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Advances in Clinical Chemistry最新文献

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Preface. 前言。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00035-4
Gregory S Makowski
{"title":"Preface.","authors":"Gregory S Makowski","doi":"10.1016/S0065-2423(21)00035-4","DOIUrl":"https://doi.org/10.1016/S0065-2423(21)00035-4","url":null,"abstract":"","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"102 ","pages":"ix-x"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0065-2423(21)00035-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary biohazard markers in firefighters. 消防员尿液生物危害标志物。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-03-18 DOI: 10.1016/bs.acc.2021.02.004
Bela Barros, Marta Oliveira, Simone Morais
{"title":"Urinary biohazard markers in firefighters.","authors":"Bela Barros,&nbsp;Marta Oliveira,&nbsp;Simone Morais","doi":"10.1016/bs.acc.2021.02.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2021.02.004","url":null,"abstract":"<p><p>Firefighters are the professional force at high risk of suffering potential health consequences due to their chronic exposure to numerous hazardous pollutants during firefighting activities. Unfortunately, determination of fire emission exposure is very challenging. As such, the identification and development of appropriate biomarkers is critical in meeting this need. This chapter presents a critical review of current information related with the use of different urinary biomarkers of effect and exposure in occupationally exposed firefighters over the last 25 years. Evidence suggests that urinary isoprostanes and mutagenicity testing are promising biomarkers of early oxidative stress. Data indicate that firefighters participating in firefighting activities present with increased urinary biomarkers of exposure. These include polycyclic aromatic hydrocarbons, heavy metals and metalloids, organo-chlorine and -phosphorus compounds, environmental phenols, phthalates, benzene and toluene. More studies are urgently needed to better evaluate firefighter occupational safety and health and to support the implementation of preventive measures and mitigation strategies to promote the protection of this chronically exposed group of workers.</p>","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"243-319"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2021.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Extracellular vesicles: Potential impact on cardiovascular diseases. 细胞外囊泡：对心血管疾病的潜在影响。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-03-10 DOI: 10.1016/bs.acc.2021.02.002
Jian Yang, Xue Zou, Pedro A Jose, Chunyu Zeng
{"title":"Extracellular vesicles: Potential impact on cardiovascular diseases.","authors":"Jian Yang, Xue Zou, Pedro A Jose, Chunyu Zeng","doi":"10.1016/bs.acc.2021.02.002","DOIUrl":"10.1016/bs.acc.2021.02.002","url":null,"abstract":"<p><p>Extracellular vesicles (EVs) have received considerable attention in biological and clinical research due to their ability to mediate cell-to-cell communication. Based on their size and secretory origin, EVs are categorized as exosomes, microvesicles, and apoptotic bodies. Increasing number of studies highlight the contribution of EVs in the regulation of a wide range of normal cellular physiological processes, including waste scavenging, cellular stress reduction, intercellular communication, immune regulation, and cellular homeostasis modulation. Altered circulating EV level, expression pattern, or content in plasma of patients with cardiovascular disease (CVD) may serve as diagnostic and prognostic biomarkers in diverse cardiovascular pathologies. Due to their inherent characteristics and physiological functions, EVs, in turn, have become potential candidates as therapeutic agents. In this review, we discuss the evolving understanding of the role of EVs in CVD, summarize the current knowledge of EV-mediated regulatory mechanisms, and highlight potential strategies for the diagnosis and therapy of CVD. We also attempt to look into the future that may advance our understanding of the role of EVs in the pathogenesis of CVD and provide novel insights into the field of translational medicine.</p>","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"49-100"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706493/pdf/nihms-1848009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prothrombotic state in cancer. 癌症中的血栓形成前状态。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-04-19 DOI: 10.1016/bs.acc.2021.03.001
Benjamín Rubio-Jurado, Lluvia Sugey Sosa-Quintero, Sandra Guzmán-Silahua, Eduardo García-Luna, Carlos Riebeling-Navarro, Arnulfo Hernán Nava-Zavala
{"title":"The prothrombotic state in cancer.","authors":"Benjamín Rubio-Jurado,&nbsp;Lluvia Sugey Sosa-Quintero,&nbsp;Sandra Guzmán-Silahua,&nbsp;Eduardo García-Luna,&nbsp;Carlos Riebeling-Navarro,&nbsp;Arnulfo Hernán Nava-Zavala","doi":"10.1016/bs.acc.2021.03.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2021.03.001","url":null,"abstract":"<p><p>Neoplasms result from changes in the mechanisms of growth, differentiation, and cellular death. Cancers are of high clinical relevance due to their prevalence and associated morbidity and mortality. The clinical and biological diversity of cancer depends mainly on cellular origin and degree of differentiation. These changes result from alterations in molecular expression that generate a complex clinical, biochemical, and morphologic phenotype. Although cancer is associated with a hypercoagulable state, few cancers result in a thrombotic event. Many factors influence thrombotic incidence, such as advanced disease, central catheter placement, chemotherapy, neoplasia, and surgery. The pro-coagulant state is associated with anomalies in the vascular wall, blood flow, blood constituents (tissue factor, thrombin), coagulation state, and cell growth factors. Tumor cells perpetuate this phenomenon by releasing tissue factor, inflammatory cytokines, and growth factors. These changes favor cellular activation that gives rise to actions involving coagulation, inflammation, thrombosis, tumor growth, angiogenesis, and tumor metastases. These, in turn, are closely linked to treatment response, tumor aggressiveness, and host survival. Activation of the coagulation cascade is related to these phenomena through molecules that interact in these processes. As such, it is necessary to identify these mediators to facilitate treatment and improve outcomes.</p>","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"213-242"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2021.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Preface. 前言。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00090-1
Gregory S Makowski
{"title":"Preface.","authors":"Gregory S Makowski","doi":"10.1016/S0065-2423(21)00090-1","DOIUrl":"https://doi.org/10.1016/S0065-2423(21)00090-1","url":null,"abstract":"","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"ix-x"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoantibodies to tumor-associated antigens in lung cancer diagnosis. 肿瘤相关抗原自身抗体在肺癌诊断中的应用。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-13 DOI: 10.1016/bs.acc.2020.08.005
Xiuzhi Zhang, Man Liu, Xue Zhang, Yulin Wang, Liping Dai
{"title":"Autoantibodies to tumor-associated antigens in lung cancer diagnosis.","authors":"Xiuzhi Zhang,&nbsp;Man Liu,&nbsp;Xue Zhang,&nbsp;Yulin Wang,&nbsp;Liping Dai","doi":"10.1016/bs.acc.2020.08.005","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.005","url":null,"abstract":"<p><p>Lung cancer (LC) accounts for the majority of cancer-related deaths worldwide. Although screening the high-risk population by low-dose CT (LDCT) has reduced mortality, the cost and high false positivity rate has prevented its general diagnostic use. As such, better and more specific minimally invasive biomarkers are needed in general and for early LC detection, specifically. Autoantibodies produced by humoral immune response to tumor-associated antigens (TAA) are emerging as a promising noninvasive biomarker for LC. Given the low sensitivity of any one single autoantibody, a panel approach could provide a more robust and promising strategy to detect early stage LC. In this review, we summarize the background of TAA autoantibodies (TAAb) and the techniques currently used for identifying TAA, as well as recent findings of LC specific antigens and TAAb. This review provides guidance toward the development of accurate and reliable TAAb as immunodiagnostic biomarkers in the early detection of LC.</p>","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"103 ","pages":"1-45"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39158773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Advances in fluorescent probes for detection and imaging of amyloid-β peptides in Alzheimer's disease. 阿尔茨海默病淀粉样蛋白-β肽荧光探针检测和成像研究进展。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-02-15 DOI: 10.1016/bs.acc.2020.08.008
Yunhua Zhang, Cen Ding, Changhong Li, Xiaohui Wang
{"title":"Advances in fluorescent probes for detection and imaging of amyloid-β peptides in Alzheimer's disease.","authors":"Yunhua Zhang,&nbsp;Cen Ding,&nbsp;Changhong Li,&nbsp;Xiaohui Wang","doi":"10.1016/bs.acc.2020.08.008","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.008","url":null,"abstract":"<p><p>Amyloid plaques generated from the accumulation of amyloid-β peptides (Aβ) fibrils in the brain is one of the main hallmarks of Alzheimer's disease (AD), a most common neurodegenerative disorder. Aβ aggregation can produce neurotoxic oligomers and fibrils, which has been widely accepted as the causative factor in AD pathogenesis. Accordingly, both soluble oligomers and insoluble fibrils have been considered as diagnostic biomarkers for AD. Among the existing analytical methods, fluorometry using fluorescent probes has exhibited promising potential in quantitative detection and imaging of both soluble and insoluble Aβ species, providing a valuable approach for the diagnosis and drug development of AD. In this review, the most recent advances in the fluorescent probes for soluble or insoluble Aβ aggregates are discussed in terms of design strategy, probing mechanism, and potential applications. In the end, future research directions of fluorescent probes for Aβ species are also proposed.</p>","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"103 ","pages":"135-190"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39158774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Copyright 版权
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00005-6
{"title":"Copyright","authors":"","doi":"10.1016/s0065-2423(21)00005-6","DOIUrl":"https://doi.org/10.1016/s0065-2423(21)00005-6","url":null,"abstract":"","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-2423(21)00005-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55860744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Index 指数
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00039-1
{"title":"Index","authors":"","doi":"10.1016/s0065-2423(21)00039-1","DOIUrl":"https://doi.org/10.1016/s0065-2423(21)00039-1","url":null,"abstract":"","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-2423(21)00039-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55860796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative stress biomarkers in the preterm infant. 早产儿的氧化应激生物标志物。
2区 医学
Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-12-17 DOI: 10.1016/bs.acc.2020.08.011
Ángel Sánchez-Illana, José David Piñeiro-Ramos, Victoria Ramos-Garcia, Isabel Ten-Doménech, Máximo Vento, Julia Kuligowski
{"title":"Oxidative stress biomarkers in the preterm infant.","authors":"Ángel Sánchez-Illana,&nbsp;José David Piñeiro-Ramos,&nbsp;Victoria Ramos-Garcia,&nbsp;Isabel Ten-Doménech,&nbsp;Máximo Vento,&nbsp;Julia Kuligowski","doi":"10.1016/bs.acc.2020.08.011","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.08.011","url":null,"abstract":"<p><p>Oxidative stress (OS) plays a key role in the pathophysiology of preterm infants. Accurate assessment of OS remains an analytical challenge that has been partially addressed during the last few decades. A plethora of approaches have been developed to assess preterm biofluids to demonstrate a link postnatally with preterm OS, giving rise to a set of widely employed biomarkers. However, the vast number of different analytic methods and lack of standardization hampers reliable comparison of OS-related biomarkers. In this chapter, we discuss approaches for the study of OS in prematurity with respect to methodologic considerations, the metabolic source of different biomarkers and their role in clinical studies.</p>","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"102 ","pages":"127-189"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.08.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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