Advances in Clinical Chemistry最新文献_第8页

Copyright 版权

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00005-6

引用次数: 0

Index 指数

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00039-1

引用次数: 0

Cytokines and the immune response in obesity-related disorders. 细胞因子与肥胖相关疾病的免疫反应。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-09-24 DOI: 10.1016/bs.acc.2020.06.004

Meysam Moghbeli, Hamed Khedmatgozar, Mehran Yadegari, Amir Avan, Gordon A Ferns, Majid Ghayour Mobarhan

引用次数: 13

Clinical relevance of biochemical and metabolic changes in osteoarthritis. 骨关节炎的生化和代谢变化的临床意义。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.acc.2020.06.001

Guangju Zhai

{"title":"Clinical relevance of biochemical and metabolic changes in osteoarthritis.","authors":"Guangju Zhai","doi":"10.1016/bs.acc.2020.06.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.06.001","url":null,"abstract":"Osteoarthritis (OA) is a multifactorial disease with huge phenotypic heterogeneity. The disease affects all tissues in the joint, and the loss of articular cartilage is its hallmark. The main biochemical components of the articular cartilage are type II collagen, aggrecan, and water. Transforming growth factor-beta (TGF-β) signaling is one of the signaling pathways that maintains the healthy cartilage. However, the two subpathways of the TGF-β signaling-TGF-β and bone morphogenetic proteins (BMP) subpathways, lose their balance in OA, resulting an increased expression of cartilage degradation enzymes including matrix metallopeptidase 13 (MMP13), cathepsin B (CTSB), and cathepsin K (CTSK) and a decreased expression of aggrecan (ACAN). Thus, restoring the balance of two subpathways might provide a new avenue for treating OA patients. Further, metabolic changes are seen in OA and can be used to distinguish different subtypes of OA patients. Metabolomics studies showed that at least three endotypes of OA can be distinguished: 11% of OA patients are characterized by an elevated blood butyryl carnitine, 33% of OA patients have significant reduced arginine concentration, and 56% with metabolic alteration in phospholipid metabolism. While these findings need to be confirmed, they are promising personalized medicine tools for OA management.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"101 ","pages":"95-120"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25466211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Preface. 前言。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00008-1

Gregory S Makowski

引用次数: 0

Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers. 癫痫定量脑电图生物标志物及其与化学生物标志物的关系。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-03 DOI: 10.1016/bs.acc.2020.08.004

Yvonne Höller, Raffaele Nardone

{"title":"Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers.","authors":"Yvonne Höller, Raffaele Nardone","doi":"10.1016/bs.acc.2020.08.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.004","url":null,"abstract":"The electroencephalogram (EEG) is the most important method to diagnose epilepsy. In clinical settings, it is evaluated by experts who identify patterns visually. Quantitative EEG is the application of digital signal processing to clinical recordings in order to automatize diagnostic procedures, and to make patterns visible that are hidden to the human eye. The EEG is related to chemical biomarkers, as electrical activity is based on chemical signals. The most well-known chemical biomarkers are blood laboratory tests to identify seizures after they have happened. However, research on chemical biomarkers is much less extensive than research on quantitative EEG, and combined studies are rarely published, but highly warranted. Quantitative EEG is as old as the EEG itself, but still, the methods are not yet standard in clinical practice. The most evident application is an automation of manual work, but also a quantitative description and localization of interictal epileptiform events as well as seizures can reveal important hints for diagnosis and contribute to presurgical evaluation. In addition, the assessment of network characteristics and entropy measures were found to reveal important insights into epileptic brain activity. Application scenarios of quantitative EEG in epilepsy include seizure prediction, pharmaco-EEG, treatment monitoring, evaluation of cognition, and neurofeedback. The main challenges to quantitative EEG are poor reliability and poor generalizability of measures, as well as the need for individualization of procedures. A main hindrance for quantitative EEG to enter clinical routine is also that training is not yet part of standard curricula for clinical neurophysiologists.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"102 ","pages":"271-336"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Translational biomarkers in the era of precision medicine. 精准医学时代的转化生物标志物。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-03 DOI: 10.1016/bs.acc.2020.08.002

Laura Bravo-Merodio, Animesh Acharjee, Dominic Russ, Vartika Bisht, John A Williams, Loukia G Tsaprouni, Georgios V Gkoutos

引用次数: 12

Copyright 版权

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00068-8

引用次数: 0

Synthetic drugs of abuse. 滥用合成药物。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-12-24 DOI: 10.1016/bs.acc.2020.10.001

Kenichi Tamama

引用次数: 6

Metabolomics applications in coronary artery disease personalized medicine. 代谢组学在冠心病个体化治疗中的应用。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-09-24 DOI: 10.1016/bs.acc.2020.08.003

Arwa M Amin

{"title":"Metabolomics applications in coronary artery disease personalized medicine.","authors":"Arwa M Amin","doi":"10.1016/bs.acc.2020.08.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.003","url":null,"abstract":"Coronary artery disease (CAD), the most common cardiovascular disease (CVD), contributes to significant mortality worldwide. CAD is a multifactorial disease wherein various factors contribute to its pathogenesis often complicating management. Biomarker based personalized medicine may provide a more effective way to individualize therapy in multifactorial diseases in general and CAD specifically. Systems' biology \"Omics\" biomarkers have been investigated for this purpose. These biomarkers provide a more comprehensive understanding on pathophysiology of the disease process and can help in identifying new therapeutic targets and tailoring therapy to achieve optimum outcome. Metabolomics biomarkers usually reflect genetic and non-genetic factors involved in the phenotype. Metabolomics analysis may provide better understanding of the disease pathogenesis and drug response variation. This will help in guiding therapy, particularly for multifactorial diseases such as CAD. In this chapter, advances in metabolomics analysis and its role in personalized medicine will be reviewed with comprehensive focus on CAD. Assessment of risk, diagnosis, complications, drug response and nutritional therapy will be discussed. Together, this chapter will review the current application of metabolomics in CAD management and highlight areas that warrant further investigation.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"102 ","pages":"233-270"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4