Advances in Parasitology最新文献

Endoparasites in large carnivores (Canidae, Felidae, Ursidae) in the Nearctic and Palearctic-an update with emphasis on the wildlife-domestic animal-human triangle. 新北极和古北大陆大型食肉动物（犬科、Felidae、Ursidae）体内的寄生虫——强调野生动物-家畜-人类三角关系的最新进展。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-06-10 DOI: 10.1016/bs.apar.2026.05.001

Andrea Springer, Alena Dusch, Christina Strube

{"title":"Endoparasites in large carnivores (Canidae, Felidae, Ursidae) in the Nearctic and Palearctic-an update with emphasis on the wildlife-domestic animal-human triangle.","authors":"Andrea Springer, Alena Dusch, Christina Strube","doi":"10.1016/bs.apar.2026.05.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2026.05.001","url":null,"abstract":"Carnivorous wild mammals often harbor a high diversity and high prevalence of parasites, many of which possess zoonotic potential or are of relevance for domestic animal health. In this Chapter, we summarize studies on endoparasites of the most common wild canids (red and arctic foxes, golden jackals, coyotes, grey wolves and raccoon dogs), felids (lynxes and European wildcats) and bears (brown and black bears) in the Palearctic and Nearctic regions since the turn of the millennium. Overall, the red fox stands out as the best-studied species, with the highest endoparasite diversity reported, and high detection rates of zoonotic parasites or parasites of significance to domestic animal health. The red fox synurbic lifestyle further underscores its relevance as a source of potential pathogen spillover. The epidemiological role of grey wolves, golden jackals, coyotes and raccoon dogs requires further investigation given their geographical expansion. Wild felids represent a potentially important reservoir for parasites that are pathogenic to domestic cats, while bears are reported to play a minor role for the circulation of zoonotic and domestic animal parasites. Identified knowledge gaps include a lack of studies from Asia and North America in comparison to Europe, and of studies on felids and bears as compared to canids.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"132 ","pages":"27-172"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the verge of zoonosis: Mechanisms and risks of parasite spillover. 濒临人畜共患病：寄生虫溢出的机制和风险。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-06-22 DOI: 10.1016/bs.apar.2026.06.001

Alicia Rojas, Alberto Solano-Barquero

{"title":"On the verge of zoonosis: Mechanisms and risks of parasite spillover.","authors":"Alicia Rojas, Alberto Solano-Barquero","doi":"10.1016/bs.apar.2026.06.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2026.06.001","url":null,"abstract":"Zoonotic parasite spillover is a multi-host process shaped by interactions among wildlife, domestic animals, vector or intermediate hosts, humans, and the environment. Transmission is governed by complex parasite life cycles involving intermediate and bridge hosts and environmental stages, all of which regulate development, persistence, and exposure. Spillover occurs when host-parasite compatibility, ecological overlap, and human behaviors converge to enable cross-species transmission. Anthropogenic changes, including deforestation, urbanization, agricultural intensification, pollution, and climate change, are increasing ecosystem permeability, altering host immunity, and intensifying contact among species, thereby elevating spillover risk. Establishment in humans depends on the ability of parasites to overcome molecular and physiological barriers and, in some cases, sustain onward transmission. Although many zoonotic parasites establish dead-end infections, they may still impose significant morbidity. This Chapter revisits key concepts, including reservoirs, intermediate and bridge hosts, and the processes of shedding, spillover, and spread, integrating ecological and evolutionary mechanisms such as host-switching and parasite adaptation. We further examine how environmental change reshapes transmission pathways and host interactions and discuss key examples of parasite zoonotic spillover. Finally, we propose a One Health framework that incorporates life cycles, environmental processes, and multi-host networks, offering a more realistic foundation to understand, anticipate, and prevent zoonotic parasite emergence in a rapidly changing world.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"132 ","pages":"173-205"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status of -omics research in platyhelminth parasites of teleost fish. 硬骨鱼扁形寄生虫组学研究现状。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-04-08 DOI: 10.1016/bs.apar.2026.03.002

Jemma Hudson, Maree Widdicombe, Paul A Ramsland, Neil D Young, Barbara F Nowak, Nathan J Bott

{"title":"Current status of -omics research in platyhelminth parasites of teleost fish.","authors":"Jemma Hudson, Maree Widdicombe, Paul A Ramsland, Neil D Young, Barbara F Nowak, Nathan J Bott","doi":"10.1016/bs.apar.2026.03.002","DOIUrl":"10.1016/bs.apar.2026.03.002","url":null,"abstract":"Parasitic platyhelminths (Trematoda, Monogenea, and Cestoda) are responsible for widespread disease in wild and cultured fish in both freshwater and marine environments globally, impacting both human health and the sustainability of aquaculture industries. Research into these parasites primarily aims to understand the impact of infections on host species, as well as developing management strategies to reduce or eliminate disease. -Omics-based research can assist in uncovering the biology of these parasites across a range of key areas, including understanding host-pathogen interactions, identifying novel drug and vaccine targets, and recognizing the overall diversity of parasite species. To date, the application of -omics technologies to piscivorous platyhelminths has been limited. This Chapter focuses on the current availability of -omics research in fish platyhelminths, with a primary focus on parasites with definitive fish hosts, and argues that the application of these technologies may provide unprecedented opportunities for the development of novel sustainable strategies for infection and disease management and control.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"131 ","pages":"1-29"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parasite-associated microbiomes: An unseen microenvironment. 与寄生虫相关的微生物群：一个看不见的微环境。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-04-25 DOI: 10.1016/bs.apar.2026.03.001

Peter McCann, Julianne Megaw, Geoffrey N Gobert

{"title":"Parasite-associated microbiomes: An unseen microenvironment.","authors":"Peter McCann, Julianne Megaw, Geoffrey N Gobert","doi":"10.1016/bs.apar.2026.03.001","DOIUrl":"10.1016/bs.apar.2026.03.001","url":null,"abstract":"Parasites harbor diverse microbial ecosystems that include not only bacteria but also archaea, fungi, viruses and microbial eukaryotes. These parasite-associated microbiomes, long overlooked, are now recognized as important determinants of parasite development, fitness, virulence and interactions with hosts across medical, veterinary, agricultural and ecological systems. However, current understanding of parasite-associated microbiomes remains fragmented, with most studies focusing on a narrow set of human parasites, relying heavily on bacterial surveys and rarely capturing the full multi-kingdom diversity of microbial partners. Important challenges include expanding research to encompass neglected parasite groups and their non-bacterial associates, establishing causal links between microbiome members and parasite phenotypes, and overcoming the technical barriers posed by low-biomass, host-contaminated and/or experimentally intractable systems. Progress will also depend on developing robust reference genomes and analytical tools that can resolve multi-kingdom communities and integrate parasite and symbiont biology. This chapter synthesizes current knowledge across helminths, protozoa, ectoparasites and plant-infecting parasites. We consider how microbiome manipulation may contribute to parasite control while recognizing the evolutionary and ecological complexities involved in altering host-parasite-microbiome interactions. Embracing an explicitly multi-kingdom, holobiont-focused perspective promises to illuminate fundamental aspects of parasitism. Such knowledge may contribute to new avenues for mitigating the impact of parasitic diseases on human and animal health, food security and ecosystems.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"131 ","pages":"31-70"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zoonotic babesiosis: A One Health menace. 人畜共患巴贝斯虫病：一种健康威胁。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-09-03 DOI: 10.1016/bs.apar.2026.07.001

Souti Prasad Sarkhel, Saroj Kumar, Anupam Brahma, Krishnendu Kundu

引用次数: 0

Targeting the malaria parasite inside the mosquito host. 以蚊子宿主体内的疟原虫为目标。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-06-22 DOI: 10.1016/bs.apar.2026.05.003

Sarah N Farrell, Geoffrey I McFadden, Christopher D Goodman

引用次数: 0

Sarcocystosis from a One Health perspective: Revisiting zoonotic potential, transmission dynamics, clinical features, and control strategies. 从同一个健康的角度看肉囊病：重新审视人畜共患的可能性、传播动力学、临床特征和控制策略。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-07-03 DOI: 10.1016/bs.apar.2026.06.003

Souti Prasad Sarkhel, Krishnendu Kundu, Tuhina Banerjee, Prasanta Kumar Koustasa Mishra, Saroj Kumar, Dipanwita Bhattacharya

{"title":"Sarcocystosis from a One Health perspective: Revisiting zoonotic potential, transmission dynamics, clinical features, and control strategies.","authors":"Souti Prasad Sarkhel, Krishnendu Kundu, Tuhina Banerjee, Prasanta Kumar Koustasa Mishra, Saroj Kumar, Dipanwita Bhattacharya","doi":"10.1016/bs.apar.2026.06.003","DOIUrl":"https://doi.org/10.1016/bs.apar.2026.06.003","url":null,"abstract":"Sarcocystosis is an emerging zoonotic disease caused by apicomplexan parasites of the genus Sarcocystis, which can infect a wide range of hosts, including humans, animals, reptiles, and birds. Humans may serve as either definitive or intermediate hosts, depending on Sarcocystis species. Consumption of undercooked beef containing mature sarcocysts of Sarcocystis hominis or Sarcocystis heydorni, or of raw or partially cooked pork containing Sarcocystis suihominis zoitocysts, may lead to intestinal sarcocystosis in humans. In contrast, muscular sarcocystosis follows ingestion of food or water contaminated with zoonotic Sarcocystis spp. sporocysts, as evidenced by infection outbreaks by Sarcocystis nesbitti among travelers returning from exotic destinations in Malaysia. Further, Sarcocystis fayeri, which cycles between horses and dogs, has been implicated in cases of food poisoning in humans following consumption of raw horse meat. Clinical features range from asymptomatic cases to acute symptoms, such as muscle pain, fever, and, in severe cases, neurological complications. Diagnosis relies on clinical presentation supported by microscopy, histopathology, serology, and advanced molecular techniques. Therapeutic options are limited; antiprotozoal agents including sulfadiazine, pyrimethamine, decoquinate, clindamycin, and triazine derivatives have shown high efficacies. Preventive measures focus on hygienic meat handling, thorough cooking, and restricting carrion scavenging by stray carnivores. Increasing human-wildlife interactions elevate the risk of cross-species transmission of novel Sarcocystis species. Adopting a One Health approach is fundamental for understanding the epidemiology and transmission dynamics of zoonotic sarcocystosis and reducing future outbreaks through effective diagnostics, therapeutics, and preventive interventions.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"133 ","pages":"61-109"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the cycle: Determinants and opportunities for sustainable control of cystic echinococcosis. 打破循环：囊性包虫病可持续控制的决定因素和机会。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-07-07 DOI: 10.1016/bs.apar.2026.06.004

Antonio Varcasia, Muhammad Furqan Arshad, Pamela Zeinoun, Claudia Tamponi, Antonio Scala

{"title":"Breaking the cycle: Determinants and opportunities for sustainable control of cystic echinococcosis.","authors":"Antonio Varcasia, Muhammad Furqan Arshad, Pamela Zeinoun, Claudia Tamponi, Antonio Scala","doi":"10.1016/bs.apar.2026.06.004","DOIUrl":"https://doi.org/10.1016/bs.apar.2026.06.004","url":null,"abstract":"Cystic echinococcosis (CE) remains one of the most persistent neglected zoonoses despite profound knowledge of the life cycle of Echinococcus granulosus sensu lato and the availability of well-established control tools. Persistence of CE is driven by interacting barriers, i.e., rapid reinfection of dogs, continued access of dogs to infected offal and carcasses, informal slaughter, suboptimal surveillance feedback, fragmented institutional responsibility, and misaligned economic incentives. These constraints are especially evident in sheep-farming and agro-pastoral systems, where dogs, livestock, household practices, and rural economies remain closely connected. Effective control requires a One Health approach that combines repeated praziquantel treatment of dogs, safe management of offal and carcasses, inspected slaughter, livestock surveillance, community engagement, and management of owned, semi-owned, and free-roaming dogs. This Chapter examines the underlying factors that challenge eradication of CE from many endemic settings. Particular attention is given to prevention, health education, and edutainment, since CE control primarily depends on achieving change in a small number of high-risk practices that are often normalized in daily pastoral life. Sardinia and comparable Mediterranean settings are used to illustrate how persistent sheep infection, fertile cysts, working-dog ecology, informal slaughter, incomplete dog prophylaxis, and governance gaps sustain endemic transmission even where the disease is well recognized. The Chapter argues that CE persistence reflects failures of continuity, traceability, and field delivery; durable control therefore depends on the organization of dog management, slaughter systems, surveillance, and community action as much as on parasitology.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"134 ","pages":"1-40"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redefining the Entamoeba landscape with next-generation sequencing: Implications for diagnosis and epidemiology. 用下一代测序重新定义内阿米巴原虫景观：对诊断和流行病学的影响。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-04-25 DOI: 10.1016/bs.apar.2026.03.003

Meriem Ali Zouaoui, Asma Guilane, Tahar Kernif, Christen Rune Stensvold, Amina Boutellis

{"title":"Redefining the Entamoeba landscape with next-generation sequencing: Implications for diagnosis and epidemiology.","authors":"Meriem Ali Zouaoui, Asma Guilane, Tahar Kernif, Christen Rune Stensvold, Amina Boutellis","doi":"10.1016/bs.apar.2026.03.003","DOIUrl":"10.1016/bs.apar.2026.03.003","url":null,"abstract":"Entamoeba is a genus of anaerobic protists that infect humans and a wide range of animal hosts worldwide, and that are also detected in environmental reservoirs. Of particular importance is Entamoeba histolytica, the causative agent of amoebiasis, which accounts for more than 55,000 deaths each year and remains a major public health concern. Given this substantial burden, and the fact that pathogenic and non-pathogenic species of Entamoeba cannot be distinguished based on morphology alone, molecular approaches have become essential for accurate diagnosis, taxonomy, and epidemiological surveillance. In this Chapter, we systematically review the impact of DNA sequencing technologies on Entamoeba research from 1987 to 2025. A bibliographic search was conducted using PubMed and Google Scholar, combining the names of all recognized Entamoeba species with keywords related to sequencing technologies, spanning from first- to fourth-generation platforms. Original research articles employing DNA sequencing for molecular identification, phylogenetic analyses, and genomic investigations were included. The literature illustrates a clear transition from morphology-based classification to Sanger sequencing of the small subunit of the ribosomal RNA (SSU rRNA) gene, which established the molecular taxonomic framework of the genus and enabled the recognition of numerous new species and ribosomal lineages. The expansion of diversity revealed by high-throughput sequencing is also addressed, together with the contribution of long-read technologies to resolving highly AT-rich and repetitive genomes. Despite these advances, challenges remain in species delineation and marker-associated biases, highlighting the ongoing need for integrative genomic approaches in Entamoeba research.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"131 ","pages":"71-119"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Equine cyathostomins-Hidden histories. 马的cyatherstomin——隐藏的历史。

3区医学

Advances in Parasitology Pub Date : 2026-01-01 Epub Date: 2026-06-26 DOI: 10.1016/bs.apar.2026.06.002

Grace Mulcahy, Orla Byrne, Nicola Walshe

引用次数: 0