来自吸虫的蛋白酶和蛋白酶抑制剂的最新情况。

3区医学 Q1 Immunology and Microbiology

Advances in Parasitology Pub Date : 2024-01-01 Epub Date: 2024-09-20 DOI:10.1016/bs.apar.2024.07.002

Martin Horn, Lucia Bieliková, Andrea Vostoupalová, Jakub Švéda, Michael Mareš

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引用次数: 0

摘要

吸虫是一类寄生性扁虫，是人类和动物多种毁灭性疾病的罪魁祸首，血吸虫病和筋膜炎就是突出的例子。参与宿主-寄生虫相互作用的吸虫蛋白水解系统已成为吸虫成功建立和维持感染的关键因素。这篇综述集中介绍了吸虫所使用的各种蛋白酶和蛋白酶抑制剂，并提供了有关其分子水平表征的最新进展，重点是功能、结构和治疗靶点的潜力。

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An update on proteases and protease inhibitors from trematodes.

Trematodes, a class of parasitic flatworms, are responsible for a variety of devastating diseases in humans and animals, with schistosomiasis and fascioliasis being prominent examples. Trematode proteolytic systems involved in the host-parasite interaction have emerged as key contributors to the success of trematodes in establishing and maintaining infections. This review concentrates on diverse proteases and protease inhibitors employed by trematodes and provides an update on recent advances in their molecular-level characterization, with a focus on function, structure, and therapeutic target potential.

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来源期刊

Advances in Parasitology 医学-寄生虫学

CiteScore

9.00

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Advances in Parasitology is recognised as a leading review serial which is consistently well placed in terms of impact factor and citations. Major reviews on all aspects of medical, veterinary and wild-life parasitology are considered. The journal provides an outlet for authoritative reviews from experts in the field. While emphasis is given to modern molecular approaches contributions across all disciplines are encouraged including traditional areas such as ecology and taxonomy. Eclectic volumes are supplemented by thematic volumes dedicated to a particular topic of recognised interest and importance.