Pharmacia最新文献_第9页

Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study 补充镁、维生素 B2 和辅酶 10 的综合疗法对前庭性偏头痛的疗效：一项回顾性队列研究

Pharmacia Pub Date : 2024-02-02 DOI: 10.3897/pharmacia.71.e112909

Ala Abu-Zaid, Sawsan Abu-Zaid, M. Barakat, Rashed Al-Huniti, Hamzeh Khair

{"title":"Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study","authors":"Ala Abu-Zaid, Sawsan Abu-Zaid, M. Barakat, Rashed Al-Huniti, Hamzeh Khair","doi":"10.3897/pharmacia.71.e112909","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e112909","url":null,"abstract":"Vestibular migraine (VM) has conventionally been treated through acute migraine-aborting therapeutic interventions and prevention to reduce migraines’ occurrence, length and intensity. There is growing attention to the development of non-pharmaceutical prophylactic interventions for migraines in the search for effective treatments, such as through mineral, vitamin and other supplementation. This research aims to examine the effectiveness of magnesium, vitamin B2 and Co-enzyme 10 supplementation to decrease vestibular migraines’ frequency, duration and severity. Method: This retrospective cohort study was conducted in a Jordanian context over 57- VM patients, each patient attending the outpatient dizziness clinic between August 2022 and February 2023. Patients were treated for six months with a combined supplementation of magnesium, vitamin B2, and Co-enzyme Q10. Assessments were made of three measures of VM attack, namely frequency, duration and severity, both before and after intervention. Result: Supplements administration demonstrated a significant reduction (by 81.1%) in VM-symptoms frequency (p < 0.001). Moreover, reductions in symptom duration in minutes occurred progressively as the treatment period continued and showed statistical significance, with impacts upon over 80% of the sample and a reduction from 763.9 minutes to 122.5 minutes (p < 0.001). The mean of pre-intervention severity was 7.2/10, with a significant decrease shown following treatment, at 2.1/10, and very positive results for over 71% of the sample (p < 0.001). Conclusion: The preliminary findings of this study showed a promising potential for such supplements in the treatment and prevention of VM; however, more research and a prospective trial are recommended.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":"12 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139869504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study 补充镁、维生素 B2 和辅酶 10 的综合疗法对前庭性偏头痛的疗效：一项回顾性队列研究

Pharmacia Pub Date : 2024-02-02 DOI: 10.3897/pharmacia.71.e112909

Ala Abu-Zaid, Sawsan Abu-Zaid, M. Barakat, Rashed Al-Huniti, Hamzeh Khair

{"title":"Effectiveness of combination therapy of magnesium, vitamin B2 and Co-enzyme 10 supplementation on vestibular migraine: a retrospective cohort study","authors":"Ala Abu-Zaid, Sawsan Abu-Zaid, M. Barakat, Rashed Al-Huniti, Hamzeh Khair","doi":"10.3897/pharmacia.71.e112909","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e112909","url":null,"abstract":"Vestibular migraine (VM) has conventionally been treated through acute migraine-aborting therapeutic interventions and prevention to reduce migraines’ occurrence, length and intensity. There is growing attention to the development of non-pharmaceutical prophylactic interventions for migraines in the search for effective treatments, such as through mineral, vitamin and other supplementation. This research aims to examine the effectiveness of magnesium, vitamin B2 and Co-enzyme 10 supplementation to decrease vestibular migraines’ frequency, duration and severity. Method: This retrospective cohort study was conducted in a Jordanian context over 57- VM patients, each patient attending the outpatient dizziness clinic between August 2022 and February 2023. Patients were treated for six months with a combined supplementation of magnesium, vitamin B2, and Co-enzyme Q10. Assessments were made of three measures of VM attack, namely frequency, duration and severity, both before and after intervention. Result: Supplements administration demonstrated a significant reduction (by 81.1%) in VM-symptoms frequency (p < 0.001). Moreover, reductions in symptom duration in minutes occurred progressively as the treatment period continued and showed statistical significance, with impacts upon over 80% of the sample and a reduction from 763.9 minutes to 122.5 minutes (p < 0.001). The mean of pre-intervention severity was 7.2/10, with a significant decrease shown following treatment, at 2.1/10, and very positive results for over 71% of the sample (p < 0.001). Conclusion: The preliminary findings of this study showed a promising potential for such supplements in the treatment and prevention of VM; however, more research and a prospective trial are recommended.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139809396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The promise and challenges of ChatGPT in community pharmacy: A comparative analysis of response accuracy 社区药房使用 ChatGPT 的前景与挑战：回复准确性比较分析

Pharmacia Pub Date : 2024-01-30 DOI: 10.3897/pharmacia.71.e116927

Ali H. Salama

{"title":"The promise and challenges of ChatGPT in community pharmacy: A comparative analysis of response accuracy","authors":"Ali H. Salama","doi":"10.3897/pharmacia.71.e116927","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e116927","url":null,"abstract":"This study evaluates ChatGPT, an AI-based language model, in addressing common pharmacist inquiries in community pharmacies. The assessment encompasses Drug-Drug Interactions, Adverse Drug Effects, Drug Dosage, and Alternative Therapies, each comprising 20 questions, totaling 80 questions. Responses from ChatGPT were compared against standard answers, generating textual and chart scores. Textual score was computed by relating correct answers to the total questions within each category, while chart score involved the total correct answers multiplied by the chart-type questions. ChatGPT exhibited distinct performance rates: 30% for Drug-Drug Interactions, 65% for Adverse Drug Effects, 35% for Drug Dosage, and an impressive 85% for Alternative Therapies. While Alternative Therapies displayed high accuracy, challenges arose in accurately addressing Drug Dosage and Drug-Drug Interactions. Conclusion: The study underscores the complexity of pharmacy-related inquiries and the necessity for AI model enhancement. Despite promising accuracy in certain categories, like Alternative Therapies, improvements are crucial for Drug Dosage and Drug-Drug Interactions. The findings emphasize the need for ongoing AI model development to optimize integration into community pharmacy settings.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":"195 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Propranolol nanoemulgel: Preparation, in-vitro and ex-vivo characterization for a potential local hemangioma therapy 普萘洛尔纳米凝胶：用于潜在局部血管瘤治疗的制备、体外和体内特性分析

Pharmacia Pub Date : 2024-01-30 DOI: 10.3897/pharmacia.71.e115330

Taif Abdullah, Khalid Al-Kinani

引用次数: 0

Association study between D2 receptor A-241G, rs1799978 genetic variation and olanzapine efficacy in Iraqi schizophrenic patients 伊拉克精神分裂症患者 D2 受体 A-241G、rs1799978 基因变异与奥氮平疗效的关联研究

Pharmacia Pub Date : 2024-01-29 DOI: 10.3897/pharmacia.71.e111984

Zahra Jawd Mohammed Ali Al-Musawi, Atheer M. R. Al-juhaishi

引用次数: 0

Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides N-(苄基)-5-甲基-4-氧代-3,4-二氢噻吩并[2,3-d]嘧啶-6-甲酰胺的合成、硅学和体外抗菌活性

Pharmacia Pub Date : 2024-01-29 DOI: 10.3897/pharmacia.71.e110013

S. Vlasov, O. Borysov, H. Severina, V. Vlasov, Amjad Ibrahim M. Abu Sharkh, V. Georgiyants

{"title":"Synthesis, in silico and in vitro antimicrobial activity of N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides","authors":"S. Vlasov, O. Borysov, H. Severina, V. Vlasov, Amjad Ibrahim M. Abu Sharkh, V. Georgiyants","doi":"10.3897/pharmacia.71.e110013","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e110013","url":null,"abstract":"According to the recent studies bezylcarboxamide fragment attached to the thiophene ring of thieno[2,3-d]pyrimidine is beneficial for antimicrobial activity of the compounds. Therefore we focused our efforts on constructing of the simple molecules such as N-(benzyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamides to get deeper insight into their antimicrobial activity. As the optimal procedure for preparation of target compounds we choose 1,1’-carbonyldiimidazole promoted interaction of 5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid with the series of substituted benzyl amines. The obtained amides showed good activity against the strains of S. aureus and B. subtilis, which was higher for the derivative without substituents in benzene ring or the compounds with small substituents like methyl or methoxyl groups in the para-position of the benzene ring. Docking studies showed that despite the good values of the scoring functions, the conformational analysis of the ligands’ poses in the active site revealed their ability for only partial inhibition of TrmD of P. aeruginosa.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":"5 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140490083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam 响应面法优化超声辅助提取工艺及对越南云杉中多酚类化合物的定量分析

Pharmacia Pub Date : 2024-01-11 DOI: 10.3897/pharmacia.71.e115528

Ngoc‐Van Thi Nguyen, Cuong V. Nguyen, Ngan Tuyet Duong, Đái Thị Xuân Trang, Kien Nguyen, Cam-Thuy Thi Le

{"title":"Optimization of ultrasound-assisted extraction using response surface methodology and quantification of polyphenol compounds in Avicennia officinalis L. from Vietnam","authors":"Ngoc‐Van Thi Nguyen, Cuong V. Nguyen, Ngan Tuyet Duong, Đái Thị Xuân Trang, Kien Nguyen, Cam-Thuy Thi Le","doi":"10.3897/pharmacia.71.e115528","DOIUrl":"https://doi.org/10.3897/pharmacia.71.e115528","url":null,"abstract":"Response surface methodology was used to estimate the optimum extraction parameters, for which the total phenolic content and total flavonoid content of Avicennia officinalis L. extract were the highest. Based on the 3D surface plots and regression analysis of the independent variables, the optimal conditions for the ultrasound-assisted extraction were as follows: methanol content, 55.27%; liquid-to-solid ratio, 14:1 (mL/g, v/w); temperature, 48.8 °C, and time, 9.66 min. Optimal extraction conditions were applied to validate the quantification. The bioactive compounds from the Avicennia officinalis L. extract were identified through ultra-fast liquid chromatography coupled to diode array detector for the first time. These methods were applied to quantify phenolic acids and flavonoids from A. officinalis extracts collected at six different locations in Vietnam. The results showed that the concentrations of these compounds varied from 0.319 ± 0.022 to 3.524 ± 0.125 mg/g in the methanol extract. The result showed that cinnamic acid is the major compound in A. officinalis collected in Vietnam. In the present study, an optimized ultrasound-assisted extraction was first designed to improve the content of phenolic acids and flavonoid compounds from A. officinalis . Additionally, the bioactive compounds from the A. officinalis extract were identified through UFLC-DAD for the first time.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":"71 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pharmacia.pensoft.net/article/115528/download/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Protective effect of lacosamide and topiramate treatment against Pentylenetetrazole-induced kindling and associated cognitive dysfunction in rats 拉科沙胺和托吡酯治疗对戊四唑诱导的大鼠点火及相关认知功能障碍的保护作用

Pharmacia Pub Date : 2022-11-16 DOI: 10.3897/pharmacia.69.e96185

Michaela Shishmanova-Doseva

{"title":"Protective effect of lacosamide and topiramate treatment against Pentylenetetrazole-induced kindling and associated cognitive dysfunction in rats","authors":"Michaela Shishmanova-Doseva","doi":"10.3897/pharmacia.69.e96185","DOIUrl":"https://doi.org/10.3897/pharmacia.69.e96185","url":null,"abstract":"Cognitive impairment is considered the most common comorbidity in epilepsy. The aim of the present study was to explore the effects of long-term treatment with lacosamide and topiramate on epileptogenesis and related cognitive dysfunction in an experimental model of pentylenetetrazole (PTZ)-induced kindling. The latter was induced by the repeated administration of subconvulsive dose of PTZ (40 mg/kg, s.c.) on every alternate day for 8–9 weeks. Both drugs were applied daily in a dose of 10 mg/kg p.o. 30 min before PTZ injection. To assess behavioral comorbidities all rats underwent one active and one passive avoidance tests. The results show that lacosamide significantly suppressed the progression of kindling, while the effect of topiramate was not so pronounced on seizure development. Long-term treatment with both antiepileptic drugs managed to ameliorate the kindling-associated impairment of learning and memory. Lacosamide and topiramate improved active and passive learning abilities and facilitated the formation of short- and long-term memory traces. Both drugs failed to prevent the hyperactivity associated with epilepsy.","PeriodicalId":508564,"journal":{"name":"Pharmacia","volume":"69 4","pages":"1005-1012"},"PeriodicalIF":0.0,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pharmacia.pensoft.net/article/96185/download/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147903587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2