Advances in Clinical Chemistry最新文献_第8页

Histone deacetylase in neuropathology. 神经病理学中的组蛋白去乙酰化酶。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-11-02 DOI: 10.1016/bs.acc.2020.09.004

Rohan Gupta, Rashmi K Ambasta, Pravir Kumar

{"title":"Histone deacetylase in neuropathology.","authors":"Rohan Gupta, Rashmi K Ambasta, Pravir Kumar","doi":"10.1016/bs.acc.2020.09.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.09.004","url":null,"abstract":"Neuroepigenetics, a new branch of epigenetics, plays an important role in the regulation of gene expression. Neuroepigenetics is associated with holistic neuronal function and helps in formation and maintenance of memory and learning processes. This includes neurodevelopment and neurodegenerative defects in which histone modification enzymes appear to play a crucial role. These modifications, carried out by acetyltransferases and deacetylases, regulate biologic and cellular processes such as apoptosis and autophagy, inflammatory response, mitochondrial dysfunction, cell-cycle progression and oxidative stress. Alterations in acetylation status of histone as well as non-histone substrates lead to transcriptional deregulation. Histone deacetylase decreases acetylation status and causes transcriptional repression of regulatory genes involved in neural plasticity, synaptogenesis, synaptic and neural plasticity, cognition and memory, and neural differentiation. Transcriptional deactivation in the brain results in development of neurodevelopmental and neurodegenerative disorders. Mounting evidence implicates histone deacetylase inhibitors as potential therapeutic targets to combat neurologic disorders. Recent studies have targeted naturally-occurring biomolecules and micro-RNAs to improve cognitive defects and memory. Multi-target drug ligands targeting HDAC have been developed and used in cell-culture and animal-models of neurologic disorders to ameliorate synaptic and cognitive dysfunction. Herein, we focus on the implications of histone deacetylase enzymes in neuropathology, their regulation of brain function and plausible involvement in the pathogenesis of neurologic defects.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":" ","pages":"151-231"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.09.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39368364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Copyright 版权

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00032-9

引用次数: 0

Index 指数

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00091-3

引用次数: 0

Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease. 肾脏疾病中基质金属蛋白酶和基质金属蛋白酶组织抑制剂的研究。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-03-09 DOI: 10.1016/bs.acc.2021.02.003

Oskar Zakiyanov, Marta Kalousová, Tomáš Zima, Vladimír Tesař

{"title":"Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease.","authors":"Oskar Zakiyanov, Marta Kalousová, Tomáš Zima, Vladimír Tesař","doi":"10.1016/bs.acc.2021.02.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2021.02.003","url":null,"abstract":"Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways. MMPs function in close interaction with the endogenous tissue inhibitors of matrix metalloproteinases (TIMPs), both of which regulate cell turnover, modulate various growth factors, and participate in the progression of tissue fibrosis and apoptosis. The multiple roles of MMPs and TIMPs are continuously elucidated in kidney development and repair, as well as in a number of kidney diseases. This chapter focuses on the current findings of the significance of MMPs and TIMPs in a wide range of kidney diseases, whether they result from kidney tissue changes, hemodynamic alterations, tubular epithelial cell apoptosis, inflammation, or fibrosis. In addition, the potential use of these endopeptidases as biomarkers of renal dysfunction and as targets for therapeutic interventions to attenuate kidney disease are also explored in this review.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"141-212"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2021.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39737297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Advances in immunosensor technology. 免疫传感器技术的进展。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-09-14 DOI: 10.1016/bs.acc.2020.08.001

Muhammet Aydin, Elif Burcu Aydin, Mustafa Kemal Sezgintürk

引用次数: 20

Advances in lung cancer biomarkers: The role of (metal-) metabolites and selenoproteins. 肺癌生物标志物研究进展:(金属)代谢物和硒蛋白的作用。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-23 DOI: 10.1016/bs.acc.2020.04.003

Belén Callejón-Leblic, Ana Arias-Borrego, Gema Rodríguez-Moro, Francisco Navarro Roldán, Antonio Pereira-Vega, José Luis Gómez-Ariza, Tamara García-Barrera

{"title":"Advances in lung cancer biomarkers: The role of (metal-) metabolites and selenoproteins.","authors":"Belén Callejón-Leblic, Ana Arias-Borrego, Gema Rodríguez-Moro, Francisco Navarro Roldán, Antonio Pereira-Vega, José Luis Gómez-Ariza, Tamara García-Barrera","doi":"10.1016/bs.acc.2020.04.003","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.04.003","url":null,"abstract":"Lung cancer (LC) is the second most common cause of death in men after prostate cancer, and the third most recurrent type of tumor in women after breast and colon cancers. Unfortunately, when LC symptoms begin to appear, the disease is already in an advanced stage and the survival rate only reaches 2%. Thus, there is an urgent need for early diagnosis of LC using specific biomarkers, as well as effective therapies and strategies against LC. On the other hand, the influence of metals on more than 50% of proteins is responsible for their catalytic properties or structure, and their presence in molecules is determined in many cases by the genome. Research has shown that redox metal dysregulation could be the basis for the onset and progression of LC disease. Moreover, metals can interact between them through antagonistic, synergistic and competitive mechanisms, and for this reason metals ratios and correlations in LC should be explored. One of the most studied antagonists against the toxic action of metals is selenium, which plays key roles in medicine, especially related to selenoproteins. The study of potential biomarkers able to diagnose the disease in early stage is conditioned by the development of new analytical methodologies. In this sense, omic methodologies like metallomics, proteomics and metabolomics can greatly assist in the discovery of biomarkers for LC early diagnosis.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"100 ","pages":"91-137"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38826915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Chimeric RNAs in cancer. 癌症中的嵌合rna。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-27 DOI: 10.1016/bs.acc.2020.04.001

Xinrui Shi, Sandeep Singh, Emily Lin, Hui Li

{"title":"Chimeric RNAs in cancer.","authors":"Xinrui Shi, Sandeep Singh, Emily Lin, Hui Li","doi":"10.1016/bs.acc.2020.04.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.04.001","url":null,"abstract":"Chimeric RNAs are hybrid transcripts containing exons from two separate genes. Chimeric RNAs are traditionally considered to be transcribed from fusion genes caused by chromosomal rearrangement. These canonical chimeric RNAs are well characterized to be expressed in a cancer-unique pattern and/or act as oncogene products. However, benefited by the development of advanced deep sequencing technologies, novel types of non-canonical chimeric RNAs have been discovered to be generated from intergenic splicing without genomic aberrations. They can be formed through trans-splicing or cis-splicing between adjacent genes (cis-SAGe) mechanisms. Non-canonical chimeric RNAs are widely detected in normal physiology, although several have been shown to have a cancer-specific expression pattern. Further studies have indicated that some of them play fundamental roles in controlling cell growth and motility, and may have functions independent of the parental genes. These discoveries are unveiling a new layer of the functional transcriptome and are also raising the possibility of utilizing non-canonical chimeric RNAs as cancer diagnostic markers and therapeutic targets. In this chapter, we will overview different categories of chimeric RNAs and their expression in various types of cancerous and normal samples. Acknowledging that chimeric RNAs are not unique to cancer, we will discuss both bioinformatic and biological methods to identify credible cancer-specific chimeric RNAs. Furthermore, we will describe downstream methods to explore their molecular processing mechanisms and potential functions. A better understanding of the biogenesis mechanisms and functional products of cancer-specific chimeric RNAs will pave ways for the development of novel cancer biomarkers and therapeutic targets.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"100 ","pages":"1-35"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38829487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Cryoglobulins: Identification, classification, and novel biomarkers of mysterious proteins. 低温球蛋白:鉴定、分类和神秘蛋白的新生物标志物。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/bs.acc.2020.09.006

Cecilia Napodano, Francesca Gulli, Gian Ludovico Rapaccini, Mariapaola Marino, Umberto Basile

{"title":"Cryoglobulins: Identification, classification, and novel biomarkers of mysterious proteins.","authors":"Cecilia Napodano, Francesca Gulli, Gian Ludovico Rapaccini, Mariapaola Marino, Umberto Basile","doi":"10.1016/bs.acc.2020.09.006","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.09.006","url":null,"abstract":"Cryoglobulins consist of serum immunoglobulins that precipitate below 37°C and resolubilize upon warming. The clinical triad of cryoglobulinemia usually includes purpura, weakness, and arthralgia. Cryoglobulinemic syndrome, clinically defined as a systemic vasculitis, is associated with chronic infection with hepatitis C virus (HCV) and autoimmune disorders and can evolve into B-cell malignancies. While the current literature about HCV-associated cryoglobulinemia is not very limited, little is known about the immunologic and serologic profiles of affected patients. Therefore, comprehension of the pathogenetic mechanisms underlying cryoprecipitation could be very helpful. Due to the persistence of viral antigenic stimulation, biomarkers to use after the worsening progression of HCV infection to lymphoproliferative and/or autoimmune diseases are widely needed. Laboratory methods used to detect and characterize low concentrations of cryoprecipitates and immunotyping patterns could improve patient management. The most critical factor affecting cryoglobulin testing is that the pre-analytical phase is not fully completed at 37°C.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"104 ","pages":"299-340"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.09.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10450251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Synuclein in neurodegeneration. 突触核蛋白在神经变性中的作用。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-20 DOI: 10.1016/bs.acc.2020.08.007

Anastasia Bougea

引用次数: 8

Preface. 前言。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00071-8

Gregory S Makowski

引用次数: 0