贝赫切特病血清纤溶蛋白样蛋白 1 水平与疾病活动性之间的关系

IF 0.2 4区 医学 Q4 RHEUMATOLOGY
Mesut Demir, I. Batmaz, M. Sarıyıldız, Aysun Ekinci, Z. A. Akar, Oznur Batmaz, Mehmet Karakoç
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引用次数: 0

摘要

摘要 引言 本研究旨在测定间充质来源的一种糖蛋白--follistatin-like protein 1(FSTL-1)的血清水平,这种糖蛋白被证明参与了许多炎症性疾病的发病机制,例如白塞氏病(BD),并研究其与疾病活动的关系。材料与方法 该研究包括 45 名符合 1990 年国际研究小组 BD 标准的新诊断贝赫切特病患者和 36 名年龄和性别匹配的健康志愿者对照组。采集了患者和对照组的外周血样本。使用酶联免疫吸附测定法检测血清 FSTL-1 水平。使用贝赫切特病活动度表(BDCAF)评估疾病活动度。结果 对患者组和对照组的血清 FSTL-1 水平进行比较后发现,患者组的 FSTL-1 水平明显更高。女性患者的血清 FSTL-1 水平明显高于男性患者。女性患者的 BDCAF 评分明显高于男性患者(P=0.008)。红细胞沉降率与血清 FSTL-1 水平呈正相关。结论 血清FSTL-1水平可能在BD的发病机制中发挥作用,也可作为确定疾病活动性的有用生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between Serum Follistatin-Like Protein 1 Levels and Disease Activity in Behçet’s Disease
Abstract Introduction This study sought to determine the serum levels of follistatin-like protein 1 (FSTL-1), a glycoprotein of mesenchymal origin shown to be involved in the pathogenesis of many inflammatory diseases, for example Behçet’s disease (BD), and to investigate its association with disease activity. Material and Methods The study included 45 patients followed for newly diagnosed Behçet’s disease who met the 1990 International Study Group criteria for BD and a control group of 36 healthy volunteers who were age- and gender-matched. Peripheral blood samples were collected from the patients and control groups. Serum FSTL-1 levels were measured using an enzyme-linked immunosorbent assay. The disease activity was assessed using the Behçet’s Disease Current Activity Form (BDCAF). Results A comparison of serum FSTL-1 levels in the patient and control groups found significantly higher levels of FSTL-1 in the patient group. Serum FSTL-1 levels were significantly higher in female patients compared with male patients. Female patients exhibited significantly higher BDCAF scores compared with male patients (p=0.008). Erythrocyte sedimentation rate and serum FSTL-1 levels were positively correlated. Conclusion Serum FSTL-1 levels may play a role in the aetiopathogenesis of BD and can also be a useful biomarker for determining disease activity.
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来源期刊
Aktuelle Rheumatologie
Aktuelle Rheumatologie 医学-风湿病学
CiteScore
0.30
自引率
0.00%
发文量
135
审稿时长
>12 weeks
期刊介绍: Immer auf dem Laufenden: - Kontinuierliche Fort- und Weiterbildung - Themenhefte mit Übersichtsarbeiten - Originalarbeiten zum Stand der Forschung - Informationen über neueste Entwicklungen Für Sie notiert - Nachrichten aus dem Fachgebiet - Aktuelle Literatur kurz referiert Das ganze Spektrum rheumatischer Erkrankungen aus internistischer und orthopädischer Sicht: - Interdisziplinär - Kompetent - Praxisnah
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