Advances in Enzymology and Related Subjects最新文献_第10页

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1007/978-3-642-76412-7_4

B. Babior

引用次数: 57

Traffic ATPases: a superfamily of transport proteins operating from Escherichia coli to humans. 运输三磷酸腺苷酶:从大肠杆菌到人类的转运蛋白超家族。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch1

G F Ames, C S Mimura, S R Holbrook, V Shyamala

引用次数: 133

Methylation of mRNA. mRNA的甲基化。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch7

P Narayan, F M Rottman

引用次数: 24

Long-range intramolecular linked functions in the calcium transport ATPase. 钙转运atp酶的分子内远程连接功能。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch5

G Inesi, D Lewis, D Nikic, A Hussain, M E Kirtley

引用次数: 34

Hydrogen bonding in carbohydrates and hydrate inclusion compounds. 碳水化合物和水合物中的氢键。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch6

G A Jeffrey

引用次数: 15

The respiratory burst oxidase. 呼吸爆发氧化酶。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch2

B M Babior

{"title":"The respiratory burst oxidase.","authors":"B M Babior","doi":"10.1002/9780470123119.ch2","DOIUrl":"https://doi.org/10.1002/9780470123119.ch2","url":null,"abstract":"<p><p>Sbarra and Karnovsky were the first to present evidence suggesting the presence in phagocytes of a special enzyme designed to generate reactive oxidants for purposes of host defense. In the years since their report appeared, a great deal has been learned about this enzyme, now known as the respiratory burst oxidase. It has been found to be a plasma membrane-bound heme- and flavin-containing enzyme, dormant in resting cells, that catalyzes the one-electron reduction of oxygen to O2- at the expense of NADPH: O2 + NADPH----O2- + NADP+ + H+ Its behavior in whole cells and its response to various activating stimuli have been described in detail, although important insights continue to emerge, as for example a very interesting new series of observations on differences in oxidase activation patterns between suspended and adherent cells. The enzyme has been shown by biochemical and genetic studies to consist of at least six components. In the resting cell, three of these components are in the cytosol and three in the plasma membrane, but when the cell passes from its resting to its activated state the cytosolic components are all transferred to the plasma membrane, presumably assembling the oxidase. Of the components initially bound to the membrane, two constitute cytochrome b558, a heme protein characteristic of the respiratory burst oxidase, and the third may represent an oxidase flavoprotein. With regard to the cytosolic components, one is a phosphoprotein and another is the NADPH-binding component, possibly a second oxidase flavoprotein. The nature of the third (p67phox) is a puzzle. Four of the six oxidase components have now been cloned and sequenced. These findings only scratch the surface, however, and many questions remain. How many oxidase components, for example, remain to be discovered, and how do they fit together to form the active enzyme? How is the route of activation of the oxidase integrated into the general signal transduction systems of the cell? How did the oxidase come to be? Could there be a widespread system that generates small amounts of O2- as an intercellular signaling molecule, as recent work is beginning to suggest, and did the ever-destructive respiratory burst oxidase arise from that innocuous system as the creation of some evolutionary Frankenstein--an oxidase from hell? Finally, will it be possible to develop drugs that specifically block the respiratory burst oxidase, and will such drugs prove to be clinically useful as anti-inflammatory agents?(ABSTRACT TRUNCATED AT 400 WORDS)</p>","PeriodicalId":50865,"journal":{"name":"Advances in Enzymology and Related Subjects","volume":"65 ","pages":"49-95"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/9780470123119.ch2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12738156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mammalian nitric oxide synthases. 哺乳动物一氧化氮合酶。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch8

D J Stuehr, O W Griffith

引用次数: 166

The redox centers of ribonucleotide reductase of Escherichia coli. 大肠杆菌核糖核酸还原酶的氧化还原中心。

Advances in Enzymology and Related Subjects Pub Date : 1992-01-01 DOI: 10.1002/9780470123119.ch4

M Fontecave, P Nordlund, H Eklund, P Reichard

引用次数: 76

Novel aspects of the biochemistry of the molybdenum cofactor. 钼辅因子生物化学的新方面。

Advances in Enzymology and Related Subjects Pub Date : 1991-01-01 DOI: 10.1002/9780470123102.ch5

K V Rajagopalan

引用次数: 69

N5-(1-carboxyethyl)ornithine and related [N-carboxyalkyl]-amino acids: structure, biosynthesis, and function. N5-(1-羧基乙基)鸟氨酸和相关的[n -羧基烷基]氨基酸:结构、生物合成和功能。

Advances in Enzymology and Related Subjects Pub Date : 1991-01-01 DOI: 10.1002/9780470123102.ch7

J Thompson, S P Miller

引用次数: 13