, are critical in regulating the structure and function of the left ventricle (LV). These forces can be assessed on cardiac magnetic resonance or transthoracic echocardiography exams using specialized software, offering a non-invasive alternative for measuring intraventricular pressure gradients. The analysis of HDFs can be a valuable tool in improving our understanding of cardiovascular disease and providing insights beyond traditional diagnostic and therapeutic approaches. For instance, HDF analysis has the potential to identify early signs of adverse remodeling and cardiac dysfunction, which may not be detected by standard imaging methods such as bidimensional or speckle-tracking echocardiography. This review aims to summarize the principles of HDF analysis and to reappraise its possible applications to cardiac disorders.","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"57 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epicardial Adipose Tissue and Diastolic Dysfunction: A Relationship With Unanswered Questions","authors":"S. Nistri, D. Mele","doi":"10.1093/ehjimp/qyae072","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae072","url":null,"abstract":"","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda Erthal, Ronaldo Lima, F. Penna, Benjamin Chow, Ronaldo Gismondi
{"title":"ESC Pre-Test Probability Estimates for Obstructive Coronary Artery Disease: Can they be used in Brazil?","authors":"Fernanda Erthal, Ronaldo Lima, F. Penna, Benjamin Chow, Ronaldo Gismondi","doi":"10.1093/ehjimp/qyae075","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae075","url":null,"abstract":"\u0000 \u0000 \u0000 Cardiovascular disease, primarily coronary artery disease (CAD), is the leading cause of mortality worldwide. Accurate diagnosis of CAD often requires pre-test probability (PTP) estimation, traditionally performed using scoring systems like the Diamond-Forrester (DF) and European Society of Cardiology (ESC) models. However, the applicability of such models in specific population may vary. This study compares the performance of DF and PTP scores in the Brazilian context, using coronary computed tomography angiography (CCTA) as a reference standard.\u0000 \u0000 \u0000 \u0000 PTP for obstructive CAD was calculated using DF and ESC scores in 409 symptomatic patients without known CAD who underwent CCTA between 2019 and 2022. Predicted PTP was compared with actual CAD prevalence. DF overestimated CAD prevalence across age and symptom categories, while ESC showed better alignment with actual prevalence.\u0000 \u0000 \u0000 \u0000 Our study confirms that the ESC PTP model is more appropriate than the DF model for determining PTP in the Brazilian population.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"15 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Pola, Z. Ashkir, S. Myerson, H. Arheden, H. Watkins, S. Neubauer, P. Arvidsson, B. Raman
{"title":"Flow inefficiencies in non-obstructive HCM revealed by left ventricular kinetic energy and hemodynamic force analysis from 4D flow CMR","authors":"K. Pola, Z. Ashkir, S. Myerson, H. Arheden, H. Watkins, S. Neubauer, P. Arvidsson, B. Raman","doi":"10.1093/ehjimp/qyae074","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae074","url":null,"abstract":"\u0000 \u0000 \u0000 Patients with non-obstructive hypertrophic cardiomyopathy (HCM) exhibit myocardial changes which may cause flow inefficiencies not detectable on echocardiogram. We investigated whether left ventricular (LV) kinetic energy (KE) and hemodynamic forces (HDF) on 4D-flow CMR provide more sensitive measures of flow in non-obstructive HCM.\u0000 \u0000 \u0000 \u0000 90 participants (70 non-obstructive HCM and 20 healthy controls) underwent 4D-flow CMR. Patients were categorized as phenotype positive (P+) based on maximum wall thickness (MWT) ≥15mm or ≥13mm for familial HCM, or pre-hypertrophic sarcomeric variant carriers (P-). LV KE and HDF were computed from 4D-flow CMR. Stroke work was computed using a previously valdated non-invasive method.\u0000 \u0000 \u0000 \u0000 P+, P- and controls had comparable diastolic velocities and LV outflow gradients on echocardiography, LV ejection fraction and stroke volume on CMR. P+ had greater stroke work than P-, higher systolic KE compared to controls (5.8vs4.1mJ, p=0.0009), and higher late diastolic KE relative to P- and controls (2.6vs1.4vs1.9 mJ, p<0.0001 respectively). MWT was associated with systolic KE (r=0.5, p<0.0001) and diastolic KE (r=0.4, p=0.005), which also correlated with stroke work. Systolic HDF ratio was increased in P+ compared to controls (1.0vs0.8, p=0.03) and correlated with MWT (r=0.3, p=0.004). Diastolic HDF was similar between groups. Sarcomeric variant status was not associated with KE or HDF.\u0000 \u0000 \u0000 \u0000 Despite normal flow velocities on echocardiography, non-obstructive HCM exhibited greater stroke work, systolic KE and HDF ratio, and late diastolic KE relative to controls. 4D-flow CMR provides more sensitive measures of hemodynamic inefficiencies in HCM, holding promise for clinical trials of novel therapies and clinical surveillance of non-obstructive HCM.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"62 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141643796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Filidei, C. Caselli, Luca Menichetti, Michela Poli, D. Petroni, Letizia Guiducci, O. Sorace, Patrizia Pisani, Silvia Pardini, Danilo Bonora, A. Giorgetti, A. Gimelli, D. Neglia
{"title":"Long-term prognostic impact of fasting plasma glucose and myocardial flow reserve beyond other risk factors and heart disease phenotypes","authors":"E. Filidei, C. Caselli, Luca Menichetti, Michela Poli, D. Petroni, Letizia Guiducci, O. Sorace, Patrizia Pisani, Silvia Pardini, Danilo Bonora, A. Giorgetti, A. Gimelli, D. Neglia","doi":"10.1093/ehjimp/qyae070","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae070","url":null,"abstract":"\u0000 \u0000 \u0000 Cardiometabolic risk factors, including high fasting plasma glucose (hFPG), are emerging prognostic determinants in patients with coronary artery disease (CAD) or heart failure (HF). Coronary microvascular dysfunction might be a comprehensive risk predictor in these patients.\u0000 \u0000 \u0000 \u0000 To assess whether hFPG and global myocardial blood flow (MBF) reserve measured by positron emission tomography (PET), expressing global coronary function, predict long-term prognosis beyond other risk factors and presence of obstructive CAD or left ventricular (LV) dysfunction associated with HF.\u0000 \u0000 \u0000 \u0000 We retrospectively collected long-term follow-up data in 103 patients (mean age 61±10 years, 74 males) with stable chest pain or dyspnea who underwent cardiac PET/CT and coronary angiography. Disease phenotypes included obstructive CAD (35%), LV dysfunction without obstructive CAD (43%) or none (22%).\u0000 \u0000 \u0000 \u0000 At multivariable logistic regression analysis, MBF reserve lower than the median value (1.8, CI 1.5-2.2), was significantly associated with male gender (OR 3.45, 95% CI 1.21-9.83) and high FPG (OR 3.87, 95%CI 1.17-12.84) among all risk factors. In a median follow-up of 10.9 years (7.8-13.9 IQR), 39 patients (37.8%) died (13.6% cardiac death).\u0000 At multivariable Cox analyses including all risk factors and disease phenotypes, age (HR 1.07, 95% CI 1.02-1.12), high FPG (HR 2.18, 95% CI 1.02-4.63) and depressed MBF reserve (HR 4.47, 95% CI 1.96-10.18) were independent predictors of death (Global χ2 37.41, P=0.0004).\u0000 \u0000 \u0000 \u0000 These results suggest a strong long-term prognostic role of high FPG and depressed MBF reserve in a high risk population of patients with high prevalence of obstructive CAD or HF.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"64 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141651641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fernanda de Azevedo Figueiredo, William Antonio M Esteves, J. Hung, N. F. A. Gomes, C. Taconeli, A. Pantaleão, Matheus Assunção Rabello de Oliveira, Silvio Mendes de Magalhães, L. Chavez, Timothy C Tan, Aditya Bhat, Robert A Levine, M. Nunes
{"title":"Left Atrial Function in Rheumatic Mitral Stenosis Patients: Addressing Prognostic Insights Beyond Atrial Fibrillation Prediction","authors":"Fernanda de Azevedo Figueiredo, William Antonio M Esteves, J. Hung, N. F. A. Gomes, C. Taconeli, A. Pantaleão, Matheus Assunção Rabello de Oliveira, Silvio Mendes de Magalhães, L. Chavez, Timothy C Tan, Aditya Bhat, Robert A Levine, M. Nunes","doi":"10.1093/ehjimp/qyae067","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae067","url":null,"abstract":"\u0000 \u0000 \u0000 Rheumatic mitral stenosis (MS) frequently leads to impaired left atrial (LA) function due to pressure overload, highlighting underlying atrial pathology. Two-dimensional speckle tracking echocardiography (2D-STE) offers early detection of LA dysfunction, potentially improving risk assessment in MS patients. This study aimed to evaluate the predictive value of LA function assessed by 2D-STE for clinical outcomes in MS patients.\u0000 \u0000 \u0000 \u0000 Between 2011 and 2021, MS patients underwent LA function assessment using 2D-STE, focusing on the reservoir phase (LASr). Atrial fibrillation (AF) development constituted the primary outcome, with death or valve replacement as secondary. Conditional inference trees were employed for analysis, validated through sample splitting. The study included 493 MS patients (mean valve area 1.1 ± 0.4 cm2, 84% female). At baseline, 166 patients (34%) had AF, with 62 patients (19%) developing AF during follow-up. LASr emerged as the primary predictor for new-onset AF, with a threshold of 17.9%. Over a mean 3.8-year follow-up, 125 patients (25%) underwent mitral valve replacement, and 32 patients (6.5%) died. Decision tree analysis identified key predictors such as age, LASr, severity of tricuspid regurgitation (TR), net atrioventricular compliance (Cn), and early percutaneous mitral valvuloplasty, especially in patients aged ≤ 49 years, where LASr, with a threshold of 12.8%, significantly predicted adverse outcomes.\u0000 \u0000 \u0000 \u0000 LASr emerged as a significant predictor of cardiovascular events in this MS cohort, validated through decision tree analysis. Patients were stratified into low or high-risk categories for adverse outcomes, taking into account LASr, age, TR severity, and Cn.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"95 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141652950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Torres-Araujo Laura Victoria, Silva-Estrada Jorge Alberto, Jiménez-Santos Moisés, Rosas-Vázquez Ana María, García-Cruz Edgar
{"title":"Torrential tricuspid regurgitation in Ebstein's Anomaly, never seen so clear!","authors":"Torres-Araujo Laura Victoria, Silva-Estrada Jorge Alberto, Jiménez-Santos Moisés, Rosas-Vázquez Ana María, García-Cruz Edgar","doi":"10.1093/ehjimp/qyae066","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae066","url":null,"abstract":"","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"136 5‐6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intravital Imaging of Cardiac Tissue Utilizing Tissue-stabilized Heart Window Chamber in Live Animal Model","authors":"Soyeon Ahn, Jung-yeon Yoon, Pilhan Kim","doi":"10.1093/ehjimp/qyae062","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae062","url":null,"abstract":"\u0000 For establishing intravital heart microimaging protocol in live mouse models, an optimized suction-based tissue motion-stabilizing cardiac imaging window chamber system has been developed to enable real-time observation of dynamic cellular behaviors within the cardiac tissue. With the assistance of AI-based motion compensation technology, this imaging approach facilitated high-quality, real-time in vivo visualization of dynamic cellular behaviors in heart tissue, including immune cell trafficking and red blood cell (RBC) flow monitoring, has been successfully analyzed in vivo. Additionally, Intravital Two-photon microscopic heart imaging enabled label-free visualization of cardiac muscle tissue by second harmonic generation (SHG) signal generated from 820-840nm two-photon laser excitation. The imaging method optimized in this study can be further investigated to identify the underlying mechanisms and develop advanced treatments related to various cardiovascular diseases.","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"273 25‐28","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Bialobroda, K. Bouazizi, M. Ponnaiah, N. Kachenoura, Etienne Charpentier, Mohamed Zarai, Karine Clement, Fabrizio Andreelli, J. Aron‐Wisnewsky, Stéphane N. Hatem, Alban Redheuil
{"title":"The Adipose Tissue Confined in the Atrio-Ventricular Groove can be used to Assess Atrial Epicardial Adipose Tissue and Atrial Dysfunction during Cardiac Magnetic Resonance Imaging","authors":"J. Bialobroda, K. Bouazizi, M. Ponnaiah, N. Kachenoura, Etienne Charpentier, Mohamed Zarai, Karine Clement, Fabrizio Andreelli, J. Aron‐Wisnewsky, Stéphane N. Hatem, Alban Redheuil","doi":"10.1093/ehjimp/qyae057","DOIUrl":"https://doi.org/10.1093/ehjimp/qyae057","url":null,"abstract":"\u0000 \u0000 \u0000 The growing interest in epicardial adipose tissue (EAT) as a biomarker of atrial fibrillation (AF) is limited by the difficulties in isolating EAT from other paracardial adipose tissues. We tested the feasibility and value of measuring the pure EAT contained in the atrio-ventricular groove (GEAT) using cardiovascular magnetic resonance imaging (CMR) in patients with distinct metabolic disorders.\u0000 \u0000 \u0000 \u0000 CMR was performed on 100 patients from the MetaCardis cohort: obese (n=18), metabolic syndrome (MSD) (n=25), type-2 diabetes (T2D) (n=42), and age and gender matched healthy controls (n=15). GEAT volume measured from long axis views was obtained in all patients with a strong correlation between GEAT and atrial EAT (r=0.95; P<0.0001). GEAT volume was higher in the 3 groups of patients with metabolic disorders and highest in the MSD group compared to controls. GEAT volume as well as body mass and body fat, allowed obese, T2D, and MSD patients to be distinguished from controls. GEAT T1 relaxation and peak longitudinal left atrial (LA) strain in CMR were decreased in T2D patients. Logistic regression and Random Forest machine-learning methods were used to create an algorithm combining GEAT volume, GEAT T1, and peak LA strain to identify T2D patients from other groups with an AUC of 0.81 (Se: 77%, Spe: 80%; 95%-CI 0.72–0.91, p<0.0001).\u0000 \u0000 \u0000 \u0000 Atrio-ventricular groove adipose tissue measured during routine CMR can be used as a proxy of atrial EAT and integrated in a multiparametric CMR biomarker for early identification of atrial cardiomyopathy.\u0000","PeriodicalId":508944,"journal":{"name":"European Heart Journal - Imaging Methods and Practice","volume":"53 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141338575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}