细胞因子与肥胖相关疾病的免疫反应。

2区医学 Q1 Chemistry

Advances in Clinical Chemistry Pub Date : 2021-01-01 Epub Date: 2020-09-24 DOI:10.1016/bs.acc.2020.06.004

Meysam Moghbeli, Hamed Khedmatgozar, Mehran Yadegari, Amir Avan, Gordon A Ferns, Majid Ghayour Mobarhan

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引用次数: 13

摘要

肥胖症的日益流行及其相关的发病率和死亡率是全球重要的公共卫生问题。不健康的生活方式与血清炎性细胞因子升高之间存在重要关系。脂肪细胞分泌几种促炎细胞因子，参与巨噬细胞的募集和激活，导致慢性低度炎症。肥胖个体细胞因子的增加与心血管疾病、高血压和胰岛素抵抗等疾病的进展有关。现就细胞因子及其炎症功能在肥胖相关免疫疾病中的重要作用进行综述。

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Cytokines and the immune response in obesity-related disorders.

The increasing prevalence of obesity and the associated morbidity and mortality are important public health problems globally. There is an important relationship between an unhealthy lifestyle and increased serum inflammatory cytokines. Adipocytes secrete several pro-inflammatory cytokines involved in the recruitment and activation of macrophages resulting in chronic low-grade inflammation. Increased cytokines in obese individual are related to the progression of several disorders including cardiovascular disease, hypertension, and insulin resistance. In present review we have summarized the crucial roles of cytokines and their inflammatory functions in obesity-related immune disorders.

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来源期刊

Advances in Clinical Chemistry 医学-医学实验技术

CiteScore

10.60

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Clinical Chemistry volumes contain material by leading experts in academia and clinical laboratory science. The reviews cover a wide variety of clinical chemistry disciplines including clinical biomarker exploration, cutting edge microarray technology, proteomics and genomics. It is an indispensable resource and practical guide for practitioners of clinical chemistry, molecular diagnostics, pathology, and clinical laboratory sciences in general.