Advances in Parasitology最新文献

{"title":"Sources and seroprevalence of toxocariasis in Turkey.","authors":"Aysegul Taylan-Ozkan","doi":"10.1016/bs.apar.2020.01.021","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.021","url":null,"abstract":"<p><p>Toxocariasis in humans is considered a rare disease in Turkey, and the absence of specific symptoms of this disease is probably the main reason for clinicians to underestimate and underdiagnose the disease. Although there are several seroepidemiological studies on visceral larva migrans in the country, a comparison between them is difficult as the serological tests are not standardised. After the introduction of the easily accessible ELISA kit in the market, the number of seroepidemiological studies has increased in which the reported rates ranged between 1% and 56%. Similar to other countries, Toxocara seropositivity in Turkey is more common in men, childhood, in those living in rural area, having a low income level, owning dogs, and biting their nails or practicing geophagia. In addition, toxocariasis is a risk factor for veterinarians, farmers, and pet-shop workers. Toxocara seroprevalence is significantly higher in respiratory, neuropsychiatric, musculoskeletal, skin and abdominal disorders. There are also many studies showing the importance of eosinophilia in toxocariasis. In conclusion, although there are many studies on toxocariasis in Turkey, it is still not well understood to what extent the infection is responsible for a plethora ascribed symptoms. Standardisation of the diagnostic methods and the use of molecular techniques could further throw light in the real epidemiology and the role played by the infection to induce signs and symptoms.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"465-482"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37911966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxocara seroprevalence in the USA and its impact for individuals and society.","authors":"Richard S Bradbury,&nbsp;Charlotte V Hobbs","doi":"10.1016/bs.apar.2020.01.035","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.035","url":null,"abstract":"<p><p>Toxocara species are intestinal helminths of dogs and cats, the larval stages of which may infect humans and cause severe neural, ocular and visceral larva migrans disease. Such cases of severe overt disease represent only a small fraction of the of the US population who have been exposed and infected with Toxocara, subsequently developing IgG antibodies to the larvae. The true impact of exposure to Toxocara in this large group of Americans remains uncertain. Toxocara antibody positivity is associated with poverty, but other specific risk factors have been identified, including sex, age, rural residence, region of residence, race and exposure to pets. This seropositive status has also been associated with several childhood diseases, including asthma and epilepsy, increased serum lead levels, and poor neurocognitive function. Three large-scale NHANES studies have provided comprehensive datasets, while several smaller studies have explored specific disease associations. Each seroprevalence study must be interpreted in consideration of the sensitivity and specificity of the individual serological methods employed. This chapter summarizes all historical Toxocara prevalence data from dogs, cats and soil in the United States. It then carefully examines all previous human Toxocara seroprevalence surveys performed in the United States. Data from these surveys is assimilated, compared and discussed to determine the validity of findings and to accurately identify risk factors for Toxocara seropositivity. The validity of associations of exposure to Toxocara larvae and childhood diseases such as asthma and epilepsy and effects neurocognitive function within the American context are also explored.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"317-339"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37913041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of Toxocara and the associated larva migrans.","authors":"Dwight D Bowman","doi":"10.1016/bs.apar.2020.01.037","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.037","url":null,"abstract":"<p><p>This review covers the systematics and nomenclature of the Ascaridoid genus toxocara, and more specifically the species Toxocara canis and Toxocara cati. Also discussed is the discovery of the persistence of these larvae in the tissues of paratenic hosts, and the role that other species of this genus might or could play in other such hosts; including those where the life cycle has been described, i.e., Toxocara vitulorum, Toxocara pteropodis, Toxocara mackerrasae, and Toxocara tanuki. Also examined is the work that led to the realization that the larval stage leaving the egg actually being a third rather than a second stage larva. Also discussed on the work showing that the larvae can persist in paratenic host with remarkable longevity without undergoing any morphological change for years and that these larvae can be transmitted from one paratenic host to another by ingestion. People are usually infected by the ingestion of eggs containing third-stage larvae, but infections also occur on occasions from the ingestion of uncooked paratenic hosts.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"17-38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37913133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributions to the lymphatic filariasis elimination programme and post-elimination surveillance in China by NIPD-CTDR.","authors":"De-Jian Sun,&nbsp;Yuan Fang,&nbsp;Yun Huang,&nbsp;Yi Zhang","doi":"10.1016/bs.apar.2020.04.007","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.04.007","url":null,"abstract":"<p><p>China was once one of the most heavily endemic for lymphatic filariasis (LF), with a heavy disease burden. Due to decades of sustained efforts, LF was eliminated from China in 2007. The historical tales in the control and elimination of LF in China and current post-elimination surveillance are reviewed and concluded. In the course of LF control and elimination, National Technical Steering Group for Filariasis Control and Research, and Collaborating Research Group on the Transmission Threshold of Filariasis, led by the National Institute of Parasitic Diseases, carried out researches, developed control measures, and applied in practical control and surveillance. The main of the results include: in theoretical study, (1) formulating the microfilaria rate below 1% as the transmission threshold of filariasis, (2) developing anti-filarial drugs and establishing animal model for drug screening, (3) studying the vectorial capacity of mosquitoes transmitted filariasis; in clinical diagnostic and therapy, (1) developing antigens for serological diagnostics, (2) studying different administration regimes for alleviating the side-response of diethylcarbamazine (DEC), (3) studying on the recurrence of acute adenolymphangitis and lymphadenitis of malayan filariasis, (4) observing lymphoedema of the lower extremity using lymphangiography; in practical control and surveillance, (1) establishing the control strategy taking elimination of infection source as the major focus, (2) formulating safe, feasible and effective DEC-mass drug administration, (3) revealing the transmission pattern of filariasis at the post-control phase, (4) establishing comprehensive active surveillance system, (5) formulating the criteria of basic elimination and elimination of filariasis. In the post-elimination surveillance phase, special monitoring and investigation in key areas were conducted for clearing way potential residual infection sources. Two schemes on LF surveillance in the post-elimination phase and caring for chronic filariasis patients were issued to maintain the diagnosis and treatment skills of filariasis all levels of disease control and prevention workers in future. Also, the Notifiable Diseases Reporting System, which included LF in 2004, plays an important role in LF post-elimination surveillance to prevent LF resurgence in China. The strategies and measures of LF control, elimination and post-elimination surveillance in China provide valuable practical experience and promote the progress of Global Programme of Elimination of Lymphatic Filariasis in worldwide.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":" ","pages":"145-183"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.04.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38065735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Toxocara spp. in dogs and cats in mainland China, 2000-2019.","authors":"Wen-Bin Zheng,&nbsp;Yang Zou,&nbsp;Guo-Hua Liu,&nbsp;Xing-Quan Zhu","doi":"10.1016/bs.apar.2020.01.031","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.031","url":null,"abstract":"<p><p>Toxocariasis is a neglected parasitic zoonosis. Although some studies have reported the Toxocara prevalence in dogs and cats in mainland China, there is a lack of comprehensive analysis of these data. Here, we conducted the first systematic review based on relevant literatures published in Web of Science, PubMed and CNKI from January 2000 to July 2019 to assess the prevalence of Toxocara infection in dogs and cats in mainland China. A total of 68 eligible papers were retrieved, including 24,490 dogs and 844 cats, with 17.34% (4246/24,490) Toxocara canis prevalence in dogs and 22.04% (186/844) Toxocara cati prevalence in cats by faecal floatation method. The prevalence and risk factors of T. canis and T. cati infection in different geographical regions, years, breeds, ages and genders were estimated in this review. This review indicates that there was high prevalence of Toxocara infection in dogs and cats in China. This finding calls for measures to reduce the potential risk of Toxocara infection and toxocariasis in humans and animals.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"843-860"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37911373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxocara canis in Australia.","authors":"David J Jenkins","doi":"10.1016/bs.apar.2020.01.033","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.033","url":null,"abstract":"<p><p>This review covers reports on prevalence Toxocara in dogs from 2000 to the present and views of the veterinary community as to the importance of it as a zoonosis within Australia. The contamination of soils in public areas with eggs of this parasite seems overall to be minimal for reasons related to required collection of faeces from pets and the use of routine deworming and combination dewormers associated with heartworm prevention. The potential of other canid hosts being sources of eggs is likely common, especially with the increasing red fox and wild dog populations in more urbanized environs. Human associated disease, e.g., visceral and ocular larva migrans, is reported very rarely in Australia.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"873-878"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37911794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sources of environmental contamination with Toxocara spp.: An omnipresent parasite.","authors":"Rolf Nijsse,&nbsp;Paul Overgaauw,&nbsp;Harm Ploeger,&nbsp;Lapo Mughini-Gras","doi":"10.1016/bs.apar.2020.01.010","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.010","url":null,"abstract":"<p><p>Embryonated Toxocara eggs in the environment are considered to be the most important source of human toxocariasis. These eggs, however, are also a source of infection for the definitive and paratenic hosts. Most available literature focuses on Toxocara canis in dogs, or other canids. There are, however, other Toxocara species with their accompanying definitive hosts. Results from studies that modelled patent infections in dogs, cats and foxes show that although dogs are a very important source for environmental contamination with Toxocara eggs, other sources cannot be ignored. For a good understanding of the relative contributions of different definitive hosts to environmental contamination with Toxocara eggs, computational models should be built and fed with data from different fields of expertise as is discussed in this paper.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"585-614"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37911898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive and neuropsychiatric effects of toxocariasis.","authors":"Shawn D Gale,&nbsp;Dawson W Hedges","doi":"10.1016/bs.apar.2020.01.009","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.009","url":null,"abstract":"<p><p>Caused by the neuroinvasive nematodes Toxocara canis and Toxocara cati, human toxocariasis has a worldwide distribution with seroprevalence in humans associated with low socioeconomic status and low educational attainment. Third-stage Toxocara larvae can invade human tissues, including the brain and spine, where they can result in encephalitis, meningitis, and inflammation. Toxocara infection in animal models has been associated with cognitive and behavioural changes. In humans, preliminary cross-sectional research suggests that Toxocara seropositivity is associated with worse cognitive function in children and adults. Additional preliminary cross-sectional findings suggest associations between Toxocara seropositivity and neuropsychiatric function, including schizophrenia and neurologic conditions such as epilepsy. Given the widespread distribution of human toxocariasis and early evidence suggesting that it can be associated with cognitive and neuropsychiatric function in humans, additional research regarding the effects of toxocariasis on the human brain is required.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"261-272"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37913137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxocariasis and the clinical spectrum.","authors":"H Auer,&nbsp;J Walochnik","doi":"10.1016/bs.apar.2020.01.005","DOIUrl":"https://doi.org/10.1016/bs.apar.2020.01.005","url":null,"abstract":"<p><p>Toxocara canis and T. cati are among the most widely distributed helminthic species in the world with a high zoonotic impact. Millions of people are infected^a and hundreds of thousands are suffering from toxocarosis, a disease encompassing four different entities: larva migrans visceralis (VLM) syndrome, ocular larva migrans (OLM) syndrome, covert toxocarosis (covT), common toxocarosis (comT) and neurotoxocarosis (NT). Toxocara infections in humans may remain clinically inapparent but may also induce severe diseases. This contribution gives a synoptic overview of the most important historical, clinical, diagnostic and therapeutical aspects of toxocarosis in humans.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"109 ","pages":"111-130"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2020.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37913196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microtubule organelles in Giardia.","authors":"Kari D Hagen,&nbsp;Shane G McInally,&nbsp;Nicholas D Hilton,&nbsp;Scott C Dawson","doi":"10.1016/bs.apar.2019.11.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2019.11.001","url":null,"abstract":"<p><p>Giardia lamblia is a widespread parasitic protist with a complex MT cytoskeleton that is critical for motility, attachment, mitosis and cell division, and transitions between its two life cycle stages-the infectious cyst and flagellated trophozoite. Giardia trophozoites have both highly dynamic and highly stable MT organelles, including the ventral disc, eight flagella, the median body and the funis. The ventral disc, an elaborate MT organelle, is essential for the parasite's attachment to the intestinal villi to avoid peristalsis. Giardia's four flagellar pairs enable swimming motility and may also promote attachment. They are maintained at different equilibrium lengths and are distinguished by their long cytoplasmic regions and novel extra-axonemal structures. The functions of the median body and funis, MT organelles unique to Giardia, remain less understood. In addition to conserved MT-associated proteins, the genome is enriched in ankyrins, NEKs, and novel hypothetical proteins that also associate with the MT cytoskeleton. High-resolution ultrastructural imaging and a current inventory of more than 300 proteins associated with Giardia's MT cytoskeleton lay the groundwork for future mechanistic analyses of parasite attachment to the host, motility, cell division, and encystation/excystation. Giardia's unique MT organelles exemplify the capacity of MT polymers to generate intricate structures that are diverse in both form and function. Thus, beyond its relevance to pathogenesis, the study of Giardia's MT cytoskeleton informs basic cytoskeletal biology and cellular evolution. With the availability of new molecular genetic tools to disrupt gene function, we anticipate a new era of cytoskeletal discovery in Giardia.</p>","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"107 ","pages":"25-96"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.apar.2019.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37697561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}