Advances in Parasitology最新文献

An update and review of arthropod vector sensory systems: Potential targets for behavioural manipulation by parasites and other disease agents. 节肢动物媒介感觉系统的更新与回顾：寄生虫和其他病原体操纵行为的潜在目标。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-03-12 DOI: 10.1016/bs.apar.2024.02.003

Jean-François Doherty, Tahnee Ames, Leisl Imani Brewster, Jonathan Chiang, Elsa Cyr, Cameron R Kelsey, Jeehan Phillip Lee, Bingzong Liu, Ivan Hok Yin Lo, Gurleen K Nirwal, Yunusa Garba Mohammed, Orna Phelan, Parsa Seyfourian, Danica Marie Shannon, Nicholas Kristoff Tochor, Benjamin John Matthews

{"title":"An update and review of arthropod vector sensory systems: Potential targets for behavioural manipulation by parasites and other disease agents.","authors":"Jean-François Doherty, Tahnee Ames, Leisl Imani Brewster, Jonathan Chiang, Elsa Cyr, Cameron R Kelsey, Jeehan Phillip Lee, Bingzong Liu, Ivan Hok Yin Lo, Gurleen K Nirwal, Yunusa Garba Mohammed, Orna Phelan, Parsa Seyfourian, Danica Marie Shannon, Nicholas Kristoff Tochor, Benjamin John Matthews","doi":"10.1016/bs.apar.2024.02.003","DOIUrl":"10.1016/bs.apar.2024.02.003","url":null,"abstract":"For over a century, vector ecology has been a mainstay of vector-borne disease control. Much of this research has focused on the sensory ecology of blood-feeding arthropods (black flies, mosquitoes, ticks, etc.) with terrestrial vertebrate hosts. Of particular interest are the cues and sensory systems that drive host seeking and host feeding behaviours as they are critical for a vector to locate and feed from a host. An important yet overlooked component of arthropod vector ecology are the phenotypic changes observed in infected vectors that increase disease transmission. While our fundamental understanding of sensory mechanisms in disease vectors has drastically increased due to recent advances in genome engineering, for example, the advent of CRISPR-Cas9, and high-throughput \"big data\" approaches (genomics, proteomics, transcriptomics, etc.), we still do not know if and how parasites manipulate vector behaviour. Here, we review the latest research on arthropod vector sensory systems and propose key mechanisms that disease agents may alter to increase transmission.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"124 ","pages":"57-89"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids. 绕过蛔虫：确定蛔虫的知识差距和研究重点。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-02-20 DOI: 10.1016/bs.apar.2023.12.002

Adrian J Wolstenholme, Erik C Andersen, Shivani Choudhary, Friederike Ebner, Susanne Hartmann, Lindy Holden-Dye, Sudhanva S Kashyap, Jürgen Krücken, Richard J Martin, Ankur Midha, Peter Nejsum, Cedric Neveu, Alan P Robertson, Georg von Samson-Himmelstjerna, Robert Walker, Jianbin Wang, Bradley J Whitehead, Paul D E Williams

{"title":"Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.","authors":"Adrian J Wolstenholme, Erik C Andersen, Shivani Choudhary, Friederike Ebner, Susanne Hartmann, Lindy Holden-Dye, Sudhanva S Kashyap, Jürgen Krücken, Richard J Martin, Ankur Midha, Peter Nejsum, Cedric Neveu, Alan P Robertson, Georg von Samson-Himmelstjerna, Robert Walker, Jianbin Wang, Bradley J Whitehead, Paul D E Williams","doi":"10.1016/bs.apar.2023.12.002","DOIUrl":"10.1016/bs.apar.2023.12.002","url":null,"abstract":"The ascarids are a large group of parasitic nematodes that infect a wide range of animal species. In humans, they cause neglected diseases of poverty; many animal parasites also cause zoonotic infections in people. Control measures include hygiene and anthelmintic treatments, but they are not always appropriate or effective and this creates a continuing need to search for better ways to reduce the human, welfare and economic costs of these infections. To this end, Le Studium Institute of Advanced Studies organized a two-day conference to identify major gaps in our understanding of ascarid parasites with a view to setting research priorities that would allow for improved control. The participants identified several key areas for future focus, comprising of advances in genomic analysis and the use of model organisms, especially Caenorhabditis elegans, a more thorough appreciation of the complexity of host-parasite (and parasite-parasite) communications, a search for novel anthelmintic drugs and the development of effective vaccines. The participants agreed to try and maintain informal links in the future that could form the basis for collaborative projects, and to co-operate to organize future meetings and workshops to promote ascarid research.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"123 ","pages":"51-123"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11143470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in protease inhibition-based chemotherapy: A decade of insights from Malaria research. 基于蛋白酶抑制剂的化疗进展：疟疾研究的十年启示。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-08-30 DOI: 10.1016/bs.apar.2024.07.001

Daniel Sojka, Pavla Šnebergerová

{"title":"Advances in protease inhibition-based chemotherapy: A decade of insights from Malaria research.","authors":"Daniel Sojka, Pavla Šnebergerová","doi":"10.1016/bs.apar.2024.07.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.07.001","url":null,"abstract":"Over the last decade, research on the most studied parasite, Plasmodium falciparum, has disclosed significant findings in protease research. Detailed descriptions of the individual roles of protease isoenzymes from various protease classes encoded by the parasite genome have been elucidated, along with their functional and biochemical characterizations. These insights have enabled the development of innovative chemotherapy using low molecular weight inhibitors targeting specific molecular sites. Progress has been made in understanding the proteolytic cascade associated with the apical complex, particularly the roles of aspartyl proteases plasmepsins IX and X as master regulators. Additionally, advancements in direct and alternative methods of proteasome inhibition and expression regulation have been achieved. Research on digestive/food vacuole-associated proteases, with a focus on essential metalloproteases, has also seen significant developments. The rise of extensive genomic datasets and functional genomic tools for other parasitic organisms now allows these approaches to be applied to the study and treatment of other, less known parasitic diseases, aiming to uncover specific biological mechanisms and develop innovative, less toxic chemotherapies.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"126 ","pages":"205-227"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astacin metalloproteases in human-parasitic nematodes. 人类寄生线虫中的天星素金属蛋白酶

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-04-14 DOI: 10.1016/bs.apar.2024.03.001

Matthew S Moser, Elissa A Hallem

{"title":"Astacin metalloproteases in human-parasitic nematodes.","authors":"Matthew S Moser, Elissa A Hallem","doi":"10.1016/bs.apar.2024.03.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.03.001","url":null,"abstract":"Parasitic nematodes infect over 2 billion individuals worldwide, primarily in low-resource areas, and are responsible for several chronic and potentially deadly diseases. Throughout their life cycle, these parasites are thought to use astacin metalloproteases, a subfamily of zinc-containing metalloendopeptidases, for processes such as skin penetration, molting, and tissue migration. Here, we review the known functions of astacins in human-infective, soil-transmitted parasitic nematodes - including the hookworms Necator americanus and Ancylostoma duodenale, the threadworm Strongyloides stercoralis, the giant roundworm Ascaris lumbricoides, and the whipworm Trichuris trichiura - as well as the human-infective, vector-borne filarial nematodes Wuchereria bancrofti, Onchocerca volvulus, and Brugia malayi. We also review astacin function in parasitic nematodes that infect other mammalian hosts and discuss the potential of astacins as anthelmintic drug targets. Finally, we highlight the molecular and genetic tools that are now available for further exploration of astacin function and discuss how a better understanding of astacin function in human-parasitic nematodes could lead to new avenues for nematode control and drug therapies.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"126 ","pages":"177-204"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasmodium proteases and their role in development of Malaria vaccines. 疟原虫蛋白酶及其在开发疟疾疫苗中的作用。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-09-25 DOI: 10.1016/bs.apar.2024.08.001

Gunjan Arora, Jiří Černý

引用次数: 0

Immunology and pathology of echinostomes and other intestinal trematodes. 棘尾虫和其他肠道吸虫的免疫学和病理学。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-03-08 DOI: 10.1016/bs.apar.2024.02.002

Rafael Toledo, Paola Cociancic, Emma Fiallos, J Guillermo Esteban, Carla Muñoz-Antoli

{"title":"Immunology and pathology of echinostomes and other intestinal trematodes.","authors":"Rafael Toledo, Paola Cociancic, Emma Fiallos, J Guillermo Esteban, Carla Muñoz-Antoli","doi":"10.1016/bs.apar.2024.02.002","DOIUrl":"10.1016/bs.apar.2024.02.002","url":null,"abstract":"Intestinal trematodes constitute a major group of helminths that parasitize humans and animals with relevant morbidity and mortality. Despite the importance of the intestinal trematodes in medical and veterinary sciences, immunology and pathology of these helminth infections have been neglected for years. Apart from the work focused on the members of the family Echnistomatidae, there are only very isolated and sporadic studies on the representatives of other families of digeneans, which makes a compilation of all these studies necessary. In the present review, the most salient literature on the immunology and pathology of intestinal trematodes in their definitive hosts in examined. Emphasis will be placed on members of the echinostomatidae family, since it is the group in which the most work has been carried out. However, we also review the information on selected species of the families Brachylaimidae, Diplostomidae, Gymnophallidae, and Heterophyidae. For most of these families, coverage is considered under the following headings: (i) Background; (ii) Pathology of the infection; (iii) Immunology of the infection; and (iv) Human infections.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"124 ","pages":"1-55"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New directions for malaria vector control using geography and geospatial analysis. 利用地理和地理空间分析控制疟疾病媒的新方向。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-06-26 DOI: 10.1016/bs.apar.2024.06.001

Andy Hardy

{"title":"New directions for malaria vector control using geography and geospatial analysis.","authors":"Andy Hardy","doi":"10.1016/bs.apar.2024.06.001","DOIUrl":"https://doi.org/10.1016/bs.apar.2024.06.001","url":null,"abstract":"As we strive towards the ambitious goal of malaria elimination, we must embrace integrated strategies and interventions. Like many diseases, malaria is heterogeneously distributed. This inherent spatial component means that geography and geospatial data is likely to have an important role in malaria control strategies. For instance, focussing interventions in areas where malaria risk is highest is likely to provide more cost-effective malaria control programmes. Equally, many malaria vector control strategies, particularly interventions like larval source management, would benefit from accurate maps of malaria vector habitats - sources of water that are used for malarial mosquito oviposition and larval development. In many landscapes, particularly in rural areas, the formation and persistence of these habitats is controlled by geographical factors, notably those related to hydrology. This is especially true for malaria vector species like Anopheles funestsus that show a preference for more permanent, often naturally occurring water sources like small rivers and spring-fed ponds. Previous work has embraced geographical concepts, techniques, and geospatial data for studying malaria risk and vector habitats. But there is much to be learnt if we are to fully exploit what the broader geographical discipline can offer in terms of operational malaria control, particularly in the face of a changing climate. This chapter outlines potential new directions related to several geographical concepts, data sources and analytical approaches, including terrain analysis, satellite imagery, drone technology and field-based observations. These directions are discussed within the context of designing new protocols and procedures that could be readily deployed within malaria control programmes, particularly those within sub-Saharan Africa, with a particular focus on experiences in the Kilombero Valley and the Zanzibar Archipelago, United Republic of Tanzania.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"125 ","pages":"1-52"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of health education activities targeting schoolchildren for the control of soil-transmitted helminthiasis in Southeast Asia, with emphasis upon the Magic Glasses approach. 东南亚针对在校学生开展的控制土壤传播蠕虫病的健康教育活动回顾，重点是 "魔法眼镜 "方法。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-02-18 DOI: 10.1016/bs.apar.2023.12.001

Mary Lorraine S Mationg, Gail M Williams, Veronica L Tallo, Remigio M Olveda, Donald P McManus, Donald E Stewart, Darren J Gray

{"title":"A review of health education activities targeting schoolchildren for the control of soil-transmitted helminthiasis in Southeast Asia, with emphasis upon the Magic Glasses approach.","authors":"Mary Lorraine S Mationg, Gail M Williams, Veronica L Tallo, Remigio M Olveda, Donald P McManus, Donald E Stewart, Darren J Gray","doi":"10.1016/bs.apar.2023.12.001","DOIUrl":"10.1016/bs.apar.2023.12.001","url":null,"abstract":"Soil-transmitted helminths continue to be a serious problem causing disease and morbidity globally. Children, mostly school-aged, are more at risk of these infections. The main strategy for control remains to be the mass drug administration (MDA) of antihelminthic drugs. With the limitation of MDA to prevent re-infection, the need for additional approaches such as hygiene education and improvements in water, sanitation and hygiene (WASH) infrastructure are required. Although the importance of health education as a crucial component of an integrated approaches to STH control is highlighted, this component has often been disregarded because the other more complex solutions have been the focus of most studies and programmes. We performed literature searches from four bibliographic databases - Scopus, PubMed, Web of Science and Cochrane Library - to determine availability of studies on the impact of health education interventions targeting STH infections on schoolchildren in Southeast Asia. Our review found only three studies that evaluated health education interventions targeting children. The current lack of evidence in this area suggests the need for more studies assessing the impact of health education intervention for STH control. A successful health education programme for STH called \"The Magic Glasses\" has been developed targeting schoolchildren in China and the Philippines. This public health intervention displayed significant impact in terms of improving knowledge, attitude and practices, reducing prevalence of STH infections in schoolchildren and encouraging compliance to MDA. This article details the successes and benefits of the Magic Glasses programme as a promising control tool for STH in the Southeast Asian region.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"123 ","pages":"1-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on proteases and protease inhibitors from trematodes. 来自吸虫的蛋白酶和蛋白酶抑制剂的最新情况。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-09-20 DOI: 10.1016/bs.apar.2024.07.002

Martin Horn, Lucia Bieliková, Andrea Vostoupalová, Jakub Švéda, Michael Mareš

引用次数: 0

Working towards the development of vaccines and chemotherapeutics against neosporosis-With all of its ups and downs-Looking ahead. 努力开发针对新孢子虫病的疫苗和化学疗法--历经坎坷--展望未来。

3区医学

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-02-06 DOI: 10.1016/bs.apar.2024.01.001

Dennis Imhof, Kai Pascal Alexander Hänggeli, Maria Cristina Ferreira De Sousa, Anitha Vigneswaran, Larissa Hofmann, Yosra Amdouni, Ghalia Boubaker, Joachim Müller, Andrew Hemphill

{"title":"Working towards the development of vaccines and chemotherapeutics against neosporosis-With all of its ups and downs-Looking ahead.","authors":"Dennis Imhof, Kai Pascal Alexander Hänggeli, Maria Cristina Ferreira De Sousa, Anitha Vigneswaran, Larissa Hofmann, Yosra Amdouni, Ghalia Boubaker, Joachim Müller, Andrew Hemphill","doi":"10.1016/bs.apar.2024.01.001","DOIUrl":"10.1016/bs.apar.2024.01.001","url":null,"abstract":"Neospora caninum is an apicomplexan and obligatory intracellular parasite, which is the leading cause of reproductive failure in cattle and affects other farm and domestic animals, but also induces neuromuscular disease in dogs of all ages. In cattle, neosporosis is an important health problem, and has a considerable economic impact. To date there is no protective vaccine or chemotherapeutic treatment on the market. Immuno-prophylaxis has long been considered as the best control measure. Proteins involved in host cell interaction and invasion, as well as antigens mediating inflammatory responses have been the most frequently assessed vaccine targets. However, despite considerable efforts no effective vaccine has been introduced to the market to date. The development of effective compounds to limit the effects of vertical transmission of N. caninum tachyzoites has emerged as an alternative or addition to vaccination, provided suitable targets and safe and efficacious drugs can be identified. Additionally, the combination of both treatment strategies might be interesting to further increase protectivity against N. caninum infections and to decrease the duration of treatment and the risk of potential drug resistance. Well-established and standardized animal infection models are key factors for the evaluation of promising vaccine and compound candidates. The vast majority of experimental animal experiments concerning neosporosis have been performed in mice, although in recent years the numbers of experimental studies in cattle and sheep have increased. In this review, we discuss the recent findings concerning the progress in drug and vaccine development against N. caninum infections in mice and ruminants.","PeriodicalId":50854,"journal":{"name":"Advances in Parasitology","volume":"124 ","pages":"91-154"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0