Advances in Clinical Chemistry最新文献_第8页

High-sensitivity methods for cardiac troponins: The mission is not over yet. 高灵敏度的心肌肌钙蛋白检测方法:任务还没有结束。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-09 DOI: 10.1016/bs.acc.2020.08.009

Aldo Clerico, Martina Zaninotto, Claudio Passino, Andrea Padoan, Marco Migliardi, Mario Plebani

{"title":"High-sensitivity methods for cardiac troponins: The mission is not over yet.","authors":"Aldo Clerico, Martina Zaninotto, Claudio Passino, Andrea Padoan, Marco Migliardi, Mario Plebani","doi":"10.1016/bs.acc.2020.08.009","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.009","url":null,"abstract":"The measurement of cardiac troponin (cTn) is recommended by all guidelines as the gold standard for the differential diagnosis of Acute Coronary Syndromes. The aim of this review is to discuss in details some key issues regarding both analytical and clinical characteristics of the high-sensitivity methods for cTn (hs-cTn), which are still considered controversial or unresolved. In particular, the major clinical concern regarding hs-cTn methods is the difficulty to differentiate the pathophysiological mechanism responsible for biomarker release from cardiomyocytes after reversible or irreversible injury, respectively. Indeed, recent experimental and clinical studies have demonstrated that different circulating forms of cTnI and cTnT can be respectively measured in plasma samples of patients with reversible or irreversible myocardial injury. Accordingly, a new generation of hs-Tn methods should be set up, based on immunometric immunoassays or chromatographic techniques, specific for circulating peptide forms more characteristics for reversible or irreversible myocardial injury. It is conceivable that this new generation of hs-cTn methods will complete the mission regarding the laboratory tests for specific cardiac biomarkers, started more than 20 years ago, which has already revolutionized the diagnosis, prognosis and management of patients with cardiac diseases.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"103 ","pages":"215-252"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39158777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Pathophysiological landscape of osteoarthritis. 骨关节炎的病理生理景观。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-29 DOI: 10.1016/bs.acc.2020.04.002

Priya Kulkarni, Aare Martson, Ragini Vidya, Shreya Chitnavis, Abhay Harsulkar

{"title":"Pathophysiological landscape of osteoarthritis.","authors":"Priya Kulkarni, Aare Martson, Ragini Vidya, Shreya Chitnavis, Abhay Harsulkar","doi":"10.1016/bs.acc.2020.04.002","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.04.002","url":null,"abstract":"A sharp rise in osteoarthritis (OA) incidence is expected as over 25% of world population ages in the coming decade. Although OA is considered a degenerative disease, mounting evidence suggests a strong connection with chronic metabolic conditions and low-grade inflammation. OA pathology is increasingly understood as a complex interplay of multiple pathological events including oxidative stress, synovitis and immune responses revealing its intricate nature. Cellular, biochemical and molecular aspects of these pathological events along with major outcomes of the relevant research studies in this area are discussed in the present review. With reference to their published and unpublished work, the authors strongly propose synovitis as a central OA pathology and the key OA pathological events are described in connection with it. Recent research outcomes also have succeeded to establish a linkage between metabolic syndrome and OA, which has been precisely included in the present review. Impact of aging process cannot be neglected in OA. Cell senescence is an important mechanism of aging through which it facilitates development of OA like other degenerative disorders, also discussed within a frame of OA. Conclusively, the reviewers urge low-grade inflammation linked to aging and derailed immune function as a pathological platform for OA development and progression. Thus, interventions targeted to prevent inflammaging hold a promising potential in effective OA management and efforts should be invested in this direction.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"100 ","pages":"37-90"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38826914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Advances in cerebral palsy biomarkers. 脑瘫生物标志物研究进展

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-23 DOI: 10.1016/bs.acc.2020.04.006

Zeynep Alpay Savasan, Sun Kwon Kim, Kyung Joon Oh, Stewart F Graham

{"title":"Advances in cerebral palsy biomarkers.","authors":"Zeynep Alpay Savasan, Sun Kwon Kim, Kyung Joon Oh, Stewart F Graham","doi":"10.1016/bs.acc.2020.04.006","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.04.006","url":null,"abstract":"Cerebral palsy (CP), defined as a group of nonprogressive disorders of movement and posture, is the most common cause of severe neurodisability in children. The prevalence of CP is the same across the globe, affecting approximately 17 million people worldwide. Cerebral Palsy is an umbrella term used to describe the disease due to its inherent heterogeneity. For instance, CP has multiple (1) causes; (2) clinical types; (3) patterns of neuropathology on brain imaging and (4) it's associated with several developmental pathologies such as intellectual disability, autism, epilepsy, and visual impairment. Understanding its physiopathology is crucial to developing protective strategies. Despite its importance, there is still insufficient progress in the areas of CP prediction, early diagnosis, treatment, and prevention. Herein we describe the current risk factors and biomarkers used for the diagnosis and prediction of CP. With the advancement in biomarker discovery, we predict that our understanding of the etiopathophysiology of CP will also increase, lending to more opportunities for developing novel treatments and prognosis.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"100 ","pages":"139-169"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38829488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cytokines in psoriasis. 银屑病中的细胞因子。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-23 DOI: 10.1016/bs.acc.2020.04.004

Camila Cataldi de Alcantara, Edna Maria Vissoci Reiche, Andréa Name Colado Simão

{"title":"Cytokines in psoriasis.","authors":"Camila Cataldi de Alcantara, Edna Maria Vissoci Reiche, Andréa Name Colado Simão","doi":"10.1016/bs.acc.2020.04.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.04.004","url":null,"abstract":"Psoriasis is chronic, immune-mediated, inflammatory disease with a multifactorial etiology that affects the skin tissue and causes the appearance of dry and scaly lesions of anywhere on the body. The study of the pathophysiology of psoriasis reveals a network of immune cells that, together with their cytokines, initiates a chronic inflammatory response. Previously attributed to T helper (Th)1 cytokines, currently the Th17 cytokine family is the major effector in the pathogenesis of psoriatic disease and strongly influences the inflammatory pattern established during the disease activity. In addition, the vast network of cells that orchestrates the pathophysiology makes psoriasis complex to study. Along with this, variations in genes that code the cytokines make psoriasis more clinically heterogeneous and present a challenge for the development of drugs that can be used in the treatment of the patients with this disease. Therefore, it is important to clarify the mechanisms by which the cytokines are involved in the pathophysiology of psoriasis and how this knowledge is translated to the medical practice.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"100 ","pages":"171-204"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38829489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Cytokines and the immune response in obesity-related disorders. 细胞因子与肥胖相关疾病的免疫反应。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-09-24 DOI: 10.1016/bs.acc.2020.06.004

Meysam Moghbeli, Hamed Khedmatgozar, Mehran Yadegari, Amir Avan, Gordon A Ferns, Majid Ghayour Mobarhan

引用次数: 13

Clinical relevance of biochemical and metabolic changes in osteoarthritis. 骨关节炎的生化和代谢变化的临床意义。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-07-07 DOI: 10.1016/bs.acc.2020.06.001

Guangju Zhai

{"title":"Clinical relevance of biochemical and metabolic changes in osteoarthritis.","authors":"Guangju Zhai","doi":"10.1016/bs.acc.2020.06.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.06.001","url":null,"abstract":"Osteoarthritis (OA) is a multifactorial disease with huge phenotypic heterogeneity. The disease affects all tissues in the joint, and the loss of articular cartilage is its hallmark. The main biochemical components of the articular cartilage are type II collagen, aggrecan, and water. Transforming growth factor-beta (TGF-β) signaling is one of the signaling pathways that maintains the healthy cartilage. However, the two subpathways of the TGF-β signaling-TGF-β and bone morphogenetic proteins (BMP) subpathways, lose their balance in OA, resulting an increased expression of cartilage degradation enzymes including matrix metallopeptidase 13 (MMP13), cathepsin B (CTSB), and cathepsin K (CTSK) and a decreased expression of aggrecan (ACAN). Thus, restoring the balance of two subpathways might provide a new avenue for treating OA patients. Further, metabolic changes are seen in OA and can be used to distinguish different subtypes of OA patients. Metabolomics studies showed that at least three endotypes of OA can be distinguished: 11% of OA patients are characterized by an elevated blood butyryl carnitine, 33% of OA patients have significant reduced arginine concentration, and 56% with metabolic alteration in phospholipid metabolism. While these findings need to be confirmed, they are promising personalized medicine tools for OA management.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"101 ","pages":"95-120"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25466211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Preface. 前言。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00008-1

Gregory S Makowski

引用次数: 0

Translational biomarkers in the era of precision medicine. 精准医学时代的转化生物标志物。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-03 DOI: 10.1016/bs.acc.2020.08.002

Laura Bravo-Merodio, Animesh Acharjee, Dominic Russ, Vartika Bisht, John A Williams, Loukia G Tsaprouni, Georgios V Gkoutos

引用次数: 12

Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers. 癫痫定量脑电图生物标志物及其与化学生物标志物的关系。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-03 DOI: 10.1016/bs.acc.2020.08.004

Yvonne Höller, Raffaele Nardone

{"title":"Quantitative EEG biomarkers for epilepsy and their relation to chemical biomarkers.","authors":"Yvonne Höller, Raffaele Nardone","doi":"10.1016/bs.acc.2020.08.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.004","url":null,"abstract":"The electroencephalogram (EEG) is the most important method to diagnose epilepsy. In clinical settings, it is evaluated by experts who identify patterns visually. Quantitative EEG is the application of digital signal processing to clinical recordings in order to automatize diagnostic procedures, and to make patterns visible that are hidden to the human eye. The EEG is related to chemical biomarkers, as electrical activity is based on chemical signals. The most well-known chemical biomarkers are blood laboratory tests to identify seizures after they have happened. However, research on chemical biomarkers is much less extensive than research on quantitative EEG, and combined studies are rarely published, but highly warranted. Quantitative EEG is as old as the EEG itself, but still, the methods are not yet standard in clinical practice. The most evident application is an automation of manual work, but also a quantitative description and localization of interictal epileptiform events as well as seizures can reveal important hints for diagnosis and contribute to presurgical evaluation. In addition, the assessment of network characteristics and entropy measures were found to reveal important insights into epileptic brain activity. Application scenarios of quantitative EEG in epilepsy include seizure prediction, pharmaco-EEG, treatment monitoring, evaluation of cognition, and neurofeedback. The main challenges to quantitative EEG are poor reliability and poor generalizability of measures, as well as the need for individualization of procedures. A main hindrance for quantitative EEG to enter clinical routine is also that training is not yet part of standard curricula for clinical neurophysiologists.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"102 ","pages":"271-336"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Copyright 版权

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00068-8

引用次数: 0