中心型肥胖 2 型糖尿病患者的内脏脂肪相关脂肪因子和代谢变量

A. Shaheer, Ashok Kumar, M. Jallo, P. Menon
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引用次数: 0

摘要

内脏肥胖与外周组织的胰岛素抵抗有关,是罹患 2 型糖尿病的另一个风险决定因素。内脏脂肪组织中巨噬细胞的浸润和脂肪因子的不可靠生成与胰岛素抵抗的进展机制有关。这项研究的目的是评估内脏脂肪相关脂肪因子与中心性肥胖 2 型糖尿病患者生化变量之间的关系。使用 Cobas® 6000 分析仪测量生化变量。结果显示,脂肪因子与空腹血浆葡萄糖(FPG)、餐后血糖(PPBG)和 HbA1c 水平之间存在显著关系(p < 0.05)。内脏脂肪相关脂肪因子与代谢变量之间的关系可能会影响中心性肥胖 2 型糖尿病患者的代谢途径。该研究提供了新的见解,需要进一步研究和了解中心性肥胖 2 型糖尿病患者的代谢途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Visceral Fat-associated Adipokines and Metabolic Variables in Central Obese Type 2 Diabetic Patients
The aim of the study was to comprehend the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients. Visceral obesity is linked with insulin resistance in peripheral tissues and is an alternative risk determinant for developing type 2 diabetes mellitus. The infiltration of macrophages in the visceral fatty tissue and the unreliable generation of adipokines are associated with mechanisms directing the progress of insulin resistance. The objective of the study was to evaluate the relationship between visceral fat-associated adipokines and biochemical variables in central obese type 2 diabetic patients. Serum adipokines were analyzed by Eenzyme-Linked Immunosorbent Assay. Biochemical variables were measured using Cobas® 6000 analyzer. HbA1c was measured by High Performance Liquid Chromatography. The results show a significant relationship (p < 0.05) between the adipokines and Fasting Plasma Glucose (FPG), Postprandial Blood Glucose (PPBG) and HbA1c levels. The results indicate a significant association (p < 0.05) between the adipokines and lipid profile with varying degrees in central obese type 2 diabetic subjects. The relationship between visceral fat-associated adipokines and metabolic variables may influence the metabolic pathways in central obese type 2 diabetic patients. The adipokines are strong predictors for the intensification of type 2 diabetes mellitus and can be used as a diagnostic tool for risk assessment in the central obese population. The study provides new insight that requires further investigations and understanding of the metabolic pathways in central obese type 2 diabetic patients.
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