Advances in Enzymology and Related Subjects最新文献

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Eukaryotic dihydrofolate reductase. 真核二氢叶酸还原酶。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123164.ch2
R L Blakley
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引用次数: 82
Structure and function of the ion channel model system annexin V. 离子通道模型系统膜联蛋白V的结构与功能。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123171.ch4
D Voges, R Berendes, P Demange, J Benz, P Göttig, S Liemann, R Huber, A Burger
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引用次数: 14
Regulation of asymmetry and polarity during the Caulobacter cell cycle. 茎状杆菌细胞周期中不对称和极性的调节。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123171.ch1
U Jenal, C Stephens, L Shapiro
{"title":"Regulation of asymmetry and polarity during the Caulobacter cell cycle.","authors":"U Jenal, C Stephens, L Shapiro","doi":"10.1002/9780470123171.ch1","DOIUrl":"https://doi.org/10.1002/9780470123171.ch1","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"71 ","pages":"1-39"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123171.ch1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19622347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The unique C-terminal domain of RNA polymerase II and its role in transcription. RNA聚合酶II独特的c端结构域及其在转录中的作用。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123171.ch2
M E Kang, M E Dahmus
{"title":"The unique C-terminal domain of RNA polymerase II and its role in transcription.","authors":"M E Kang, M E Dahmus","doi":"10.1002/9780470123171.ch2","DOIUrl":"https://doi.org/10.1002/9780470123171.ch2","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"71 ","pages":"41-77"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123171.ch2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19622351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Tyrosine hydroxylase. 酪氨酸羟化酶。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123164.ch3
S Kaufman
{"title":"Tyrosine hydroxylase.","authors":"S Kaufman","doi":"10.1002/9780470123164.ch3","DOIUrl":"https://doi.org/10.1002/9780470123164.ch3","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"70 ","pages":"103-220"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123164.ch3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19616556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exopolysaccharide alginate synthesis in Pseudomonas aeruginosa: enzymology and regulation of gene expression. 铜绿假单胞菌胞外海藻酸盐合成:酶学和基因表达调控。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123164.ch4
S Shankar, R W Ye, D Schlictman, A M Chakrabarty
{"title":"Exopolysaccharide alginate synthesis in Pseudomonas aeruginosa: enzymology and regulation of gene expression.","authors":"S Shankar, R W Ye, D Schlictman, A M Chakrabarty","doi":"10.1002/9780470123164.ch4","DOIUrl":"https://doi.org/10.1002/9780470123164.ch4","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"70 ","pages":"221-55"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123164.ch4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19616557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
Cytochrome c oxidase: chemistry of a molecular machine. 细胞色素氧化酶:分子机器的化学。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123171.ch3
S M Musser, M H Stowell, S I Chan
{"title":"Cytochrome c oxidase: chemistry of a molecular machine.","authors":"S M Musser,&nbsp;M H Stowell,&nbsp;S I Chan","doi":"10.1002/9780470123171.ch3","DOIUrl":"https://doi.org/10.1002/9780470123171.ch3","url":null,"abstract":"<p><p>The plethora of proposed chemical models attempting to explain the proton pumping reactions catalyzed by the CcO complex, especially the number of recent models, makes it clear that the problem is far from solved. Although we have not discussed all of the models proposed to date, we have described some of the more detailed models in order to illustrate the theoretical concepts introduced at the beginning of this section on proton pumping as well as to illustrate the rich possibilities available for effecting proton pumping. It is clear that proton pumping is effected by conformational changes induced by oxidation/reduction of the various redox centers in the CcO complex. It is for this reason that the CcO complex is called a redox-linked proton pump. The conformational changes of the proton pump cycle are usually envisioned to be some sort of ligand-exchange reaction arising from unstable geometries upon oxidation/reduction of the various redox centers. However, simple geometrical rearrangements, as in the Babcock and Mitchell models are also possible. In any model, however, hydrogen bonds must be broken and reformed due to conformational changes that result from oxidation/reduction of the linkage site during enzyme turnover. Perhaps the most important point emphasized in this discussion, however, is the fact that proton pumping is a directed process and it is electron and proton gating mechanisms that drive the proton pump cycle in the forward direction. Since many of the models discussed above lack effective electron and/or proton gating, it is clear that the major difficulty in developing a viable chemical model is not formulating a cyclic set of protein conformational changes effecting proton pumping (redox linkage) but rather constructing the model with a set of physical constraints so that the proposed cycle proceeds efficiently as postulated. In our discussion of these models, we have not been too concerned about which electron of the catalytic cycle was entering the site of linkage, but merely whether an ET to the binuclear center played a role. However, redox linkage only occurs if ET to the activated binuclear center is coupled to the proton pump. Since all of the models of proton pumping presented here, with the exception of the Rousseau expanded model and the Wikström model, have a maximum stoichiometry of 1 H+/e-, they inadequately explain the 2 H+/e- ratio for the third and fourth electrons of the dioxygen reduction cycle (see Section V.B). One way of interpreting this shortfall of protons is that the remaining protons are pumped by an as yet undefined indirectly coupled mechanism. In this scenario, the site of linkage could be coupled to the pumping of one proton in a direct fashion and one proton in an indirect fashion for a given electron. For a long time, it was assumed that at least some elements of such an indirect mechanism reside in subunit III. While recent evidence argues against the involvement of subunit III in the","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"71 ","pages":"79-208"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123171.ch3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19622352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Fibronectin and cell adhesion: specificity of integrin-ligand interaction. 纤维连接蛋白与细胞粘附:整合素-配体相互作用的特异性。
Advances in Enzymology and Related Subjects Pub Date : 1995-01-01 DOI: 10.1002/9780470123164.ch1
S Aota, K M Yamada
{"title":"Fibronectin and cell adhesion: specificity of integrin-ligand interaction.","authors":"S Aota,&nbsp;K M Yamada","doi":"10.1002/9780470123164.ch1","DOIUrl":"https://doi.org/10.1002/9780470123164.ch1","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"70 ","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"1995-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123164.ch1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19616555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme. 磷酸烯醇丙酮酸羧激酶(GTP):基因和酶。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123157.ch6
R W Hanson, Y M Patel
{"title":"Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme.","authors":"R W Hanson,&nbsp;Y M Patel","doi":"10.1002/9780470123157.ch6","DOIUrl":"https://doi.org/10.1002/9780470123157.ch6","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"69 ","pages":"203-81"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123157.ch6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18818573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 153
Aspartate transcarbamylase from Escherichia coli: activity and regulation. 大肠杆菌的天冬氨酸转氨基酶:活性和调控。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123140.ch3
W N Lipscomb
{"title":"Aspartate transcarbamylase from Escherichia coli: activity and regulation.","authors":"W N Lipscomb","doi":"10.1002/9780470123140.ch3","DOIUrl":"https://doi.org/10.1002/9780470123140.ch3","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"68 ","pages":"67-151"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123140.ch3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19145318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 119
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