Z. Tolou_Ghamari, Arezoo Pourdad, Zahra Foroughi, B. Ataei, A A. Palizban
{"title":"Prevalence of Nosocomial Infections and the Pattern of Microbial Resistance in\u0000a Tertiary Care Referral Hospital (Alzahra), Isfahan, Iran","authors":"Z. Tolou_Ghamari, Arezoo Pourdad, Zahra Foroughi, B. Ataei, A A. Palizban","doi":"10.2174/0102506882306922240603081511","DOIUrl":"https://doi.org/10.2174/0102506882306922240603081511","url":null,"abstract":"\u0000\u0000Nowadays, the resistance to available antibiotics could be mentioned as a global threat to public health. The aim of this preliminary study was to\u0000conduct a retrospective survey associated with the prevalence of Nosocomial Infections (NIs) and the pattern of microbial resistance in a tertiary\u0000care referral hospital (Alzahra), Isfahan, Iran.\u0000\u0000\u0000\u0000The data between the years 2016 to 2022 were extracted from the official database of hospital NI records. The microbiological culture results,\u0000represented by non-repetitive specimens, were further analyzed for pathogens and the pattern of antibiotic resistance. Then antibiotic susceptibility\u0000testing was done using standard methods of disk diffusion or Phoenix M50. The recorded variables have been presented as mean ± standard\u0000deviation, prevalence, and percentage. Data were analyzed using SPSS version 20.\u0000\u0000\u0000\u0000For a duration of 5.5 years, the period prevalence of NIs was recorded as 2%, with more than 50% associated with ventilator-associated events and\u0000urinary tract infections. Klebsiella pneumonia, Acinetobacter baumannii, and Staphylococcus were the main pathogens. Further study of specimens\u0000from the year 2022 (n= 898) confirmed the most isolated bacteria as Klebsiella pneumonia (n = 290, 32%), Acinetobacter baumannii (n= 206,\u000023%), Enterococcus (faecium-fecalis n=125, 14%), Escherichia coli (n = 116, 13%), Staphylococcus aureus (n = 95, 11%), and Pseudomonas\u0000aeruginosa (n = 66, 7%). Resistance (R%) in Isfahan versus the whole country was confirmed for Klebsiella pneumonia (third or fourth generation\u0000of cephalosporins: R = 80.9 vs. 82%), fluoroquinolones (R = 76.6 vs. 73%), beta-lactamase inhibitors (R = 75 vs. 79%), carbapenems (R = 65.7 vs.\u000066%), and so on, respectively.\u0000\u0000\u0000\u0000There has been reported an increase in the proportion of isolates resistant to cephalosporins, fluoroquinolones, and others. The variety of latent\u0000pathogens resistant to frequently administered antibiotics highlights the significance of continued and homogenous antimicrobial evidence-based\u0000pharmacotherapy investigations in Isfahan, Iran. Further studies in this direction are recommended.\u0000","PeriodicalId":508641,"journal":{"name":"New Emirates Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141821533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}