Advances in Parasitology最新文献_第2页

New directions for malaria vector control using geography and geospatial analysis. 利用地理和地理空间分析控制疟疾病媒的新方向。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-06-26 DOI: 10.1016/bs.apar.2024.06.001

Andy Hardy

{"title":"New directions for malaria vector control using geography and geospatial analysis.","authors":"Andy Hardy","doi":"10.1016/bs.apar.2024.06.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.06.001","url":null,"abstract":"As we strive towards the ambitious goal of malaria elimination, we must embrace integrated strategies and interventions. Like many diseases, malaria is heterogeneously distributed. This inherent spatial component means that geography and geospatial data is likely to have an important role in malaria control strategies. For instance, focussing interventions in areas where malaria risk is highest is likely to provide more cost-effective malaria control programmes. Equally, many malaria vector control strategies, particularly interventions like larval source management, would benefit from accurate maps of malaria vector habitats - sources of water that are used for malarial mosquito oviposition and larval development. In many landscapes, particularly in rural areas, the formation and persistence of these habitats is controlled by geographical factors, notably those related to hydrology. This is especially true for malaria vector species like Anopheles funestsus that show a preference for more permanent, often naturally occurring water sources like small rivers and spring-fed ponds. Previous work has embraced geographical concepts, techniques, and geospatial data for studying malaria risk and vector habitats. But there is much to be learnt if we are to fully exploit what the broader geographical discipline can offer in terms of operational malaria control, particularly in the face of a changing climate. This chapter outlines potential new directions related to several geographical concepts, data sources and analytical approaches, including terrain analysis, satellite imagery, drone technology and field-based observations. These directions are discussed within the context of designing new protocols and procedures that could be readily deployed within malaria control programmes, particularly those within sub-Saharan Africa, with a particular focus on experiences in the Kilombero Valley and the Zanzibar Archipelago, United Republic of Tanzania.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"125 ","pages":"1-52"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of health education activities targeting schoolchildren for the control of soil-transmitted helminthiasis in Southeast Asia, with emphasis upon the Magic Glasses approach. 东南亚针对在校学生开展的控制土壤传播蠕虫病的健康教育活动回顾，重点是 "魔法眼镜 "方法。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-02-18 DOI: 10.1016/bs.apar.2023.12.001

Mary Lorraine S Mationg, Gail M Williams, Veronica L Tallo, Remigio M Olveda, Donald P McManus, Donald E Stewart, Darren J Gray

{"title":"A review of health education activities targeting schoolchildren for the control of soil-transmitted helminthiasis in Southeast Asia, with emphasis upon the Magic Glasses approach.","authors":"Mary Lorraine S Mationg, Gail M Williams, Veronica L Tallo, Remigio M Olveda, Donald P McManus, Donald E Stewart, Darren J Gray","doi":"10.1016/bs.apar.2023.12.001","DOIUrl":"10.1016/bs.apar.2023.12.001","url":null,"abstract":"Soil-transmitted helminths continue to be a serious problem causing disease and morbidity globally. Children, mostly school-aged, are more at risk of these infections. The main strategy for control remains to be the mass drug administration (MDA) of antihelminthic drugs. With the limitation of MDA to prevent re-infection, the need for additional approaches such as hygiene education and improvements in water, sanitation and hygiene (WASH) infrastructure are required. Although the importance of health education as a crucial component of an integrated approaches to STH control is highlighted, this component has often been disregarded because the other more complex solutions have been the focus of most studies and programmes. We performed literature searches from four bibliographic databases - Scopus, PubMed, Web of Science and Cochrane Library - to determine availability of studies on the impact of health education interventions targeting STH infections on schoolchildren in Southeast Asia. Our review found only three studies that evaluated health education interventions targeting children. The current lack of evidence in this area suggests the need for more studies assessing the impact of health education intervention for STH control. A successful health education programme for STH called \"The Magic Glasses\" has been developed targeting schoolchildren in China and the Philippines. This public health intervention displayed significant impact in terms of improving knowledge, attitude and practices, reducing prevalence of STH infections in schoolchildren and encouraging compliance to MDA. This article details the successes and benefits of the Magic Glasses programme as a promising control tool for STH in the Southeast Asian region.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"123 ","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on proteases and protease inhibitors from trematodes. 来自吸虫的蛋白酶和蛋白酶抑制剂的最新情况。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-09-20 DOI: 10.1016/bs.apar.2024.07.002

Martin Horn, Lucia Bieliková, Andrea Vostoupalová, Jakub Švéda, Michael Mareš

引用次数: 0

Working towards the development of vaccines and chemotherapeutics against neosporosis-With all of its ups and downs-Looking ahead. 努力开发针对新孢子虫病的疫苗和化学疗法--历经坎坷--展望未来。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-02-06 DOI: 10.1016/bs.apar.2024.01.001

Dennis Imhof, Kai Pascal Alexander Hänggeli, Maria Cristina Ferreira De Sousa, Anitha Vigneswaran, Larissa Hofmann, Yosra Amdouni, Ghalia Boubaker, Joachim Müller, Andrew Hemphill

{"title":"Working towards the development of vaccines and chemotherapeutics against neosporosis-With all of its ups and downs-Looking ahead.","authors":"Dennis Imhof, Kai Pascal Alexander Hänggeli, Maria Cristina Ferreira De Sousa, Anitha Vigneswaran, Larissa Hofmann, Yosra Amdouni, Ghalia Boubaker, Joachim Müller, Andrew Hemphill","doi":"10.1016/bs.apar.2024.01.001","DOIUrl":"10.1016/bs.apar.2024.01.001","url":null,"abstract":"Neospora caninum is an apicomplexan and obligatory intracellular parasite, which is the leading cause of reproductive failure in cattle and affects other farm and domestic animals, but also induces neuromuscular disease in dogs of all ages. In cattle, neosporosis is an important health problem, and has a considerable economic impact. To date there is no protective vaccine or chemotherapeutic treatment on the market. Immuno-prophylaxis has long been considered as the best control measure. Proteins involved in host cell interaction and invasion, as well as antigens mediating inflammatory responses have been the most frequently assessed vaccine targets. However, despite considerable efforts no effective vaccine has been introduced to the market to date. The development of effective compounds to limit the effects of vertical transmission of N. caninum tachyzoites has emerged as an alternative or addition to vaccination, provided suitable targets and safe and efficacious drugs can be identified. Additionally, the combination of both treatment strategies might be interesting to further increase protectivity against N. caninum infections and to decrease the duration of treatment and the risk of potential drug resistance. Well-established and standardized animal infection models are key factors for the evaluation of promising vaccine and compound candidates. The vast majority of experimental animal experiments concerning neosporosis have been performed in mice, although in recent years the numbers of experimental studies in cattle and sheep have increased. In this review, we discuss the recent findings concerning the progress in drug and vaccine development against N. caninum infections in mice and ruminants.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"124 ","pages":"91-154"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The proteasome as a drug target for treatment of parasitic diseases. 蛋白酶体作为治疗寄生虫病的药物靶点。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-09-23 DOI: 10.1016/bs.apar.2024.04.001

Lawrence J Liu, Anthony J O'Donoghue, Conor R Caffrey

引用次数: 0

Unveiling the peptidases of parasites from the office chair - The endothelin-converting enzyme case study. 从办公椅上揭开寄生虫肽酶的神秘面纱--内皮素转化酶案例研究。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-07-08 DOI: 10.1016/bs.apar.2024.05.003

Lukáš Konečný, Kristýna Peterková

{"title":"Unveiling the peptidases of parasites from the office chair - The endothelin-converting enzyme case study.","authors":"Lukáš Konečný, Kristýna Peterková","doi":"10.1016/bs.apar.2024.05.003","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.05.003","url":null,"abstract":"The emergence of high-throughput methodologies such as next-generation sequencing and proteomics has necessitated significant advancements in biological databases and bioinformatic tools, therefore reshaping the landscape of research into parasitic peptidases. In this review we outline the development of these resources along the -omics technologies and their transformative impact on the field. Apart from extensive summary of general and specific databases and tools, we provide a general pipeline on how to use these resources effectively to identify candidate peptidases from these large datasets and how to gain as much information about them as possible without leaving the office chair. This pipeline is then applied in an illustrative case study on the endothelin-converting enzyme 1 homologue from Schistosoma mansoni and attempts to highlight the contemporary capabilities of bioinformatics. The case study demonstrate how such approach can aid to hypothesize enzyme functions and interactions through computational analysis alone effectively and emphasizes how such virtual investigations can guide and optimize subsequent wet lab experiments therefore potentially saving precious time and resources. Finally, by showing what can be achieved without traditional wet laboratory methods, this review provides a compelling narrative on the use of bioinformatics to bridge the gap between big data and practical research applications, highlighting the key role of these technologies in furthering our understanding of parasitic diseases.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"126 ","pages":"1-52"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parasites in ancient Egypt and Nubia: Malaria, schistosomiasis and the pharaohs. 古埃及和努比亚的寄生虫：疟疾、血吸虫病和法老。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2023-12-28 DOI: 10.1016/bs.apar.2023.12.003

Piers D Mitchell

引用次数: 0

PfEMP1 and var genes - Still of key importance in Plasmodium falciparum malaria pathogenesis and immunity. PfEMP1 和 var 基因--仍然是恶性疟原虫疟疾发病机制和免疫中的关键基因。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-03-23 DOI: 10.1016/bs.apar.2024.02.001

Lars Hviid, Anja R Jensen, Kirk W Deitsch

引用次数: 0

Proteases and protease inhibitors in saliva of hard ticks: Biological role and pharmacological potential. 硬蜱唾液中的蛋白酶和蛋白酶抑制剂：生物学作用和药理学潜力

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-10-18 DOI: 10.1016/bs.apar.2024.09.001

Jiří Černý, Gunjan Arora

{"title":"Proteases and protease inhibitors in saliva of hard ticks: Biological role and pharmacological potential.","authors":"Jiří Černý, Gunjan Arora","doi":"10.1016/bs.apar.2024.09.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.09.001","url":null,"abstract":"Hard ticks (family Ixodidae) are significant vectors of pathogens affecting humans and animals. This review explores the composition of tick saliva, focusing on proteases and protease inhibitors, their biological roles, and their potential in vaccines and therapies. Tick saliva contains various proteases, mostly metalloproteases, serpins, cystatins, and Kunitz-type inhibitors, which modulate host hemostatic, immune, and wound healing responses to facilitate blood feeding and pathogen transmission. Proteases inhibit blood clotting, degrade extracellular matrix components, and modulate immune responses. Serpins, cystatins, and Kunitz-type inhibitors further inhibit key proteases involved in coagulation and inflammation, making them promising candidates for anticoagulant, anti-inflammatory, and immunomodulatory therapies. Several tick proteases and protease inhibitors have shown potential as vaccine targets, reducing tick feeding success and pathogen transmission. Future research should focus on comprehensive proteomic and genomic analyses, detailed structural and functional studies, and vaccine trials. Advanced omics approaches and bioinformatics tools will be crucial in uncovering the complex interactions between ticks, hosts, and pathogens, improving tick control strategies and public health outcomes.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"126 ","pages":"229-251"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fish ectoparasite detection, collection and curation. 鱼类体外寄生虫的检测、收集和整理。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-07-04 DOI: 10.1016/bs.apar.2024.05.001

Xian Zhe Chew, Jennifer Cobcroft, Kate S Hutson

{"title":"Fish ectoparasite detection, collection and curation.","authors":"Xian Zhe Chew, Jennifer Cobcroft, Kate S Hutson","doi":"10.1016/bs.apar.2024.05.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.05.001","url":null,"abstract":"Fish parasitology is a dynamic and internationally important discipline with numerous biological, ecological and practical applications. We reviewed optimal fish and parasite sampling methods for key ectoparasite phyla (i.e. Ciliophora, Platyhelminthes, Annelida and Arthropoda) as well as recent advances in molecular detection of ectoparasites in aquatic environments. Ideally, fish capture and anaesthesia as well as parasite recovery methods should be validated to eliminate potential sampling bias and inaccuracy in determining ectoparasite population parameters. There are considerable advantages to working with fresh samples and live parasites, when combined with appropriate fixation methods, as sampling using dead or decaying materials can lead to rapid decomposition of soft-bodied parasites and subsequent challenges for identification. Sampling methods differ between target phyla, and sometimes genera, with optimum techniques largely associated with identification of parasite microhabitat and the method of attachment. International advances in fish parasitology can be achieved through the accession of whole specimens and/or molecular voucher specimens (i.e. hologenophores) in curated collections for further study. This approach is now critical for data quality because of the increased application of environmental DNA (eDNA) for the detection and surveillance of parasites in aquatic environments where the whole organism may be unavailable. Optimal fish parasite sampling methods are emphasised to aid repeatability and reliability of parasitological studies that require accurate biodiversity and impact assessments, as well as precise surveillance and diagnostics.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"125 ","pages":"105-157"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0