Mesut Demir, I. Batmaz, M. Sarıyıldız, Aysun Ekinci, Z. A. Akar, Oznur Batmaz, Mehmet Karakoç
{"title":"Association between Serum Follistatin-Like Protein 1 Levels and Disease Activity in Behçet’s Disease","authors":"Mesut Demir, I. Batmaz, M. Sarıyıldız, Aysun Ekinci, Z. A. Akar, Oznur Batmaz, Mehmet Karakoç","doi":"10.1055/a-2201-6125","DOIUrl":"https://doi.org/10.1055/a-2201-6125","url":null,"abstract":"Abstract Introduction This study sought to determine the serum levels of follistatin-like protein 1 (FSTL-1), a glycoprotein of mesenchymal origin shown to be involved in the pathogenesis of many inflammatory diseases, for example Behçet’s disease (BD), and to investigate its association with disease activity. Material and Methods The study included 45 patients followed for newly diagnosed Behçet’s disease who met the 1990 International Study Group criteria for BD and a control group of 36 healthy volunteers who were age- and gender-matched. Peripheral blood samples were collected from the patients and control groups. Serum FSTL-1 levels were measured using an enzyme-linked immunosorbent assay. The disease activity was assessed using the Behçet’s Disease Current Activity Form (BDCAF). Results A comparison of serum FSTL-1 levels in the patient and control groups found significantly higher levels of FSTL-1 in the patient group. Serum FSTL-1 levels were significantly higher in female patients compared with male patients. Female patients exhibited significantly higher BDCAF scores compared with male patients (p=0.008). Erythrocyte sedimentation rate and serum FSTL-1 levels were positively correlated. Conclusion Serum FSTL-1 levels may play a role in the aetiopathogenesis of BD and can also be a useful biomarker for determining disease activity.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":" 5","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Solitary Bone Plasmacytoma Mimicking Oral Cavity Neoplasm - A Rare Case.","authors":"Vikrant Kamboj, Vijendra Shenoy S, Susmita Sriperumbudur, Navya Parvathareddy","doi":"10.1007/s12070-023-03875-2","DOIUrl":"10.1007/s12070-023-03875-2","url":null,"abstract":"<p><p>Plasmacytomas are localized monoclonal plasma cell lesions with no evidence of systemic involvement which are divided into solitary bone plasmacytoma (SBP) and extra-medullary plasmacytoma (EMP). The diagnosis of plasmacytomas (PCM) in the oral regions is challenging given the atypical clinical manifestations and low frequency. Here, we report an extremely rare case of plasmacytoma in an elderly male which initially appeared to be arising from the left buccal mucosa on clinical examination but after radiological imaging and intra-operative findings, the epicentre was found to be in the left infratemporal fossa (ITF). The patient underwent en-bloc compartment resection with high clearance of the ITF which proved to be an effective management strategy. It is crucial for the head and neck surgeon to be aware of the solitary bone plasmacytoma in the oral and maxillofacial region in order to identify it early and provide these patients with the best care possible before complications arise.</p>","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"27 1","pages":"2809-2813"},"PeriodicalIF":0.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10645874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75805424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Riesenzellarteriitis: Erweiterte Sonografie detektiert Beteiligung großer Gefäße","authors":"","doi":"10.1055/a-2119-1995","DOIUrl":"https://doi.org/10.1055/a-2119-1995","url":null,"abstract":"Die Ultraschalldiagnostik bei Riesenzellarteriitis schließt üblicherweise die Temporal- und die distalen Axillararterien ein. Wie häufig entgeht dieser Untersuchungstechnik eine Beteiligung weiterer großer Gefäße? Und wie häufig kann diese mithilfe einer erweiterten anteromedialen Ultraschalluntersuchung detektiert werden? Diesen und weiteren Fragen ging ein norwegisches Forscherteam im Rahmen einer Querschnittstudie nach.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"565 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139224620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Systemischer Lupus erythematodes: Azathioprin schützt vor kognitiven Defiziten","authors":"","doi":"10.1055/a-2119-1963","DOIUrl":"https://doi.org/10.1055/a-2119-1963","url":null,"abstract":"Etwa 40% der Menschen mit einem systemischen Lupus erythematodes (SLE) leiden an kognitiven Störungen. Diese beeinträchtigen die Lebensqualität und verschlechtern die Prognose. Wirksame Therapien existieren nicht. Es wird vermutet, dass aktivierte ZNS-eigene Immunzellen, die Mikroglia, bei der Pathogenese der kognitiven Defizite eine Rolle spielen. Daher stellt sich die Frage, ob möglicherweise Immunsuppressiva vor dieser SLE-Komplikation schützen.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139220244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Einer von 5 JIA-Patienten setzt Biologika-Therapie ab","authors":"","doi":"10.1055/a-2117-6325","DOIUrl":"https://doi.org/10.1055/a-2117-6325","url":null,"abstract":"Biologika werden bei Patienten mit juveniler idiopathischer Arthritis (JIA) eingesetzt, wenn konventionelle synthetische DMARDs oder steroidale und nicht-steroidale Antirheumatika nicht wirksam sind oder Nebenwirkungen verursachen. Biologika können bei Bedenken bzgl. der Sicherheit abgesetzt werden, sobald eine Remission erreicht ist. Kearsley-Fleet et al. evaluierten Faktoren, die den Gebrauch von Biologika in einer JIA-Population charakterisieren.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"61 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139219946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Die Rolle von Pneumocystis jirovecii Infektionen bei Rheuma-Patienten","authors":"Daniel Vagedes","doi":"10.1055/a-2202-5239","DOIUrl":"https://doi.org/10.1055/a-2202-5239","url":null,"abstract":"Zusammenfassung Bei immunsuppremierten Patienten, Patienten mit einer fortgeschrittenen HIV-Infektion, onkologische Patienten mit und ohne Therapie sowie Patienten mit rheumatologischen Grunderkrankungen kann es zu Infektionen mit Pneumocystis jirovecii kommen. In diesem Artikel wird die in veröffentlichen Analysen / Registerdaten beschriebene Häufigkeit bei Patienten mit verschiedenen rheumatologischen Grunderkrankungen, an einer Pneumocystis jirovecii Infektion zu erkranken und eine Pneumonie zu entwickeln, untersucht. Ferner wird die Frage nach auslösenden antirheumatischen Therapien sowie nach der Notwendigkeit der Gabe einer Prophylaxe gestellt. Insgesamt ist jedoch das Risiko, an einer Infektion mit Pneumocystis jirovecii zu erkranken, für Patienten mit rheumatologischen Grunderkrankungen gering.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139224461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"COBRA-light bei rheumatoider Arthritis: Bei Nichtansprechen Therapieeskalation","authors":"","doi":"10.1055/a-2117-6233","DOIUrl":"https://doi.org/10.1055/a-2117-6233","url":null,"abstract":"Das bei der rheumatischen Arthritis (RA) eingesetzte sogenannte COBRA-light-Therapieregime umfasst die Kombination aus Methotrexat und Prednisolon. Allerdings sprechen nicht alle Patientinnen und Patienten mit einem frühen RA-Stadium gleich gut auf diese Behandlung an. Ob eine Therapieintensivierung nach 13 Wochen im Sinne des Treat-to-Target-Konzepts häufiger zum Therapieerfolg führt, untersuchte nun ein niederländisches Forscherteam.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139216927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Schwer behandelbare rheumatoide Arthritis zeichnet sich schon früh ab","authors":"","doi":"10.1055/a-2119-1979","DOIUrl":"https://doi.org/10.1055/a-2119-1979","url":null,"abstract":"Schätzungen zu Folge leiden zwischen 6 und 17% der Menschen mit einer rheumatischen Arthritis (RA) an einer schwer zu behandelnden Erkrankungsform (engl. difficult-to-treat RA; D2T-RA). Sie sprechen nicht auf multiple DMARDs (Disease-Modifying Antirheumatic Drugs) an und leiden anhaltend an einer starken Krankheitsaktivität. Liegen die Ursachen für diese Problematik möglicherweise in einem ungünstigen initialen Management der Erkrankung?","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"76 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139216944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gonarthrose: Wie wirken nicht chirurgische Therapiestrategien?","authors":"","doi":"10.1055/a-2088-1126","DOIUrl":"https://doi.org/10.1055/a-2088-1126","url":null,"abstract":"Eine operative Arthrosetherapie soll erst nach Ausschöpfen der nicht chirurgischen Behandlungsoptionen erfolgen. Nicht alle Betroffene sprechen jedoch gleichermaßen auf konservative Therapien an. Das liegt möglicherweise daran, dass intermediäre Faktoren, welche das Behandlungsergebnis beeinflussen, nicht berücksichtigt werden. Ein Forscherteam aus Australien beschäftigte sich mit dieser Thematik im Rahmen einer Auswertung von Mediationsanalysen.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"24 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139215195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rheumatoide Arthritis: Alkohol mindert Krankheitsaktivität","authors":"","doi":"10.1055/a-2117-6166","DOIUrl":"https://doi.org/10.1055/a-2117-6166","url":null,"abstract":"Untersuchungen deuten darauf hin, dass Alkoholkonsum bei rheumatoider Arthritis (RA) mit einer schwächeren Krankheitsaktivität korreliert. Unklar ist jedoch, ob dieser Zusammenhang auf umgekehrter Kausalität basiert: Möglicherweise schränken Personen mit hoher Krankheitsaktivität ihren Alkoholkonsum deutlicher ein als weniger stark Erkrankte. Ein schwedisches Forscherteam untersuchte nun diese Thematik mithilfe einer Bevölkerungsstudie.","PeriodicalId":50831,"journal":{"name":"Aktuelle Rheumatologie","volume":"46 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139216089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}