Pharmacia最新文献

{"title":"Drug interaction detection and glycemic control – telepharmacy’s role in diabetes management: before-after study","authors":"Ida Lisni, Irma Rahayu Latarissa, Lucia Rizka Andalusia, Keri Lestari","doi":"10.3897/pharmacia.71.e123313","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e123313","url":null,"abstract":"Introduction: Diabetes management faces intertwined challenges like polypharmacy and adherence complexities, hindering effective care delivery. Telepharmacy emerges as a promising solution, revolutionizing diabetes care by enhancing pharmacists’ pivotal role. However, a tailored model for Indonesia is still lacking.\u0000 Purpose: This study aimed to assess the potential effectiveness of a telepharmacy application in improving the detection of drug-drug interactions and glycemic control.\u0000 Methods: We conducted an observational before-and-after study among type 2 diabetic patients in Indonesia.\u0000 Results: We noted a significant surge in detected drug interactions. Patients counseled through telepharmacy had 3.653 times higher likelihood of achieving good glycemic control.\u0000 Conclusion: The study underscores the positive impact of telepharmacy on drug interaction detection and glycemic control among Indonesian diabetics.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of dietary intervention on myokines: a narrative review","authors":"Yavor Assyov, Kristian Chechev, Antoaneta Gateva, Karamfilova Vera, Tsvetan Gatev, Dobrin Popov, Yuliyan Naydenov, Emanuela Zaharieva, Natalia Konova, Savelia Yordanova, Bozhidar Marinov, Diana Nikolova, Zdravko Kamenov","doi":"10.3897/pharmacia.71.e123805","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e123805","url":null,"abstract":"This review elucidates the role of dietary factors in influencing myokine secretion, complementing the recognized benefits of physical activity on metabolic health. While exercise is known to positively modulate myokines, contributing to their health-promoting effects, an exploration into how diet affects these critical cytokines remains sparse. Through analysis of the literature, this work identifies dietary patterns that markedly affect myokine levels, underscoring the complex relationship between nutrition and myokine activity. The investigation reveals that specific dietary approaches can profoundly alter myokine secretion, suggesting an essential avenue for combined dietary and exercise interventions to optimize health outcomes. These insights highlight the need for further detailed study into diet-induced myokine modulation.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141106041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and application of gold nanoparticles as antioxidants","authors":"B. A. Suliasih, Setia Budi, Haliza Katas","doi":"10.3897/pharmacia.71.e112322","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e112322","url":null,"abstract":"Non-communicable diseases (NCDs) and premature aging, caused by free radicals, have spurred a demand for extensive research into finding effective antioxidants. Currently, there is an abundance of both natural and synthetic antioxidants, including metal nanoparticles with high antioxidant activity. Among these, gold nanoparticles (AuNPs) stand out as favoured antioxidants because of their minimal toxicity, simple synthesis, and detectability. The antioxidant properties of AuNPs enhance its wide-ranging potential for use in healthcare including applications as anti-aging, anti-inflammatory, and wound healing agents, as well as treatment for various diseases. This review highlights recent progress in the synthesis of AuNPs as antioxidants and method for assessing their antioxidant capacity as well as delves into their mechanism of action and explores their potential health applications. In conclusion, considering the physicochemical and biological properties, along with the benefits and potential challenges for future development, AuNPs are deemed promising and effective antioxidants suitable for clinical applications.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of biological medicinal products and tyrosine kinase inhibitors in rheumatoid arthritis and COVID-19: A systematic review of scientific literature","authors":"I. Parvova, E. Yordanov, E. Hristov, V. Petkova","doi":"10.3897/pharmacia.71.e124471","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e124471","url":null,"abstract":"We analyzed whether commonly used biological medicinal products and/or tyrosine kinase inhibitors with indications for treatment of rheumatologic diseases can be used in patients with concurrent COVID-19 by systematically reviewing scientific articles. The articles were selected according to PRISMA by keywords in the MEDLINE and Central Medical Library - MU Sofia databases for the period January 2020–December 2023. We found 168 scientific publications, of which 9 met the set criteria. Results were evaluated using descriptive methods and the PICOS tool. We found no evidence that the use of BMPs and TKIs in patients with rheumatologic diseases leads to an increased risk of COVID-19 infection and/or a more severe course of SARS-CoV-2 infection. Several cases of prolonged or atypical COVID-19-induced pneumonia have been identified in patients treated with Rituximab. This suggests the need for caution in the use of this medicinal product in patients with COVID-19. The 2022 EULAR recommendations are in the same spirit.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141109182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of CYP2C19 genotypes on steady-state plasma concentration of escitalopram in South Indian population with Major Depressive Disorder","authors":"B. Jeevan Kumar, Vijayakumar Thangavel Mahalingam, Ganesh Kumar M","doi":"10.3897/pharmacia.71.e123645","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e123645","url":null,"abstract":"Background: Among depressed patients, escitalopram plasma levels differed between those who were considered as extensive metabolizers and poor metabolizers of CYP2C19. However, the majority of research utilized the dose-response relationship. Consequently, we investigated the effect of variations in the CYP2C19 gene on the levels of drug in the bloodstream of individuals suffering from Major Depressive Disorder (MDD) in south India.\u0000 Methods: A total of 109 individuals with MDD who were prescribed escitalopram at doses of 5, 10, 15, or 20 mg daily participated in this research. We used HPLC with SPD-10AVP UV-Visible detector to measure the escitalopram concentrations in the blood. The polymorphisms of the CYP2C19 were determined by employing the PCR techniques.\u0000 Results: Our study found that 55% of the subjects were intermediate metabolizers, followed by extensive (19.3%), poor (17.4%), and ultra-rapid (8.3%). The significant correlation is identified between the steady state plasma concentration and Sex with (P - Value < 0.05), insignificant correlation was seen in Age and BMI with (P - Value > 0.05). The majority of gene variants seen in the study population were CYP2C19*1/*2, accounting for 49 individuals (44.9%).\u0000 Conclusion: These findings showed that sex had a substantial impact on the CYP2C19 genetic variation. Medication administration to individuals with CYP2C19PM requires special caution.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141113208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological prophylaxis and functional restoration of the lower limb in total knee arthroprosthesis","authors":"Mariya Vakrilova Becheva, A. Kirkova-Bogdanova, Stefka Achkova Ivanova, Krasimira Milcheva Kazalakova","doi":"10.3897/pharmacia.71.e124586","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e124586","url":null,"abstract":"The complexity of the movements of the bones of the knee joint requires an anatomical study to construct a knee prosthesis. The reasons for knee replacement are related to wear of the articular cartilage, which leads to pain, deformation, and limitation of movements. The consequences of the surgical intervention allow functional restoration of the knee joint and the supporting function of the lower limb. Kinesitherapy begins the day after surgery and aims to reduce pain, restore mobility of the knee joint, actively lock the knee during extension, increase and maintain muscle strength, and ensure the functional independence of patients. To a large extent, the volume of movement is restored, and the pain symptoms are reduced. Patients have the comfort of everyday movements and the possibility of participating in certain sports activities—swimming, cycling, and golf. The paper deals with pharmacological prophylaxis, the kinesitherapeutic program, and total knee arthroprosthesis.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141122007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing knowledge, perceptions, and readiness of telemedicine recipients: A cross-sectional study","authors":"Iman Hamdan, Enas Alkhader","doi":"10.3897/pharmacia.71.e122134","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e122134","url":null,"abstract":"Objectives: The current study aimed to assess the knowledge and perceptions of telemedicine recipients. Secondly, to evaluate their readiness towards adopting telemedicine in clinical settings.\u0000 Methods: A cross-sectional survey study was conducted in Jordan and designed to show the demographics of participants. The questionnaire was piloted for validity and reliability to achieve the aim of the study, and a collective of 420 participants were recruited.\u0000 Findings: Multiple regression analysis conducted showed that telemedicine services were significant at a level of α ≤ 0.05. Whereas the Pearson’s correlation of the dependent and independent variables was also significant at a level of α ≤ 0.05 as a function of age, working status, and income.\u0000 Conclusions: Regardless of the fact that participants showed a limited knowledge of telemedicine services, most of the participants expressed positive perceptions towards telemedicine services and its adoption in the clinical settings.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140967096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety in the emergency medical practice – its psychiatric and somatic origin, comorbidities, behavior and treatment","authors":"Silvia Sarakostova, Diyana Pantileeva, D. Dilkov, Niya Semerdzhieva, M. Chaneva, S. Ivanova, Ventseslava Atanasova, P. Atanasov, Diana Rangelova","doi":"10.3897/pharmacia.71.e124695","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e124695","url":null,"abstract":"Anxiety conditions and disorders are common in the general population, and patients suffering from them often seek the services of emergency departments. Anxiety is a psychopathological symptom that accompanies not only psychiatric conditions, but a wide range of somatic diseases, and a combination of both. The biochemical and pathophysiological mechanisms of psychosomatic interrelationship and comorbidity are complex and multi-layered. Thus, diagnosing the root cause of anxiety is a clinical challenge. Early, and on time, recognition of an anxiety disorder helps to avoid unnecessary investigations, ensures correct treatment and saves hospital resources. Careful use of medications, psychoeducation and referral to a specialist improves patient outcome with this potentially debilitating disease.\u0000 In this article, the authors aim to present in a synthesized form the main epidemiological data on the prevalence of anxiety symptoms and disorders, anatomical localization and biochemical mechanisms and relationships in the pathogenesis of anxiety symptoms, as well as to derive the main guidelines for recognizing and differentiating clinicopathological constellations in somatic conditions in emergency medical practice.\u0000 Materials and methods. Existing published studies from an international database, related to the subject of the article, have been thoroughly studied.\u0000 Results. Anxiety symptoms, in particular panic attacks and disorders, are widespread in primary care and occupy a significant part of the work process, especially at times of peak loads, natural disasters and situations of mass traumatism.\u0000 Conclusions. Timely training and good preparation for recognition and adequate assessment of anxiety conditions in primary and emergency medical care significantly shorten the therapeutic route of patients. They receive competent help on time, and the cost of their treatment is significantly reduced.\u0000 Discussion. Modern medical science, including psychiatric, offers advanced drug and non-drug methods for the treatment and prevention of anxiety conditions and disorders.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of acute, sub-chronic toxicity, effects of mangiferin and mangiferin solid dispersion (HPTR) on Triton WR1339-induced hyperlipidemia on Swiss albino mice","authors":"Duyen Thi My Huynh, Linh My Le, Lam Thanh Nguyen, Trung Ho Nhan Nguyen, Minh Hoang Nguyen, Khang Tran Vinh Nguyen, Khanh Quoc Tran, Trung Le Quoc Tran, Minh-Ngoc Thi Le, H. Mai","doi":"10.3897/pharmacia.71.e123277","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e123277","url":null,"abstract":"\u0000 Mangiferin is a xanthonoid found in Mango leaves in abundance with many effects as a hypoglycemic, antioxidant, and anti-inflammatory agent, plant metabolite, and so on. However, nowadays, mango leaves are merely a waste product in Vietnam. To take advantage of this valuable medicinal resource, extraction conditions of mangiferin using classical and ultrasound methods were researched, and mangiferin was purified from Cat Chu mango leaves (Mangifera indica L., Anacardiaceae) collected in Dong Thap. Ultrasound-assisted extraction method was conducted with the following conditions and mangiferin was extracted at a percentage of 6.728% with a purity of 91.11%. Purified mangiferin was evaluated using molecular absorption spectroscopy UV-Vis, scanning electron microscopy (SEM), X-ray diffraction (XRD) spectroscopy, simultaneous thermal analysis (STA: TGA/DSC), and dissolution measurement method. To optimize the solubility and permeability of mangiferin, the solid dispersion system (HPTR) was made by the combination of HPMC 6M:mangiferin at the ratio of 1:5. To investigate the acute, sub-chronic toxicity and hypolipidemia effect of HPTR as compared to purified mangiferin, we followed guidelines for preclinical and clinical trials of Traditional Medicine and Herbal Medicines by the Vietnam Ministry of Health and OECD, and used tyloxapol (Triton WR1339, 400 mg/kg, i.p.) to induce hyperlipidemia. Our results indicated that purified mangiferin and HPTR extract showed no acute toxicity and sub-chronic toxicity and has potential as an antihyperlipidemic agent. The HPTR brought about a significant decrease in total cholesterol, triglycerides and LDL-c when compared to mangiferin, however there was no significance between them.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140973731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coating methotrexate-PLGA nanoparticles with folic acid-chitosan conjugate for cancer targeting","authors":"Nusaiba Al-Nemrawi, Rowaida Altawabeyeh, Ruba S. Darweesh, Soraya Alnabulsi","doi":"10.3897/pharmacia.71.e120072","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e120072","url":null,"abstract":"Background: Loading Methotrexate, a chemotherapeutic agent, in a nanocarrier can improve its efficacy and lower its side effects. Both PLGA and chitosan were used to formulate Methotrexate nanoparticles. Folate acts as a targeting ligand for anticancer medications. Therefore, folate, chitosan, and PLGA were used to deliver methotrexate.\u0000 Methods: Folic acid and Chitosan (FA-CS) were conjugated and used to coat Methotrexate-PLGA nanoparticles. The conjugate and the nanoparticles were characterized using Zetasizer to test particle size, polydispersity and charge, SEM was used to test particles’ morphology. Both %EE and %LC of MTX in the NPs were measured. Finally, MTX release and the system cytotoxicity were tested in vitro.\u0000 Results: FTIR, NMR, and XRD proved the successful formation of FA-CS, and the formation of the coated nanoparticles. The particles were spherical with a size ~385 nm, a disparity ~0.27, and a charge ~+15 mV. The %EE and the % LC were 79% and 21.2%, respectively. In vitro release studies revealed nearly complete MTX release after 48 h. In vitro cytotoxicity testing demonstrated that the formulation components are safe and that the incorporation of MTX within the nanoparticles enhanced the drug’s cytotoxic effect in comparison to the free drug.\u0000 Conclusion: loading of MTX in the NPs enhances its chemotherapeutic effect, hence, this system can be used to target carcinogenic cells.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140976047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}