Advances in Enzymology and Related Subjects最新文献

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Regulation of cholesteryl ester hydrolases. 胆固醇酯水解酶的调节。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123157.ch2
D P Hajjar
{"title":"Regulation of cholesteryl ester hydrolases.","authors":"D P Hajjar","doi":"10.1002/9780470123157.ch2","DOIUrl":"https://doi.org/10.1002/9780470123157.ch2","url":null,"abstract":"<p><p>Recent developments in understanding the biochemical and molecular nature of the CE hydrolases and their impact on cellular cholesterol trafficking have further defined the enzyme's mechanism of action with reasonable clarity. The availability of the cDNA probe for the human lysosomal acid lipase/CE hydrolase and the hormone-sensitive lipase now makes it possible to study CE hydrolase gene regulation and expression in human tissue; and it can now be stated with more assurance that the cytoplasmic CE hydrolase (NCEH) is most likely activated through phosphorylation by the cyclic AMP-dependent protein kinase. Evidence also shows that the NCEH is most likely identical to the hormone-sensitive lipase and that it plays an important role in cholesterol efflux properties of the cell. Recent advances in the discovery of the role of the eicosanoid/cytokine network in the regulation of CE hydrolysis, highlighted in Figure 10, further emphasize the interesting but complex nature of the cholesterol trafficking processes in cells, particularly under pathophysiological conditions such as cell injury, repair, and inflammation. It can be speculated that in several years, when the crystal structure of the CE hydrolase is known, the structure-function properties of this enzyme's catalytic domain, as it relates to the physical state of the CE substrates, should further clarify the precise role of this enzyme in intracellular cholesterol mobilization and trafficking under a variety of cellular conditions.</p>","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"69 ","pages":"45-82"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123157.ch2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18818574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Protein tyrosine phosphatases: mechanism of catalysis and substrate specificity. 蛋白酪氨酸磷酸酶:催化机制和底物特异性。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123140.ch1
Z Y Zhang, J E Dixon
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引用次数: 62
Microtubule dynamics: bioenergetics and control. 微管动力学:生物能量学和控制。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123157.ch4
D L Purich, J M Angelastro
{"title":"Microtubule dynamics: bioenergetics and control.","authors":"D L Purich,&nbsp;J M Angelastro","doi":"10.1002/9780470123157.ch4","DOIUrl":"https://doi.org/10.1002/9780470123157.ch4","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"69 ","pages":"121-54"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123157.ch4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18818571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues. 晶体蛋白/小热休克蛋白/分子伴侣基因在晶状体和其他组织中的表达。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123157.ch5
C M Sax, J Piatigorsky
{"title":"Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues.","authors":"C M Sax,&nbsp;J Piatigorsky","doi":"10.1002/9780470123157.ch5","DOIUrl":"https://doi.org/10.1002/9780470123157.ch5","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"69 ","pages":"155-201"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123157.ch5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18818572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 148
Structure and mechanism of bovine lens leucine aminopeptidase. 牛晶状体亮氨酸氨基肽酶的结构与作用机制。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123140.ch4
H Kim, W N Lipscomb
{"title":"Structure and mechanism of bovine lens leucine aminopeptidase.","authors":"H Kim,&nbsp;W N Lipscomb","doi":"10.1002/9780470123140.ch4","DOIUrl":"https://doi.org/10.1002/9780470123140.ch4","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"68 ","pages":"153-213"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123140.ch4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19147428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 43
Glutathione S-transferases: structure and mechanism of an archetypical detoxication enzyme. 谷胱甘肽s -转移酶:一种典型解毒酶的结构和机制。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123157.ch1
R N Armstrong
{"title":"Glutathione S-transferases: structure and mechanism of an archetypical detoxication enzyme.","authors":"R N Armstrong","doi":"10.1002/9780470123157.ch1","DOIUrl":"https://doi.org/10.1002/9780470123157.ch1","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"69 ","pages":"1-44"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123157.ch1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18818570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 69
Heterologous expression of mammalian P450 enzymes. 哺乳动物P450酶的异源表达。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123140.ch2
M R Waterman
{"title":"Heterologous expression of mammalian P450 enzymes.","authors":"M R Waterman","doi":"10.1002/9780470123140.ch2","DOIUrl":"https://doi.org/10.1002/9780470123140.ch2","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"68 ","pages":"37-66"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123140.ch2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19145317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The new biology of adenosine receptors. 腺苷受体的新生物学。
Advances in Enzymology and Related Subjects Pub Date : 1994-01-01 DOI: 10.1002/9780470123157.ch3
T M Palmer, G L Stiles
{"title":"The new biology of adenosine receptors.","authors":"T M Palmer,&nbsp;G L Stiles","doi":"10.1002/9780470123157.ch3","DOIUrl":"https://doi.org/10.1002/9780470123157.ch3","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"69 ","pages":"83-120"},"PeriodicalIF":0.0,"publicationDate":"1994-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123157.ch3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18818575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Chemical and genetic probes of the active site of D-ribulose-1,5-bisphosphate carboxylase/oxygenase: a retrospective based on the three-dimensional structure. d -核酮糖-1,5-二磷酸羧化酶/加氧酶活性位点的化学和遗传探针:基于三维结构的回顾。
Advances in Enzymology and Related Subjects Pub Date : 1993-01-01 DOI: 10.1002/9780470123133.ch1
F C Hartman, M R Harpel
{"title":"Chemical and genetic probes of the active site of D-ribulose-1,5-bisphosphate carboxylase/oxygenase: a retrospective based on the three-dimensional structure.","authors":"F C Hartman,&nbsp;M R Harpel","doi":"10.1002/9780470123133.ch1","DOIUrl":"https://doi.org/10.1002/9780470123133.ch1","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"67 ","pages":"1-75"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123133.ch1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19310465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
The phenylalanine hydroxylating system. 苯丙氨酸羟基化系统。
Advances in Enzymology and Related Subjects Pub Date : 1993-01-01 DOI: 10.1002/9780470123133.ch2
S Kaufman
{"title":"The phenylalanine hydroxylating system.","authors":"S Kaufman","doi":"10.1002/9780470123133.ch2","DOIUrl":"https://doi.org/10.1002/9780470123133.ch2","url":null,"abstract":"","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"67 ","pages":"77-264"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123133.ch2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19310470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 117
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