Advances in Clinical Chemistry最新文献_第10页

Preface. 前言。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00035-4

Gregory S Makowski

引用次数: 0

Urinary biohazard markers in firefighters. 消防员尿液生物危害标志物。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-03-18 DOI: 10.1016/bs.acc.2021.02.004

Bela Barros, Marta Oliveira, Simone Morais

{"title":"Urinary biohazard markers in firefighters.","authors":"Bela Barros, Marta Oliveira, Simone Morais","doi":"10.1016/bs.acc.2021.02.004","DOIUrl":"https://doi.org/10.1016/bs.acc.2021.02.004","url":null,"abstract":"Firefighters are the professional force at high risk of suffering potential health consequences due to their chronic exposure to numerous hazardous pollutants during firefighting activities. Unfortunately, determination of fire emission exposure is very challenging. As such, the identification and development of appropriate biomarkers is critical in meeting this need. This chapter presents a critical review of current information related with the use of different urinary biomarkers of effect and exposure in occupationally exposed firefighters over the last 25 years. Evidence suggests that urinary isoprostanes and mutagenicity testing are promising biomarkers of early oxidative stress. Data indicate that firefighters participating in firefighting activities present with increased urinary biomarkers of exposure. These include polycyclic aromatic hydrocarbons, heavy metals and metalloids, organo-chlorine and -phosphorus compounds, environmental phenols, phthalates, benzene and toluene. More studies are urgently needed to better evaluate firefighter occupational safety and health and to support the implementation of preventive measures and mitigation strategies to promote the protection of this chronically exposed group of workers.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"243-319"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2021.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Extracellular vesicles: Potential impact on cardiovascular diseases. 细胞外囊泡：对心血管疾病的潜在影响。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-03-10 DOI: 10.1016/bs.acc.2021.02.002

Jian Yang, Xue Zou, Pedro A Jose, Chunyu Zeng

{"title":"Extracellular vesicles: Potential impact on cardiovascular diseases.","authors":"Jian Yang, Xue Zou, Pedro A Jose, Chunyu Zeng","doi":"10.1016/bs.acc.2021.02.002","DOIUrl":"10.1016/bs.acc.2021.02.002","url":null,"abstract":"Extracellular vesicles (EVs) have received considerable attention in biological and clinical research due to their ability to mediate cell-to-cell communication. Based on their size and secretory origin, EVs are categorized as exosomes, microvesicles, and apoptotic bodies. Increasing number of studies highlight the contribution of EVs in the regulation of a wide range of normal cellular physiological processes, including waste scavenging, cellular stress reduction, intercellular communication, immune regulation, and cellular homeostasis modulation. Altered circulating EV level, expression pattern, or content in plasma of patients with cardiovascular disease (CVD) may serve as diagnostic and prognostic biomarkers in diverse cardiovascular pathologies. Due to their inherent characteristics and physiological functions, EVs, in turn, have become potential candidates as therapeutic agents. In this review, we discuss the evolving understanding of the role of EVs in CVD, summarize the current knowledge of EV-mediated regulatory mechanisms, and highlight potential strategies for the diagnosis and therapy of CVD. We also attempt to look into the future that may advance our understanding of the role of EVs in the pathogenesis of CVD and provide novel insights into the field of translational medicine.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"49-100"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9706493/pdf/nihms-1848009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prothrombotic state in cancer. 癌症中的血栓形成前状态。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-04-19 DOI: 10.1016/bs.acc.2021.03.001

Benjamín Rubio-Jurado, Lluvia Sugey Sosa-Quintero, Sandra Guzmán-Silahua, Eduardo García-Luna, Carlos Riebeling-Navarro, Arnulfo Hernán Nava-Zavala

{"title":"The prothrombotic state in cancer.","authors":"Benjamín Rubio-Jurado, Lluvia Sugey Sosa-Quintero, Sandra Guzmán-Silahua, Eduardo García-Luna, Carlos Riebeling-Navarro, Arnulfo Hernán Nava-Zavala","doi":"10.1016/bs.acc.2021.03.001","DOIUrl":"https://doi.org/10.1016/bs.acc.2021.03.001","url":null,"abstract":"Neoplasms result from changes in the mechanisms of growth, differentiation, and cellular death. Cancers are of high clinical relevance due to their prevalence and associated morbidity and mortality. The clinical and biological diversity of cancer depends mainly on cellular origin and degree of differentiation. These changes result from alterations in molecular expression that generate a complex clinical, biochemical, and morphologic phenotype. Although cancer is associated with a hypercoagulable state, few cancers result in a thrombotic event. Many factors influence thrombotic incidence, such as advanced disease, central catheter placement, chemotherapy, neoplasia, and surgery. The pro-coagulant state is associated with anomalies in the vascular wall, blood flow, blood constituents (tissue factor, thrombin), coagulation state, and cell growth factors. Tumor cells perpetuate this phenomenon by releasing tissue factor, inflammatory cytokines, and growth factors. These changes favor cellular activation that gives rise to actions involving coagulation, inflammation, thrombosis, tumor growth, angiogenesis, and tumor metastases. These, in turn, are closely linked to treatment response, tumor aggressiveness, and host survival. Activation of the coagulation cascade is related to these phenomena through molecules that interact in these processes. As such, it is necessary to identify these mediators to facilitate treatment and improve outcomes.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"105 ","pages":"213-242"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2021.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39648309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preface. 前言。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/S0065-2423(21)00090-1

Gregory S Makowski

引用次数: 0

Autoantibodies to tumor-associated antigens in lung cancer diagnosis. 肿瘤相关抗原自身抗体在肺癌诊断中的应用。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-10-13 DOI: 10.1016/bs.acc.2020.08.005

Xiuzhi Zhang, Man Liu, Xue Zhang, Yulin Wang, Liping Dai

引用次数: 10

Advances in fluorescent probes for detection and imaging of amyloid-β peptides in Alzheimer's disease. 阿尔茨海默病淀粉样蛋白-β肽荧光探针检测和成像研究进展。

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2021-02-15 DOI: 10.1016/bs.acc.2020.08.008

Yunhua Zhang, Cen Ding, Changhong Li, Xiaohui Wang

引用次数: 9

Copyright 版权

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00005-6

引用次数: 0

Index 指数

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 DOI: 10.1016/s0065-2423(21)00039-1

引用次数: 0

Advances in cerebral palsy biomarkers. 脑瘫生物标志物研究进展

2区医学

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-05-23 DOI: 10.1016/bs.acc.2020.04.006

Zeynep Alpay Savasan, Sun Kwon Kim, Kyung Joon Oh, Stewart F Graham

{"title":"Advances in cerebral palsy biomarkers.","authors":"Zeynep Alpay Savasan, Sun Kwon Kim, Kyung Joon Oh, Stewart F Graham","doi":"10.1016/bs.acc.2020.04.006","DOIUrl":"https://doi.org/10.1016/bs.acc.2020.04.006","url":null,"abstract":"Cerebral palsy (CP), defined as a group of nonprogressive disorders of movement and posture, is the most common cause of severe neurodisability in children. The prevalence of CP is the same across the globe, affecting approximately 17 million people worldwide. Cerebral Palsy is an umbrella term used to describe the disease due to its inherent heterogeneity. For instance, CP has multiple (1) causes; (2) clinical types; (3) patterns of neuropathology on brain imaging and (4) it's associated with several developmental pathologies such as intellectual disability, autism, epilepsy, and visual impairment. Understanding its physiopathology is crucial to developing protective strategies. Despite its importance, there is still insufficient progress in the areas of CP prediction, early diagnosis, treatment, and prevention. Herein we describe the current risk factors and biomarkers used for the diagnosis and prediction of CP. With the advancement in biomarker discovery, we predict that our understanding of the etiopathophysiology of CP will also increase, lending to more opportunities for developing novel treatments and prognosis.","PeriodicalId":50872,"journal":{"name":"Advances in Clinical Chemistry","volume":"100 ","pages":"139-169"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.acc.2020.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38829488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5